Journal of Pharmacology and Experimental Therapeutics: 294 (1)

July 01, 2000; Volume 294,Issue 1

PERSPECTIVES IN PHARMACOLOGY

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Endocannabinoids and Vascular Function
Cecilia J. Hillard

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 27-32;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Organic Anion-Transporting Polypeptides Mediate Transport of Opioid Peptides across Blood-Brain Barrier
Bo Gao, Bruno Hagenbuch, Gerd A. Kullak-Ublick, Dietmar Benke, Adriano Aguzzi and Peter J. Meier

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 73-79;
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Phenacetin Deacetylase Activity in Human Liver Microsomes: Distribution, Kinetics, and Chemical Inhibition and Stimulation
Shoji Kudo, Ken Umehara, Masakiyo Hosokawa, Gohachiro Miyamoto, Kan Chiba and Tetsuo Satoh

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 80-88;
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Inhibition of Human Cytochrome P450 Enzymes by Constituents of St. John's Wort, an Herbal Preparation Used in the Treatment of Depression
R. Scott Obach

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 88-95;
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Chronic Oral Administration of ATP Modulates Nucleoside Transport and Purine Metabolism in Rats
Ketty Kichenin and Michel Seman

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 126-133;
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The Effects of Cocaine and Nicotine on Amino Acid Transport across the Human Placental Cotyledon Perfused In Vitro
Aleksandra Pastrakuljic, Lidia O. Derewlany, Brenda Knie and Gideon Koren

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 141-146;
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Persistent Expression of 3-Methylcholanthrene-Inducible Cytochromes P4501A in Rat Hepatic and Extrahepatic Tissues
Bhagavatula Moorthy

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 313-322;
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Quantification of Pharmacodynamic Interactions between Dexmedetomidine and Midazolam in the Rat
Cornelis J. J. G. Bol, John P. W. Vogelaar, Jian-Ping Tang and Jaap W. Mandema

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 347-355;

CARDIOVASCULAR

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Z-338 Facilitates Acetylcholine Release from Enteric Neurons Due to Blockade of Muscarinic Autoreceptors in Guinea Pig Stomach
Masayuki Ogishima, Muneshige Kaibara, Shigeru Ueki, Tadashi Kurimoto and Kohtaro Taniyama

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 33-37;
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Effect of Allelic Polymorphism of the B₁ and B₂ Receptor Genes on the Contractile Responses of the Human Umbilical Vein to Kinins
Steeve Houle, Michelle Landry, Ritchie Audet, Johanne Bouthillier, Dimcho R. Bachvarov and François Marceau

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 45-51;
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Tachykinin Receptor Subtypes in the Isolated Guinea Pig Heart and Their Role in Mediating Responses to Neurokinin A
Yingzi Chang, Donald B. Hoover, John C. Hancock and Frank M. Smith

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 147-154;
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Differential Inhibition of the Prejunctional Actions of Angiotensin II in Rat Atria by Valsartan, Irbesartan, Eprosartan, and Losartan
Suraj S. Shetty and Dominick DelGrande

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 179-186;
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A Molecular Model of Agonist and Nonpeptide Antagonist Binding to the Human V₁ Vascular Vasopressin Receptor
Marc Thibonnier, Patrick Coles, Doreen M. Conarty, Christine L. Plesnicher and Menachem Shoham

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 195-203;
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Effects ofN ^G-Monomethyl-l-arginine on Ca²⁺ Current and Nitric-Oxide Synthase in Rat Ventricular Myocytes
Shigeji Matsumoto, Toshiaki Takahashi, Mizuho Ikeda, Toshimi Nishikawa, Shinki Yoshida and Tomoyuki Kawase

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 216-223;
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Brainstem Nicotinic Receptor Subtypes That Influence Intragastric and Arterial Blood Pressures
Manuel Ferreira, Anu Singh, Kenneth L. Dretchen, Kenneth J. Kellar and Richard A. Gillis

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 230-238;
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Angiotensin-Converting Enzyme-Independent Angiotensin Formation in a Human Model of Myocardial Ischemia: Modulation of Norepinephrine Release by Angiotensin Type 1 and Angiotensin Type 2 Receptors
Ryushi Maruyama, Eiichiro Hatta, Keishu Yasuda, Neil C. E. Smith and Roberto Levi

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 248-254;
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Metabolism of Bradykinin In Vivo in Humans: Identification of BK1-5 as a Stable Plasma Peptide Metabolite
Laine J. Murphey, David L. Hachey, John A. Oates, Jason D. Morrow and Nancy J. Brown

