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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

March 01, 2000; Volume 292,Issue 3

PERSPECTIVES IN PHARMACOLOGY

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    Histamine H3-Receptors: A New Frontier in Myocardial Ischemia
    Roberto Levi and Neil C. E. Smith
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 825-830;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Anti-Phencyclidine Monoclonal Antibodies Provide Long-Term Reductions in Brain Phencyclidine Concentrations during Chronic Phencyclidine Administration in Rats
    Joel W. Proksch, W. Brooks Gentry and S. Michael Owens
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 831-837;
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    Disposition of Dodecanedioic Acid in Humans
    Alessandro Bertuzzi, Geltrude Mingrone, Alberto Gandolfi, Aldo Virgilio Greco and Serenella Salinari
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 846-852;
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    Structure-Pharmacokinetics Relationship of Series of Aminosteroidal Neuromuscular Blocking Agents in the Cat
    Johannes H. Proost, J. Mark K. H. Wierda, Martin C. Houwertjes, Jan Roggeveld and Dirk K. F. Meijer
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 861-869;
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    c-Myc Antisense Limits Rat Liver Regeneration and Indicates Role for c-Myc in Regulating Cytochrome P-450 3A Activity
    Vikram Arora, Derek C. Knapp, Barbara L. Smith, Mary L. Statdfield, David A. Stein, Muralimohan T. Reddy, Dwight D. Weller and Patrick L. Iversen
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 921-928;
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    Carrier-Mediated Uptake of the Endogenous Cannabinoid Anandamide in RBL-2H3 Cells
    Fariborz Rakhshan, Theresa A. Day, Randy D. Blakely and Eric L. Barker
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 960-967;
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    Metabolite Anion Carriers Mediate the Uptake of the Anionic Drug Fluorescein in Renal Cortical Mitochondria
    Sylvie A. Terlouw, Orhangazi Tanriseven, Frans G. M. Russel and Rosalinde Masereeuw
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 968-973;
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    Induction of Cytochrome P-450 1A2 by Oxidized Tryptophan in Hepa lclc7 Cells
    Ram K. Sindhu, Masato Mitsuhashi and Yutaka Kikkawa
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1008-1014;
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    Effects of Age on In Vitro Midazolam Biotransformation in Male CD-1 Mouse Liver Microsomes
    Jill S. Warrington, Joseph W. Poku, Lisa L. von Moltke, Richard I. Shader, Jerold S. Harmatz and David J. Greenblatt
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1024-1031;
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    Disposition of Methamphetamine and Its Metabolite Amphetamine in Brain and Other Tissues in Rats after Intravenous Administration
    Gilles J. Rivière, W. Brooks Gentry and S. Michael Owens
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1042-1047;
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    Targeting Rat Anti-Mouse Transferrin Receptor Monoclonal Antibodies through Blood-Brain Barrier in Mouse
    Hwa Jeong Lee, Britta Engelhardt, Jayne Lesley, Ulrich Bickel and William M. Pardridge
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1048-1052;
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    Accelerated Blood Clearance and Altered Biodistribution of Repeated Injections of Sterically Stabilized Liposomes
    Els T. M. Dams, Peter Laverman, Wim J. G. Oyen, Gert Storm, Gerrit L. Scherphof, Jos W. M. van der Meer, Frans H. M. Corstens and Otto C. Boerman
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1071-1079;
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    Suppression of a High-Affinity Transport System for Manganese in Cadmium-Resistant Metallothionein-Null Cells
    Takahiro Yanagiya, Nobumasa Imura, Shuichi Enomoto, Yukihiro Kondo and Seiichiro Himeno
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1080-1086;
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    Benazeprilat Disposition and Effect in Dogs Revisited with a Pharmacokinetic/Pharmacodynamic Modeling Approach
    Pierre-Louis Toutain, Hervé P. Lefebvre and Jon N. King
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1087-1093;
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    New Insights on Effect of Kidney Insufficiency on Disposition of Angiotensin-Converting Enzyme Inhibitors: Case of Enalapril and Benazepril in Dogs
    Pierre-Louis Toutain, Hervé P. Lefebvre and Valérie Laroute
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1094-1103;
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    Quantitative Prediction of Metabolic Inhibition of Midazolam by Erythromycin, Diltiazem, and Verapamil in Rats: Implication of Concentrative Uptake of Inhibitors into Liver
    Katsuhiro Yamano, Koujirou Yamamoto, Hajime Kotaki, Sayuri Takedomi, Hirotami Matsuo, Yasufumi Sawada and Tatsuji Iga
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1118-1126;

