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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

February 01, 2000; Volume 292,Issue 2

PERSPECTIVES IN PHARMACOLOGY

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    Neuronal Nicotinic Acetylcholine Receptors as Novel Drug Targets
    G. Kenneth Lloyd and Michael Williams
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 461-467;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Phosphorothioate Oligodeoxynucleotides Distribute Similarly in Class A Scavenger Receptor Knockout and Wild-Type Mice
    Madeline Butler, Rosanne M. Crooke, Mark J. Graham, Kristina M. Lemonidis, Marilee Lougheed, Susan F. Murray, Donna Witchell, Urs Steinbrecher and C. Frank Bennett
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 489-496;
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    Characterization of the Transport Properties of Organic Anion Transporting Polypeptide 1 (oatp1) and Na+/Taurocholate Cotransporting Polypeptide (Ntcp): Comparative Studies on the Inhibitory Effect of their Possible Substrates in Hepatocytes and cDNA-Transfected COS-7 Cells
    Hirokazu Kouzuki, Hiroshi Suzuki, Bruno Stieger, Peter J. Meier and Yuichi Sugiyama
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 505-511;
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    Midazolam and Triazolam Biotransformation in Mouse and Human Liver Microsomes: Relative Contribution of CYP3A and CYP2C Isoforms
    Michael D. Perloff, Lisa L. von Moltke, Michael H. Court, Tsutomu Kotegawa, Richard I. Shader and David J. Greenblatt
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 618-628;

CARDIOVASCULAR

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    Effects of the T-Type Ca2+ Channel Blocker Mibefradil on Repolarization of Guinea Pig, Rabbit, Dog, Monkey, and Human Cardiac Tissue
    Agnès Bénardeau, Jacques Weissenburger, Luc Hondeghem and Eric A. Ertel
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 561-575;
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    Inositol Phosphate Metabolism and Nitric-Oxide Synthase Activity in Endothelial Cells Are Involved in the Vasorelaxant Activity of Nebivolol
    Astrid Parenti, Sandra Filippi, Sandra Amerini, Harris J. Granger, Alessandro Fazzini and Fabrizio Ledda
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 698-703;
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    Differential Sensitivity among Nitric Oxide Donors toward ODQ-Mediated Inhibition of Vascular Relaxation
    Chih-Ming Leo Tseng, Mohammad A. Tabrizi-Fard and Ho-Leung Fung
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 737-742;
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    Diuretic Response to Adenosine A1 Receptor Blockade in Normotensive and Spontaneously Hypertensive Rats: Role of Pertussis Toxin-Sensitive G-Proteins
    Curtis K. Kost, William A. Herzer, Barbara R. Rominski, Zaichuan Mi and Edwin K. Jackson
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 752-760;
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    Predominant Contribution of the G Protein-Mediated Mechanism to NaF-Induced Vascular Contractions in Diabetic Rats: Association with an Increased Level of Gqα Expression
    Yuichi Hattori, Naoyuki Matsuda, Atsushi Sato, Satoko Watanuki, Hiroshi Tomioka, Hisao Kawasaki and Morio Kanno
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 761-768;
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    Intrapericardial Delivery of Fibroblast Growth Factor-2 Induces Neovascularization in a Porcine Model of Chronic Myocardial Ischemia
    Roger J. Laham, Mehrdad Rezaee, Mark Post, Debborah Novicki, Frank W. Sellke, Justin D. Pearlman, Michael Simons and David Hung
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 795-802;

CELLULAR AND MOLECULAR

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    In Vivo Antitumor Activity and Induction of Insulin-Like Growth Factor-1-Resistant Apoptosis by SC-ααδ9
    Andreas Vogt, Angela S. Wang, Candace S. Johnson, James P. Fabisiak, Peter Wipf and John S. Lazo
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 530-537;
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    Nifedipine and Diltiazem but Not Verapamil Up-Regulate Endothelial Nitric-Oxide Synthase Expression
    Yaoxian Ding and Nosratola D. Vaziri
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 606-609;
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    The Roles of Protein Kinase C and Tyrosine Kinases in Mediating Endothelin-1-Stimulated Phospholipase D Activity in Rat Myometrium: Differential Inhibition by Ceramides and Cyclic AMP
    Hervé Le Stunff, Lien Dokhac and Simone Harbon
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 629-637;
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    Facilitation of Constitutive α2A-Adrenoceptor Activity by Both Single Amino Acid Mutation (Thr373Lys) and Gαo Protein Coexpression: Evidence for Inverse Agonism
    Petrus J. Pauwels, Stéphanie Tardif, Thierry Wurch and Francis C. Colpaert
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 654-663;
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    Bidirectional Allosteric Effects of Agonists and GTP at α2A/D-Adrenoceptors
    Wang-Ni Tian, Duane D. Miller and Richard C. Deth
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 664-671;
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    5-Hydroxytryptamine1A Receptor-Stimulated [35S]GTPγS Binding in Rat Brain: Absence of Regional Differences in Coupling Efficiency
    Emanuel Meller, Hua Li, Kenneth D. Carr and Jacob M. Hiller
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 684-691;
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    Bisprasin, a Novel Ca2+ Releaser with Caffeine-Like Properties from a Marine Sponge, Dysideaspp., Acts on Ca2+-Induced Ca2+ Release Channels of Skeletal Muscle Sarcoplasmic Reticulum
    Atsuko Suzuki, Kimihiro Matsunaga, Heejae Shin, Jioji Tabudrav, Yoshikazu Shizuri and Yasushi Ohizumi
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 725-730;
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    Stimulation of Cl− Secretion by Chlorzoxazone
    Ashvani K. Singh, Daniel C. Devor, Aaron C. Gerlach, Margaret Gondor, Joseph M. Pilewski and Robert J. Bridges
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 778-787;

