Journal of Pharmacology and Experimental Therapeutics: 293 (2)

May 01, 2000; Volume 293,Issue 2

PERSPECTIVES IN PHARMACOLOGY

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New Molecular Targets for Cholesterol-Lowering Therapy
Najwa N. Izzat, Mitchell E. Deshazer and David S. Loose-Mitchell

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 315-320;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Microsomal Binding of Amitriptyline: Effect on Estimation of Enzyme Kinetic Parameters In Vitro
Karthik Venkatakrishnan, Lisa L. von Moltke, R. Scott Obach and David J. Greenblatt

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 343-350;
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Characterization of the Major Metabolites of Verapamil as Substrates and Inhibitors of P-glycoprotein
Christiane Pauli-Magnus, Oliver von Richter, Oliver Burk, Anja Ziegler, Thomas Mettang, Michel Eichelbaum and Martin F. Fromm

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 376-382;
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Designing Stable Blood-Brain Barrier-Permeable Prosaptide Peptides for Treatment of Central Nervous System Neurodegeneration
Eve M. Taylor, Deborah A. Otero, William A. Banks and John S. O'Brien

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 403-409;
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Comparative Kinetics and Response to the Benzodiazepine Agonists Triazolam and Zolpidem: Evaluation of Sex-Dependent Differences
David J. Greenblatt, Jerold S. Harmatz, Lisa L. von Moltke, C. Eugene Wright, Anna Liza B. Durol, Lisa M. Harrel-Joseph and Richard I. Shader

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 435-443;
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Evaluation of the Use of Accelerated Infusions for the Determination of Pharmacokinetic Linearity
Keith W. Ward, Robin Griffiths, Mark A. Levy and Brian R. Smith

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 468-479;
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Verapamil Stimulates Glutathione Transport by the 190-kDa Multidrug Resistance Protein 1 (MRP1)
Douglas W. Loe, Roger G. Deeley and Susan P. C. Cole

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 530-538;
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Dual Role of Human Cytochrome P450 3A4 Residue Phe-304 in Substrate Specificity and Cooperativity
Tammy L. Domanski, You-Ai He, Greg R. Harlow and James R. Halpert

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 585-591;
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Expression of Glutathione-Dependent Enzymes and Cytochrome P450s in Freshly Isolated and Primary Cultures of Proximal Tubular Cells from Human Kidney
Brian S. Cummings, Jerome M. Lasker and Lawrence H. Lash

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 677-685;

CARDIOVASCULAR

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Nitric-Oxide Synthase-Containing Nerves Facilitate Adrenergic Transmitter Release in Sheep Middle Cerebral Arteries
Emmanuel N. Mbaku, Lubo Zhang, Sue P. Duckles and John Buchholz

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 397-402;
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Effects of Mitoxantrone on Excitation-Contraction Coupling in Guinea Pig Ventricular Myocytes
Ge-Xin Wang, Xiao-Bo Zhou and Michael Korth

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 501-508;
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Effects of the Flavoprotein Inhibitor, Diphenyleneiodonium Sulfate, on Ex Vivo Organic Nitrate Tolerance in the Rat
Jodan D. Ratz, John J. McGuire, Diane J. Anderson and Brian M. Bennett

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 569-577;
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Enhanced Responses to 17β-Estradiol in Rat Hearts Treated with Isoproterenol: Involvement of a Cyclic AMP-Dependent Pathway
Hong-Yu Li, Jin-Song Bian, Yiu Wa Kwan and Tak Ming Wong

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 592-598;
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Effects of Cyclopentyladenosine on Isoproterenol Response in Adult and Senescent Cardiac Tissue from Fischer 344 Rats
Chris L. Kapicka, Stephen C. Montamat, Ramagopal V. Mudumbi, Shelley M. Jacks, Richard D. Olson and Robert E. Vestal

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 599-606;

CELLULAR AND MOLECULAR

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In Vitro Studies of Striatal Vesicles Containing the Vesicular Monoamine Transporter (VMAT2): Rat versus Mouse Differences in Sequestration of 1-Methyl-4-phenylpyridinium
Roland G. W. Staal, Kelly A. Hogan, Chang-Lin Liang, Dwight C. German and Patricia K. Sonsalla

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 329-335;
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Inhibition of Brain Vesicular Monoamine Transporter (VMAT2) Enhances 1-Methyl-4-phenylpyridinium Neurotoxicity In Vivo in Rat Striata
Roland G. W. Staal and Patricia K. Sonsalla

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 336-342;
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Effects of Volatile Anesthetics on the Direct and Indirect Protein Kinase C-Mediated Enhancement of α1E-Type Ca²⁺Current in Xenopus Oocytes
Ganesan L. Kamatchi, Shveta N. Tiwari, Marcel E. Durieux and Carl Lynch

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 360-369;
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Cyclooxygenase-2 Contributes toN-Methyl-d-aspartate-Mediated Neuronal Cell Death in Primary Cortical Cell Culture
Sandra J. Hewett, Tracy F. Uliasz, Aniruddha S. Vidwans and James A. Hewett

