Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn

Table of Contents

April 01, 2000; Volume 293,Issue 1

PERSPECTIVES IN PHARMACOLOGY

  • You have access
    In Vivo Gene Modification Elucidates Subtype-Specific Functions of α2-Adrenergic Receptors
    Joseph W. Kable, L. Charles Murrin and David B. Bylund
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 1-7;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

  • You have access
    Polymethoxylated Flavones in Orange Juice Are Inhibitors of P-glycoprotein but Not Cytochrome P450 3A4
    Hitomi Takanaga, Ayako Ohnishi, Shiho Yamada, Hirotami Matsuo, Satoshi Morimoto, Yukihiro Shoyama, Hisakazu Ohtani and Yasufumi Sawada
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 230-236;
  • You have access
    Plasma and Lymph Pharmacokinetics of Recombinant Human Interleukin-2 and Polyethylene Glycol-Modified Interleukin-2 in Pigs
    Sharon A. Chen, Ronald J. Sawchuk, Richard C. Brundage, Christopher Horvath, H. Vincent Mendenhall, Robert A. Gunther and Rene A. Braeckman
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 248-259;
  • You have access
    Synthesis and Characterization of a Fluorescent Substrate for the N-Arachidonoylethanolamine (Anandamide) Transmembrane Carrier
    Shanmugam Muthian, Kasem Nithipatikom, William B. Campbell and Cecilia J. Hillard
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 289-295;
  • You have access
    R115866 Inhibits All-trans-Retinoic Acid Metabolism and Exerts Retinoidal Effects in Rodents
    Paul Stoppie, Marcel Borgers, Peter Borghgraef, Lieve Dillen, Jan Goossens, Gerard Sanz, Heidi Szel, Carl Van Hove, Greta Van Nyen, Geert Nobels, Hugo Vanden Bossche, Marc Venet, Gustaaf Willemsens and Jean Van Wauwe
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 304-312;

CARDIOVASCULAR

  • You have access
    Effect of β-Adrenoceptor Blockers on Sarcoplasmic Reticular Function and Gene Expression in the Ischemic-Reperfused Heart
    Rana M. Temsah, Chadwyn Dyck, Thomas Netticadan, Donald Chapman, Vijayan Elimban and Naranjan S. Dhalla
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 15-23;
  • You have access
    Oxidative Stress Induced by tert-Butyl Hydroperoxide Causes Vasoconstriction in the Aorta from Hypertensive and Aged Rats: Role of Cyclooxygenase-2 Isoform
    Edith-Clara Garcia-Cohen, Jesus Marin, Luis D. Diez-Picazo, Ana B. Baena, Mercedes Salaices and M. Angeles Rodriguez-Martinez
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 75-81;
  • You have access
    Signaling Mechanisms for Muscarinic Receptor-Mediated Coronary Vasoconstriction in Isolated Rat Hearts
    Yi Zhang and Donald B. Hoover
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 96-106;
  • You have access
    Tertiapin Potently and Selectively Blocks Muscarinic K+ Channels in Rabbit Cardiac Myocytes
    Hidetsuna Kitamura, Mitsuhiro Yokoyama, Hozuka Akita, Kenji Matsushita, Yoshihisa Kurachi and Mitsuhiko Yamada
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 196-205;
  • You have access
    A Novel Angiotensin Analog with Subnanomolar Affinity for Angiotensin-Converting Enzyme
    Luke T. Krebs, Jodie M. Hanesworth, Michael F. Sardinia, Robert C. Speth, John W. Wright and Joseph W. Harding
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 260-267;

CELLULAR AND MOLECULAR

  • You have access
    Pyrrolo-1,5-benzoxazepines Induce Apoptosis in HL-60, Jurkat, and Hut-78 Cells: A New Class of Apoptotic Agents
    Daniela M. Zisterer, Giuseppe Campiani, Vito Nacci and D. Clive Williams
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 48-59;
  • You have access
    Ras/Mitogen-Activated Protein Kinase Mediates Norepinephrine-Induced Phospholipase D Activation in Rabbit Aortic Smooth Muscle Cells by a Phosphorylation-Dependent Mechanism
    Mubarack M. Muthalif, Jean-Hugues Parmentier, Ibrahim F. Benter, Nour Karzoun, Aftab Ahmed, Zinat Khandekar, Mohamed Z. Adl, Sylvain Bourgoin and Kafait U. Malik
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 268-274;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

