Journal of Pharmacology and Experimental Therapeutics: 293 (1)

April 01, 2000; Volume 293,Issue 1

PERSPECTIVES IN PHARMACOLOGY

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In Vivo Gene Modification Elucidates Subtype-Specific Functions of α₂-Adrenergic Receptors
Joseph W. Kable, L. Charles Murrin and David B. Bylund

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 1-7;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Polymethoxylated Flavones in Orange Juice Are Inhibitors of P-glycoprotein but Not Cytochrome P450 3A4
Hitomi Takanaga, Ayako Ohnishi, Shiho Yamada, Hirotami Matsuo, Satoshi Morimoto, Yukihiro Shoyama, Hisakazu Ohtani and Yasufumi Sawada

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 230-236;
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Plasma and Lymph Pharmacokinetics of Recombinant Human Interleukin-2 and Polyethylene Glycol-Modified Interleukin-2 in Pigs
Sharon A. Chen, Ronald J. Sawchuk, Richard C. Brundage, Christopher Horvath, H. Vincent Mendenhall, Robert A. Gunther and Rene A. Braeckman

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 248-259;
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Synthesis and Characterization of a Fluorescent Substrate for the N-Arachidonoylethanolamine (Anandamide) Transmembrane Carrier
Shanmugam Muthian, Kasem Nithipatikom, William B. Campbell and Cecilia J. Hillard

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 289-295;
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R115866 Inhibits All-trans-Retinoic Acid Metabolism and Exerts Retinoidal Effects in Rodents
Paul Stoppie, Marcel Borgers, Peter Borghgraef, Lieve Dillen, Jan Goossens, Gerard Sanz, Heidi Szel, Carl Van Hove, Greta Van Nyen, Geert Nobels, Hugo Vanden Bossche, Marc Venet, Gustaaf Willemsens and Jean Van Wauwe

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 304-312;

CARDIOVASCULAR

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Effect of β-Adrenoceptor Blockers on Sarcoplasmic Reticular Function and Gene Expression in the Ischemic-Reperfused Heart
Rana M. Temsah, Chadwyn Dyck, Thomas Netticadan, Donald Chapman, Vijayan Elimban and Naranjan S. Dhalla

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 15-23;
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Oxidative Stress Induced by tert-Butyl Hydroperoxide Causes Vasoconstriction in the Aorta from Hypertensive and Aged Rats: Role of Cyclooxygenase-2 Isoform
Edith-Clara Garcia-Cohen, Jesus Marin, Luis D. Diez-Picazo, Ana B. Baena, Mercedes Salaices and M. Angeles Rodriguez-Martinez

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 75-81;
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Signaling Mechanisms for Muscarinic Receptor-Mediated Coronary Vasoconstriction in Isolated Rat Hearts
Yi Zhang and Donald B. Hoover

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 96-106;
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Tertiapin Potently and Selectively Blocks Muscarinic K⁺ Channels in Rabbit Cardiac Myocytes
Hidetsuna Kitamura, Mitsuhiro Yokoyama, Hozuka Akita, Kenji Matsushita, Yoshihisa Kurachi and Mitsuhiko Yamada

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 196-205;
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A Novel Angiotensin Analog with Subnanomolar Affinity for Angiotensin-Converting Enzyme
Luke T. Krebs, Jodie M. Hanesworth, Michael F. Sardinia, Robert C. Speth, John W. Wright and Joseph W. Harding

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 260-267;

CELLULAR AND MOLECULAR

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Pyrrolo-1,5-benzoxazepines Induce Apoptosis in HL-60, Jurkat, and Hut-78 Cells: A New Class of Apoptotic Agents
Daniela M. Zisterer, Giuseppe Campiani, Vito Nacci and D. Clive Williams