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 417-425;
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Altered Regulation of the D₁ Dopamine Receptor in Mutant Chinese Hamster Ovary Cells Deficient in Cyclic AMP-Dependent Protein Kinase Activity
Ana Lucia Marques Ventura and David R. Sibley

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 426-434;
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Extracellular Signal-Regulated Kinases Are Involved in the Antiapoptotic Effect of Endothelin-1
Jinshyun R. Wu-Wong, William J. Chiou and Jiahong Wang

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 514-521;
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Neurokinin₃ Receptors Couple to the Activation of Neuronal Nitric-Oxide Synthase in Stably Transfected Chinese Hamster Ovary Cells
David R. Linden, Melissa J. Chell, Esam E. El-Fakahany and Virginia S. Seybold

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 559-568;
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Direct Block by Bisindolylmaleimide of Rat Kv1.5 Expressed in Chinese Hamster Ovary Cells
Bok Hee Choi, Jin-Sung Choi, Seong-Whan Jeong, Sang June Hahn, Shin Hee Yoon, Yang-Hyeok Jo and Myung-Suk Kim

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 634-640;
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Outward Transfer of Dopamine Precursor l-3,4-Dihydroxyphenylalanine (l-dopa) by Native and Human P-glycoprotein in LLC-PK₁ and LLC-GA5 Col300 Renal Cells
Patrício Soares-da-Silva and Maria Paula Serrão

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 697-704;

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Expression of Antisense RNA to Aldehyde Dehydrogenase Class-1 Sensitizes Tumor Cells to 4-Hydroperoxycyclophosphamide In Vitro
Jan S. Moreb, Chalesea Maccow, Mark Schweder and Jaima Hecomovich

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 390-396;

ENDOCRINE AND REPRODUCTIVE

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Long-Term Effects of the Endothelin_A Receptor Antagonist LU 135252 and the Angiotensin-Converting Enzyme Inhibitor Trandolapril on Diabetic Angiopathy and Nephropathy in a Chronic Type I Diabetes Mellitus Rat Model
Stefan Dhein, Stefan Hochreuther, Christian aus dem Spring, Klaus Bollig, Christine Hufnagel and Manfred Raschack

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 351-359;
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Pancreatic β-Cell K _ATP Channel Activity and Membrane-Binding Studies with Nateglinide: A Comparison with Sulfonylureas and Repaglinide
Shiling Hu, Shuya Wang, Barbara Fanelli, Philip A. Bell, Beth E. Dunning, Sabine Geisse, Rita Schmitz and Brian R. Boettcher

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 444-452;
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Troglitazone Directly Inhibits CO₂ Production from Glucose and Palmitate in Isolated Rat Skeletal Muscle
Clemens Fürnsinn, Barbara Brunmair, Susanne Neschen, Michael Roden and Werner Waldhäusl

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 487-493;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Role of Constitutive Cyclooxygenase-2 in Prostaglandin-Dependent Secretion in Mouse Colon In Vitro
Wallace K. MacNaughton and Kelly Cushing

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 539-544;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Affinities, Selectivities, Potencies, and Intrinsic Activities of Natural and Synthetic Prostanoids Using Endogenous Receptors: Focus on DP Class Prostanoids
Najam A. Sharif, Julie Y. Crider, Shouxi X. Xu and Gary W. Williams

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 321-328;
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Selective Inhibitor of p38 Mitogen-Activated Protein Kinase Inhibits Lipopolysaccharide-Induced Interleukin-8 Expression in Human Pulmonary Vascular Endothelial Cells
Shu Hashimoto, Yasuhiro Gon, Ken Matsumoto, Shuichiro Maruoka, Ikuko Takeshita, Shinichi Hayashi, Yasukiyo Asai, Yoshito Asai, Itsuro Jibiki, Tatsuya Machino and Takashi Horie

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 370-375;
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Role of Cysteinyl Leukotrienes in CD4⁺ T Cell-Driven Late Allergic Airway Responses
Masayuki Hojo, Masaru Suzuki, Karim Maghni, Qutayba Hamid, William S. Powell and James G. Martin

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 410-416;
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Major Role of Human Liver Microsomal Cytochrome P450 2C9 (CYP2C9) in the Oxidative Metabolism of Celecoxib, a Novel Cyclooxygenase-II Inhibitor
Cuyue Tang, Magang Shou, Qin Mei, Thomas H. Rushmore and A. David Rodrigues

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 453-459;
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Adenoviral Vector-Mediated Transfer of Human Heme Oxygenase in Rats Decreases Renal Heme-Dependent Arachidonic Acid Epoxygenase Activity
Nader G. Abraham, Shanlong Jiang, Liming Yang, Barbara A. Zand, Michal Laniado-Schwartzman, Jackleen Marji, George S. Drummond and Attallah Kappas

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 494-500;
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Inhibition of Cyclooxygenase-2 Decreases DNA Synthesis Induced by Platelet-Derived Growth Factor in Swiss 3T3 Fibroblasts
Esther Castaño, Ramon Bartrons and Joan Gil

