Journal of Pharmacology and Experimental Therapeutics: 293 (3)

June 01, 2000; Volume 293,Issue 3

PERSPECTIVES IN PHARMACOLOGY

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Combinatorial Chemistry and Contemporary Pharmacology
John S. Lazo and Peter Wipf

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 705-709;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Computational Model of Intracellular Pharmacokinetics of Paclitaxel
Hyo-Jeong Kuh, Seong Hoon Jang, M. Guillaume Wientjes and Jessie L.-S. Au

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 761-770;
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AIT-082, a Cognitive Enhancer, Is Transported into Brain by a Nonsaturable Influx Mechanism and out of Brain by a Saturable Efflux Mechanism
Eve M. Taylor, Rongzi Yan, Nils Hauptmann, Timothy J. Maher, Daniela Djahandideh and Alvin J. Glasky

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 813-821;
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Evaluation of a Minimal Experimental Design for Determination of Enzyme Kinetic Parameters and Inhibition Mechanism
Tarundeep Kakkar, Yvonne Pak and Michael Mayersohn

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 861-869;
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Catalytic Antibodies that Hydrolyze (−)-Cocaine Obtained by a High-Throughput Procedure
John R. Cashman, Clifford E. Berkman and Gail E. Underiner

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 952-961;
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Preclinical and Clinical Evidence for Disappearance of Long-Circulating Characteristics of Polyethylene Glycol Liposomes at Low Lipid Dose
Peter Laverman, Adrienne H. Brouwers, Els Th. M. Dams, Wim J. G. Oyen, Gert Storm, Nico van Rooijen, Frans H. M. Corstens and Otto C. Boerman

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 996-1001;
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Latent Overexpression of Hepatic CYP2C7 in Adult Male and Female Rats Neonatally Exposed to Phenobarbital: A Developmental Profile of Gender-Dependent P450s
Arun K. Agrawal and Bernard H. Shapiro

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 1027-1033;
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Trans-Stimulation Effects of Folic Acid Derivatives on Methotrexate Transport by Rat Renal Organic Anion Transporter, OAT-K1
Ayako Takeuchi, Satohiro Masuda, Hideyuki Saito, Yukiya Hashimoto and Ken-ichi Inui

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 1034-1039;
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Activity-Dependent Neurotrophic Factor: Intranasal Administration of Femtomolar-Acting Peptides Improve Performance in a Water Maze
Illana Gozes, Eliezer Giladi, Albert Pinhasov, Amos Bardea and Douglas E. Brenneman

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 1091-1098;
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Inactivation of Hepatic CYP2E1 by an Epoxide of Diallyl Sulfone
Peter D. Premdas, Raymond J. Bowers and Poh-Gek Forkert

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 1112-1120;

CARDIOVASCULAR

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Characterization of Contractile P2 Receptors in Human Coronary Arteries by Use of the Stable Pyrimidines Uridine 5′-O-Thiodiphosphate and Uridine 5′-O-3-Thiotriphosphate
Malin Malmsjö, Mingyan Hou, T. Kendall Harden, William Pendergast, Emil Pantev, Lars Edvinsson and David Erlinge

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 755-760;
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Down-Regulation of Vascular Endothelial Growth Factor Expression after A_2A Adenosine Receptor Activation in PC12 Pheochromocytoma Cells
Mark E. Olah and Francine L. Roudabush

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 779-787;
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Selective Vasopressin, Angiotensin II, or Dual Receptor Blockade with Developing Congestive Heart Failure
Mark J. Clair, Mary K. King, Aron T. Goldberg, Jennifer W. Hendrick, Riccardo Nisato, David M. Gay, Allison E. Morrison, James H. McElmurray, R. Stephen Krombach, Brian R. Bond, Catherine Cazaubon, Dino Nisato and Francis G. Spinale

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 852-860;
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Protective Effects of I₁-Antihypertensive Agent Moxonidine against Neurogenic Cardiac Arrhythmias in Halothane-Anesthetized Rabbits
Denise Poisson, Marie-Odile Christen and Frederic Sannajust

