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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

May 01, 2000; Volume 293,Issue 2

PERSPECTIVES IN PHARMACOLOGY

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    New Molecular Targets for Cholesterol-Lowering Therapy
    Najwa N. Izzat, Mitchell E. Deshazer and David S. Loose-Mitchell
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 315-320;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Microsomal Binding of Amitriptyline: Effect on Estimation of Enzyme Kinetic Parameters In Vitro
    Karthik Venkatakrishnan, Lisa L. von Moltke, R. Scott Obach and David J. Greenblatt
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 343-350;
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    Characterization of the Major Metabolites of Verapamil as Substrates and Inhibitors of P-glycoprotein
    Christiane Pauli-Magnus, Oliver von Richter, Oliver Burk, Anja Ziegler, Thomas Mettang, Michel Eichelbaum and Martin F. Fromm
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 376-382;
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    Designing Stable Blood-Brain Barrier-Permeable Prosaptide Peptides for Treatment of Central Nervous System Neurodegeneration
    Eve M. Taylor, Deborah A. Otero, William A. Banks and John S. O'Brien
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 403-409;
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    Comparative Kinetics and Response to the Benzodiazepine Agonists Triazolam and Zolpidem: Evaluation of Sex-Dependent Differences
    David J. Greenblatt, Jerold S. Harmatz, Lisa L. von Moltke, C. Eugene Wright, Anna Liza B. Durol, Lisa M. Harrel-Joseph and Richard I. Shader
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 435-443;
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    Evaluation of the Use of Accelerated Infusions for the Determination of Pharmacokinetic Linearity
    Keith W. Ward, Robin Griffiths, Mark A. Levy and Brian R. Smith
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 468-479;
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    Verapamil Stimulates Glutathione Transport by the 190-kDa Multidrug Resistance Protein 1 (MRP1)
    Douglas W. Loe, Roger G. Deeley and Susan P. C. Cole
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 530-538;
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    Dual Role of Human Cytochrome P450 3A4 Residue Phe-304 in Substrate Specificity and Cooperativity
    Tammy L. Domanski, You-Ai He, Greg R. Harlow and James R. Halpert
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 585-591;
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    Expression of Glutathione-Dependent Enzymes and Cytochrome P450s in Freshly Isolated and Primary Cultures of Proximal Tubular Cells from Human Kidney
    Brian S. Cummings, Jerome M. Lasker and Lawrence H. Lash
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 677-685;

CARDIOVASCULAR

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    Nitric-Oxide Synthase-Containing Nerves Facilitate Adrenergic Transmitter Release in Sheep Middle Cerebral Arteries
    Emmanuel N. Mbaku, Lubo Zhang, Sue P. Duckles and John Buchholz
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 397-402;
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    Effects of Mitoxantrone on Excitation-Contraction Coupling in Guinea Pig Ventricular Myocytes
    Ge-Xin Wang, Xiao-Bo Zhou and Michael Korth
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 501-508;
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    Effects of the Flavoprotein Inhibitor, Diphenyleneiodonium Sulfate, on Ex Vivo Organic Nitrate Tolerance in the Rat
    Jodan D. Ratz, John J. McGuire, Diane J. Anderson and Brian M. Bennett
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 569-577;
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    Enhanced Responses to 17β-Estradiol in Rat Hearts Treated with Isoproterenol: Involvement of a Cyclic AMP-Dependent Pathway
    Hong-Yu Li, Jin-Song Bian, Yiu Wa Kwan and Tak Ming Wong
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 592-598;
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    Effects of Cyclopentyladenosine on Isoproterenol Response in Adult and Senescent Cardiac Tissue from Fischer 344 Rats
    Chris L. Kapicka, Stephen C. Montamat, Ramagopal V. Mudumbi, Shelley M. Jacks, Richard D. Olson and Robert E. Vestal
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 599-606;