  • You have access
    Induction of Apoptosis by theO-Hydroxyethyl-d(Ser)8-cyclosporine A Derivative SDZ IMM 125 in Rat Hepatocytes
    Sibylle Grub, Elke Persohn, Wolfgang E. Trommer and Armin Wolf
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 24-32;
  • You have access
    Neuromuscular Dysfunction in the Jejunum and Colon of Human Leukocyte Antigen B27 Transgenic Rats
    Kalina Venkova, S. Terence Dunn, Adekunle M. Adesina and Beverley Greenwood-Van Meerveld
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 60-66;
  • You have access
    Taurine and Niacin Block Lung Injury and Fibrosis by Down-Regulating Bleomycin-Induced Activation of Transcription Nuclear Factor-κB in Mice ,
    Gopalakrishnan Gurujeyalakshmi, Yingjin Wang and Shri N. Giri
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 82-90;
  • You have access
    Stimulation of the Na+-K+ Pump in Cultured Guinea Pig Airway Smooth Muscle Cells by Serotonin
    Kerry J. Rhoden, Alicia M. Dodson and Betty Ky
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 107-112;
  • You have access
    Enhancement by Epinephrine of Benzylpenicillin Transport in Rat Small Intestine
    Mariusz T. Skowronski, Yasuko Ishikawa and Hajime Ishida
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 128-135;
  • You have access
    Substance P in the Dorsal Motor Nucleus of the Vagus Evokes Gastric Motor Inhibition via Neurokinin 1 Receptor in Rat
    Zbigniew K. Krowicki and Pamela J. Hornby
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 214-221;

INFLAMMATION AND IMMUNOPHARMACOLOGY

  • You have access
    Comparative Pharmacodynamics of Keliximab and Clenoliximab in Transgenic Mice Bearing Human CD4
    Amarnath Sharma, Charles B. Davis, Lee Ann P. Tobia, Deborah C. Kwok, Marcella G. Tucci, Elizabeth R. Gore, Danuta J. Herzyk and Timothy K. Hart
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 33-41;
  • You have access
    Effects of Cannabinoid Receptor Agonist and Antagonist Ligands on Production of Inflammatory Cytokines and Anti-Inflammatory Interleukin-10 in Endotoxemic Mice
    Sidney R. Smith, Carol Terminelli and Georgetta Denhardt
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 136-150;
  • You have access
    Effects of Cigarette Smoke on Immune Response: Chronic Exposure to Cigarette Smoke Impairs Antigen-Mediated Signaling in T Cells and Depletes IP3-Sensitive Ca2+ Stores
    Roma Kalra, Shashi P. Singh, Susan M. Savage, Gregory L. Finch and Mohan L. Sopori
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 166-171;
  • You have access
    Signal Transduction Cascade in Staurosporine-Induced Prostaglandin E2 Production by Rat Peritoneal Macrophages
    Kouya Yamaki, Takayuki Yonezawa and Kazuo Ohuchi
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 206-213;
  • You have access
    Diffusion of Peroxynitrite into the Human Platelet Inhibits Cyclooxygenase via Nitration of Tyrosine Residues
    Christine Boulos, Houli Jiang and Michael Balazy
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 222-229;
  • You have access
    SB 239063, a Potent p38 MAP Kinase Inhibitor, Reduces Inflammatory Cytokine Production, Airways Eosinophil Infiltration, and Persistence
    David C. Underwood, Ruth R. Osborn, Charles J. Kotzer, Jerry L. Adams, John C. Lee, Edward F. Webb, Donald C. Carpenter, Steven Bochnowicz, Heath C. Thomas, Douglas W. P. Hay and Don E. Griswold
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 281-288;