CARDIOVASCULAR

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    Targeted Antioxidant Properties ofN-[(Tetramethyl-3-pyrroline-3-carboxamido)propyl]phthalimide and Its Nitroxide Metabolite in Preventing Postischemic Myocardial Injury
    Ravi A. Shankar, Kalman Hideg, Jay L. Zweier and Periannan Kuppusamy
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 838-845;
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    M2 and M4 Receptor Knockout Mice: Muscarinic Receptor Function in Cardiac and Smooth Muscle In Vitro
    Peter W. Stengel, Jesus Gomeza, Jurgen Wess and Marlene L. Cohen
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 877-885;
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    Peroxynitrite, a Two-Edged Sword in Post-Ischemic Myocardial Injury—Dichotomy of Action in Crystalloid- Versus Blood-Perfused Hearts
    Xin-Liang Ma, Feng Gao, Bernard L. Lopez, Theodore A. Christopher and Jakob Vinten-Johansen
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 912-920;
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    Sustained Reduction in Myocardial Reperfusion Injury with an Adenosine Receptor Antagonist: Possible Role of the Neutrophil Chemoattractant Response
    Mervyn B. Forman, João V. Vitola, Carlos E. Velasco, John J. Murray, Raghvendra K. Dubey and Edwin K. Jackson
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 929-938;
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    Radiotelemetric Evaluation of Hemodynamic Effects of Long-Term Ethanol in Spontaneously Hypertensive and Wistar-Kyoto Rats
    Mahmoud M. El-Mas and Abdel A. Abdel-Rahman
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 944-951;
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    Block of Human Heart hH1 Sodium Channels by Amitriptyline
    Carla Nau, Margaret Seaver, Sho-Ya Wang and Ging Kuo Wang
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1015-1023;
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    Cytochrome P450 ω/ω-1 Hydroxylase-Derived Eicosanoids Contribute to EndothelinA and EndothelinBReceptor-Mediated Vasoconstriction to Endothelin-1 in the Rat Preglomerular Arteriole
    Hantz C. Hercule and Adebayo O. Oyekan
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1153-1160;

CELLULAR AND MOLECULAR

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    Cloning and Pharmacological Characterization of the Rat CB2 Cannabinoid Receptor
    Graeme Griffin, Qing Tao and Mary E. Abood
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 886-894;
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    Modulation of Cellular Calcium by Sigma-2 Receptors: Release from Intracellular Stores in Human SK-N-SH Neuroblastoma Cells
    Bertold J. Vilner and Wayne D. Bowen
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 900-911;
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    Ca2+ Mobilization Evoked by Chloroform in Madin-Darby Canine Kidney Cells
    Chung-Ren Jan, Lee-Wei Chen and Ming-Wei Lin
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 995-1001;
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    Polarized Distribution of Interleukin-1 Receptors and Their Role in Regulation of Serotonin Transporter in Placenta
    Ramesh Kekuda, Frederick H. Leibach, Todd C. Furesz, Carl H. Smith and Vadivel Ganapathy
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1032-1041;
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    The Role of Phosphodiesterase in Mediating the Effect of Protein Kinase C on Cyclic AMP Accumulation upon κ-Opioid Receptor Stimulation in the Rat Heart
    Jin-Song Bian, Wei-Min Zhang, Jian-Ming Pei and Tak-Ming Wong
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1065-1070;

ENDOCRINE AND REPRODUCTIVE

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    A Mibefradil Metabolite Is a Potent Intracellular Blocker of L-Type Ca2+ Currents in Pancreatic β-Cells
    Songwei Wu, Min Zhang, Pamela A. Vest, Arin Bhattacharjee, Li Liu and Ming Li
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 939-943;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Kinetic and Selectivity Differences between Rodent, Rabbit, and Human Organic Cation Transporters (OCT1)
    Mark J. Dresser, Andrew T. Gray and Kathleen M. Giacomini
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1146-1152;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Interleukin-13 Modulates Collagen Homeostasis in Human Skin and Keloid Fibroblasts
    Alfonso Oriente, Neal S. Fedarko, Sarah E. Pacocha, Shau-Ku Huang, Lawrence M. Lichtenstein and David M. Essayan
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 988-994;
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    Effects of Selective and Unselective Cyclooxygenase Inhibitors on Prostanoid Release from Various Rat Organs
    Irmgard Tegeder, Werner Neupert, Hans Gühring and Gerd Geisslinger
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1161-1168;