CELLULAR AND MOLECULAR

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    In Vitro Studies of Striatal Vesicles Containing the Vesicular Monoamine Transporter (VMAT2): Rat versus Mouse Differences in Sequestration of 1-Methyl-4-phenylpyridinium
    Roland G. W. Staal, Kelly A. Hogan, Chang-Lin Liang, Dwight C. German and Patricia K. Sonsalla
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 329-335;
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    Inhibition of Brain Vesicular Monoamine Transporter (VMAT2) Enhances 1-Methyl-4-phenylpyridinium Neurotoxicity In Vivo in Rat Striata
    Roland G. W. Staal and Patricia K. Sonsalla
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 336-342;
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    Effects of Volatile Anesthetics on the Direct and Indirect Protein Kinase C-Mediated Enhancement of α1E-Type Ca2+Current in Xenopus Oocytes
    Ganesan L. Kamatchi, Shveta N. Tiwari, Marcel E. Durieux and Carl Lynch
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 360-369;
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    Cyclooxygenase-2 Contributes toN-Methyl-d-aspartate-Mediated Neuronal Cell Death in Primary Cortical Cell Culture
    Sandra J. Hewett, Tracy F. Uliasz, Aniruddha S. Vidwans and James A. Hewett
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 417-425;
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    Altered Regulation of the D1 Dopamine Receptor in Mutant Chinese Hamster Ovary Cells Deficient in Cyclic AMP-Dependent Protein Kinase Activity
    Ana Lucia Marques Ventura and David R. Sibley
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 426-434;
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    Extracellular Signal-Regulated Kinases Are Involved in the Antiapoptotic Effect of Endothelin-1
    Jinshyun R. Wu-Wong, William J. Chiou and Jiahong Wang
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 514-521;
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    Neurokinin3 Receptors Couple to the Activation of Neuronal Nitric-Oxide Synthase in Stably Transfected Chinese Hamster Ovary Cells
    David R. Linden, Melissa J. Chell, Esam E. El-Fakahany and Virginia S. Seybold
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 559-568;
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    Direct Block by Bisindolylmaleimide of Rat Kv1.5 Expressed in Chinese Hamster Ovary Cells
    Bok Hee Choi, Jin-Sung Choi, Seong-Whan Jeong, Sang June Hahn, Shin Hee Yoon, Yang-Hyeok Jo and Myung-Suk Kim
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 634-640;
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    Outward Transfer of Dopamine Precursor l-3,4-Dihydroxyphenylalanine (l-dopa) by Native and Human P-glycoprotein in LLC-PK1 and LLC-GA5 Col300 Renal Cells
    Patrício Soares-da-Silva and Maria Paula Serrão
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 697-704;

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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    Expression of Antisense RNA to Aldehyde Dehydrogenase Class-1 Sensitizes Tumor Cells to 4-Hydroperoxycyclophosphamide In Vitro
    Jan S. Moreb, Chalesea Maccow, Mark Schweder and Jaima Hecomovich
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 390-396;

ENDOCRINE AND REPRODUCTIVE

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    Long-Term Effects of the EndothelinA Receptor Antagonist LU 135252 and the Angiotensin-Converting Enzyme Inhibitor Trandolapril on Diabetic Angiopathy and Nephropathy in a Chronic Type I Diabetes Mellitus Rat Model
    Stefan Dhein, Stefan Hochreuther, Christian aus dem Spring, Klaus Bollig, Christine Hufnagel and Manfred Raschack
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 351-359;
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    Pancreatic β-Cell K ATP Channel Activity and Membrane-Binding Studies with Nateglinide: A Comparison with Sulfonylureas and Repaglinide
    Shiling Hu, Shuya Wang, Barbara Fanelli, Philip A. Bell, Beth E. Dunning, Sabine Geisse, Rita Schmitz and Brian R. Boettcher
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 444-452;
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    Troglitazone Directly Inhibits CO2 Production from Glucose and Palmitate in Isolated Rat Skeletal Muscle
    Clemens Fürnsinn, Barbara Brunmair, Susanne Neschen, Michael Roden and Werner Waldhäusl
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 487-493;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Role of Constitutive Cyclooxygenase-2 in Prostaglandin-Dependent Secretion in Mouse Colon In Vitro
    Wallace K. MacNaughton and Kelly Cushing
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 539-544;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Affinities, Selectivities, Potencies, and Intrinsic Activities of Natural and Synthetic Prostanoids Using Endogenous Receptors: Focus on DP Class Prostanoids
    Najam A. Sharif, Julie Y. Crider, Shouxi X. Xu and Gary W. Williams
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 321-328;
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    Selective Inhibitor of p38 Mitogen-Activated Protein Kinase Inhibits Lipopolysaccharide-Induced Interleukin-8 Expression in Human Pulmonary Vascular Endothelial Cells
    Shu Hashimoto, Yasuhiro Gon, Ken Matsumoto, Shuichiro Maruoka, Ikuko Takeshita, Shinichi Hayashi, Yasukiyo Asai, Yoshito Asai, Itsuro Jibiki, Tatsuya Machino and Takashi Horie
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 370-375;
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    Role of Cysteinyl Leukotrienes in CD4+ T Cell-Driven Late Allergic Airway Responses
    Masayuki Hojo, Masaru Suzuki, Karim Maghni, Qutayba Hamid, William S. Powell and James G. Martin
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 410-416;
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    Major Role of Human Liver Microsomal Cytochrome P450 2C9 (CYP2C9) in the Oxidative Metabolism of Celecoxib, a Novel Cyclooxygenase-II Inhibitor
    Cuyue Tang, Magang Shou, Qin Mei, Thomas H. Rushmore and A. David Rodrigues
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 453-459;
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    Adenoviral Vector-Mediated Transfer of Human Heme Oxygenase in Rats Decreases Renal Heme-Dependent Arachidonic Acid Epoxygenase Activity
    Nader G. Abraham, Shanlong Jiang, Liming Yang, Barbara A. Zand, Michal Laniado-Schwartzman, Jackleen Marji, George S. Drummond and Attallah Kappas
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 494-500;
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    Inhibition of Cyclooxygenase-2 Decreases DNA Synthesis Induced by Platelet-Derived Growth Factor in Swiss 3T3 Fibroblasts
    Esther Castaño, Ramon Bartrons and Joan Gil
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 509-513;
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    Pharmacokinetics, Pharmacodynamics, Allometry, and Dose Selection of rPSGL-Ig for Phase I Trial
    Soo Peang Khor, Kyle McCarthy, Michelle DuPont, Kristin Murray and Gregg Timony
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 618-624;
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    Pentoxifylline Ameliorates Cerulein-Induced Pancreatitis in Rats: Role of Glutathione and Nitric Oxide
    Luis Gómez-Cambronero, Bruno Camps, José García de la Asunción, Miguel Cerdá, Antonio Pellín, Federico V. Pallardó, Julio Calvete, Jacob H. Sweiry, Giovanni E. Mann, José Viña and Juan Sastre
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 670-676;