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 509-513;
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Pharmacokinetics, Pharmacodynamics, Allometry, and Dose Selection of rPSGL-Ig for Phase I Trial
Soo Peang Khor, Kyle McCarthy, Michelle DuPont, Kristin Murray and Gregg Timony

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 618-624;
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Pentoxifylline Ameliorates Cerulein-Induced Pancreatitis in Rats: Role of Glutathione and Nitric Oxide
Luis Gómez-Cambronero, Bruno Camps, José García de la Asunción, Miguel Cerdá, Antonio Pellín, Federico V. Pallardó, Julio Calvete, Jacob H. Sweiry, Giovanni E. Mann, José Viña and Juan Sastre

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 670-676;

NEUROPHARMACOLOGY

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Cocaine Potentiates Ethanol-Induced Excitation of Dopaminergic Reward Neurons in the Ventral Tegmental Area
E. Bradshaw Bunney, Sarah B. Appel and Mark S. Brodie

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 383-389;
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Coexpression of Full-Length γ-Aminobutyric Acid_B(GABA_B) Receptors with Truncated Receptors and Metabotropic Glutamate Receptor 4 Supports the GABA_B Heterodimer as the Functional Receptor
Richard Sullivan, Anne Chateauneuf, Nathalie Coulombe, Lee F. Kolakowski, Michael P. Johnson, Terence E. Hebert, Nathalie Ethier, Michel Belley, Kathleen Metters, Mark Abramovitz, Gary P. O'Neill and Gordon Y. K. Ng

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 460-467;
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Inhibition of Glutamate-Induced Mitochondrial Depolarization by Tamoxifen in Cultured Neurons
Kari R. Hoyt, Beth Ann McLaughlin, Donald S. Higgins and Ian J. Reynolds

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 480-486;
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Preferential Inhibition by a Novel Na⁺/Ca²⁺ Channel Blocker NS-7 of Severe to Mild Hypoxic Injury in Rat Cerebrocortical Slices: A Possible Involvement of a Highly Voltage-Dependent Blockade of Ca²⁺ Channel
Michiko Oka, Yoshinori Itoh and Yojiro Ukai

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 522-529;
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Nitric Oxide Redox Species Exert Differential Permeability Effects on the Blood-Brain Barrier
Kathleen M. K. Boje and Sukwinder Singh Lakhman

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 545-550;
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Effects of Ethanol on Working Memory and Attention in Pigeons
Charlotte A. Dayer, Scott Baron, Kim E. Light and Galen R. Wenger

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 551-558;
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Changes in Catecholaminergic Pathways Innervating Paraventricular Nucleus and Pituitary-Adrenal Axis Response during Morphine Dependence: Implication of α₁- and α₂-Adrenoceptors
Maria Luisa Laorden, Gregorio Fuertes, Ana González-Cuello and Maria Victoria Milanés

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 578-584;
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Naloxone Protects Rat Dopaminergic Neurons against Inflammatory Damage through Inhibition of Microglia Activation and Superoxide Generation
Bin Liu, Lina Du and Jau-Shyong Hong

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 607-617;
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Toward Development of an In Vitro Model of Methamphetamine-Induced Dopamine Nerve Terminal Toxicity
Saejeong Kim, Robert Westphalen, Brian Callahan, George Hatzidimitriou, Jie Yuan and George A. Ricaurte

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 625-633;
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Pharmacokinetic-Pharmacodynamic Modeling of the Antinociceptive Effects of Main Active Metabolites of Tramadol, (+)-O-Desmethyltramadol and (−)-O-Desmethyltramadol, in Rats
Marta Valle, María J. Garrido, Juan M. Pavón, Rosario Calvo and Iñaki F. Trocóniz

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 646-653;
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Ethanol Enhances γ-Aminobutyric Acid Responses in a Subpopulation of Nucleus Accumbens Neurons: Role of Metabotropic Glutamate Receptors
Zhiguo Nie, Samuel G. Madamba and George R. Siggins

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 654-661;
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Protein Kinase C-Mediated Acute Tolerance to Peripheral μ-Opioid Analgesia in the Bradykinin-Nociception Test in Mice
Makoto Inoue and Hiroshi Ueda

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 662-669;
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Characterization of a Tropane Radioligand, [³H]2β-Propanoyl-3β-(4-tolyl) Tropane ([³H]PTT), for Dopamine Transport Sites in Rat Brain
Sharon R. Letchworth, Hilary R. Smith, Linda J. Porrino, Barbara A. Bennett, Huw M. L. Davies, Tammy Sexton and Steven R. Childers

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 686-696;

TOXICOLOGY

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Acute Oxygen Supplementation Restores Markers of Hepatocyte Energy Status and Hypoxia in Cirrhotic Rats
Peta J. Harvey, Jill E. Gready, Zhanli Yin, David G. Le Couteur and Allan J. McLean

Journal of Pharmacology and Experimental Therapeutics May 2000, 293 (2) 641-645;

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

ENDOCRINE AND REPRODUCTIVE

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

TOXICOLOGY

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