NEUROPHARMACOLOGY

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    Central Administration of Methamphetamine Synergizes with Metabolic Inhibition to Deplete Striatal Monoamines
    Kristan B. Burrows, Wendy L. Nixdorf and Bryan K. Yamamoto
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 853-860;
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    Inhibitors of Phospholipase C Prevent Glutamate Neurotoxicity in Primary Cultures of Cerebellar Neurons
    Marta Llansola, Pilar Monfort and Vicente Felipo
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 870-876;
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    6-NO2-Norepinephrine Increases Norepinephrine Release and Inhibits Norepinephrine Uptake in Rat Spinal Synaptosomes
    Xinhui Li, George Rose, Astrid Chiari, Hui-Lin Pan, Joseph R. Tobin and James C. Eisenach
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 895-899;
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    D2, but Not D1 Dopamine Receptor Agonists Potentiate Cannabinoid-Induced Sedation in Nonhuman Primates ,
    Justin P. Meschler, Francis A. Clarkson, Patricia J. Mathews, Allyn C. Howlett and Bertha K. Madras
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 952-959;
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    Effects of Intracavernous Administration of Selective Antagonists of α1-Adrenoceptor Subtypes on Erection in Anesthetized Rats and Dogs
    Giorgio Sironi, Davide Colombo, Elena Poggesi, Amedeo Leonardi, Rodolfo Testa, Olivier Rampin, Jacques Bernabé and Francois Giuliano
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 974-981;
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    Probable Involvement of the 5-Hydroxytryptamine4Receptor in Methotrexate-Induced Delayed Emesis in Dogs
    Hisashi Yamakuni, Hiroe Sawai, Yasue Maeda, Katsunori Imazumi, Hiroyuki Sakuma, Masahiko Matsuo, Seitaro Mutoh and Jiro Seki
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1002-1007;
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    Reward and Somatic Changes during Precipitated Nicotine Withdrawal in Rats: Centrally and Peripherally Mediated Effects ,
    Shelly S. Watkins, Luis Stinus, George F. Koob and Athina Markou
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1053-1064;
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    Inhibition by Intracellular Mg2+ of RecombinantN-Methyl-d-aspartate Receptors Expressed in Chinese Hamster Ovary Cells
    Yingying Li-Smerin, Elias Aizenman and Jon W. Johnson
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1104-1110;
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    Regulation of Extracellular Concentrations of 5-Hydroxytryptamine (5-HT) in Mouse Striatum by 5-HT1A and 5-HT1B Receptors
    Deborah A. Knobelman, Hank F. Kung and Irwin Lucki
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1111-1117;
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    Ligand-Induced Changes in Surface μ-Opioid Receptor Number: Relationship to G Protein Activation?
    Paulette A. Zaki, Duane E. Keith, George A. Brine, F. Ivy Carroll and Christopher J. Evans
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1127-1134;
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    Imidazoline-Binding Domains on Monoamine Oxidase B and Subpopulations of Enzyme
    Rita Raddatz, Sandra L. Savic, Venkatesalu Bakthavachalam, John Lesnick, Jeffrey R. Jasper, Christopher R. McGrath, Angelo Parini and Stephen M. Lanier
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1135-1145;
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    Native N-Methyl-d-aspartate Receptors Containing NR2A and NR2B Subunits Have Pharmacologically Distinct Competitive Antagonist Binding Sites
    Jason M. Christie, David E. Jane and Daniel T. Monaghan
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1169-1174;

TOXICOLOGY

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    Possible Mechanism of Hepatocyte Injury Induced by Diphenylamine and Its Structurally Related Nonsteroidal Anti-Inflammatory Drugs
    Yasuhiro Masubuchi, Shoko Yamada and Toshiharu Horie
    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 982-987;

Erratum

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    Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1175;
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Journal of Pharmacology and Experimental Therapeutics: 292 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 292, Issue 3
1 Mar 2000
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  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • ENDOCRINE AND REPRODUCTIVE
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
  • Erratum
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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