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 263-269;
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Inhibitory Effects of Vesnarinone on Cloned Cardiac Delayed Rectifier K⁺ Channels Expressed in a Mammalian Cell Line
Yusuke Katayama, Akikazu Fujita, Tohru Ohe, Ian Findlay and Yoshihisa Kurachi

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 339-346;
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Cardiac Peroxynitrite Formation and Left Ventricular Dysfunction following Doxorubicin Treatment in Mice
David M. Weinstein, Michael John Mihm and John Anthony Bauer

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 396-401;

CELLULAR AND MOLECULAR

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Amylin Receptor Phenotypes Derived from Human Calcitonin Receptor/RAMP Coexpression Exhibit Pharmacological Differences Dependent on Receptor Isoform and Host Cell Environment
Nanda Tilakaratne, George Christopoulos, Emma T. Zumpe, Steven M. Foord and Patrick M. Sexton

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 61-72;
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MK-886, a Leukotriene Biosynthesis Inhibitor, as an Activator of Ca²⁺ Mobilization in Madin-Darby Canine Kidney (MDCK) Cells
Chung-Ren Jan and Ching-Jiunn Tseng

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 96-102;
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Adrenal Glucocorticoids Modulate [³H]Cyclic AMP Binding to Protein Kinase A (PKA), Cyclic AMP-Dependent PKA Activity, and Protein Levels of Selective Regulatory and Catalytic Subunit Isoforms of PKA in Rat Brain
Yogesh Dwivedi and Ghanshyam N. Pandey

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 103-116;
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CB1 Cannabinoid Receptor-Mediated Cell Migration
Zhao-Hui Song and Miao Zhong

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 204-209;
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Depletion of Natriuretic Peptide C Receptors Eliminates Inhibitory Effects of C-Type Natriuretic Peptide on Evoked Neurotransmitter Efflux
George J. Trachte

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 210-215;

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Biospecific Interaction Analysis (BIA) of Low-Molecular Weight DNA-Binding Drugs
Roberto Gambari, Giordana Feriotto, Cristina Rutigliano, Nicoletta Bianchi and Carlo Mischiati

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 370-377;
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Detoxication of Vinca Alkaloids by Human P450 CYP3A4-Mediated Metabolism: Implications for the Development of Drug Resistance
Denggao Yao, Shaohong Ding, Brian Burchell, C. Roland Wolf and Thomas Friedberg

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 387-395;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Involvement of a Receptor-Mediated Component in Cellular Translocation of Riboflavin
Se-Ne Huang and Peter W. Swaan

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 117-125;
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Nitric Oxide from Enteric Nerves Acts by a Different Mechanism from Myogenic Nitric Oxide in Canine Lower Esophageal Sphincter
Edwin E. Daniel, Jennifer Jury, Anne Marie Salapatek, Tim Bowes, Annette Lam, Shoba Thomas, Michelle Ramnarain, Vicky Nguyen and Valerie Mistry

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 270-279;
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Nicotinic Acetylcholine Receptors at Sites of Neurotransmitter Release to the Guinea Pig Intestinal Circular Muscle
David A. Schneider, Mike Perrone and James J. Galligan

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 363-369;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Effect of Lipoteichoic Acid on Dermal Vascular Permeability in Mice
Keiji Wada, Emiko Fujii, Hiroyasu Ishida, Toshimasa Yoshioka and Takamura Muraki

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 280-286;
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Tissue Distribution and Clinical Monitoring of the Novel Macrolide Immunosuppressant SDZ-RAD and Its Metabolites in Monkey Lung Transplant Recipients: Interaction with Cyclosporine
Natalie Serkova, Bernard Hausen, Gerald J. Berry, Wolfgang Jacobsen, Leslie Z. Benet, Randall E. Morris and Uwe Christians

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 323-332;
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Resveratrol Modulates Arachidonic Acid Release, Prostaglandin Synthesis, and 3T6 Fibroblast Growth
Juan J. Moreno

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 333-338;

NEUROPHARMACOLOGY

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Evidence for Y1-Receptor-Mediated Facilitatory, Modulatory Cotransmission by NPY in the Rat Anococcygeus Muscle
Yolanda Hoyo, John C. McGrath and Elisabet Vila

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 38-44;
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Induction of cAMP Response Element Modulator (CREM) and Inducible cAMP Early Repressor (ICER) Expression in Rat Brain by UncompetitiveN-Methyl-d-aspartate Receptor Antagonists
Markus Storvik, Anni-Maija Lindén, Outi Kontkanen, Merja Lakso, Eero Castrén and Garry Wong

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 52-60;
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Iron-Mediated Free Radical Injury in Ethanol-Exposed Mouse Neural Crest Cells
Shao-yu Chen and Kathleen K. Sulik

