Journal of Pharmacology and Experimental Therapeutics: 292 (3)

March 01, 2000; Volume 292,Issue 3

PERSPECTIVES IN PHARMACOLOGY

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Histamine H₃-Receptors: A New Frontier in Myocardial Ischemia
Roberto Levi and Neil C. E. Smith

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 825-830;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Anti-Phencyclidine Monoclonal Antibodies Provide Long-Term Reductions in Brain Phencyclidine Concentrations during Chronic Phencyclidine Administration in Rats
Joel W. Proksch, W. Brooks Gentry and S. Michael Owens

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 831-837;
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Disposition of Dodecanedioic Acid in Humans
Alessandro Bertuzzi, Geltrude Mingrone, Alberto Gandolfi, Aldo Virgilio Greco and Serenella Salinari

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 846-852;
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Structure-Pharmacokinetics Relationship of Series of Aminosteroidal Neuromuscular Blocking Agents in the Cat
Johannes H. Proost, J. Mark K. H. Wierda, Martin C. Houwertjes, Jan Roggeveld and Dirk K. F. Meijer

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 861-869;
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c-Myc Antisense Limits Rat Liver Regeneration and Indicates Role for c-Myc in Regulating Cytochrome P-450 3A Activity
Vikram Arora, Derek C. Knapp, Barbara L. Smith, Mary L. Statdfield, David A. Stein, Muralimohan T. Reddy, Dwight D. Weller and Patrick L. Iversen

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 921-928;
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Carrier-Mediated Uptake of the Endogenous Cannabinoid Anandamide in RBL-2H3 Cells
Fariborz Rakhshan, Theresa A. Day, Randy D. Blakely and Eric L. Barker

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 960-967;
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Metabolite Anion Carriers Mediate the Uptake of the Anionic Drug Fluorescein in Renal Cortical Mitochondria
Sylvie A. Terlouw, Orhangazi Tanriseven, Frans G. M. Russel and Rosalinde Masereeuw

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 968-973;
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Induction of Cytochrome P-450 1A2 by Oxidized Tryptophan in Hepa lclc7 Cells
Ram K. Sindhu, Masato Mitsuhashi and Yutaka Kikkawa

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1008-1014;
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Effects of Age on In Vitro Midazolam Biotransformation in Male CD-1 Mouse Liver Microsomes
Jill S. Warrington, Joseph W. Poku, Lisa L. von Moltke, Richard I. Shader, Jerold S. Harmatz and David J. Greenblatt

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1024-1031;
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Disposition of Methamphetamine and Its Metabolite Amphetamine in Brain and Other Tissues in Rats after Intravenous Administration
Gilles J. Rivière, W. Brooks Gentry and S. Michael Owens

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1042-1047;
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Targeting Rat Anti-Mouse Transferrin Receptor Monoclonal Antibodies through Blood-Brain Barrier in Mouse
Hwa Jeong Lee, Britta Engelhardt, Jayne Lesley, Ulrich Bickel and William M. Pardridge

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1048-1052;
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Accelerated Blood Clearance and Altered Biodistribution of Repeated Injections of Sterically Stabilized Liposomes
Els T. M. Dams, Peter Laverman, Wim J. G. Oyen, Gert Storm, Gerrit L. Scherphof, Jos W. M. van der Meer, Frans H. M. Corstens and Otto C. Boerman

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1071-1079;
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Suppression of a High-Affinity Transport System for Manganese in Cadmium-Resistant Metallothionein-Null Cells
Takahiro Yanagiya, Nobumasa Imura, Shuichi Enomoto, Yukihiro Kondo and Seiichiro Himeno

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1080-1086;
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Benazeprilat Disposition and Effect in Dogs Revisited with a Pharmacokinetic/Pharmacodynamic Modeling Approach
Pierre-Louis Toutain, Hervé P. Lefebvre and Jon N. King

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1087-1093;
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New Insights on Effect of Kidney Insufficiency on Disposition of Angiotensin-Converting Enzyme Inhibitors: Case of Enalapril and Benazepril in Dogs
Pierre-Louis Toutain, Hervé P. Lefebvre and Valérie Laroute