NEUROPHARMACOLOGY

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    Cocaine Potentiates Ethanol-Induced Excitation of Dopaminergic Reward Neurons in the Ventral Tegmental Area
    E. Bradshaw Bunney, Sarah B. Appel and Mark S. Brodie
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 383-389;
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    Coexpression of Full-Length γ-Aminobutyric AcidB(GABAB) Receptors with Truncated Receptors and Metabotropic Glutamate Receptor 4 Supports the GABAB Heterodimer as the Functional Receptor
    Richard Sullivan, Anne Chateauneuf, Nathalie Coulombe, Lee F. Kolakowski, Michael P. Johnson, Terence E. Hebert, Nathalie Ethier, Michel Belley, Kathleen Metters, Mark Abramovitz, Gary P. O'Neill and Gordon Y. K. Ng
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 460-467;
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    Inhibition of Glutamate-Induced Mitochondrial Depolarization by Tamoxifen in Cultured Neurons
    Kari R. Hoyt, Beth Ann McLaughlin, Donald S. Higgins and Ian J. Reynolds
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 480-486;
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    Preferential Inhibition by a Novel Na+/Ca2+ Channel Blocker NS-7 of Severe to Mild Hypoxic Injury in Rat Cerebrocortical Slices: A Possible Involvement of a Highly Voltage-Dependent Blockade of Ca2+ Channel
    Michiko Oka, Yoshinori Itoh and Yojiro Ukai
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 522-529;
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    Nitric Oxide Redox Species Exert Differential Permeability Effects on the Blood-Brain Barrier
    Kathleen M. K. Boje and Sukwinder Singh Lakhman
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 545-550;
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    Effects of Ethanol on Working Memory and Attention in Pigeons
    Charlotte A. Dayer, Scott Baron, Kim E. Light and Galen R. Wenger
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 551-558;
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    Changes in Catecholaminergic Pathways Innervating Paraventricular Nucleus and Pituitary-Adrenal Axis Response during Morphine Dependence: Implication of α1- and α2-Adrenoceptors
    Maria Luisa Laorden, Gregorio Fuertes, Ana González-Cuello and Maria Victoria Milanés
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 578-584;
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    Naloxone Protects Rat Dopaminergic Neurons against Inflammatory Damage through Inhibition of Microglia Activation and Superoxide Generation
    Bin Liu, Lina Du and Jau-Shyong Hong
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 607-617;
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    Toward Development of an In Vitro Model of Methamphetamine-Induced Dopamine Nerve Terminal Toxicity
    Saejeong Kim, Robert Westphalen, Brian Callahan, George Hatzidimitriou, Jie Yuan and George A. Ricaurte
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 625-633;
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    Pharmacokinetic-Pharmacodynamic Modeling of the Antinociceptive Effects of Main Active Metabolites of Tramadol, (+)-O-Desmethyltramadol and (−)-O-Desmethyltramadol, in Rats
    Marta Valle, María J. Garrido, Juan M. Pavón, Rosario Calvo and Iñaki F. Trocóniz
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 646-653;
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    Ethanol Enhances γ-Aminobutyric Acid Responses in a Subpopulation of Nucleus Accumbens Neurons: Role of Metabotropic Glutamate Receptors
    Zhiguo Nie, Samuel G. Madamba and George R. Siggins
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 654-661;
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    Protein Kinase C-Mediated Acute Tolerance to Peripheral μ-Opioid Analgesia in the Bradykinin-Nociception Test in Mice
    Makoto Inoue and Hiroshi Ueda
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 662-669;
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    Characterization of a Tropane Radioligand, [3H]2β-Propanoyl-3β-(4-tolyl) Tropane ([3H]PTT), for Dopamine Transport Sites in Rat Brain
    Sharon R. Letchworth, Hilary R. Smith, Linda J. Porrino, Barbara A. Bennett, Huw M. L. Davies, Tammy Sexton and Steven R. Childers
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 686-696;

TOXICOLOGY

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    Acute Oxygen Supplementation Restores Markers of Hepatocyte Energy Status and Hypoxia in Cirrhotic Rats
    Peta J. Harvey, Jill E. Gready, Zhanli Yin, David G. Le Couteur and Allan J. McLean
    Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 641-645;
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Journal of Pharmacology and Experimental Therapeutics: 293 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 293, Issue 2
1 May 2000
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  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  • ENDOCRINE AND REPRODUCTIVE
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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