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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

June 01, 2000; Volume 293,Issue 3

PERSPECTIVES IN PHARMACOLOGY

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    Combinatorial Chemistry and Contemporary Pharmacology
    John S. Lazo and Peter Wipf
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 705-709;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Computational Model of Intracellular Pharmacokinetics of Paclitaxel
    Hyo-Jeong Kuh, Seong Hoon Jang, M. Guillaume Wientjes and Jessie L.-S. Au
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 761-770;
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    AIT-082, a Cognitive Enhancer, Is Transported into Brain by a Nonsaturable Influx Mechanism and out of Brain by a Saturable Efflux Mechanism
    Eve M. Taylor, Rongzi Yan, Nils Hauptmann, Timothy J. Maher, Daniela Djahandideh and Alvin J. Glasky
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 813-821;
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    Evaluation of a Minimal Experimental Design for Determination of Enzyme Kinetic Parameters and Inhibition Mechanism
    Tarundeep Kakkar, Yvonne Pak and Michael Mayersohn
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 861-869;
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    Catalytic Antibodies that Hydrolyze (−)-Cocaine Obtained by a High-Throughput Procedure
    John R. Cashman, Clifford E. Berkman and Gail E. Underiner
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 952-961;
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    Preclinical and Clinical Evidence for Disappearance of Long-Circulating Characteristics of Polyethylene Glycol Liposomes at Low Lipid Dose
    Peter Laverman, Adrienne H. Brouwers, Els Th. M. Dams, Wim J. G. Oyen, Gert Storm, Nico van Rooijen, Frans H. M. Corstens and Otto C. Boerman
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 996-1001;
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    Latent Overexpression of Hepatic CYP2C7 in Adult Male and Female Rats Neonatally Exposed to Phenobarbital: A Developmental Profile of Gender-Dependent P450s
    Arun K. Agrawal and Bernard H. Shapiro
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 1027-1033;
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    Trans-Stimulation Effects of Folic Acid Derivatives on Methotrexate Transport by Rat Renal Organic Anion Transporter, OAT-K1
    Ayako Takeuchi, Satohiro Masuda, Hideyuki Saito, Yukiya Hashimoto and Ken-ichi Inui
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 1034-1039;
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    Activity-Dependent Neurotrophic Factor: Intranasal Administration of Femtomolar-Acting Peptides Improve Performance in a Water Maze
    Illana Gozes, Eliezer Giladi, Albert Pinhasov, Amos Bardea and Douglas E. Brenneman
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 1091-1098;
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    Inactivation of Hepatic CYP2E1 by an Epoxide of Diallyl Sulfone
    Peter D. Premdas, Raymond J. Bowers and Poh-Gek Forkert
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 1112-1120;

CARDIOVASCULAR

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    Characterization of Contractile P2 Receptors in Human Coronary Arteries by Use of the Stable Pyrimidines Uridine 5′-O-Thiodiphosphate and Uridine 5′-O-3-Thiotriphosphate
    Malin Malmsjö, Mingyan Hou, T. Kendall Harden, William Pendergast, Emil Pantev, Lars Edvinsson and David Erlinge
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 755-760;
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    Down-Regulation of Vascular Endothelial Growth Factor Expression after A2A Adenosine Receptor Activation in PC12 Pheochromocytoma Cells
    Mark E. Olah and Francine L. Roudabush
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 779-787;
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    Selective Vasopressin, Angiotensin II, or Dual Receptor Blockade with Developing Congestive Heart Failure
    Mark J. Clair, Mary K. King, Aron T. Goldberg, Jennifer W. Hendrick, Riccardo Nisato, David M. Gay, Allison E. Morrison, James H. McElmurray, R. Stephen Krombach, Brian R. Bond, Catherine Cazaubon, Dino Nisato and Francis G. Spinale
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 852-860;
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    Protective Effects of I1-Antihypertensive Agent Moxonidine against Neurogenic Cardiac Arrhythmias in Halothane-Anesthetized Rabbits
    Denise Poisson, Marie-Odile Christen and Frederic Sannajust
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 929-938;
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    Intrarenal Effects of Ecadotril during Acute Volume Expansion in Dogs with Congestive Heart Failure
    Philip Solter, David Sisson, William Thomas and Leopold Goetze
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 989-995;