NEUROPHARMACOLOGY

  • You have access
    Comparison of the Effects of Clozapine, Risperidone, and Olanzapine on Ketamine-Induced Alterations in Regional Brain Metabolism
    Gary E. Duncan, Seiya Miyamoto, Jeremy N. Leipzig and Jeffrey A. Lieberman
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 8-14;
  • You have access
    A Subtype of the γ-Aminobutyric AcidB Receptor Regulates Cholinergic Twitch Response in the Guinea Pig Ileum
    Manuela Marcoli, Simona Scarrone, Guido Maura, Giambattista Bonanno and Maurizio Raiteri
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 42-47;
  • You have access
    Potential Role of the α4 and α6 Nicotinic Receptor Subunits in Regulating Nicotine-Induced Seizures
    Jerry A. Stitzel, Melissa Jimenez, Michael J. Marks, Theresa Tritto and Allan C. Collins
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 67-74;
  • You have access
    Dopamine Decreases Melatonin Content in Golden Hamster Retina
    Carolina O. Jaliffa, Francisco Firpo Lacoste, Diego Weinberg Llomovatte, María I. Keller Sarmiento and Ruth E. Rosenstein
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 91-95;
  • You have access
    Selected Cysteine Residues in Transmembrane Domains of μ-Opioid Receptor Are Critical for Effects of Sulfhydryl Reagents
    Hong Bing Deng, Wei Guang and Jia Bei Wang
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 113-120;
  • You have access
    Strain Differences in Basal and Cocaine-Evoked Dopamine Dynamics in Mouse Striatum
    Ming He and Toni S. Shippenberg
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 121-127;
  • You have access
    Antinociceptive Activity of [β-Methyl-2′,6′-dimethyltyrosine1]-Substituted Cyclic [d-Pen2,d-Pen5]Enkephalin and [d-Ala2,Asp4]Deltorphin Analogs
    Edward J. Bilsky, Xinhua Qian, Victor J. Hruby and Frank Porreca
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 151-158;
  • You have access
    Effect of Chronic Ethanol and Withdrawal on the μ-Opioid Receptor- and 5-Hydroxytryptamine1A Receptor-Stimulated Binding of [35S]Guanosine-5′-O-(3-thio)triphosphate in the Fawn-Hooded Rat Brain: A Quantitative Autoradiography Study
    Feng Chen and Andrew J. Lawrence
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 159-165;
  • You have access
    ATP Inhibits Glutamate Synaptic Release by Acting at P2Y Receptors in Pyramidal Neurons of Hippocampal Slices
    Victor Mendoza-Fernández, R. David Andrew and Carlos Barajas-López
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 172-179;
  • You have access
    Cocaine-Induced Seizure Thresholds: Quantitative Trait Loci Detection and Mapping in Two Populations Derived from the C57BL/6 and DBA/2 Mouse Strains
    Heather S. Hain, John C. Crabbe, Susan E. Bergeson and John K. Belknap
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 180-187;
  • You have access
    Selectively Bred Lines of Mice Show Response and Drug Specificity for Genetic Regulation of Acute Functional Tolerance to Ethanol and Pentobarbital
    V. Gene Erwin, Vaughn M. Gehle and Richard A. Deitrich
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 188-195;
  • You have access
    Internalization and Recycling of δ-Opioid Receptor Are Dependent on a Phosphorylation-Dephosphorylation Mechanism
    Ahmed Hasbi, Stéphane Allouche, François Sichel, Laura Stanasila, Dominique Massotte, Gérard Landemore, Jocelyne Polastron and Philippe Jauzac
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 237-247;
  • You have access
    Pharmacological Characterization of 125I-1229U91 Binding to Y1 and Y4 Neuropeptide Y/Peptide YY Receptors
    Douglas A. Schober, Susan L. Gackenheimer, Mark L. Heiman and Donald R. Gehlert
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 275-280;

TOXICOLOGY

  • You have access
    Allopurinol Prevents Early Alcohol-Induced Liver Injury in Rats
    Hiroshi Kono, Ivan Rusyn, Blair U. Bradford, Henry D. Connor, Ronald P. Mason and Ronald G. Thurman
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 296-303;

Erratum

  • You have access
    Journal of Pharmacology and Experimental Therapeutics April 2000, 293 (1) 313;
Back to top
PreviousNext

In this issue

Journal of Pharmacology and Experimental Therapeutics: 293 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 293, Issue 1
1 Apr 2000
  • Table of Contents
  • About the Cover
  • Index by author
Sign up for alerts

Jump to

  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
  • Erratum
  • Most Cited
  • Most Read
Loading
  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
More...
Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics