Table of Contents

Articles

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  Effect of Molecular Charge on Intestinal Epithelial Drug Transport: pH-Dependent Transport of Cationic Drugs

  Katrin Palm, Kristina Luthman, Jenny Ros, Johan Gråsjö and Per Artursson

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 435-443;
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  Pharmacogenetic Evidence for the Involvement of 5-Hydroxytryptamine (Serotonin)-1B Receptors in the Mediation of Morphine Antinociceptive Sensitivity

  Heather S. Hain, John K. Belknap and Jeffrey S. Mogil

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 444-449;
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  Biological Effects of 1α-Hydroxy- and 1β-(Hydroxymethyl)-Vitamin D Compounds Relevant for Potential Colorectal Cancer Therapy

  Harald Hofer, Guan-min Ho, Meinrad Peterlik, Milan R. Uskokovic, Jae Kyoo Lee, M. Christina White, Gary H. Posner and Heide S. Cross

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 450-455;
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  LLC-PK₁ Cells Stably Expressing the Human Norepinephrine Transporter: A Functional Model of Carrier-Mediated Norepinephrine Release in Protracted Myocardial Ischemia

  Neil C. E. Smith and Roberto Levi

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 456-463;
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  Selectivities of Dihydropyridine Derivatives in Blocking Ca²⁺ Channel Subtypes Expressed in XenopusOocytes

  Taiji Furukawa, Takeshi Yamakawa, Takayuki Midera, Toshio Sagawa, Yasuo Mori and Toshihide Nukada

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 464-473;
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  ATP-Sensitive Potassium Channel Blocker HMR 1883 Reduces Mortality and Ischemia-Associated Electrocardiographic Changes in Pigs with Coronary Occlusion

  Klaus J. Wirth, Björn Rosenstein, Jörg Uhde, Heinrich C. Englert, Andreas E. Busch and Bernward A. Schölkens

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 474-481;
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  Effects of Regulators of G Protein-Signaling Proteins on the Functional Response of the μ-Opioid Receptor in a Melanophore-Based Assay

  Marc N. Potenza, Stephen J. Gold, Alison Roby-Shemkowitz, Michael R. Lerner and Eric J. Nestler

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 482-491;
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  Influence of Exogenous Thiols on Inorganic Mercury-Induced Injury in Renal Proximal and Distal Tubular Cells from Normal and Uninephrectomized Rats

  Lawrence H. Lash, David A. Putt and Rudolfs K. Zalups

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 492-502;
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  Agonist-Induced Sensitization of β-Adrenoceptor Signaling in Neonatal Rat Heart: Expression and Catalytic Activity of Adenylyl Cyclase

  J. L. Zeiders, F. J. Seidler and T. A. Slotkin

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 503-510;
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  5-Oxo-6,8,11,14-eicosatetraenoic Acid Stimulates Isotonic Volume Reduction of Guinea Pig Jejunal Crypt Epithelial Cells

  R. John MacLeod, P. Lembessis, J. R. Hamilton and William S. Powell

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 511-516;
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  Inhibitors of Chymase as Mast Cell-Stabilizing Agents: Contribution of Chymase in the Activation of Human Mast Cells

  Shaoheng He, Marianna D. A. Gaça, Alan R. McEuen and Andrew F. Walls

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 517-523;
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  Estrogen Alters Relative Contributions of Nitric Oxide and Cyclooxygenase Products to Endothelium-Dependent Vasodilation

  Jennifer Case and Cathy A. Davison

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 524-530;
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  Role of Adenosine andN-Methyl-d-aspartate Receptors in Mediating Haloperidol-Induced Gene Expression and Catalepsy

  Elena H. Chartoff, Raymond P. Ward and Daniel M. Dorsa

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 531-537;
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  Effects of Delphinium Alkaloids on Neuromuscular Transmission

  Peter Dobelis, James E. Madl, James A. Pfister, Gary D. Manners and John P. Walrond

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 538-546;
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  Pharmacokinetic-Pharmacodynamic Modeling of Tolerance to the Prolactin-Secreting Effect of Chlorprothixene after Different Modes of Drug Administration

  Metin Bagli, Richard Süverkrüp, Ralph Quadflieg, Gereon Höflich, Siegfried Kasper, Hans-Jürgen Möller, Michael Langer, Uwe Barlage and Marie Luise Rao

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 547-554;
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  Chlorotrifluoroethylcysteine Interaction with Rabbit Proximal Tubule Cell Basolateral Membrane Organic Anion Transport and Apical Membrane Amino Acid Transport

  Carlotta E. Groves and Mark N. Morales

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 555-561;
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  Bepridil Blunts the Shortening of Action Potential Duration Caused by Metabolic Inhibition via Blockade of ATP-Sensitive K⁺ Channels and Na⁺-Activated K⁺Channels