CELLULAR AND MOLECULAR

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    A Highly Conserved Aspartic Acid (Asp-155) Anchors the Terminal Amine Moiety of Tryptamines and Is Involved in Membrane Targeting of the 5-HT2A Serotonin Receptor But Does Not Participate in Activation via a “Salt-Bridge Disruption” Mechanism
    Kurt Kristiansen, Wesley K. Kroeze, David L. Willins, Edward I. Gelber, Jason E. Savage, Richard A. Glennon and Bryan L. Roth
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 735-746;
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    Cloning of Rat Histamine H3 Receptor Reveals Distinct Species Pharmacological Profiles
    Timothy W. Lovenberg, Jayashree Pyati, Hong Chang, Sandy J. Wilson and Mark G. Erlander
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 771-778;
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    Ca2+ Signaling via ς1-Receptors: Novel Regulatory Mechanism Affecting Intracellular Ca2+Concentration
    Teruo Hayashi, Tangui Maurice and Tsung-Ping Su
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 788-798;
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    Cannabinoids Protect Cells from Oxidative Cell Death: A Receptor-Independent Mechanism
    Yanqiu Chen and Jochen Buck
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 807-812;
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    Ochratoxin A Induces JNK Activation and Apoptosis in MDCK-C7 Cells at Nanomolar Concentrations
    Michael Gekle, Gerald Schwerdt, Ruth Freudinger, Sigrid Mildenberger, Doris Wilflingseder, Verena Pollack, Martina Dander and Herbert Schramek
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 837-844;
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    Transporter-Mediated Release: A Superfusion Study on Human Embryonic Kidney Cells Stably Expressing the Human Serotonin Transporter
    Petra Scholze, Julia Zwach, Alexandra Kattinger, Christian Pifl, Ernst A. Singer and Harald H. Sitte
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 870-878;
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    Receptor-Mediated Inhibition of Keratinocyte Migration by Nicotine Involves Modulations of Calcium Influx and Intracellular Concentration
    Shaheen Zia, Assane Ndoye, Tou X. Lee, Robert J. Webber and Sergei A. Grando
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 973-981;
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    Tectoridins Modulate Skeletal and Cardiac Muscle Sarcoplasmic Reticulum Calcium-Release Channels
    Keshore R. Bidasee, Anderson Maxwell, William F. Reynolds, Vimalkumar Patel and Henry R. Besch
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 1074-1083;