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 929-938;
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Intrarenal Effects of Ecadotril during Acute Volume Expansion in Dogs with Congestive Heart Failure
Philip Solter, David Sisson, William Thomas and Leopold Goetze

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 989-995;

CELLULAR AND MOLECULAR

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A Highly Conserved Aspartic Acid (Asp-155) Anchors the Terminal Amine Moiety of Tryptamines and Is Involved in Membrane Targeting of the 5-HT_2A Serotonin Receptor But Does Not Participate in Activation via a “Salt-Bridge Disruption” Mechanism
Kurt Kristiansen, Wesley K. Kroeze, David L. Willins, Edward I. Gelber, Jason E. Savage, Richard A. Glennon and Bryan L. Roth

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 735-746;
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Cloning of Rat Histamine H₃ Receptor Reveals Distinct Species Pharmacological Profiles
Timothy W. Lovenberg, Jayashree Pyati, Hong Chang, Sandy J. Wilson and Mark G. Erlander

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 771-778;
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Ca²⁺ Signaling via ς₁-Receptors: Novel Regulatory Mechanism Affecting Intracellular Ca²⁺Concentration
Teruo Hayashi, Tangui Maurice and Tsung-Ping Su

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 788-798;
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Cannabinoids Protect Cells from Oxidative Cell Death: A Receptor-Independent Mechanism
Yanqiu Chen and Jochen Buck

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 807-812;
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Ochratoxin A Induces JNK Activation and Apoptosis in MDCK-C7 Cells at Nanomolar Concentrations
Michael Gekle, Gerald Schwerdt, Ruth Freudinger, Sigrid Mildenberger, Doris Wilflingseder, Verena Pollack, Martina Dander and Herbert Schramek

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 837-844;
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Transporter-Mediated Release: A Superfusion Study on Human Embryonic Kidney Cells Stably Expressing the Human Serotonin Transporter
Petra Scholze, Julia Zwach, Alexandra Kattinger, Christian Pifl, Ernst A. Singer and Harald H. Sitte

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 870-878;
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Receptor-Mediated Inhibition of Keratinocyte Migration by Nicotine Involves Modulations of Calcium Influx and Intracellular Concentration
Shaheen Zia, Assane Ndoye, Tou X. Lee, Robert J. Webber and Sergei A. Grando

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 973-981;
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Tectoridins Modulate Skeletal and Cardiac Muscle Sarcoplasmic Reticulum Calcium-Release Channels
Keshore R. Bidasee, Anderson Maxwell, William F. Reynolds, Vimalkumar Patel and Henry R. Besch

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 1074-1083;

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Intravenous Cereport (RMP-7) Modifies Topographic Uptake Profile of Carboplatin within Rat Glioma and Brain surrounding Tumor, Elevates Platinum Levels, and Enhances Survival
Raymond T. Bartus, Pamela Snodgrass, Joanne Marsh, Mary Agostino, Alexis Perkins and Dwaine F. Emerich

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 903-911;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Expression and Localization of Multidrug Resistant Protein mrp2 in Rat Small Intestine
Aldo D. Mottino, Tim Hoffman, Lothar Jennes and Mary Vore

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 717-723;
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Effect of Ozone Treatment on Airway Reactivity and Epithelium-Derived Relaxing Factor in Guinea Pigs
Jeffrey S. Fedan, Lyndell L. Millecchia, Richard A. Johnston, Appavoo Rengasamy, Ann Hubbs, Richard D. Dey, Long-Xing Yuan, David Watson, W. Travis Goldsmith, Jeffrey S. Reynolds, Larry Orsini, Juanita Dortch-Carnes, Deborah Cutler and David G. Frazer

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 724-734;
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Role of the β₃-Adrenoceptor in Urine Storage in the Rat: Comparison between the Selective β₃-Adrenoceptor Agonist, CL316,243, and Various Smooth Muscle Relaxants
Hiroo Takeda, Yoshinobu Yamazaki, Masuo Akahane, Yasuhiko Igawa, Yukiyoshi Ajisawa and Osamu Nishizawa

