Journal of Pharmacology and Experimental Therapeutics: 292 (2)

February 01, 2000; Volume 292,Issue 2

PERSPECTIVES IN PHARMACOLOGY

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Neuronal Nicotinic Acetylcholine Receptors as Novel Drug Targets
G. Kenneth Lloyd and Michael Williams

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 461-467;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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Phosphorothioate Oligodeoxynucleotides Distribute Similarly in Class A Scavenger Receptor Knockout and Wild-Type Mice
Madeline Butler, Rosanne M. Crooke, Mark J. Graham, Kristina M. Lemonidis, Marilee Lougheed, Susan F. Murray, Donna Witchell, Urs Steinbrecher and C. Frank Bennett

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 489-496;
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Characterization of the Transport Properties of Organic Anion Transporting Polypeptide 1 (oatp1) and Na⁺/Taurocholate Cotransporting Polypeptide (Ntcp): Comparative Studies on the Inhibitory Effect of their Possible Substrates in Hepatocytes and cDNA-Transfected COS-7 Cells
Hirokazu Kouzuki, Hiroshi Suzuki, Bruno Stieger, Peter J. Meier and Yuichi Sugiyama

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 505-511;
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Midazolam and Triazolam Biotransformation in Mouse and Human Liver Microsomes: Relative Contribution of CYP3A and CYP2C Isoforms
Michael D. Perloff, Lisa L. von Moltke, Michael H. Court, Tsutomu Kotegawa, Richard I. Shader and David J. Greenblatt

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 618-628;

CARDIOVASCULAR

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Effects of the T-Type Ca²⁺ Channel Blocker Mibefradil on Repolarization of Guinea Pig, Rabbit, Dog, Monkey, and Human Cardiac Tissue
Agnès Bénardeau, Jacques Weissenburger, Luc Hondeghem and Eric A. Ertel

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 561-575;
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Inositol Phosphate Metabolism and Nitric-Oxide Synthase Activity in Endothelial Cells Are Involved in the Vasorelaxant Activity of Nebivolol
Astrid Parenti, Sandra Filippi, Sandra Amerini, Harris J. Granger, Alessandro Fazzini and Fabrizio Ledda

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 698-703;
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Differential Sensitivity among Nitric Oxide Donors toward ODQ-Mediated Inhibition of Vascular Relaxation
Chih-Ming Leo Tseng, Mohammad A. Tabrizi-Fard and Ho-Leung Fung

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 737-742;
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Diuretic Response to Adenosine A₁ Receptor Blockade in Normotensive and Spontaneously Hypertensive Rats: Role of Pertussis Toxin-Sensitive G-Proteins
Curtis K. Kost, William A. Herzer, Barbara R. Rominski, Zaichuan Mi and Edwin K. Jackson

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 752-760;
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Predominant Contribution of the G Protein-Mediated Mechanism to NaF-Induced Vascular Contractions in Diabetic Rats: Association with an Increased Level of G_qα Expression
Yuichi Hattori, Naoyuki Matsuda, Atsushi Sato, Satoko Watanuki, Hiroshi Tomioka, Hisao Kawasaki and Morio Kanno

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 761-768;
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Intrapericardial Delivery of Fibroblast Growth Factor-2 Induces Neovascularization in a Porcine Model of Chronic Myocardial Ischemia
Roger J. Laham, Mehrdad Rezaee, Mark Post, Debborah Novicki, Frank W. Sellke, Justin D. Pearlman, Michael Simons and David Hung

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 795-802;

CELLULAR AND MOLECULAR

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In Vivo Antitumor Activity and Induction of Insulin-Like Growth Factor-1-Resistant Apoptosis by SC-ααδ9
Andreas Vogt, Angela S. Wang, Candace S. Johnson, James P. Fabisiak, Peter Wipf and John S. Lazo

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 530-537;
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Nifedipine and Diltiazem but Not Verapamil Up-Regulate Endothelial Nitric-Oxide Synthase Expression
Yaoxian Ding and Nosratola D. Vaziri

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 606-609;
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The Roles of Protein Kinase C and Tyrosine Kinases in Mediating Endothelin-1-Stimulated Phospholipase D Activity in Rat Myometrium: Differential Inhibition by Ceramides and Cyclic AMP
Hervé Le Stunff, Lien Dokhac and Simone Harbon

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 629-637;
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Facilitation of Constitutive α_2A-Adrenoceptor Activity by Both Single Amino Acid Mutation (Thr³⁷³Lys) and G_αo Protein Coexpression: Evidence for Inverse Agonism
Petrus J. Pauwels, Stéphanie Tardif, Thierry Wurch and Francis C. Colpaert

