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Research ArticleGASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

Subthreshold Doses of Specific Phosphodiesterase Type 3 and 4 Inhibitors Enhance the Pulmonary Vasodilatory Response to Nebulized Prostacyclin with Improvement in Gas Exchange

Ralph Theo Schermuly, Axel Roehl, Norbert Weissmann, Hossein Ardeschir Ghofrani, Christian Schudt, Herrmann Tenor, Friedrich Grimminger, Werner Seeger and Dieter Walmrath
Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 512-520;

Article Information

vol. 292 no. 2 512-520
PubMed 
10640287
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Accepted October 7, 1999
  • Published online February 1, 2000.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ralph Theo Schermuly1,
  2. Axel Roehl1,
  3. Norbert Weissmann1,
  4. Hossein Ardeschir Ghofrani1,
  5. Christian Schudt2,
  6. Herrmann Tenor2,
  7. Friedrich Grimminger1,
  8. Werner Seeger1 and
  9. Dieter Walmrath1
  1. 1Department of Internal Medicine, Justus-Liebig-University Giessen, Giessen (R.T.S., A.R., N.W., H.A.G., F.G., W.S., D.W.); and 2Byk Gulden Pharmaceuticals, Konstanz (C.S., H.T.), Germany.
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    Research ArticleGASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

    Subthreshold Doses of Specific Phosphodiesterase Type 3 and 4 Inhibitors Enhance the Pulmonary Vasodilatory Response to Nebulized Prostacyclin with Improvement in Gas Exchange

    Ralph Theo Schermuly, Axel Roehl, Norbert Weissmann, Hossein Ardeschir Ghofrani, Christian Schudt, Herrmann Tenor, Friedrich Grimminger, Werner Seeger and Dieter Walmrath
    Journal of Pharmacology and Experimental Therapeutics February 1, 2000, 292 (2) 512-520;
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