Table of Contents

Articles

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  Cellular Adaptation: Journey from Smooth Muscle Cells to Neurons

  William W. Fleming

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 925-931;
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  Antagonist-Induced Reversal of Functional and Structural Measures of Hippocampal Benzodiazepine Tolerance

  Elizabeth I. Tietz, Xu J. Zeng, Shanyi Chen, Scott M. Lilly, Howard C. Rosenberg and Peter Kometiani

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 932-942;
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  Distribution in Rat Brain of Binding Sites of Kaliotoxin, a Blocker of Kv1.1 and Kv1.3 α-Subunits

  Christiane Mourre, Marina N. Chernova, Marie-France Martin-Eauclaire, Richard Bessone, Guy Jacquet, Maurice Gola, Seth. L. Alper and Marcel Crest

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 943-952;
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  Down-Regulation of Rat Hepatic Microsomal Cytochromes P-450 in Microvesicular Steatosis Induced by Orotic Acid

  Gloria M. Su, Rachel M. Sefton and Michael Murray

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 953-959;
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  Use of Intravenous Microdialysis to Monitor Changes in Serotonin Release and Metabolism Induced by Cisplatin in Cancer Patients: Comparative Effects of Granisetron and Ondansetron

  Ana M. Castejon, Ximena Paez, Luis Hernandez and Luigi X. Cubeddu

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 960-966;
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  Analysis of Expression of cGMP-Dependent Protein Kinase in Rabbit Heart Cells

  Rajiv Kumar, Ronald W. Joyner, Padmini Komalavilas and Thomas M. Lincoln

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 967-975;
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  Xestoquinone, Isolated from Sea Sponge, Causes Ca²⁺Release through Sulfhydryl Modification from Skeletal Muscle Sarcoplasmic Reticulum

  Masaaki Ito, Yutaka Hirata, Hideshi Nakamura and Yasushi Ohizumi

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 976-981;
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  Effect of Angiotensin-Converting Enzyme Inhibition on Plasma, Urine, and Tissue Concentrations of Hemoregulatory Peptide Acetyl-Ser-Asp-Lys-Pro in Rats

  Christophe Junot, Laurence Nicolet, Eric Ezan, Marie-Francoise Gonzales, Joel Menard and Michel Azizi

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 982-987;
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  Adenosine A₁ Receptor Antagonist KW-3902 Prevents Hypoxia-Induced Renal Vasoconstriction

  Akira Nishiyama, Akira Miyatake, Yasuharu Aki, Toshiki Fukui, Matlubur Rahman, Shoji Kimura and Youichi Abe

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 988-993;
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  Dopamine D₃ Receptors Modulate Evoked Dopamine Release from Slices of Rat Nucleus Accumbens Via Muscarinic Receptors, But Not from the Striatum

  Shigeto Yamada, Mutsuo Harano, Naoko Annoh and Masatoshi Tanaka

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 994-998;
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  Reduction of 5-Hydroxytryptamine (5-HT)_1A-Mediated Temperature and Neuroendocrine Responses and 5-HT_1A Binding Sites in 5-HT Transporter Knockout Mice

  Qian Li, Christine Wichems, Armin Heils, Louis D. Van de Kar, Klaus-Peter Lesch and Dennis L. Murphy

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 999-1007;
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  Antinociceptive Properties of Fenfluramine, a Serotonin Reuptake Inhibitor, in a Rat Model of Neuropathy

  Yong-Xiang Wang, S. Scott Bowersox, Mark Pettus and Da Gao

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1008-1016;
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  Evaluation of Effect of Charge and Lipid Coating on Ability of 60-nm Nanoparticles to Cross an In Vitro Model of the Blood-Brain Barrier

  L. Fenart, A. Casanova, B. Dehouck, C. Duhem, S. Slupek, R. Cecchelli and D. Betbeder

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1017-1022;
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  Evidence That Melanocortin 4 Receptor Mediates Hemorrhagic Shock Reversal Caused by Melanocortin Peptides

  Salvatore Guarini, Carla Bazzani, Maria Michela Cainazzo, Chiara Mioni, Giuseppe Ferrazza, Anna Valeria Vergoni, Helgi B. Schiöth, Jarl E. S. Wikberg and Alfio Bertolini

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1023-1027;
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  Neural and Endocrine Mechanisms Mediating Noxious Stimulus-Induced Inhibition of Bradykinin Plasma Extravasation in the Rat

