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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Microsomal Binding of Amitriptyline: Effect on Estimation of Enzyme Kinetic Parameters In Vitro

Karthik Venkatakrishnan, Lisa L. von Moltke, R. Scott Obach and David J. Greenblatt
Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 343-350;

Article Information

vol. 293 no. 2 343-350
PubMed 
10773001
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received October 5, 1999
  • Accepted January 6, 2000
  • Published online May 1, 2000.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Karthik Venkatakrishnan1,2,
  2. Lisa L. von Moltke1,2,
  3. R. Scott Obach3 and
  4. David J. Greenblatt1,2
  1. 1Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, Massachusetts (K.V., L.L.v.M., D.J.G.); 2Division of Clinical Pharmacology, New England Medical Center Hospital, Boston, Massachusetts (K.V., L.L.v.M., D.J.G.); and 3Department of Drug Metabolism, Pfizer Central Research, Groton, Connecticut (R.S.O.)
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    Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

    Microsomal Binding of Amitriptyline: Effect on Estimation of Enzyme Kinetic Parameters In Vitro

    Karthik Venkatakrishnan, Lisa L. von Moltke, R. Scott Obach and David J. Greenblatt
    Journal of Pharmacology and Experimental Therapeutics May 1, 2000, 293 (2) 343-350;
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