  Yulong Li, Toshiaki Sato and Makoto Arita

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 562-568;
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  Effect of Poststroke Captopril Treatment on Mortality Associated with Hemorrhagic Stroke in Stroke-Prone Rats

  John Smeda, Sudesh Vasdev and Shelley R. King

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 569-575;
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  Sex Differences in the Pentylenetetrazol-Like Stimulus Induced by Ethanol Withdrawal

  Marianna E. Jung, Cleatus J. Wallis, Michael B. Gatch and Harbans Lal

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 576-582;
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  Functional Evidence for an Angiotensin IV Receptor in Rat Resistance Arteries

  Laurent Loufrani, Daniel Henrion, Dominique Chansel, Raymond Ardaillou and Bernard I. Levy

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 583-588;
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  Effects of Atrial Natriuretic Peptide on Left Ventricular Performance in Conscious Dogs Before and After Pacing-Induced Heart Failure

  Nobuyuki Ohte, Che-Ping Cheng, Makoto Suzuki and William C. Little

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 589-595;
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  Molecular Cloning and Functional Characterization of a Polyspecific Organic Anion Transporter from Caenorhabditis elegans

  Ronald L. George, Xiang Wu, Wei Huang, You-Jun Fei, Frederick H. Leibach and Vadivel Ganapathy

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 596-603;
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  Mechanisms of Action of OPC-28326, a Selective Hindlimb Vasodilator

  Kensuke Orito, Takashi Imaizumi, Kenji Yoshida, Hiroyuki Fujiki, Masami Kishi, Shuji Teramoto, Michinori Tanaka, Hiroshi Shimizu, Michiaki Tominaga, Yukio Kimura, Junichi Kambayashi and Toyoki Mori

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 604-611;
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  Design and Characterization of Orally Active Arg-Gly-Asp Peptidomimetic Vitronectin Receptor Antagonist SB 265123 for Prevention of Bone Loss in Osteoporosis

  Michael W. Lark, George B. Stroup, Shing Mei Hwang, Ian E. James, David J. Rieman, Fred H. Drake, Jeremy N. Bradbeer, Ashwini Mathur, Karl F. Erhard, Kenneth A. Newlander, Stephen T. Ross, Kevin L. Salyers, Brian R. Smith, William H. Miller, William F. Huffman and Maxine Gowen

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 612-617;
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  Cannabinoid Receptors Can Activate and Inhibit G Protein-Coupled Inwardly Rectifying Potassium Channels in a Xenopus Oocyte Expression System

  Sean D. McAllister, Graeme Griffin, Leslie S. Satin and Mary E. Abood

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 618-626;
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  Developmental Regulation of Endothelial Nitric Oxide Synthase in Cerebral Vessels of Newborn Pig by Prostaglandin E₂

  Isabelle Dumont, Xin Hou, Pierre Hardy, Krishna G. Peri, Martin Beauchamp, Taline Najarian, Stéphane Molotchnikoff, Daya R. Varma and Sylvain Chemtob

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 627-633;
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  Regulation by Endogenous Interleukin-1 of mRNA Expression of Healing-Related Factors in Gastric Ulcers in Rats

  Satoru Takahashi, Norihiro Kobayashi and Susumu Okabe

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 634-641;
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  Beneficial Effects of Ropivacaine in Rat Experimental Colitis

  Titti Martinsson, Tryggve Ljung, Carlos Rubio and Per M. Hellström

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 642-647;
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  Pharmacological Characterization of (E)-N-(3-iodoprop-2-enyl)-2β-Carbomethoxy-3β-(4′-methylphenyl)nortropane as a Selective and Potent Inhibitor of the Neuronal Dopamine Transporter

  Sylvie Chalon, Lucette Garreau, Patrick Emond, Luc Zimmer, Marie-Paule Vilar, Jean-Claude Besnard and Denis Guilloteau

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 648-654;
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  Adenosine A_2A Receptors Mediate Coronary Microvascular Dilation to Adenosine: Role of Nitric Oxide and ATP-Sensitive Potassium Channels

  Travis W. Hein, Luiz Belardinelli and Lih Kuo

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 655-664;
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  Characterization of Interleukin-1α Binding to Mouse Brain Endothelial Cells

  William A. Banks

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 665-670;
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  α-Adrenoceptors in Canine Mesenteric Artery Are Predominantly 1A Subtype: Pharmacological and Immunochemical Evidence

  E. E. Daniel, R. Dale Brown, Y. F. Wang, A. M. Low, H. Lu-Chao and C.-Y. Kwan

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 671-679;
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  RWJ 67657, a Potent, Orally Active Inhibitor of p38 Mitogen-Activated Protein Kinase

  Scott A. Wadsworth, Druie E. Cavender, Scott A. Beers, Praful Lalan, Peter H. Schafer, Elizabeth A. Malloy, Wei Wu, Bohumila Fahmy, Gilbert C. Olini, Janet E. Davis, J. Lee Pellegrino-Gensey, Michael P. Wachter and John J. Siekierka