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 134-140;
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Chronic l-α-Acetylmethadol (LAAM) in Rhesus Monkeys: Tolerance and Cross-Tolerance to the Antinociceptive, Ventilatory, and Rate-Decreasing Effects of Opioids
Michael R. Brandt and Charles P. France

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 168-178;
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Biochemical and Neurobehavioral Profile of CHF2819, a Novel, Orally Active Acetylcholinesterase Inhibitor for Alzheimer's Disease
Luigia Trabace, Tommaso Cassano, Luca Steardo, Claudio Pietra, Gino Villetti, Keith M. Kendrick and Vincenzo Cuomo

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 187-194;
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An Investigation of the Uroselective Properties of Four Novel α_1a-Adrenergic Receptor Subtype-Selective Antagonists
Virginia L. Pulito, Xiaobing Li, Sally S. Varga, Linda S. Mulcahy, Kerry S. Clark, Sheridan A. Halbert, Allen B. Reitz, William V. Murray and Linda K. Jolliffe

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 224-229;
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Effects of Cocaine Self-Administration on Plasma Corticosterone and Prolactin in Rats
John R. Mantsch, Stefan D. Schlussman, Ann Ho and Mary Jeanne Kreek

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 239-247;
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Microinjection of Nociceptin (Orphanin FQ) into Nucleus Tractus Solitarii Elevates Blood Pressure and Heart Rate in Both Anesthetized and Conscious Rats
Limin Mao and John Q. Wang

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 255-262;
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Mechanisms ofN-Methyl-d-aspartate-Induced Apoptosis in Phencyclidine-Treated Cultured Forebrain Neurons
Cheng Wang, Joel A. Kaufmann, Monica G. Sanchez-Ross and Kenneth M. Johnson

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 287-295;
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Coadministration of 5-Hydroxytryptamine_1AAntagonist WAY-100635 Prevents Fluoxetine-Induced Desensitization of Postsynaptic 5-Hydroxytryptamine_1A Receptors in Hypothalamus
Florence Serres, Nancy A. Muma, Daní K. Raap, Francisca Garcia, George Battaglia and Louis D. Van de Kar

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 296-301;
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Multiple Cellular Mechanisms Mediate the Effect of Lobeline on the Release of Norepinephrine
Ernô Sántha, Beáta Sperlágh, Tibor Zelles, Gabriella Zsilla, Péter T. Tóth, Balázs Lendvai, Mária Baranyi and E. Sylvester Vizi

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 302-307;
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Characterization of the α₂-Adrenoceptor Subtype, Which Functions as α₂-Autoreceptor in Human Neocortex
Thomas J. Feuerstein, Boris Huber, Jan Vetter, Heike Aranda, Vera Van Velthoven and Norbert Limberger

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 356-362;
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Neuroprotective Efficacy and Therapeutic Window of the High-Affinity N-Methyl-d-aspartate Antagonist Conantokin-G: In Vitro (Primary Cerebellar Neurons) and In Vivo (Rat Model of Transient Focal Brain Ischemia) Studies
Anthony J. Williams, Jitendra R. Dave, James B. Phillips, Yu Lin, R. Tyler McCabe and Frank C. Tortella

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 378-386;

THE 2000 ASPET OTTO KRAYER AWARD LECTURE

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Neuroreceptors and Ion Channels as the Basis for Drug Action: Past, Present, and Future
Toshio Narahashi

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 1-26;

TOXICOLOGY

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Effect of Oral and IntravenousS,N-Diacetylcysteine Monoethyl Ester on Circulating and Hepatic Sulfhydryls in the Rat
Ignazio Grattagliano, Gianluigi Vendemiale, Veronika B. Deiss, Edith Junker and Bernhard H. Lauterburg

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 155-159;
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Hepatotoxicity of Tacrine: Occurrence of Membrane Fluidity Alterations without Involvement of Lipid Peroxidation
Milagros Galisteo, Mary Rissel, Odile Sergent, Martine Chevanne, Josiane Cillard, André Guillouzo and Dominique Lagadic-Gossmann

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 160-167;
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Effect of Methoxychlor Administration to Male Rats on Hepatic, Microsomal Iodothyronine 5′-Deiodinase, Form I
Shana L. Morrell, James A. Fuchs and Jordan L. Holtzman

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 308-312;

ASPET MEETING REPORT

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Meeting Report of the ASPET-Ray Fuller Symposium: Insulin Resistance in Diabetes and Hypertension: Syndrome X and Beyond
Helmut Steinberg

Journal of Pharmacology and Experimental Therapeutics July 2000, 294 (1) 402-406;

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

THE 2000 ASPET OTTO KRAYER AWARD LECTURE

TOXICOLOGY

ASPET MEETING REPORT

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