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 939-945;
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Subsensitivity to Opioids Is Receptor-Specific in Isolated Guinea Pig Ileum and Mouse Vas Deferens after Obstructive Cholestasis
Ahmad R. Dehpour, Hossein Rastegar, Masoumeh Jorjani, Farshad Roushanzamir, Khojasteh Joharchi and Abolhasan Ahmadiani

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 946-951;
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Inhibitory Effects of AE0047, a New Dihydropyridine Ca²⁺ Channel Blocker, on Renal Nerve Stimulation-Induced Renal Actions in Anesthetized Dogs
Tomoyuki Yamasaki, Masaji Ohmagari, Isao Tamai, Kazutaka Hayashi and Yasuo Matsumura

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 1040-1047;
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Intracisternal Injection of Somatostatin Receptor 5-Preferring Agonists Induces a Vagal Cholinergic Stimulation of Gastric Emptying in Rats
Vicente Martínez, Jean Rivier, David Coy and Yvette Taché

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 1099-1105;
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Effect of Novel Motilide ABT-229 versus Erythromycin and Cisapride on Gastric Emptying in Dogs
Verne E. Cowles, Hugh N. Nellans, Terese R. Seifert, Leslie M. Besecke, Jason A. Segreti, Kurt M. Mohning, Ramin Faghih, Marleen H. Verlinden and Craig D. Wegner

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 1106-1111;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Alkanols Inhibit Respiration of Intact Mitochondria and Display Cutoff Similar to That Measured In Vivo
David G. Hammond and Isao Kubo

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 822-828;
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Isoprostanes, Novel Eicosanoids That Produce Nociception and Sensitize Rat Sensory Neurons
Angela R. Evans, Heidi Junger, Michael D. Southall, Grant D. Nicol, Linda S. Sorkin, James T. Broome, Timothy W. Bailey and Michael R. Vasko

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 912-920;

NEUROPHARMACOLOGY

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Mechanisms and Sites of Ocular Action of 7-Hydroxy-2-dipropylaminotetralin: A Dopamine₃ Receptor Agonist
Eugenia Chu, Teh-Ching Chu and David E. Potter

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 710-716;
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Geometry and Charge Determine Pharmacological Effects of Steroids on N-Methyl-d-aspartate Receptor-Induced Ca²⁺ Accumulation and Cell Death
Charles E. Weaver, Michele B. Land, Robert H. Purdy, Kyle G. Richards, Terrell T. Gibbs and David H. Farb

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 747-754;
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Role of Corticotropin-Releasing Factor (CRF) Receptors in the Anorexic Syndrome Induced by CRF
Mary Ann Pelleymounter, Margaret Joppa, Michelle Carmouche, Mary Jane Cullen, Brock Brown, Brian Murphy, Dimitri E. Grigoriadis, Nick Ling and Alan C. Foster

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 799-806;
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Effects of Cholinomimetic Injection into the Brain Stem Reticular Formation on Halothane Anesthesia and Antinociception in Rats
Yumiko Ishizawa, Hai-Chun Ma, Shuji Dohi and Hiroyuki Shimonaka

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 845-851;
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Influence of Ovarian Hormones and Estrous Cycle on the Behavioral Response to Cocaine in Female Rats
Stacy L. Sell, Joanne M. Scalzitti, Mary L. Thomas and Kathryn A. Cunningham

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 879-886;
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Single-Cell Recombinant Pharmacology: Bovine α_1a-Adrenoceptors in Rat-1 Fibroblasts Release Intracellular Ca²⁺, Display Subtype-Characteristic Agonism and Antagonism, and Exhibit an Antagonist-Reversible Inverse Concentration-Response Phase
John Daniel Pediani, Janet Fraser MacKenzie, Robert Paul Heeley, Craig James Daly and John Christie McGrath

