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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

January 01, 2000; Volume 292,Issue 1

EDITORIAL

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    Editorial
    S. J. Enna
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 1-2;

PERSPECTIVES IN PHARMACOLOGY

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    γ-Aminobutyric AcidB Receptors: First of the Functional Metabotropic Heterodimers
    Norman G. Bowery and S. J. Enna
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 2-7;

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

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    Metabolism of Antisense Oligonucleotides in Rat Liver Homogenates
    Rosanne M. Crooke, Mark J. Graham, Michael J. Martin, Kristina M. Lemonidis, Tad Wyrzykiewiecz and Lendell L. Cummins
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 140-149;
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    N-Acetylation of Paraphenylenediamine in Human Skin and Keratinocytes
    Yo Kawakubo, Hans F. Merk, Tlaytmas Al Masaoudi, Sonja Sieben and Brunhilde Blömeke
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 150-155;
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    Differential Expression of Gender-Dependent Hepatic Isoforms of Cytochrome P-450 by Pulse Signals in the Circulating Masculine Episodic Growth Hormone Profile of the Rat
    Arun K. Agrawal and Bernard H. Shapiro
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 228-237;
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    Function and Expression of Multidrug Resistance-Associated Protein Family in Human Colon Adenocarcinoma Cells (Caco-2)
    Tomoko Hirohashi, Hiroshi Suzuki, Xiao-Yan Chu, Ikumi Tamai, Akira Tsuji and Yuichi Sugiyama
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 265-270;
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    Influence of P-Glycoprotein on the Transport and Metabolism of Indinavir in Caco-2 Cells Expressing Cytochrome P-450 3A4
    Jerome H. Hochman, Masato Chiba, Joy Nishime, Masayo Yamazaki and Jiunn H. Lin
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 310-318;
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    Inhibition of Platelet Aggregation with Glyceryl Trinitrate and Xanthine Oxidoreductase
    Sharon O'Byrne, Cheerag Shirodaria, Timothy Millar, Cliff Stevens, David Blake and Nigel Benjamin
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 326-330;
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    Role of Drug Release and Liposome-Mediated Drug Delivery in Governing the Therapeutic Activity of Liposomal Mitoxantrone Used to Treat Human A431 and LS180 Solid Tumors
    Howard J. Lim, Dana Masin, Natashia L. McIntosh, Thomas D. Madden and Marcel B. Bally
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 337-345;

CARDIOVASCULAR

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    Carboxyamido-triazole Inhibits Angiogenesis by Blocking the Calcium-Mediated Nitric-Oxide Synthase-Vascular Endothelial Growth Factor Pathway
    Kenneth S. Bauer, Kelly J. Cude, Shannon C. Dixon, Erwin A. Kruger and William D. Figg
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 31-37;
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    MCC-134, a Novel Vascular Relaxing Agent, Is an Inverse Agonist for the Pancreatic-Type ATP-Sensitive K+Channel
    Takashi Shindo, Yusuke Katayama, Yoshiyuki Horio and Yoshihisa Kurachi
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 131-135;
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    Characterization of Tetrandrine-Induced Inhibition of Large-Conductance Calcium-Activated Potassium Channels in a Human Endothelial Cell Line (HUV-EC-C)
    Sheng-Nan Wu, Hui-Fang Li and Yi-Ching Lo
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 188-195;
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    Effects of Captopril Treatment of Renovascular Hypertension on β-Adrenergic Modulation of L-Type Ca2+Current
    Xiaoping Xu, Seth J. Rials, Ying Wu, Tengxian Liu, Roger A. Marinchak and Peter R. Kowey
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 196-200;
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    Acute Cocaine Exposure Up-Regulates Complement Expression in Rabbit Heart
    Elaine J. Tanhehco, Koji Yasojima, Patrick L. McGeer and Benedict R. Lucchesi
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 201-208;
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    Novel Angiotensin II AT1 Receptor Antagonist Irbesartan Prevents Thromboxane A2-Induced Vasoconstriction in Canine Coronary Arteries and Human Platelet Aggregation
    Ping Li, Masayo Fukuhara, Debra I. Diz, Carlos M. Ferrario and K. Bridget Brosnihan
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 238-246;
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    Characterization of a Novel Porcine EndothelinBReceptor Splice Variant
    Ponnal Nambi, Hsiao-Ling Wu, Diana Ye, Alison Gagnon and Nabil Elshourbagy
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 247-253;
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    Loratadine Blockade of K+ Channels in Human Heart: Comparison with Terfenadine under Physiological Conditions
    William J. Crumb
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 261-264;
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    Inhibition of Aminopeptidase P Potentiates Wheal Response to Bradykinin in Angiotensin-Converting Enzyme Inhibitor-Treated Humans
    Kyung-Soo Kim, Sandeep Kumar, William H. Simmons and Nancy J. Brown
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 295-298;
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    Nonpeptide Factor Xa Inhibitors: I. Studies with SF303 and SK549, a New Class of Potent Antithrombotics
    Pancras C. Wong, Mimi L. Quan, Earl J., Crain, Carol A. Watson, Ruth R. Wexler and Robert M. Knabb
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 351-357;
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    Nitric Oxide-Dependent and -Independent Mechanisms Account for Gender Differences in Vasodilation to Acetylcholine
    Richard M. White, Carlos O. Rivera and Cathy A. Davison
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 375-380;
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    Dispersion of Ventricular Repolarization and Ventricular Fibrillation in Left Ventricular Hypertrophy: Influence of Selective Potassium Channel Blockers
    Anne M. Gillis, Heather J. Mathison, Elzbieta Kulisz and Wanda M. Lester
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 381-386;
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    Endogenously Generated Nitric Oxide by Nitric-Oxide Synthase Gene Transfer Inhibits Cellular Proliferation
    Yoshikazu Maeda, Uichi Ikeda, Ken-ichi Oya, Masahisa Shimpo, Shuichi Ueno, Koji Okada, Toshikazu Saito, Hiroyuki Mano, Keiya Ozawa and Kazuyuki Shimada
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 387-393;
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    Cellular and In Vivo Electrophysiological Effects of Dronedarone in Normal and Postmyocardial Infarcted Rats
    Frank Aimond, Lionel Beck, Patrick Gautier, Ouafiya K. Chérif, Jean-Marc Davy, Paco Lorente, Dino Nisato and Guy Vassort
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 415-424;
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    Contractile and Arrhythmic Effects of Endothelin Receptor Agonists in Human Heart In Vitro: Blockade with SB 209670
    Kylie M. Burrell, Peter Molenaar, Peter J. Dawson and Alberto J. Kaumann
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 449-459;

