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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

July 01, 2000; Volume 294,Issue 1

PERSPECTIVES IN PHARMACOLOGY

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    Endocannabinoids and Vascular Function
    Cecilia J. Hillard
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 27-32;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Organic Anion-Transporting Polypeptides Mediate Transport of Opioid Peptides across Blood-Brain Barrier
    Bo Gao, Bruno Hagenbuch, Gerd A. Kullak-Ublick, Dietmar Benke, Adriano Aguzzi and Peter J. Meier
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 73-79;
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    Phenacetin Deacetylase Activity in Human Liver Microsomes: Distribution, Kinetics, and Chemical Inhibition and Stimulation
    Shoji Kudo, Ken Umehara, Masakiyo Hosokawa, Gohachiro Miyamoto, Kan Chiba and Tetsuo Satoh
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 80-88;
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    Inhibition of Human Cytochrome P450 Enzymes by Constituents of St. John's Wort, an Herbal Preparation Used in the Treatment of Depression
    R. Scott Obach
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 88-95;
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    Chronic Oral Administration of ATP Modulates Nucleoside Transport and Purine Metabolism in Rats
    Ketty Kichenin and Michel Seman
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 126-133;
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    The Effects of Cocaine and Nicotine on Amino Acid Transport across the Human Placental Cotyledon Perfused In Vitro
    Aleksandra Pastrakuljic, Lidia O. Derewlany, Brenda Knie and Gideon Koren
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 141-146;
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    Persistent Expression of 3-Methylcholanthrene-Inducible Cytochromes P4501A in Rat Hepatic and Extrahepatic Tissues
    Bhagavatula Moorthy
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 313-322;
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    Quantification of Pharmacodynamic Interactions between Dexmedetomidine and Midazolam in the Rat
    Cornelis J. J. G. Bol, John P. W. Vogelaar, Jian-Ping Tang and Jaap W. Mandema
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 347-355;

CARDIOVASCULAR

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    Z-338 Facilitates Acetylcholine Release from Enteric Neurons Due to Blockade of Muscarinic Autoreceptors in Guinea Pig Stomach
    Masayuki Ogishima, Muneshige Kaibara, Shigeru Ueki, Tadashi Kurimoto and Kohtaro Taniyama
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 33-37;
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    Effect of Allelic Polymorphism of the B1 and B2 Receptor Genes on the Contractile Responses of the Human Umbilical Vein to Kinins
    Steeve Houle, Michelle Landry, Ritchie Audet, Johanne Bouthillier, Dimcho R. Bachvarov and François Marceau
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 45-51;
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    Tachykinin Receptor Subtypes in the Isolated Guinea Pig Heart and Their Role in Mediating Responses to Neurokinin A
    Yingzi Chang, Donald B. Hoover, John C. Hancock and Frank M. Smith
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 147-154;
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    Differential Inhibition of the Prejunctional Actions of Angiotensin II in Rat Atria by Valsartan, Irbesartan, Eprosartan, and Losartan
    Suraj S. Shetty and Dominick DelGrande
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 179-186;
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    A Molecular Model of Agonist and Nonpeptide Antagonist Binding to the Human V1 Vascular Vasopressin Receptor
    Marc Thibonnier, Patrick Coles, Doreen M. Conarty, Christine L. Plesnicher and Menachem Shoham
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 195-203;
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    Effects ofN G-Monomethyl-l-arginine on Ca2+ Current and Nitric-Oxide Synthase in Rat Ventricular Myocytes
    Shigeji Matsumoto, Toshiaki Takahashi, Mizuho Ikeda, Toshimi Nishikawa, Shinki Yoshida and Tomoyuki Kawase
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 216-223;
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    Brainstem Nicotinic Receptor Subtypes That Influence Intragastric and Arterial Blood Pressures
    Manuel Ferreira, Anu Singh, Kenneth L. Dretchen, Kenneth J. Kellar and Richard A. Gillis
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 230-238;
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    Angiotensin-Converting Enzyme-Independent Angiotensin Formation in a Human Model of Myocardial Ischemia: Modulation of Norepinephrine Release by Angiotensin Type 1 and Angiotensin Type 2 Receptors
    Ryushi Maruyama, Eiichiro Hatta, Keishu Yasuda, Neil C. E. Smith and Roberto Levi
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 248-254;
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    Metabolism of Bradykinin In Vivo in Humans: Identification of BK1-5 as a Stable Plasma Peptide Metabolite
    Laine J. Murphey, David L. Hachey, John A. Oates, Jason D. Morrow and Nancy J. Brown
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 263-269;
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    Inhibitory Effects of Vesnarinone on Cloned Cardiac Delayed Rectifier K+ Channels Expressed in a Mammalian Cell Line
    Yusuke Katayama, Akikazu Fujita, Tohru Ohe, Ian Findlay and Yoshihisa Kurachi
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 339-346;
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    Cardiac Peroxynitrite Formation and Left Ventricular Dysfunction following Doxorubicin Treatment in Mice
    David M. Weinstein, Michael John Mihm and John Anthony Bauer
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 396-401;

