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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Quantitative Prediction of Metabolic Inhibition of Midazolam by Erythromycin, Diltiazem, and Verapamil in Rats: Implication of Concentrative Uptake of Inhibitors into Liver

Katsuhiro Yamano, Koujirou Yamamoto, Hajime Kotaki, Sayuri Takedomi, Hirotami Matsuo, Yasufumi Sawada and Tatsuji Iga
Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1118-1126;

Article Information

vol. 292 no. 3 1118-1126
PubMed 
10688631
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received May 4, 1999
  • Accepted November 15, 1999
  • Published online March 1, 2000.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Katsuhiro Yamano1,3,
  2. Koujirou Yamamoto4,
  3. Hajime Kotaki2,
  4. Sayuri Takedomi5,
  5. Hirotami Matsuo5,
  6. Yasufumi Sawada5 and
  7. Tatsuji Iga1
  1. 1Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine (Ka.Y., T.I.), and 2Department of Pharmacy, The Research Hospital, The Institute of Medical Science (H.K.), University of Tokyo, Tokyo; 3Biopharmaceutical and Pharmacokinetic Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka (Ka.Y.); 4Department of Clinical Pharmacology School of Medicine, Gunma University, Maebashi (Ko.Y.); and 5Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka (S.T., H.M., Y.S.), Japan
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    Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

    Quantitative Prediction of Metabolic Inhibition of Midazolam by Erythromycin, Diltiazem, and Verapamil in Rats: Implication of Concentrative Uptake of Inhibitors into Liver

    Katsuhiro Yamano, Koujirou Yamamoto, Hajime Kotaki, Sayuri Takedomi, Hirotami Matsuo, Yasufumi Sawada and Tatsuji Iga
    Journal of Pharmacology and Experimental Therapeutics March 1, 2000, 292 (3) 1118-1126;
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