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Research ArticleINFLAMMATION AND IMMUNOPHARMACOLOGY

Resveratrol Modulates Arachidonic Acid Release, Prostaglandin Synthesis, and 3T6 Fibroblast Growth

Juan J. Moreno
Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 333-338;
Juan J. Moreno
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Abstract

Previous results suggested that the cyclooxygenase-2 pathway and prostaglandins might modulate 3T6 fibroblast growth. This study shows the effect of resveratrol on the main elements of arachidonic acid (AA) cascade and 3T6 fibroblast growth. The polyphenol reduced the reactive oxygen species production stimulated by fetal calf serum or platelet-derived growth factor, as well as phospholipase A2activity translocation and the subsequent [3H]AA release and prostaglandin E2 synthesis induced by these growth factors. A Western blot analysis demonstrated that cyclooxygenase-2 induction stimulated by fetal calf serum or platelet-derived growth factor was inhibited by resveratrol. The effects of resveratrol on AA cascade were correlated with an impairment of 3T6 fibroblast proliferation and DNA synthesis. These results suggest that reactive oxygen species and AA, and/or prostaglandins such as prostaglandin E2 might be involved in the control of 3T6 fibroblast growth by resveratrol.

Footnotes

  • Send reprint requests to: Dr. Juan J. Moreno, Departamento de Fisiologı́a, Facultad de Farmacia, Universidad de Barcelona, Avda. Joan XXIII s/n, E-08028 Barcelona, Spain. E-mail:moreno{at}farmacia.far.ub.es

  • ↵1 This study was supported by Spanish Ministry of Education Grants PM97-0110 and PM98-0191.

  • Abbreviations:
    AA
    arachidonic acid
    PLA2
    phospholipase A2
    COX
    cyclooxygenase
    PG
    prostaglandin
    FCS
    fetal calf serum
    PDGF
    platelet-derived growth factor
    ROS
    reactive oxygenated species
    DCFL-DA
    2′,7′-dichlorofluorescein diacetate
    • Received December 3, 1999.
    • Accepted April 10, 2000.
  • The American Society for Pharmacology and Experimental Therapeutics
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Journal of Pharmacology and Experimental Therapeutics: 294 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 294, Issue 1
1 Jul 2000
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Research ArticleINFLAMMATION AND IMMUNOPHARMACOLOGY

Resveratrol Modulates Arachidonic Acid Release, Prostaglandin Synthesis, and 3T6 Fibroblast Growth

Juan J. Moreno
Journal of Pharmacology and Experimental Therapeutics July 1, 2000, 294 (1) 333-338;

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Research ArticleINFLAMMATION AND IMMUNOPHARMACOLOGY

Resveratrol Modulates Arachidonic Acid Release, Prostaglandin Synthesis, and 3T6 Fibroblast Growth

Juan J. Moreno
Journal of Pharmacology and Experimental Therapeutics July 1, 2000, 294 (1) 333-338;
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