CELLULAR AND MOLECULAR

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    Amylin Receptor Phenotypes Derived from Human Calcitonin Receptor/RAMP Coexpression Exhibit Pharmacological Differences Dependent on Receptor Isoform and Host Cell Environment
    Nanda Tilakaratne, George Christopoulos, Emma T. Zumpe, Steven M. Foord and Patrick M. Sexton
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 61-72;
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    MK-886, a Leukotriene Biosynthesis Inhibitor, as an Activator of Ca2+ Mobilization in Madin-Darby Canine Kidney (MDCK) Cells
    Chung-Ren Jan and Ching-Jiunn Tseng
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 96-102;
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    Adrenal Glucocorticoids Modulate [3H]Cyclic AMP Binding to Protein Kinase A (PKA), Cyclic AMP-Dependent PKA Activity, and Protein Levels of Selective Regulatory and Catalytic Subunit Isoforms of PKA in Rat Brain
    Yogesh Dwivedi and Ghanshyam N. Pandey
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 103-116;
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    CB1 Cannabinoid Receptor-Mediated Cell Migration
    Zhao-Hui Song and Miao Zhong
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 204-209;
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    Depletion of Natriuretic Peptide C Receptors Eliminates Inhibitory Effects of C-Type Natriuretic Peptide on Evoked Neurotransmitter Efflux
    George J. Trachte
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 210-215;

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Biospecific Interaction Analysis (BIA) of Low-Molecular Weight DNA-Binding Drugs
    Roberto Gambari, Giordana Feriotto, Cristina Rutigliano, Nicoletta Bianchi and Carlo Mischiati
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 370-377;
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    Detoxication of Vinca Alkaloids by Human P450 CYP3A4-Mediated Metabolism: Implications for the Development of Drug Resistance
    Denggao Yao, Shaohong Ding, Brian Burchell, C. Roland Wolf and Thomas Friedberg
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 387-395;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Involvement of a Receptor-Mediated Component in Cellular Translocation of Riboflavin
    Se-Ne Huang and Peter W. Swaan
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 117-125;
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    Nitric Oxide from Enteric Nerves Acts by a Different Mechanism from Myogenic Nitric Oxide in Canine Lower Esophageal Sphincter
    Edwin E. Daniel, Jennifer Jury, Anne Marie Salapatek, Tim Bowes, Annette Lam, Shoba Thomas, Michelle Ramnarain, Vicky Nguyen and Valerie Mistry
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 270-279;
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    Nicotinic Acetylcholine Receptors at Sites of Neurotransmitter Release to the Guinea Pig Intestinal Circular Muscle
    David A. Schneider, Mike Perrone and James J. Galligan
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 363-369;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Effect of Lipoteichoic Acid on Dermal Vascular Permeability in Mice
    Keiji Wada, Emiko Fujii, Hiroyasu Ishida, Toshimasa Yoshioka and Takamura Muraki
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 280-286;
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    Tissue Distribution and Clinical Monitoring of the Novel Macrolide Immunosuppressant SDZ-RAD and Its Metabolites in Monkey Lung Transplant Recipients: Interaction with Cyclosporine
    Natalie Serkova, Bernard Hausen, Gerald J. Berry, Wolfgang Jacobsen, Leslie Z. Benet, Randall E. Morris and Uwe Christians
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 323-332;
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    Resveratrol Modulates Arachidonic Acid Release, Prostaglandin Synthesis, and 3T6 Fibroblast Growth
    Juan J. Moreno
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 333-338;