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 48-59;
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Ras/Mitogen-Activated Protein Kinase Mediates Norepinephrine-Induced Phospholipase D Activation in Rabbit Aortic Smooth Muscle Cells by a Phosphorylation-Dependent Mechanism
Mubarack M. Muthalif, Jean-Hugues Parmentier, Ibrahim F. Benter, Nour Karzoun, Aftab Ahmed, Zinat Khandekar, Mohamed Z. Adl, Sylvain Bourgoin and Kafait U. Malik

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 268-274;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Induction of Apoptosis by theO-Hydroxyethyl-d(Ser)⁸-cyclosporine A Derivative SDZ IMM 125 in Rat Hepatocytes
Sibylle Grub, Elke Persohn, Wolfgang E. Trommer and Armin Wolf

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 24-32;
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Neuromuscular Dysfunction in the Jejunum and Colon of Human Leukocyte Antigen B27 Transgenic Rats
Kalina Venkova, S. Terence Dunn, Adekunle M. Adesina and Beverley Greenwood-Van Meerveld

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 60-66;
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Taurine and Niacin Block Lung Injury and Fibrosis by Down-Regulating Bleomycin-Induced Activation of Transcription Nuclear Factor-κB in Mice ,
Gopalakrishnan Gurujeyalakshmi, Yingjin Wang and Shri N. Giri

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 82-90;
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Stimulation of the Na⁺-K⁺ Pump in Cultured Guinea Pig Airway Smooth Muscle Cells by Serotonin
Kerry J. Rhoden, Alicia M. Dodson and Betty Ky

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 107-112;
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Enhancement by Epinephrine of Benzylpenicillin Transport in Rat Small Intestine
Mariusz T. Skowronski, Yasuko Ishikawa and Hajime Ishida

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 128-135;
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Substance P in the Dorsal Motor Nucleus of the Vagus Evokes Gastric Motor Inhibition via Neurokinin 1 Receptor in Rat
Zbigniew K. Krowicki and Pamela J. Hornby

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 214-221;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Comparative Pharmacodynamics of Keliximab and Clenoliximab in Transgenic Mice Bearing Human CD4
Amarnath Sharma, Charles B. Davis, Lee Ann P. Tobia, Deborah C. Kwok, Marcella G. Tucci, Elizabeth R. Gore, Danuta J. Herzyk and Timothy K. Hart

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 33-41;
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Effects of Cannabinoid Receptor Agonist and Antagonist Ligands on Production of Inflammatory Cytokines and Anti-Inflammatory Interleukin-10 in Endotoxemic Mice
Sidney R. Smith, Carol Terminelli and Georgetta Denhardt

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 136-150;
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Effects of Cigarette Smoke on Immune Response: Chronic Exposure to Cigarette Smoke Impairs Antigen-Mediated Signaling in T Cells and Depletes IP3-Sensitive Ca²⁺ Stores
Roma Kalra, Shashi P. Singh, Susan M. Savage, Gregory L. Finch and Mohan L. Sopori

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 166-171;
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Signal Transduction Cascade in Staurosporine-Induced Prostaglandin E₂ Production by Rat Peritoneal Macrophages
Kouya Yamaki, Takayuki Yonezawa and Kazuo Ohuchi

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 206-213;
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Diffusion of Peroxynitrite into the Human Platelet Inhibits Cyclooxygenase via Nitration of Tyrosine Residues
Christine Boulos, Houli Jiang and Michael Balazy

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 222-229;
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SB 239063, a Potent p38 MAP Kinase Inhibitor, Reduces Inflammatory Cytokine Production, Airways Eosinophil Infiltration, and Persistence
David C. Underwood, Ruth R. Osborn, Charles J. Kotzer, Jerry L. Adams, John C. Lee, Edward F. Webb, Donald C. Carpenter, Steven Bochnowicz, Heath C. Thomas, Douglas W. P. Hay and Don E. Griswold

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 281-288;

NEUROPHARMACOLOGY

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Comparison of the Effects of Clozapine, Risperidone, and Olanzapine on Ketamine-Induced Alterations in Regional Brain Metabolism
Gary E. Duncan, Seiya Miyamoto, Jeremy N. Leipzig and Jeffrey A. Lieberman