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Intravenous Cereport (RMP-7) Modifies Topographic Uptake Profile of Carboplatin within Rat Glioma and Brain surrounding Tumor, Elevates Platinum Levels, and Enhances Survival
    Raymond T. Bartus, Pamela Snodgrass, Joanne Marsh, Mary Agostino, Alexis Perkins and Dwaine F. Emerich
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 903-911;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Expression and Localization of Multidrug Resistant Protein mrp2 in Rat Small Intestine
    Aldo D. Mottino, Tim Hoffman, Lothar Jennes and Mary Vore
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 717-723;
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    Effect of Ozone Treatment on Airway Reactivity and Epithelium-Derived Relaxing Factor in Guinea Pigs
    Jeffrey S. Fedan, Lyndell L. Millecchia, Richard A. Johnston, Appavoo Rengasamy, Ann Hubbs, Richard D. Dey, Long-Xing Yuan, David Watson, W. Travis Goldsmith, Jeffrey S. Reynolds, Larry Orsini, Juanita Dortch-Carnes, Deborah Cutler and David G. Frazer
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 724-734;
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    Role of the β3-Adrenoceptor in Urine Storage in the Rat: Comparison between the Selective β3-Adrenoceptor Agonist, CL316,243, and Various Smooth Muscle Relaxants
    Hiroo Takeda, Yoshinobu Yamazaki, Masuo Akahane, Yasuhiko Igawa, Yukiyoshi Ajisawa and Osamu Nishizawa
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 939-945;
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    Subsensitivity to Opioids Is Receptor-Specific in Isolated Guinea Pig Ileum and Mouse Vas Deferens after Obstructive Cholestasis
    Ahmad R. Dehpour, Hossein Rastegar, Masoumeh Jorjani, Farshad Roushanzamir, Khojasteh Joharchi and Abolhasan Ahmadiani
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 946-951;
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    Inhibitory Effects of AE0047, a New Dihydropyridine Ca2+ Channel Blocker, on Renal Nerve Stimulation-Induced Renal Actions in Anesthetized Dogs
    Tomoyuki Yamasaki, Masaji Ohmagari, Isao Tamai, Kazutaka Hayashi and Yasuo Matsumura
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 1040-1047;
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    Intracisternal Injection of Somatostatin Receptor 5-Preferring Agonists Induces a Vagal Cholinergic Stimulation of Gastric Emptying in Rats
    Vicente Martínez, Jean Rivier, David Coy and Yvette Taché
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 1099-1105;
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    Effect of Novel Motilide ABT-229 versus Erythromycin and Cisapride on Gastric Emptying in Dogs
    Verne E. Cowles, Hugh N. Nellans, Terese R. Seifert, Leslie M. Besecke, Jason A. Segreti, Kurt M. Mohning, Ramin Faghih, Marleen H. Verlinden and Craig D. Wegner
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 1106-1111;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Alkanols Inhibit Respiration of Intact Mitochondria and Display Cutoff Similar to That Measured In Vivo
    David G. Hammond and Isao Kubo
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 822-828;
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    Isoprostanes, Novel Eicosanoids That Produce Nociception and Sensitize Rat Sensory Neurons
    Angela R. Evans, Heidi Junger, Michael D. Southall, Grant D. Nicol, Linda S. Sorkin, James T. Broome, Timothy W. Bailey and Michael R. Vasko
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 912-920;