NEUROPHARMACOLOGY

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    Evidence for Y1-Receptor-Mediated Facilitatory, Modulatory Cotransmission by NPY in the Rat Anococcygeus Muscle
    Yolanda Hoyo, John C. McGrath and Elisabet Vila
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 38-44;
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    Induction of cAMP Response Element Modulator (CREM) and Inducible cAMP Early Repressor (ICER) Expression in Rat Brain by UncompetitiveN-Methyl-d-aspartate Receptor Antagonists
    Markus Storvik, Anni-Maija Lindén, Outi Kontkanen, Merja Lakso, Eero Castrén and Garry Wong
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 52-60;
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    Iron-Mediated Free Radical Injury in Ethanol-Exposed Mouse Neural Crest Cells
    Shao-yu Chen and Kathleen K. Sulik
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 134-140;
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    Chronic l-α-Acetylmethadol (LAAM) in Rhesus Monkeys: Tolerance and Cross-Tolerance to the Antinociceptive, Ventilatory, and Rate-Decreasing Effects of Opioids
    Michael R. Brandt and Charles P. France
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 168-178;
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    Biochemical and Neurobehavioral Profile of CHF2819, a Novel, Orally Active Acetylcholinesterase Inhibitor for Alzheimer's Disease
    Luigia Trabace, Tommaso Cassano, Luca Steardo, Claudio Pietra, Gino Villetti, Keith M. Kendrick and Vincenzo Cuomo
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 187-194;
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    An Investigation of the Uroselective Properties of Four Novel α1a-Adrenergic Receptor Subtype-Selective Antagonists
    Virginia L. Pulito, Xiaobing Li, Sally S. Varga, Linda S. Mulcahy, Kerry S. Clark, Sheridan A. Halbert, Allen B. Reitz, William V. Murray and Linda K. Jolliffe
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 224-229;
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    Effects of Cocaine Self-Administration on Plasma Corticosterone and Prolactin in Rats
    John R. Mantsch, Stefan D. Schlussman, Ann Ho and Mary Jeanne Kreek
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 239-247;
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    Microinjection of Nociceptin (Orphanin FQ) into Nucleus Tractus Solitarii Elevates Blood Pressure and Heart Rate in Both Anesthetized and Conscious Rats
    Limin Mao and John Q. Wang
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 255-262;
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    Mechanisms ofN-Methyl-d-aspartate-Induced Apoptosis in Phencyclidine-Treated Cultured Forebrain Neurons
    Cheng Wang, Joel A. Kaufmann, Monica G. Sanchez-Ross and Kenneth M. Johnson
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 287-295;
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    Coadministration of 5-Hydroxytryptamine1AAntagonist WAY-100635 Prevents Fluoxetine-Induced Desensitization of Postsynaptic 5-Hydroxytryptamine1A Receptors in Hypothalamus
    Florence Serres, Nancy A. Muma, Daní K. Raap, Francisca Garcia, George Battaglia and Louis D. Van de Kar
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 296-301;
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    Multiple Cellular Mechanisms Mediate the Effect of Lobeline on the Release of Norepinephrine
    Ernô Sántha, Beáta Sperlágh, Tibor Zelles, Gabriella Zsilla, Péter T. Tóth, Balázs Lendvai, Mária Baranyi and E. Sylvester Vizi
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 302-307;
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    Characterization of the α2-Adrenoceptor Subtype, Which Functions as α2-Autoreceptor in Human Neocortex
    Thomas J. Feuerstein, Boris Huber, Jan Vetter, Heike Aranda, Vera Van Velthoven and Norbert Limberger
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 356-362;
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    Neuroprotective Efficacy and Therapeutic Window of the High-Affinity N-Methyl-d-aspartate Antagonist Conantokin-G: In Vitro (Primary Cerebellar Neurons) and In Vivo (Rat Model of Transient Focal Brain Ischemia) Studies
    Anthony J. Williams, Jitendra R. Dave, James B. Phillips, Yu Lin, R. Tyler McCabe and Frank C. Tortella
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 378-386;

THE 2000 ASPET OTTO KRAYER AWARD LECTURE

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    Neuroreceptors and Ion Channels as the Basis for Drug Action: Past, Present, and Future
    Toshio Narahashi
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 1-26;

TOXICOLOGY

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    Effect of Oral and IntravenousS,N-Diacetylcysteine Monoethyl Ester on Circulating and Hepatic Sulfhydryls in the Rat
    Ignazio Grattagliano, Gianluigi Vendemiale, Veronika B. Deiss, Edith Junker and Bernhard H. Lauterburg
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 155-159;
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    Hepatotoxicity of Tacrine: Occurrence of Membrane Fluidity Alterations without Involvement of Lipid Peroxidation
    Milagros Galisteo, Mary Rissel, Odile Sergent, Martine Chevanne, Josiane Cillard, André Guillouzo and Dominique Lagadic-Gossmann
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 160-167;
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    Effect of Methoxychlor Administration to Male Rats on Hepatic, Microsomal Iodothyronine 5′-Deiodinase, Form I
    Shana L. Morrell, James A. Fuchs and Jordan L. Holtzman
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 308-312;

ASPET MEETING REPORT

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    Meeting Report of the ASPET-Ray Fuller Symposium: Insulin Resistance in Diabetes and Hypertension: Syndrome X and Beyond
    Helmut Steinberg
    Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 402-406;
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Journal of Pharmacology and Experimental Therapeutics: 294 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 294, Issue 1
1 Jul 2000
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  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • THE 2000 ASPET OTTO KRAYER AWARD LECTURE
  • TOXICOLOGY
  • ASPET MEETING REPORT
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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