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1094-1103;
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Quantitative Prediction of Metabolic Inhibition of Midazolam by Erythromycin, Diltiazem, and Verapamil in Rats: Implication of Concentrative Uptake of Inhibitors into Liver
Katsuhiro Yamano, Koujirou Yamamoto, Hajime Kotaki, Sayuri Takedomi, Hirotami Matsuo, Yasufumi Sawada and Tatsuji Iga

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1118-1126;

CARDIOVASCULAR

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Targeted Antioxidant Properties ofN-[(Tetramethyl-3-pyrroline-3-carboxamido)propyl]phthalimide and Its Nitroxide Metabolite in Preventing Postischemic Myocardial Injury
Ravi A. Shankar, Kalman Hideg, Jay L. Zweier and Periannan Kuppusamy

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 838-845;
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M₂ and M₄ Receptor Knockout Mice: Muscarinic Receptor Function in Cardiac and Smooth Muscle In Vitro
Peter W. Stengel, Jesus Gomeza, Jurgen Wess and Marlene L. Cohen

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 877-885;
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Peroxynitrite, a Two-Edged Sword in Post-Ischemic Myocardial Injury—Dichotomy of Action in Crystalloid- Versus Blood-Perfused Hearts
Xin-Liang Ma, Feng Gao, Bernard L. Lopez, Theodore A. Christopher and Jakob Vinten-Johansen

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 912-920;
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Sustained Reduction in Myocardial Reperfusion Injury with an Adenosine Receptor Antagonist: Possible Role of the Neutrophil Chemoattractant Response
Mervyn B. Forman, João V. Vitola, Carlos E. Velasco, John J. Murray, Raghvendra K. Dubey and Edwin K. Jackson

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 929-938;
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Radiotelemetric Evaluation of Hemodynamic Effects of Long-Term Ethanol in Spontaneously Hypertensive and Wistar-Kyoto Rats
Mahmoud M. El-Mas and Abdel A. Abdel-Rahman

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 944-951;
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Block of Human Heart hH1 Sodium Channels by Amitriptyline
Carla Nau, Margaret Seaver, Sho-Ya Wang and Ging Kuo Wang

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1015-1023;
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Cytochrome P450 ω/ω-1 Hydroxylase-Derived Eicosanoids Contribute to Endothelin_A and Endothelin_BReceptor-Mediated Vasoconstriction to Endothelin-1 in the Rat Preglomerular Arteriole
Hantz C. Hercule and Adebayo O. Oyekan

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1153-1160;

CELLULAR AND MOLECULAR

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Cloning and Pharmacological Characterization of the Rat CB₂ Cannabinoid Receptor
Graeme Griffin, Qing Tao and Mary E. Abood

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 886-894;
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Modulation of Cellular Calcium by Sigma-2 Receptors: Release from Intracellular Stores in Human SK-N-SH Neuroblastoma Cells
Bertold J. Vilner and Wayne D. Bowen

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 900-911;
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Ca²⁺ Mobilization Evoked by Chloroform in Madin-Darby Canine Kidney Cells
Chung-Ren Jan, Lee-Wei Chen and Ming-Wei Lin

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 995-1001;
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Polarized Distribution of Interleukin-1 Receptors and Their Role in Regulation of Serotonin Transporter in Placenta
Ramesh Kekuda, Frederick H. Leibach, Todd C. Furesz, Carl H. Smith and Vadivel Ganapathy

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1032-1041;
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The Role of Phosphodiesterase in Mediating the Effect of Protein Kinase C on Cyclic AMP Accumulation upon κ-Opioid Receptor Stimulation in the Rat Heart
Jin-Song Bian, Wei-Min Zhang, Jian-Ming Pei and Tak-Ming Wong

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1065-1070;

ENDOCRINE AND REPRODUCTIVE

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A Mibefradil Metabolite Is a Potent Intracellular Blocker of L-Type Ca²⁺ Currents in Pancreatic β-Cells
Songwei Wu, Min Zhang, Pamela A. Vest, Arin Bhattacharjee, Li Liu and Ming Li

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 939-943;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Kinetic and Selectivity Differences between Rodent, Rabbit, and Human Organic Cation Transporters (OCT1)
Mark J. Dresser, Andrew T. Gray and Kathleen M. Giacomini

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1146-1152;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Interleukin-13 Modulates Collagen Homeostasis in Human Skin and Keloid Fibroblasts
Alfonso Oriente, Neal S. Fedarko, Sarah E. Pacocha, Shau-Ku Huang, Lawrence M. Lichtenstein and David M. Essayan