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 680-687;
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  Effects of Treatment with Haloperidol, Chlorpromazine, and Clozapine on Protein Kinase C (PKC) and Phosphoinositide-Specific Phospholipase C (PI-PLC) Activity and on mRNA and Protein Expression of PKC and PLC Isozymes in Rat Brain

  Yogesh Dwivedi and Ghanshyam N. Pandey

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 688-704;
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  Recognition of l-Amino Acid Ester Compounds by Rat Peptide Transporters PEPT1 and PEPT2

  Kyoko Sawada, Tomohiro Terada, Hideyuki Saito, Yukiya Hashimoto and Ken-Ichi Inui

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 705-709;
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  Role of an ATP-Sensitive Potassium Channel Opener, YM934, in Mitochondrial Energy Production in Ischemic/Reperfused Heart

  Kouichi Tanonaka, Taku Taguchi, Miki Koshimizu, Tsuyoshi Ando, Tomohiro Morinaka, Tomoya Yogo, Fusako Konishi and Satoshi Takeo

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 710-716;
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  K⁺-Induced Neurogenic Relaxation of Rat Distal Colon

  Lars Börjesson, Svante Nordgren and Dick S. Delbro

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 717-724;
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  Canine Cardiac Muscarinic Receptors, G Proteins, and Adenylate Cyclase after Long-Term Morphine

  Leslie D. Napier, Sandra C. Roerig, Darice A. Yoshishige, Barbara A. Barron and James L. Caffrey

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 725-732;
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  Hypoxia-Reoxygenation-Induced Apoptosis in Cultured Adult Rat Myocytes and the Protective Effect of Platelets and Transforming Growth Factor-β₁

  B. C. Yang, D. S. Zander and J. L. Mehta

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 733-738;
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  Inhibition of Epidermal Growth Factor Receptor-Associated Tyrosine Phosphorylation in Human Carcinomas with CP-358,774: Dynamics of Receptor Inhibition In Situ and Antitumor Effects in Athymic Mice

  Vincent A. Pollack, Douglas M. Savage, Deborah A. Baker, Konstantinos E. Tsaparikos, Donald E. Sloan, James D. Moyer, Elsa G. Barbacci, Leslie R. Pustilnik, Teresa A. Smolarek, John A. Davis, Madhur P. Vaidya, Lee D. Arnold, John L. Doty, Kenneth K. Iwata and Michael J. Morin

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 739-748;
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  Role of a Potent Inhibitory Monoclonal Antibody to Cytochrome P-450 3A4 in Assessment of Human Drug Metabolism

  Qin Mei, Cuyue Tang, Carol Assang, Yuh Lin, Donald Slaughter, A. David Rodrigues, Thomas A. Baillie, Thomas H. Rushmore and Magang Shou

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 749-759;
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  High-Affinity Interaction of (des-Tyrosyl)Dynorphin A(2-17) with NMDA Receptors

  Qingbo Tang, Ronnie Gandhoke, Andrew Burritt, Victor J. Hruby, Frank Porreca and Josephine Lai

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 760-765;
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  A Transgenic Model of Acetaldehyde Overproduction Accelerates Alcohol Cardiomyopathy

  Qiangrong Liang, Edward C. Carlson, Anthony J. Borgerding and Paul N. Epstein

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 766-772;
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  Combined Effects of Buffer and Adrenergic Agents on Postresuscitation Myocardial Function

  Shijie Sun, Max Harry Weil, Wanchun Tang, Heitor P. Povoas and Earl Mason

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 773-777;
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  Na⁺-Dependent Carnitine Transport by Organic Cation Transporter (OCTN2): Its Pharmacological and Toxicological Relevance

  Rikiya Ohashi, Ikumi Tamai, Hikaru Yabuuchi, Jun-Ichi Nezu, Asuka Oku, Yoshimichi Sai, Miyuki Shimane and Akira Tsuji

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 778-784;
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  A Critical Role of theN-Methyl-d-aspartate (NMDA) Receptor Subunit (NR) 2A in the Expression of Redox Sensitivity of NR1/NR2A Recombinant NMDA Receptors

  Jessica C. Brimecombe, William K. Potthoff and Elias Aizenman

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 785-792;
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  Variability in Phenylephrine Response and Essential Hypertension: A Search for Human α_1B-Adrenergic Receptor Polymorphisms

  Rainer Büscher, Volker Herrmann, Kevin M. Ring, Mala T. Kailasam, Daniel T. O’Connor, Robert J. Parmer and Paul A. Insel

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 793-798;
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  Angiotensin-Converting Enzyme and Matrix Metalloproteinase Inhibition with Developing Heart Failure: Comparative Effects on Left Ventricular Function and Geometry