  Frederick Jia-Pei Miao and Jon D. Levine

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1028-1037;
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  Differential Effects of Mibefradil, Verapamil, and Amlodipine on Myocardial Function and Intracellular Ca²⁺ Handling in Rats with Chronic Myocardial Infarction

  Jiang-Yong Min, Steffen Sandmann, Achim Meissner, Thomas Unger and Ruediger Simon

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1038-1044;
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  Adaptive Responses of γ-Aminobutyric Acid Neurons in the Ventral Tegmental Area to Chronic Ethanol

  Roger A. Gallegos, Rong-Sheng Lee, José R. Criado, Steven J. Henriksen and Scott C. Steffensen

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1045-1053;
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  Interactive Role for Neurosteroids in Ethanol Enhancement of γ-Aminobutyric Acid-Gated Currents from Dissociated Substantia Nigra Reticulata Neurons

  Hugh E. Criswell, Thomas J. McCown, Zhen Ming, Robert A. Mueller and George R. Breese

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1054-1059;
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  Pharmacokinetics and Pharmacodynamics of SB-240563, a Humanized Monoclonal Antibody Directed to Human Interleukin-5, in Monkeys

  P. Zia-Amirhosseini, E. Minthorn, L. J. Benincosa, T. K. Hart, C. S. Hottenstein, L. A. P. Tobia and C. B. Davis

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1060-1067;
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  Interaction of Diclofenac and Quinidine in Monkeys: Stimulation of Diclofenac Metabolism

  Wei Tang, Ralph A. Stearns, Gloria Y. Kwei, Susan A. Iliff, Randall R. Miller, Marjorie A. Egan, Nathan X. Yu, Dennis C. Dean, Sanjeev Kumar, Magang Shou, Jiunn H. Lin and Thomas A. Baillie

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1068-1074;
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  Ethanol-Induced Barrier Dysfunction and Its Prevention by Growth Factors in Human Intestinal Monolayers: Evidence for Oxidative and Cytoskeletal Mechanisms

  A. Banan, S. Choudhary, Y. Zhang, J. Z. Fields and A. Keshavarzian

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1075-1085;
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  Streptococcus pneumoniae Pneumonia in Mice: Optimal Amoxicillin Dosing Predicted from a Pharmacokinetic-Pharmacodynamic Model

  Pierre Moine and Jean Xavier Mazoit

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1086-1092;
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  Ring-Constrained Orvinols as Analogs of Buprenorphine: Differences in Opioid Activity Related to Configuration of C₂₀ Hydroxyl Group

  J. R. Traynor, L. Guo, A. Coop, J. W. Lewis and J. H. Woods

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1093-1099;
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  Pharmacodynamics of Immunosuppression by Mycophenolic Acid: Inhibition of Both Lymphocyte Proliferation and Activation Correlates with Pharmacokinetics

  Jan F. Gummert, Markus J. Barten, Steve W. Sherwood, Teun van Gelder and Randall E. Morris

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1100-1112;
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  Intracisternal Nor-Binaltorphimine Distinguishes Central and Peripheral κ-Opioid Antinociception in Rhesus Monkeys

  M. C. Holden Ko, Mark D. Johnson, Eduardo R. Butelman, Kurt J. Willmont, Henry I. Mosberg and James H. Woods

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1113-1120;
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  Powerful Activation of Skeletal Muscle Actomyosin ATPase by Goniodomin A Is Highly Sensitive to Troponin/Tropomyosin Complex

  Kimihiro Matsunaga, Keigo Nakatani, Masahiro Murakami, Katsumi Yamaguchi and Yasushi Ohizumi

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1121-1126;
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  Desensitization of Nicotinic Agonist-Induced [³H]γ-Aminobutyric Acid Release from Mouse Brain Synaptosomes Is Produced by Subactivating Concentrations of Agonists

  Ying Lu, Michael J. Marks and Allan C. Collins

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1127-1134;
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  Allosteric Modulation and Accelerated Resensitization of Human P2X₃ Receptors by Cibacron Blue

  Karen Alexander, Wende Niforatos, Bruce Bianchi, Edward C. Burgard, Kevin J. Lynch, Elizabeth A. Kowaluk, Michael F. Jarvis and Tim van Biesen

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1135-1142;
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  Dexfenfluramine Elevates Systemic Blood Pressure by Inhibiting Potassium Currents in Vascular Smooth Muscle Cells

  Evangelos D. Michelakis, E. Kenneth Weir, Daniel P. Nelson, Helen L. Reeve, Simona Tolarova and Stephen L. Archer