ENDOCRINE AND REPRODUCTIVE

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    Functional and Molecular Properties of the Human Recombinant Y4 Receptor: Resistance to Agonist-Promoted Desensitization
    Thierry Voisin, Mathieu Goumain, Anne-Marie Lorinet, Jean-José Maoret and Marc Laburthe
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 638-646;
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    Pregnancy Induces a Modulation of the cAMP Phosphodiesterase 4-Conformers Ratio in Human Myometrium: Consequences for the Utero-Relaxant Effect of PDE4-Selective Inhibitors
    Céline Méhats, Gisèle Tanguy, Brigitte Paris, Brigitte Robert, Nadja Pernin, Françoise Ferré and Marie-Josèphe Leroy
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 817-823;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Subthreshold Doses of Specific Phosphodiesterase Type 3 and 4 Inhibitors Enhance the Pulmonary Vasodilatory Response to Nebulized Prostacyclin with Improvement in Gas Exchange
    Ralph Theo Schermuly, Axel Roehl, Norbert Weissmann, Hossein Ardeschir Ghofrani, Christian Schudt, Herrmann Tenor, Friedrich Grimminger, Werner Seeger and Dieter Walmrath
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 512-520;
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    Acute Effect of Cadmium-Metallothionein on Glucose and Amino Acid Transport across the Apical Membrane of the Rabbit Proximal Tubule Perfused In Vitro
    Shuichi Tsuruoka, Koh-ichi Sugimoto, Shigeaki Muto, Kazuo Nomiyama, Akio Fujimura and Masashi Imai
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 769-777;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Chemically Modified Oligonucleotides Exhibit Decreased Immune Stimulation in Mice
    Scott Henry, Kim Stecker, Doug Brooks, David Monteith, Boyd Conklin and C. Frank Bennett
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 468-479;
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    Enhanced Anti-Inflammatory Activity of a Liposomal Intercellular Adhesion Molecule-1 Antisense Oligodeoxynucleotide in an Acute Model of Contact Hypersensitivity
    Sandra K. Klimuk, Sean C. Semple, Patrick N. Nahirney, Michelle C. Mullen, C. Frank Bennett, Peter Scherrer and Michael J. Hope
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 480-488;
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    Role of Nuclear Factor of Activated T-Cells and Activator Protein-1 in the Inhibition of Interleukin-2 Gene Transcription by Cannabinol in EL4 T-Cells
    Sung Su Yea, Kyu-Hwan Yang and Norbert E. Kaminski
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 597-605;
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    Anti-Inflammatory Activities of a New Series of Selective Phosphodiesterase 4 Inhibitors Derived from 9-Benzyladenine
    Elisabeth Boichot, John L. Wallace, Noëlla Germain, Marianne Corbel, Claire Lugnier, Vincent Lagente and Jean-Jacques Bourguignon
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 647-653;
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    Pharmacokinetics and Pharmacodynamics of a Humanized Monoclonal Antibody to Factor IX in Cynomolgus Monkeys
    Lisa J. Benincosa, Fung-Sing Chow, Leeann P. Tobia, Deborah C. Kwok, Charles B. Davis and William J. Jusko
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 810-816;