  James H. McElmurray, Rupak Mukherjee, R. Brent New, Angela C. Sampson, Mary K. King, Jennifer W. Hendrick, Aron Goldberg, Thomas J. Peterson, Hussein Hallak, Michael R. Zile and Francis G. Spinale

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 799-811;
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  Milameline (CI-979/RU35926): A Muscarinic Receptor Agonist with Cognition-Activating Properties: Biochemical and In Vivo Characterization

  Roy D. Schwarz, Michael J. Callahan, Linda L. Coughenour, Melvin R. Dickerson, Jack J. Kinsora, William J. Lipinski, Charlotte A. Raby, Carolyn J. Spencer and Haile Tecle

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 812-822;
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  An Unusual Ca²⁺ Entry Pathway Activated by Protein Kinase C in Dog Splenic Artery

  Mohammad A. Khoyi, Lisa G. Gregory, Andrew D. Smith, Kathleen D. Keef and David P. Westfall

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 823-828;
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  α₁-Adrenoceptor Subtypes Mediating Inotropic Responses in Rat Heart

  You-Yi Zhang, Kai-Ming Xu and Chide Han

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 829-836;
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  The Third Transmembrane Helix of the Cannabinoid Receptor Plays a Role in the Selectivity of Aminoalkylindoles for CB2, Peripheral Cannabinoid Receptor

  Chen-ni Chin, James W. Murphy, John W. Huffman and Debra A. Kendall

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 837-844;
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  Modification of Cardiac Na⁺ Current by RWJ 24517 and Its Enantiomers in Guinea Pig Ventricular Myocytes

  Robert G. Tsushima, James E. Kelly, Joseph J. Salata, Kristine N. Liberty and J. Andrew Wasserstrom

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 845-855;
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  Species-Dependent Differences in Monoamine Oxidase A and B-Catalyzed Oxidation of Various C4 Substituted 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridinyl Derivatives

  Hiroyuki Inoue, Kay Castagnoli, Cornelis Van der Schyf, Stéphane Mabic, Kazuo Igarashi and Neal Castagnoli

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 856-864;
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  Safety, Pharmacokinetics, and Tissue Distribution of Liposomal P-Ethoxy Antisense Oligonucleotides Targeted to Bcl-2

  Yolanda Gutiérrez-Puente, Ana M. Tari, Clifton Stephens, Michael Rosenblum, Reyes Tamez Guerra and Gabriel Lopez-Berestein

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 865-869;
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  Thioguanine Administered as a Continuous Intravenous Infusion to Pediatric Patients Is Metabolized to the Novel Metabolite 8-Hydroxy-Thioguanine

  Brenda J. Kitchen, Asher Moser, Elizabeth Lowe, Frank M. Balis, Brigitte Widemann, Lawrence Anderson, John Strong, Susan M. Blaney, Stacey L. Berg, Michelle O’Brien and Peter C. Adamson

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 870-874;
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  β-Adrenoceptor Subtype Activities of Trimetoquinol Derivatives: Biochemical Studies on Human β-Adrenoceptors Expressed in Chinese Hamster Ovary Cells

  Anish A. Konkar, Sandeep S. Vansal, Gamal Shams, Paul F. Fraundorfer, Wei-Ping Zheng, Victor I. Nikulin, Joseph De Los Angeles, Richard H. Fertel, Duane D. Miller and Dennis R. Feller

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 875-883;
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  Nicotine Infusion Modulates Immobilization Stress-Triggered Induction of Gene Expression of Rat Catecholamine Biosynthetic Enzymes

  Lidia Serova, Emil Danailov, Firas Chamas and Esther L. Sabban

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 884-892;
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  Cannabinoid Receptors Differentially Modulate Potassium A and D Currents in Hippocampal Neurons in Culture

  Jian Mu, Shou-yuan Zhuang, M. Todd Kirby, Robert E. Hampson and Sam A. Deadwyler

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 893-902;
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  Repeated Measurement of Intestinal Permeability as an Assessment of Colitis Severity in HLA-B27 Transgenic Rats

  Steven W. Kerr, Walter W. Wolyniec, Zoran Filipovic, Suzanne G. Nodop, Frank Braza, Raymond J. Winquist and Thomas C. Noonan

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 903-910;
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  Spin Trap (N-t-butyl-α-phenylnitrone)-Mediated Suprainduction of Heme Oxygenase-1 in Kidney Ischemia/Reperfusion Model: Role of the Oxygenase in Protection against Oxidative Injury

  Mahin D. Maines, Vulapali S. Raju and Nariman Panahian

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 911-919;
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  Regulation of Aquaporin-2 Expression by the α₂-Adrenoceptor Agonist Clonidine in the Rat

  Asad Junaid, Li Cui, S. Brian Penner and Donald D. Smyth

  Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 920-923;