CELLULAR AND MOLECULAR

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    Cocaine Induces Apoptosis in Fetal Myocardial Cells through a Mitochondria-Dependent Pathway
    Yuhui Xiao, Jiale He, Raymond D. Gilbert and Lubo Zhang
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 8-14;
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    Effect of Mibefradil on Voltage-Dependent Gating and Kinetics of T-Type Ca2+ Channels in Cortisol-Secreting Cells
    Juan Carlos Gomora, Lin Xu, Judith A. Enyeart and John J. Enyeart
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 96-103;
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    Compound 48/80 Activates Mast Cell Phospholipase D via Heterotrimeric GTP-Binding Proteins
    Ahmed Chahdi, Paul F. Fraundorfer and Michael A. Beaven
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 122-130;
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    Characterization of Promoter Elements Mediating Ethanol Regulation of hsc70 Gene Transcription
    Norbert Wilke, Michael W. Sganga, Gregory G. Gayer, Kwei-Perng Hsieh and Michael F. Miles
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 173-180;
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    W-7 Induces [Ca2+]i Increases in Madin-Darby Canine Kidney (MDCK) Cells
    Chung-Ren Jan and Ching-Jiunn Tseng
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 358-365;
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    A Na+-Dependent Nucleoside Transporter in Microglia
    MeeRa Hong, Lyanne Schlichter and Reina Bendayan
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 366-374;
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    Influence of a Lysine 331 Counterion on the pK a of Aspartic Acid 125: Evidence for a Salt-Bridge Interaction and Role in α1b-Adrenergic Receptor Activation
    James E. Porter and Dianne M. Perez
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 440-448;

ENDOCRINE AND REPRODUCTIVE

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    Effects of β-Adrenergic Stimulation on the Acutely Obstructed Ureter in Dogs
    Makoto Murakami, Yoshitaka Tomiyama, Kohichi Hayakawa, Masuo Akahane, Yukiyoshi Ajisawa, Young-Chol Park, Norio Ohnishi, Takahide Sugiyama and Takashi Kurita
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 67-75;