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 654-663;
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Bidirectional Allosteric Effects of Agonists and GTP at α_2A/D-Adrenoceptors
Wang-Ni Tian, Duane D. Miller and Richard C. Deth

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 664-671;
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5-Hydroxytryptamine_1A Receptor-Stimulated [³⁵S]GTPγS Binding in Rat Brain: Absence of Regional Differences in Coupling Efficiency
Emanuel Meller, Hua Li, Kenneth D. Carr and Jacob M. Hiller

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 684-691;
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Bisprasin, a Novel Ca²⁺ Releaser with Caffeine-Like Properties from a Marine Sponge, Dysideaspp., Acts on Ca²⁺-Induced Ca²⁺ Release Channels of Skeletal Muscle Sarcoplasmic Reticulum
Atsuko Suzuki, Kimihiro Matsunaga, Heejae Shin, Jioji Tabudrav, Yoshikazu Shizuri and Yasushi Ohizumi

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 725-730;
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Stimulation of Cl⁻ Secretion by Chlorzoxazone
Ashvani K. Singh, Daniel C. Devor, Aaron C. Gerlach, Margaret Gondor, Joseph M. Pilewski and Robert J. Bridges

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 778-787;

ENDOCRINE AND REPRODUCTIVE

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Functional and Molecular Properties of the Human Recombinant Y4 Receptor: Resistance to Agonist-Promoted Desensitization
Thierry Voisin, Mathieu Goumain, Anne-Marie Lorinet, Jean-José Maoret and Marc Laburthe

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 638-646;
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Pregnancy Induces a Modulation of the cAMP Phosphodiesterase 4-Conformers Ratio in Human Myometrium: Consequences for the Utero-Relaxant Effect of PDE4-Selective Inhibitors
Céline Méhats, Gisèle Tanguy, Brigitte Paris, Brigitte Robert, Nadja Pernin, Françoise Ferré and Marie-Josèphe Leroy

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 817-823;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Subthreshold Doses of Specific Phosphodiesterase Type 3 and 4 Inhibitors Enhance the Pulmonary Vasodilatory Response to Nebulized Prostacyclin with Improvement in Gas Exchange
Ralph Theo Schermuly, Axel Roehl, Norbert Weissmann, Hossein Ardeschir Ghofrani, Christian Schudt, Herrmann Tenor, Friedrich Grimminger, Werner Seeger and Dieter Walmrath

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 512-520;
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Acute Effect of Cadmium-Metallothionein on Glucose and Amino Acid Transport across the Apical Membrane of the Rabbit Proximal Tubule Perfused In Vitro
Shuichi Tsuruoka, Koh-ichi Sugimoto, Shigeaki Muto, Kazuo Nomiyama, Akio Fujimura and Masashi Imai

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 769-777;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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Chemically Modified Oligonucleotides Exhibit Decreased Immune Stimulation in Mice
Scott Henry, Kim Stecker, Doug Brooks, David Monteith, Boyd Conklin and C. Frank Bennett

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 468-479;
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Enhanced Anti-Inflammatory Activity of a Liposomal Intercellular Adhesion Molecule-1 Antisense Oligodeoxynucleotide in an Acute Model of Contact Hypersensitivity
Sandra K. Klimuk, Sean C. Semple, Patrick N. Nahirney, Michelle C. Mullen, C. Frank Bennett, Peter Scherrer and Michael J. Hope

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 480-488;
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Role of Nuclear Factor of Activated T-Cells and Activator Protein-1 in the Inhibition of Interleukin-2 Gene Transcription by Cannabinol in EL4 T-Cells
Sung Su Yea, Kyu-Hwan Yang and Norbert E. Kaminski

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 597-605;
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Anti-Inflammatory Activities of a New Series of Selective Phosphodiesterase 4 Inhibitors Derived from 9-Benzyladenine
Elisabeth Boichot, John L. Wallace, Noëlla Germain, Marianne Corbel, Claire Lugnier, Vincent Lagente and Jean-Jacques Bourguignon

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 647-653;
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Pharmacokinetics and Pharmacodynamics of a Humanized Monoclonal Antibody to Factor IX in Cynomolgus Monkeys
Lisa J. Benincosa, Fung-Sing Chow, Leeann P. Tobia, Deborah C. Kwok, Charles B. Davis and William J. Jusko

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 810-816;

NEUROPHARMACOLOGY

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Interleukin-1β Inhibits γ-Aminobutyric Acid Type A (GABA_A) Receptor Current in Cultured Hippocampal Neurons
Sam Wang, Qing Cheng, Sundeep Malik and Jay Yang