NEUROPHARMACOLOGY

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    Mechanisms and Sites of Ocular Action of 7-Hydroxy-2-dipropylaminotetralin: A Dopamine3 Receptor Agonist
    Eugenia Chu, Teh-Ching Chu and David E. Potter
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 710-716;
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    Geometry and Charge Determine Pharmacological Effects of Steroids on N-Methyl-d-aspartate Receptor-Induced Ca2+ Accumulation and Cell Death
    Charles E. Weaver, Michele B. Land, Robert H. Purdy, Kyle G. Richards, Terrell T. Gibbs and David H. Farb
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 747-754;
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    Role of Corticotropin-Releasing Factor (CRF) Receptors in the Anorexic Syndrome Induced by CRF
    Mary Ann Pelleymounter, Margaret Joppa, Michelle Carmouche, Mary Jane Cullen, Brock Brown, Brian Murphy, Dimitri E. Grigoriadis, Nick Ling and Alan C. Foster
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 799-806;
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    Effects of Cholinomimetic Injection into the Brain Stem Reticular Formation on Halothane Anesthesia and Antinociception in Rats
    Yumiko Ishizawa, Hai-Chun Ma, Shuji Dohi and Hiroyuki Shimonaka
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 845-851;
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    Influence of Ovarian Hormones and Estrous Cycle on the Behavioral Response to Cocaine in Female Rats
    Stacy L. Sell, Joanne M. Scalzitti, Mary L. Thomas and Kathryn A. Cunningham
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 879-886;
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    Single-Cell Recombinant Pharmacology: Bovine α1a-Adrenoceptors in Rat-1 Fibroblasts Release Intracellular Ca2+, Display Subtype-Characteristic Agonism and Antagonism, and Exhibit an Antagonist-Reversible Inverse Concentration-Response Phase
    John Daniel Pediani, Janet Fraser MacKenzie, Robert Paul Heeley, Craig James Daly and John Christie McGrath
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 887-895;
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    Effects of Aniracetam on Bladder Overactivity in Rats with Cerebral Infarction
    Yasushi Nakada, Osamu Yokoyama, Kazuto Komatsu, Koichi Kodama, Satoshi Yotsuyanagi, Susumu Niikura, Yasuhiro Nagasaka and Mikio Namiki
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 921-928;
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    Dextromethorphan and Its Metabolite Dextrorphan Block α3β4 Neuronal Nicotinic Receptors ,
    Susan C. Hernandez, Maria Bertolino, Yingxian Xiao, Kenneth E. Pringle, Frank S. Caruso and Kenneth J. Kellar
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 962-967;
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    μ-Opioid Receptor Knockout Mice Do Not Self-Administer Alcohol ,
    Amanda J. Roberts, Jeffrey S. McDonald, Charles J. Heyser, Brigitte L. Kieffer, Hans W. D. Matthes, George F. Koob and Lisa H. Gold
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 1002-1008;
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    Enantioselectivity of Pregnanolone-Induced γ-Aminobutyric AcidA Receptor Modulation and Anesthesia
    Douglas F. Covey, Devi Nathan, Melissa Kalkbrenner, Kent R. Nilsson, Yuefei Hu, Charles F. Zorumski and Alex S. Evers
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 1009-1016;
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    Dissociation of Cocaine-Antagonist Properties and Motoric Effects of the D1 Receptor Partial Agonists SKF 83959 and SKF 77434
    Donna M. Platt, James K. Rowlett and Roger D. Spealman
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 1017-1026;
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    S33084, a Novel, Potent, Selective, and Competitive Antagonist at Dopamine D3-Receptors: I. Receptorial, Electrophysiological and Neurochemical Profile Compared with GR218,231 and L741,626
    Mark J. Millan, Alain Gobert, Adrian Newman-Tancredi, Françoise Lejeune, Didier Cussac, Jean-Michel Rivet, Valérie Audinot, Thierry Dubuffet and Gilbert Lavielle
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 1048-1062;
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    S33084, a Novel, Potent, Selective, and Competitive Antagonist at Dopamine D3-Receptors: II. Functional and Behavioral Profile Compared with GR218,231 and L741,626
    Mark J. Millan, Anne Dekeyne, Jean-Michel Rivet, Thierry Dubuffet, Gilbert Lavielle and Mauricette Brocco
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 1063-1073;
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    γ-Aminobutyric AcidA (GABAA) Agonist 4,5,6,7-Tetrahydroisoxazolo[4,5-c]pyridin-3-ol Persistently Increases Sleep Maintenance and Intensity during Chronic Administration to Rats
    Marike Lancel and Anke Langebartels
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 1084-1090;

TOXICOLOGY

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    Reduction of Cisplatin Nephrotoxicity by Procainamide: Does the Formation of a Cisplatin-Procainamide Complex Play a Role?
    Maurizio Viale, Maria Ornella Vannozzi, Ilaria Pastrone, Maria A. Mariggiò, Antonio Zicca, Angela Cadoni, Sergio Cafaggi, Giuseppina Tolino, Gianluigi Lunardi, Dario Civalleri, W. Edward Lindup and Mauro Esposito
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 829-836;
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    Postnatal Developmental Delay and Supersensitivity to Organophosphate in Gene-Targeted Mice Lacking Acetylcholinesterase
    Weihua Xie, Judith A. Stribley, Arnaud Chatonnet, Phillip J. Wilder, Angie Rizzino, Rodney D. McComb, Palmer Taylor, Steven H. Hinrichs and Oksana Lockridge
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 896-902;
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    Oxidant Stress in Rat Liver after Lipopolysaccharide Administration: Effect of Inducible Nitric-Oxide Synthase Inhibition
    Chaojie Zhang, Lisa M. Walker, Jack A. Hinson and Philip R. Mayeux
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 968-972;
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    Reactive Oxygen Species-Induced Apoptosis in PC12 Cells and Protective Effect of Bilobalide
    Li-Jun Zhou and Xing-Zu Zhu
    Journal of Pharmacology and Experimental Therapeutics June 2000, 293 (3) 982-988;
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Journal of Pharmacology and Experimental Therapeutics: 293 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 293, Issue 3
1 Jun 2000
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  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
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  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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