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Research ArticleArticle

Beneficial Effects of Ropivacaine in Rat Experimental Colitis

Titti Martinsson, Tryggve Ljung, Carlos Rubio and Per M. Hellström
Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 642-647;
Titti Martinsson
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Tryggve Ljung
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Carlos Rubio
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Per M. Hellström
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Abstract

Ropivacaine, a new, long-acting local anesthetic agent, has been shown to have beneficial effects in the treatment of ulcerative colitis. Treatment with this drug results in prompt symptomatic relief. The aim of this study was to examine the effects of ropivacaine on mucosal healing and to investigate whether ropivacaine can restore the decreased colonic contractility seen in the diseased state. Colitis was induced in rats by a single intrarectal administration of trinitrobenzene sulfonic acid. Mucosal healing was assessed after 1 week of therapy. The effects on colonic contractility were examined either after 1 week of treatment or by application of the drugs to untreated, inflamed rat colon segments placed in organ baths. After the induction of colitis, daily intracolonic treatment with ropivacaine for 1 week reduced morphological damage and myeloperoxidase activity. One week of treatment also restored the contractile response to acetylcholine. By adding ropivacaine directly to untreated inflamed colonic segments in organ baths, the contractile response to acetylcholine was increased compared with controls. For comparison, the effects of budesonide and 5-aminosalicylic acid were also examined. Ropivacaine improved mucosal healing and restored colonic motor activity in experimental colitis, similar to budesonide but superior to 5-aminosalicylic acid.

Footnotes

  • Send reprint requests to: Dr. Titti Martinsson, Astra Pain Control AB, Discovery Division, SE-141 57 Huddinge, Sweden. E-mail:titti.martinsson{at}pain.se.astra.com

  • ↵1 The study was supported by Swedish Medical Research Council Grant 7916.

  • Abbreviations:
    UC
    ulcerative colitis
    ACh
    acetylcholine
    Emax
    maximal contractile response
    LTB4
    leukotriene B4
    5-ASA
    5-aminosalicylic acid
    MPO
    myeloperoxidase
    TNBS
    trinitrobenzene sulfonic acid
    • Received February 1, 1999.
    • Accepted July 27, 1999.
  • The American Society for Pharmacology and Experimental Therapeutics
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Journal of Pharmacology and Experimental Therapeutics: 291 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 291, Issue 2
1 Nov 1999
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Research ArticleArticle

Beneficial Effects of Ropivacaine in Rat Experimental Colitis

Titti Martinsson, Tryggve Ljung, Carlos Rubio and Per M. Hellström
Journal of Pharmacology and Experimental Therapeutics November 1, 1999, 291 (2) 642-647;

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Research ArticleArticle

Beneficial Effects of Ropivacaine in Rat Experimental Colitis

Titti Martinsson, Tryggve Ljung, Carlos Rubio and Per M. Hellström
Journal of Pharmacology and Experimental Therapeutics November 1, 1999, 291 (2) 642-647;
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