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1143-1149;
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  Effects of Antidepressants and Benzodiazepine-Type Anxiolytic Agents on Hepatic Porphyrin Accumulation in Primary Cultures of Chick Embryo Liver Cells

  Richard W. Lambrecht, Otto S. Gildemeister, Joyce A. Pepe, Kristina D. Tortorelli, Alyssa Williams and Herbert L. Bonkovsky

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1150-1155;
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  Cannabinol-Mediated Inhibition of Nuclear Factor-κB, cAMP Response Element-Binding Protein, and Interleukin-2 Secretion by Activated Thymocytes

  Amy C. Herring and Norbert E. Kaminski

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1156-1163;
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  Binding, Partial Agonism, and Potentiation of α₁-Adrenergic Receptor Function by Benzodiazepines: A Potential Site of Allosteric Modulation

  David J. J. Waugh, Robert J. Gaivin, Derek S. Damron, Paul A. Murray and Dianne M. Perez

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1164-1171;
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  Neuropeptide-Y Stimulation of Extracellular Signal-Regulated Kinases in Human Erythroleukemia Cells

  Susanne Keffel, Martina Schmidt, Angela Bischoff and Martin C. Michel

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1172-1178;
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  Mechanisms of 5-Hydroxytryptamine_2A Receptor Activation of the Mitogen-Activated Protein Kinase Pathway in Vascular Smooth Muscle

  A. Banes, J. A. Florian and S. W. Watts

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1179-1187;
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  Activation of Protein Kinase A Increases Phospholipase D Activity and Inhibits Phospholipase D Activation by Acetylcholine in Tracheal Smooth Muscle

  A. M. Mamoon, J. Smith, R. C. Baker and J. M. Farley

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1188-1195;
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  Ethnic Differences in N-Glucuronidation of Nicotine and Cotinine

  Neal L. Benowitz, Eliseo J. Perez-Stable, Irving Fong, Gunnard Modin, Brenda Herrera and Peyton Jacob

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1196-1203;
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  Modulation by Drugs of Human Hepatic Sodium-Dependent Bile Acid Transporter (Sodium Taurocholate Cotransporting Polypeptide) Activity

  Richard B. Kim, Brenda Leake, Mirjana Cvetkovic, Mark M. Roden, Jessica Nadeau, Andrew Walubo and Grant R. Wilkinson

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1204-1209;
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  Uptake and Glutathione Conjugation of Ethacrynic Acid and Efflux of the Glutathione Adduct by Periportal and Perivenous Rat Hepatocytes

  Rommel G. Tirona, Eugene Tan, Galina Meier and K. Sandy Pang

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1210-1219;
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  Spontaneous Locomotor Activity and Pharmacokinetics of Intravenous Methamphetamine and Its Metabolite Amphetamine in the Rat

  Gilles J. Rivière, Kelly A. Byrnes, W. Brooks Gentry and S. Michael Owens

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1220-1226;
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  R(+)-8-OH-DPAT, a Serotonin_1A Receptor Agonist, Potentiated S(−)-Sulpiride-Induced Dopamine Release in Rat Medial Prefrontal Cortex and Nucleus Accumbens But Not Striatum

  Junji Ichikawa and Herbert Y. Meltzer

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1227-1232;
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  Discriminative Stimulus Effects of Zolpidem in Squirrel Monkeys: Comparison with Conventional Benzodiazepines and Sedative-Hypnotics

  James K. Rowlett, Roger D. Spealman and Snjezana Lelas

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1233-1241;
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  Characterization and Function of the Bovine Kidney Epithelial Angiotensin Receptor Subtype 4 Using Angiotensin IV and Divalinal Angiotensin IV as Receptor Ligands

  Rajash K. Handa, Joseph W. Harding and Steven M. Simasko

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1242-1249;
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  Activation of G Proteins by Neuropeptide Y and γ-Aminobutyric Acid_B Receptor Agonists in Rat Cerebral Cortical Membranes through Distinct Modes of Action

  Yuji Odagaki, Nobuyuki Nishi, Shin Nakagawa and Tsukasa Koyama

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1250-1256;
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  Flumazenil Discrimination by Humans under a Two-Response and a Novel-Response Procedure

  Brandi J. Smith and Warren K. Bickel

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1257-1268;
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  Prolonged Inhibition ofO ⁶-Methylguanine DNA Methyltransferase in Human Tumor Cells by O ⁶-Benzylguanine In Vitro and In Vivo

  Emiko L. Kreklau, Chandrika Kurpad, David A. Williams and Leonard C. Erickson

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1269-1275;
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  4-Methylcatechol Increases Brain-Derived Neurotrophic Factor Content and mRNA Expression in Cultured Brain Cells and in Rat Brain In Vivo