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 497-504;
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Comparative Behavioral Pharmacology of Cocaine and the Selective Dopamine Uptake Inhibitor RTI-113 in the Squirrel Monkey
Leonard L. Howell, Paul W. Czoty, Michael J. Kuhar and F. Ivy Carrol

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 521-529;
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Effects of Spinal Cholecystokinin Receptor Antagonists on Morphine Antinociception in a Model of Visceral Pain in the Rat
Ann E. Friedrich and Gerald F. Gebhart

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 538-544;
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Novel UncompetitiveN-Methyl-d-Aspartate (NMDA)-Receptor Antagonist MRZ 2/579 Suppresses Ethanol Intake in Long-Term Ethanol-Experienced Rats and Generalizes to Ethanol Cue in Drug Discrimination Procedure
Sabine M. Hölter, Wojciech Danysz and Rainer Spanagel

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 545-552;
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Differential Antinociceptive Effects of Endomorphin-1 and Endomorphin-2 in the Mouse
Leon F. Tseng, Minoru Narita, Chiaki Suganuma, Hirokazu Mizoguchi, Masahiro Ohsawa, Hiroshi Nagase and John P. Kampine

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 576-583;
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The Preclinical Pharmacological Profile of WAY-132983, a Potent M1 Preferring Agonist
Adam C. Bartolomeo, Herman Morris, Jerry J. Buccafusco, Nancy Kille, Sharon Rosenzweig-Lipson, Morris G. Husbands, Annmarie L. Sabb, Magid Abou-Gharbia, John A. Moyer and Carl A. Boast

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 584-596;
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The Effects of the 5-Hydroxytryptamine_1A Agonist 8-Hydroxy-2-(di-n-propylamino)tetralin on Spontaneous Activity, Cocaine-Induced Hyperactivity and Behavioral Sensitization: A Microanalysis of Locomotor Activity
Richard De La Garza and Kathryn A. Cunningham

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 610-617;
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Induction of Spontaneous Tail-Flicks in Rats by Blockade of Transmission at N-Methyl-d-Aspartate Receptors: Roles of Multiple Monoaminergic Receptors in Relation to the Actions of Antipsychotic Agents
Mark J. Millan, Alain Gobert, Karin Bervoets, Jean-Michel Rivet, Sylvie Veiga and Mauricette Brocco

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 672-683;
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Pharmacological Characterization of Endogenous Acetylcholine Release from Primary Septal Cultures
Daniel S. Auld, Jamie C. Day, Françoise Mennicken and Rémi Quirion

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 692-697;
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Reversal of Morphine-Induced Apnea in the Anesthetized Rat by Drugs that Activate 5-Hydroxytryptamine_1AReceptors
Niaz Sahibzada, Manuel Ferreira, Adam M. Wasserman, Angelo M. Taveira-DaSilva and Richard A. Gillis

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 704-713;
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D₁ Dopamine Receptor Agonists Are More Effective in Alleviating Advanced than Mild Parkinsonism in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Treated Monkeys
Martin Goulet and Bertha K. Madras

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 714-724;
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Atypical Antipsychotics and Dopamine D₁ Receptor Agonism: An In Vivo Experimental Study Using Core Temperature Measurements in the Rat
Sandra Oerther and Sven Ahlenius

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 731-736;
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Intrathecally Administered Gabapentin Inhibits Formalin-Evoked Nociception and the Expression of Fos-Like Immunoreactivity in the Spinal Cord of the Rat
Megumi Kaneko, Christine Mestre, Edgard H. Sánchez and Donna L. Hammond

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 743-751;
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FA-70, A Novel Selective and Irreversible Monoamine Oxidase-A Inhibitor: Effect on Monoamine Metabolism in Mouse Cerebral Cortex
José A. Morón, Virgili Pérez, Manel Pastó, José Miguel Lizcano and Mercedes Unzeta

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 788-794;
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The Antitussive Activity of δ-Opioid Receptor Stimulation in Guinea Pigs
Charles J. Kotzer, Douglas W. P. Hay, Giulio Dondio, Giuseppe Giardina, Paola Petrillo and David C. Underwood

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 803-809;

TOXICOLOGY

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Potentiation of Oxygen-Induced Lung Injury in Rats by the Mechanism-Based Cytochrome P-450 Inhibitor, 1-Aminobenzotriazole
Bhagavatula Moorthy, Kristen M. Parker, Charles V. Smith, John R. Bend and Stephen E. Welty

Journal of Pharmacology and Experimental Therapeutics February 2000, 292 (2) 553-560;

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Table of Contents

PERSPECTIVES IN PHARMACOLOGY

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

CARDIOVASCULAR

CELLULAR AND MOLECULAR

ENDOCRINE AND REPRODUCTIVE

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION AND IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

TOXICOLOGY

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