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 8-14;
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A Subtype of the γ-Aminobutyric Acid_B Receptor Regulates Cholinergic Twitch Response in the Guinea Pig Ileum
Manuela Marcoli, Simona Scarrone, Guido Maura, Giambattista Bonanno and Maurizio Raiteri

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 42-47;
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Potential Role of the α4 and α6 Nicotinic Receptor Subunits in Regulating Nicotine-Induced Seizures
Jerry A. Stitzel, Melissa Jimenez, Michael J. Marks, Theresa Tritto and Allan C. Collins

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 67-74;
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Dopamine Decreases Melatonin Content in Golden Hamster Retina
Carolina O. Jaliffa, Francisco Firpo Lacoste, Diego Weinberg Llomovatte, María I. Keller Sarmiento and Ruth E. Rosenstein

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 91-95;
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Selected Cysteine Residues in Transmembrane Domains of μ-Opioid Receptor Are Critical for Effects of Sulfhydryl Reagents
Hong Bing Deng, Wei Guang and Jia Bei Wang

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 113-120;
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Strain Differences in Basal and Cocaine-Evoked Dopamine Dynamics in Mouse Striatum
Ming He and Toni S. Shippenberg

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 121-127;
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Antinociceptive Activity of [β-Methyl-2′,6′-dimethyltyrosine¹]-Substituted Cyclic [d-Pen²,d-Pen⁵]Enkephalin and [d-Ala²,Asp⁴]Deltorphin Analogs
Edward J. Bilsky, Xinhua Qian, Victor J. Hruby and Frank Porreca

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 151-158;
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Effect of Chronic Ethanol and Withdrawal on the μ-Opioid Receptor- and 5-Hydroxytryptamine_1A Receptor-Stimulated Binding of [³⁵S]Guanosine-5′-O-(3-thio)triphosphate in the Fawn-Hooded Rat Brain: A Quantitative Autoradiography Study
Feng Chen and Andrew J. Lawrence

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 159-165;
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ATP Inhibits Glutamate Synaptic Release by Acting at P2Y Receptors in Pyramidal Neurons of Hippocampal Slices
Victor Mendoza-Fernández, R. David Andrew and Carlos Barajas-López

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 172-179;
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Cocaine-Induced Seizure Thresholds: Quantitative Trait Loci Detection and Mapping in Two Populations Derived from the C57BL/6 and DBA/2 Mouse Strains
Heather S. Hain, John C. Crabbe, Susan E. Bergeson and John K. Belknap

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 180-187;
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Selectively Bred Lines of Mice Show Response and Drug Specificity for Genetic Regulation of Acute Functional Tolerance to Ethanol and Pentobarbital
V. Gene Erwin, Vaughn M. Gehle and Richard A. Deitrich

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 188-195;
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Internalization and Recycling of δ-Opioid Receptor Are Dependent on a Phosphorylation-Dephosphorylation Mechanism
Ahmed Hasbi, Stéphane Allouche, François Sichel, Laura Stanasila, Dominique Massotte, Gérard Landemore, Jocelyne Polastron and Philippe Jauzac

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 237-247;
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Pharmacological Characterization of ¹²⁵I-1229U91 Binding to Y1 and Y4 Neuropeptide Y/Peptide YY Receptors
Douglas A. Schober, Susan L. Gackenheimer, Mark L. Heiman and Donald R. Gehlert

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 275-280;

TOXICOLOGY

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Allopurinol Prevents Early Alcohol-Induced Liver Injury in Rats
Hiroshi Kono, Ivan Rusyn, Blair U. Bradford, Henry D. Connor, Ronald P. Mason and Ronald G. Thurman

Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 296-303;

Erratum

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Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 313;

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

CARDIOVASCULAR

CELLULAR AND MOLECULAR

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

TOXICOLOGY

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