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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    Specific Type IV Phosphodiesterase Inhibitor Rolipram Mitigates Experimental Colitis in Mice
    Gunther Hartmann, Christoph Bidlingmaier, Britta Siegmund, Stefan Albrich, Johannes Schulze, Katharina Tschoep, Andreas Eigler, Hans Anton Lehr and Stefan Endres
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 22-30;
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    Mercaptoethylguanidine Inhibits the Inflammatory Response in a Murine Model of Chronic Infection with Pseudomonas aeruginosa
    Robert W. Wilmott, Joseph A. Kitzmiller, Csaba Szabó, Garry J. Southan and Andrew L. Salzman
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 88-95;
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    Inhibitory Mechanism of Aloe Single Component (Alprogen) on Mediator Release in Guinea Pig Lung Mast Cells Activated with Specific Antigen-Antibody Reactions
    Jai Youl Ro, Byung Chul Lee, Ji Young Kim, Yean Jun Chung, Myung Hee Chung, Seung Kee Lee, Tae Hyung Jo, Kyung Hwan Kim and Young In Park
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 114-121;
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    Pharmacological Limitation of Damage to Renal Medulla after Cold Storage and Transplantation by Trimetazidine
    Thierry Hauet, Herve Baumert, Imed Ben Amor, Helene Gibelin, Claude Tallineau, Michel Eugene, Jean Paul Tillement and Michel Carretier
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 254-260;
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    β-Adrenergic Relaxation of Rabbit Tracheal Smooth Muscle: A Receptor Deficit That Improves with Corticosteroid Administration
    Craig M. Schramm
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 280-287;
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    Effects of the V2-Receptor Antagonist OPC-41061 and the Loop Diuretic Furosemide Alone and in Combination in Rats
    Takahiro Hirano, Yoshitaka Yamamura, Shigeki Nakamura, Toshiyuki Onogawa and Toyoki Mori
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 288-294;
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    Pharmacological Examination of the Neurokinin-1 Receptor Mediating Relaxation of Human Intralobar Pulmonary Artery
    Karen E. Pedersen, Carl K. Buckner, Sonya N. Meeker and Bradley J. Undem
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 319-325;
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    Involvement of an Organic Anion Transporter (Canalicular Multispecific Organic Anion Transporter/Multidrug Resistance-Associated Protein 2) in Gastrointestinal Secretion of Glutathione Conjugates in Rats
    Yasumasa Gotoh, Hiroshi Suzuki, Setsuo Kinoshita, Tomoko Hirohashi, Yukio Kato and Yuichi Sugiyama
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 433-439;

INFLAMMATION AND IMMUNOPHARMACOLOGY

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    Development of an Oral Drug Delivery System Targeting Immune-Regulating Cells in Experimental Inflammatory Bowel Disease: A New Therapeutic Strategy
    Hiroshi Nakase, Kazuichi Okazaki, Yasuhiko Tabata, Suguru Uose, Masaya Ohana, Kazushige Uchida, Yumi Matsushima, Chiharu Kawanami, Chikashi Oshima, Yoshito Ikada and Tsutomu Chiba
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 15-21;
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    Anti-Inflammatory Activity of Macrolide Antibiotics
    Angela Ianaro, Armando Ialenti, Pasquale Maffia, Lidia Sautebin, Laura Rombolà, Rosa Carnuccio, Teresa Iuvone, Fulvio D'Acquisto and Massimo Di Rosa
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 156-163;
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    Diphenyleneiodium Chloride Blocks Inflammatory Cytokine-Induced Up-Regulation of Group IIA Phospholipase A2 in Rat Mesangial Cells
    Glenn Dorsam, Mohinddin M. Taher, Kristoffer C. Valerie, Nancy B. Kuemmerle, James C. Chan and Richard C. Franson
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 271-279;
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    Pyridoxal-phosphate-6-azophenyl-2′,4′-disulfonate (PPADS), a Putative P2Y1 Receptor Antagonist, Blocks Signaling at a Site Distal to the Receptor in Madin-Darby Canine Kidney-D1Cells
    Darakhshanda Shehnaz, Brian Torres, Maria A. Balboa and Paul A. Insel
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 346-350;