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 887-895;
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Effects of Aniracetam on Bladder Overactivity in Rats with Cerebral Infarction
Yasushi Nakada, Osamu Yokoyama, Kazuto Komatsu, Koichi Kodama, Satoshi Yotsuyanagi, Susumu Niikura, Yasuhiro Nagasaka and Mikio Namiki

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 921-928;
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Dextromethorphan and Its Metabolite Dextrorphan Block α3β4 Neuronal Nicotinic Receptors ,
Susan C. Hernandez, Maria Bertolino, Yingxian Xiao, Kenneth E. Pringle, Frank S. Caruso and Kenneth J. Kellar

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 962-967;
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μ-Opioid Receptor Knockout Mice Do Not Self-Administer Alcohol ,
Amanda J. Roberts, Jeffrey S. McDonald, Charles J. Heyser, Brigitte L. Kieffer, Hans W. D. Matthes, George F. Koob and Lisa H. Gold

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 1002-1008;
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Enantioselectivity of Pregnanolone-Induced γ-Aminobutyric Acid_A Receptor Modulation and Anesthesia
Douglas F. Covey, Devi Nathan, Melissa Kalkbrenner, Kent R. Nilsson, Yuefei Hu, Charles F. Zorumski and Alex S. Evers

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 1009-1016;
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Dissociation of Cocaine-Antagonist Properties and Motoric Effects of the D1 Receptor Partial Agonists SKF 83959 and SKF 77434
Donna M. Platt, James K. Rowlett and Roger D. Spealman

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 1017-1026;
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S33084, a Novel, Potent, Selective, and Competitive Antagonist at Dopamine D₃-Receptors: I. Receptorial, Electrophysiological and Neurochemical Profile Compared with GR218,231 and L741,626
Mark J. Millan, Alain Gobert, Adrian Newman-Tancredi, Françoise Lejeune, Didier Cussac, Jean-Michel Rivet, Valérie Audinot, Thierry Dubuffet and Gilbert Lavielle

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 1048-1062;
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S33084, a Novel, Potent, Selective, and Competitive Antagonist at Dopamine D₃-Receptors: II. Functional and Behavioral Profile Compared with GR218,231 and L741,626
Mark J. Millan, Anne Dekeyne, Jean-Michel Rivet, Thierry Dubuffet, Gilbert Lavielle and Mauricette Brocco

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 1063-1073;
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γ-Aminobutyric Acid_A (GABA_A) Agonist 4,5,6,7-Tetrahydroisoxazolo[4,5-c]pyridin-3-ol Persistently Increases Sleep Maintenance and Intensity during Chronic Administration to Rats
Marike Lancel and Anke Langebartels

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 1084-1090;

TOXICOLOGY

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Reduction of Cisplatin Nephrotoxicity by Procainamide: Does the Formation of a Cisplatin-Procainamide Complex Play a Role?
Maurizio Viale, Maria Ornella Vannozzi, Ilaria Pastrone, Maria A. Mariggiò, Antonio Zicca, Angela Cadoni, Sergio Cafaggi, Giuseppina Tolino, Gianluigi Lunardi, Dario Civalleri, W. Edward Lindup and Mauro Esposito

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 829-836;
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Postnatal Developmental Delay and Supersensitivity to Organophosphate in Gene-Targeted Mice Lacking Acetylcholinesterase
Weihua Xie, Judith A. Stribley, Arnaud Chatonnet, Phillip J. Wilder, Angie Rizzino, Rodney D. McComb, Palmer Taylor, Steven H. Hinrichs and Oksana Lockridge

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 896-902;
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Oxidant Stress in Rat Liver after Lipopolysaccharide Administration: Effect of Inducible Nitric-Oxide Synthase Inhibition
Chaojie Zhang, Lisa M. Walker, Jack A. Hinson and Philip R. Mayeux

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 968-972;
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Reactive Oxygen Species-Induced Apoptosis in PC12 Cells and Protective Effect of Bilobalide
Li-Jun Zhou and Xing-Zu Zhu

Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 982-988;

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

TOXICOLOGY

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