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 988-994;
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Effects of Selective and Unselective Cyclooxygenase Inhibitors on Prostanoid Release from Various Rat Organs
Irmgard Tegeder, Werner Neupert, Hans Gühring and Gerd Geisslinger

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1161-1168;

NEUROPHARMACOLOGY

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Central Administration of Methamphetamine Synergizes with Metabolic Inhibition to Deplete Striatal Monoamines
Kristan B. Burrows, Wendy L. Nixdorf and Bryan K. Yamamoto

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 853-860;
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Inhibitors of Phospholipase C Prevent Glutamate Neurotoxicity in Primary Cultures of Cerebellar Neurons
Marta Llansola, Pilar Monfort and Vicente Felipo

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 870-876;
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6-NO₂-Norepinephrine Increases Norepinephrine Release and Inhibits Norepinephrine Uptake in Rat Spinal Synaptosomes
Xinhui Li, George Rose, Astrid Chiari, Hui-Lin Pan, Joseph R. Tobin and James C. Eisenach

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 895-899;
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D₂, but Not D₁ Dopamine Receptor Agonists Potentiate Cannabinoid-Induced Sedation in Nonhuman Primates ,
Justin P. Meschler, Francis A. Clarkson, Patricia J. Mathews, Allyn C. Howlett and Bertha K. Madras

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 952-959;
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Effects of Intracavernous Administration of Selective Antagonists of α₁-Adrenoceptor Subtypes on Erection in Anesthetized Rats and Dogs
Giorgio Sironi, Davide Colombo, Elena Poggesi, Amedeo Leonardi, Rodolfo Testa, Olivier Rampin, Jacques Bernabé and Francois Giuliano

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 974-981;
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Probable Involvement of the 5-Hydroxytryptamine₄Receptor in Methotrexate-Induced Delayed Emesis in Dogs
Hisashi Yamakuni, Hiroe Sawai, Yasue Maeda, Katsunori Imazumi, Hiroyuki Sakuma, Masahiko Matsuo, Seitaro Mutoh and Jiro Seki

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1002-1007;
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Reward and Somatic Changes during Precipitated Nicotine Withdrawal in Rats: Centrally and Peripherally Mediated Effects ,
Shelly S. Watkins, Luis Stinus, George F. Koob and Athina Markou

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1053-1064;
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Inhibition by Intracellular Mg²⁺ of RecombinantN-Methyl-d-aspartate Receptors Expressed in Chinese Hamster Ovary Cells
Yingying Li-Smerin, Elias Aizenman and Jon W. Johnson

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1104-1110;
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Regulation of Extracellular Concentrations of 5-Hydroxytryptamine (5-HT) in Mouse Striatum by 5-HT_1A and 5-HT_1B Receptors
Deborah A. Knobelman, Hank F. Kung and Irwin Lucki

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1111-1117;
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Ligand-Induced Changes in Surface μ-Opioid Receptor Number: Relationship to G Protein Activation?
Paulette A. Zaki, Duane E. Keith, George A. Brine, F. Ivy Carroll and Christopher J. Evans

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1127-1134;
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Imidazoline-Binding Domains on Monoamine Oxidase B and Subpopulations of Enzyme
Rita Raddatz, Sandra L. Savic, Venkatesalu Bakthavachalam, John Lesnick, Jeffrey R. Jasper, Christopher R. McGrath, Angelo Parini and Stephen M. Lanier

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1135-1145;
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Native N-Methyl-d-aspartate Receptors Containing NR2A and NR2B Subunits Have Pharmacologically Distinct Competitive Antagonist Binding Sites
Jason M. Christie, David E. Jane and Daniel T. Monaghan

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1169-1174;

TOXICOLOGY

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Possible Mechanism of Hepatocyte Injury Induced by Diphenylamine and Its Structurally Related Nonsteroidal Anti-Inflammatory Drugs
Yasuhiro Masubuchi, Shoko Yamada and Toshiharu Horie

Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 982-987;

Erratum

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Journal of Pharmacology and Experimental Therapeutics March 2000, 292 (3) 1175;

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

CARDIOVASCULAR

CELLULAR AND MOLECULAR

ENDOCRINE AND REPRODUCTIVE

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

TOXICOLOGY

Erratum

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