NEUROPHARMACOLOGY

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    Interleukin-1β Inhibits γ-Aminobutyric Acid Type A (GABAA) Receptor Current in Cultured Hippocampal Neurons
    Sam Wang, Qing Cheng, Sundeep Malik and Jay Yang
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 497-504;
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    Comparative Behavioral Pharmacology of Cocaine and the Selective Dopamine Uptake Inhibitor RTI-113 in the Squirrel Monkey
    Leonard L. Howell, Paul W. Czoty, Michael J. Kuhar and F. Ivy Carrol
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 521-529;
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    Effects of Spinal Cholecystokinin Receptor Antagonists on Morphine Antinociception in a Model of Visceral Pain in the Rat
    Ann E. Friedrich and Gerald F. Gebhart
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 538-544;
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    Novel UncompetitiveN-Methyl-d-Aspartate (NMDA)-Receptor Antagonist MRZ 2/579 Suppresses Ethanol Intake in Long-Term Ethanol-Experienced Rats and Generalizes to Ethanol Cue in Drug Discrimination Procedure
    Sabine M. Hölter, Wojciech Danysz and Rainer Spanagel
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 545-552;
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    Differential Antinociceptive Effects of Endomorphin-1 and Endomorphin-2 in the Mouse
    Leon F. Tseng, Minoru Narita, Chiaki Suganuma, Hirokazu Mizoguchi, Masahiro Ohsawa, Hiroshi Nagase and John P. Kampine
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 576-583;
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    The Preclinical Pharmacological Profile of WAY-132983, a Potent M1 Preferring Agonist
    Adam C. Bartolomeo, Herman Morris, Jerry J. Buccafusco, Nancy Kille, Sharon Rosenzweig-Lipson, Morris G. Husbands, Annmarie L. Sabb, Magid Abou-Gharbia, John A. Moyer and Carl A. Boast
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 584-596;
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    The Effects of the 5-Hydroxytryptamine1A Agonist 8-Hydroxy-2-(di-n-propylamino)tetralin on Spontaneous Activity, Cocaine-Induced Hyperactivity and Behavioral Sensitization: A Microanalysis of Locomotor Activity
    Richard De La Garza and Kathryn A. Cunningham
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 610-617;
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    Induction of Spontaneous Tail-Flicks in Rats by Blockade of Transmission at N-Methyl-d-Aspartate Receptors: Roles of Multiple Monoaminergic Receptors in Relation to the Actions of Antipsychotic Agents
    Mark J. Millan, Alain Gobert, Karin Bervoets, Jean-Michel Rivet, Sylvie Veiga and Mauricette Brocco
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 672-683;
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    Pharmacological Characterization of Endogenous Acetylcholine Release from Primary Septal Cultures
    Daniel S. Auld, Jamie C. Day, Françoise Mennicken and Rémi Quirion
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 692-697;
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    Reversal of Morphine-Induced Apnea in the Anesthetized Rat by Drugs that Activate 5-Hydroxytryptamine1AReceptors
    Niaz Sahibzada, Manuel Ferreira, Adam M. Wasserman, Angelo M. Taveira-DaSilva and Richard A. Gillis
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 704-713;
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    D1 Dopamine Receptor Agonists Are More Effective in Alleviating Advanced than Mild Parkinsonism in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Treated Monkeys
    Martin Goulet and Bertha K. Madras
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 714-724;
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    Atypical Antipsychotics and Dopamine D1 Receptor Agonism: An In Vivo Experimental Study Using Core Temperature Measurements in the Rat
    Sandra Oerther and Sven Ahlenius
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 731-736;
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    Intrathecally Administered Gabapentin Inhibits Formalin-Evoked Nociception and the Expression of Fos-Like Immunoreactivity in the Spinal Cord of the Rat
    Megumi Kaneko, Christine Mestre, Edgard H. Sánchez and Donna L. Hammond
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 743-751;
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    FA-70, A Novel Selective and Irreversible Monoamine Oxidase-A Inhibitor: Effect on Monoamine Metabolism in Mouse Cerebral Cortex
    José A. Morón, Virgili Pérez, Manel Pastó, José Miguel Lizcano and Mercedes Unzeta
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 788-794;
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    The Antitussive Activity of δ-Opioid Receptor Stimulation in Guinea Pigs
    Charles J. Kotzer, Douglas W. P. Hay, Giulio Dondio, Giuseppe Giardina, Paola Petrillo and David C. Underwood
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 803-809;

TOXICOLOGY

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    Potentiation of Oxygen-Induced Lung Injury in Rats by the Mechanism-Based Cytochrome P-450 Inhibitor, 1-Aminobenzotriazole
    Bhagavatula Moorthy, Kristen M. Parker, Charles V. Smith, John R. Bend and Stephen E. Welty
    Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 553-560;
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Journal of Pharmacology and Experimental Therapeutics: 292 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 292, Issue 2
1 Feb 2000
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  • PERSPECTIVES IN PHARMACOLOGY
  • ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  • CARDIOVASCULAR
  • CELLULAR AND MOLECULAR
  • ENDOCRINE AND REPRODUCTIVE
  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  • INFLAMMATION AND IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • TOXICOLOGY
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