NEUROPHARMACOLOGY

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    S18327 (1-{2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperid-1-yl]ethyl}3-phenyl imidazolin-2-one), a Novel, Potential Antipsychotic Displaying Marked Antagonist Properties at α1- and α2-Adrenergic Receptors: I. Receptorial, Neurochemical, and Electrophysiological Profile
    Mark J. Millan, Alain Gobert, Adrian Newman-Tancredi, Françoise Lejeune, Didier Cussac, Jean-Michel Rivet, Valérie Audinot, Agnès Adhumeau, Mauricette Brocco, Jean-Paul Nicolas, Jean A. Boutin, Nicole Despaux and Jean-Louis Peglion
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 38-53;
  • You have access
    S18327 (1-{2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperid-1-yl]ethyl}3-phenyl imidazolin-2-one), a Novel, Potential Antipsychotic Displaying Marked Antagonist Properties at α1- and α2-Adrenergic Receptors: II. Functional Profile and a Multiparametric Comparison with Haloperidol, Clozapine, and 11 Other Antipsychotic Agents
    Mark J. Millan, Mauricette Brocco, Jean-Michel Rivet, Valérie Audinot, Adrian Newman-Tancredi, Lisa Maiofiss, Sophie Queriaux, Nicole Despaux, Jean-Louis Peglion and Anne Dekeyne
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 54-66;
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    Physiological Antagonism between 5-Hydroxytryptamine2A and Group II Metabotropic Glutamate Receptors in Prefrontal Cortex
    Gerard J. Marek, Rebecca A. Wright, Darryle D. Schoepp, James A. Monn and George K. Aghajanian
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 76-87;
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    Rats Selectively Bred for Responsiveness to 5-Hydroxytryptamine1A Receptor Stimulation: Differences in Differential Reinforcement of Low Rate 72-Second Performance and Response to Serotonergic Drugs
    Michael S. Cousins, Georgetta Vosmer, David H. Overstreet and Lewis S. Seiden
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 104-113;
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    Involvement of Cannabinoid Receptors in the Intraocular Pressure-Lowering Effects of WIN55212-2
    Zhao-Hui Song and Carole-Anne Slowey
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 136-139;
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    Assessment of Mechanisms Involved in Antinociception Caused by Sesquiterpene Polygodial
    Gilboé L. Mendes, Adair R. S. Santos, Angela Malheiros, Valdir Cechinel Filho, Rosendo A. Yunes and João B. Calixto
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 164-172;
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    Corticotropin-Releasing Hormone1 Receptors Mediate Consensus Interferon-α YM643-Induced Depression-Like Behavior in Mice
    Mayumi Yamano, Hidenobu Yuki, Syuhei Yasuda and Keiji Miyata
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 181-187;
  • You have access
    Coupling of Human δ-Opioid Receptor to Retinal Rod Transducin in Chinese Hamster Ovary Cells
    Eva V. Varga, Dagmar Stropova, Tae Kim, Man Wang, William R. Roeske and Henry I. Yamamura
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 209-214;
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    Novel Structure Having Antagonist Actions at Both the Glycine Site of the N-Methyl-d-Aspartate Receptor and Neuronal Voltage-Sensitive Sodium Channels: Biochemical, Electrophysiological, and Behavioral Characterization
    Lawrence D. Snell, David J. Claffey, James A. Ruth, C. Fernando Valenzuela, Rita Cardoso, Zejun Wang, Simon R. Levinson, William A. Sather, Anna V. Williamson, Nan C. Ingersoll, Larissa Ovchinnikova, Sanjiv V. Bhave, Paula L. Hoffman and Boris Tabakoff
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 215-227;
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    Effect of Gender on Anti-Inflammatory and Analgesic Actions of Two κ-Opioids
    Waltraud Binder, John Carmody and Judith Walker
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 303-309;
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    Effect of Intrathecal Nocistatin on the Formalin-Induced Pain in Mice Versus That of Nociceptin/Orphanin FQ
    Hiroyuki Nakano, Toshiaki Minami, Kohji Abe, Tohko Arai, Miwa Tokumura, Nobuhiro Ibii, Emiko Okuda-Ashitaka, Hidemaro Mori and Seiji Ito
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 331-336;
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    Differential Change in Neuroactive Steroid Sensitivity during Ethanol Withdrawal
    Deborah A. Finn, Edward J. Gallaher and John C. Crabbe
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 394-405;
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    Regulation of Locomotor Activity by Metabotropic Glutamate Receptors in the Nucleus Accumbens and Ventral Tegmental Area
    Chad J. Swanson and Peter W. Kalivas
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 406-414;
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    In Vitro and In Vivo Characterization of Conantokin-R, a Selective Nmda Receptor Antagonist Isolated from the Venom of the Fish-Hunting Snail Conus radiatus 1
    H. Steve White, R. Tyler McCabe, Heather Armstrong, Sean D. Donevan, Lourdes J. Cruz, Fe C. Abogadie, Josep Torres, Jean E. Rivier, Ingo Paarmann, Michael Hollmann and Baldomero M. Olivera
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 425-432;

TOXICOLOGY

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    Metallothionein Acts as a Cytoprotectant against Doxorubicin Toxicity
    Tomoki Kimura, Isami Fujita, Norio Itoh, Norio Muto, Tsuyoshi Nakanishi, Kyoko Takahashi, Junichi Azuma and Keiichi Tanaka
    Journal of Pharmacology and Experimental Therapeutics January 2000, 292 (1) 299-302;
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Journal of Pharmacology and Experimental Therapeutics: 292 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 292, Issue 1
1 Jan 2000
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  • GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
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