  Atsumi Nitta, Megumi Ito, Hidefumi Fukumitsu, Makoto Ohmiya, Hisanori Ito, Ayako Sometani, Hiroshi Nomoto, Yoshiko Furukawa and Shoei Furukawa

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1276-1283;
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  Pharmacological Characterization of Nicotine-Induced Seizures in Mice

  M. I. Damaj, W. Glassco, M. Dukat and B. R. Martin

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1284-1291;
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  O ⁶-Benzylguanine Enhances the In Vitro Immunotoxic Activity of Temozolomide on Natural or Antigen-Dependent Immunity

  Ester Alvino, Rita Pepponi, Elena Pagani, Pedro Miguel Lacal, Corrado Nunziata, Enzo Bonmassar and Stefania D'Atri

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1292-1300;
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  Toxicity, Biological Activity, and Pharmacokinetics of TXU (Anti-CD7)-Pokeweed Antiviral Protein in Chimpanzees and Adult Patients Infected with Human Immunodeficiency Virus

  Fatih M. Uckun, Kelly Bellomy, Karen O'Neill, Yoav Messinger, Trista Johnson and Chun-Lin Chen

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1301-1307;
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  Modifications of Blood Volume Alter the Disposition of Markers of Blood Volume, Extracellular Fluid, and Total Body Water

  Tom C. Krejcie, Thomas K. Henthorn, W. Brooks Gentry, Claus U. Niemann, Cheri Enders-Klein, Colin A. Shanks and Michael J. Avram

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1308-1316;
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  Response-Rate Suppression in Operant Paradigm as Predictor of Soporific Potency in Rats and Identification of Three Novel Sedative-Hypnotic Neuroactive Steroids

  Kimberly E. Vanover, Dale M. Edgar, Wesley F. Seidel, Derk J. Hogenkamp, David B. Fick, Nancy C. Lan, Kelvin W. Gee and Richard B. Carter

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1317-1323;
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  Use-Dependent ‘Agonist’ Effect of Azimilide on the HERG Channel

  Min Jiang, Wen Dun, Jing-Song Fan and Gea-Ny Tseng

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1324-1336;
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  Antagonism of Immunostimulatory CpG-Oligodeoxynucleotides by 4-Aminoquinolines and Other Weak Bases: Mechanistic Studies

  Lori Manzel, Lucjan Strekowski, Fyaz M. D. Ismail, Jerry C. Smith and Donald E. Macfarlane

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1337-1347;
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  Glutathione Peptidomimetic Drug Modulator of Multidrug Resistance-Associated Protein

  Miechelle L. O'Brien, Bojana Vulevic, Seema Freer, Jonathan Boyd, Hongxie Shen and Kenneth D. Tew

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1348-1355;
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  Is Hydroxylamine-Induced Cytotoxicity a Valid Marker for Hypersensitivity Reactions to Sulfamethoxazole in Human Immunodeficiency Virus-Infected Individuals?

  Timothy P. Reilly, Rodger D. MacArthur, Marti J. Farrough, Lawrence R. Crane, Patrick M. Woster and Craig K. Svensson

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1356-1364;
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  l-Glutamate and γ-Aminobutyric Acid Efflux from Rat Cerebrocortical Synaptosomes: Modulation by κ- and μ- but Not δ- and Opioid Receptor Like-1 Receptors

  Simone Sbrenna, Matteo Marti, Michele Morari, Girolamo Calo, Remo Guerrini, Lorenzo Beani and Clementina Bianchi

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1365-1371;
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  Tissue Selectivity of Antidiabetic Agent Nateglinide: Study on Cardiovascular and β-Cell K_ATP Channels

  Shiling Hu, Shuya Wang and Beth E. Dunning

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1372-1379;
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  Idoxifene, a Novel Selective Estrogen Receptor Modulator, Is Effective in a Rat Model of Adjuvant-Induced Arthritis

  Alison M. Badger, Simon M. Blake, Robert A. Dodds, Don E. Griswold, Barbara A. Swift, David J. Rieman, George B. Stroup, Sandra J. Hoffman and Maxine Gowen

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1380-1386;
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  Meeting Report for the ASPET–Ray Fuller Symposium: Cellular Mechanisms and Novel Strategies for Pain Control

  Michael Vasko and Jerry Gebhart

  Journal of Pharmacology and Experimental Therapeutics December 1999, 291 (3) 1387-1388;