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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

November 01, 1999; Volume 291,Issue 2

Articles

  • You have access
    Effect of Molecular Charge on Intestinal Epithelial Drug Transport: pH-Dependent Transport of Cationic Drugs
    Katrin Palm, Kristina Luthman, Jenny Ros, Johan Gråsjö and Per Artursson
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 435-443;
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    Pharmacogenetic Evidence for the Involvement of 5-Hydroxytryptamine (Serotonin)-1B Receptors in the Mediation of Morphine Antinociceptive Sensitivity
    Heather S. Hain, John K. Belknap and Jeffrey S. Mogil
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 444-449;
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    Biological Effects of 1α-Hydroxy- and 1β-(Hydroxymethyl)-Vitamin D Compounds Relevant for Potential Colorectal Cancer Therapy
    Harald Hofer, Guan-min Ho, Meinrad Peterlik, Milan R. Uskokovic, Jae Kyoo Lee, M. Christina White, Gary H. Posner and Heide S. Cross
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 450-455;
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    LLC-PK1 Cells Stably Expressing the Human Norepinephrine Transporter: A Functional Model of Carrier-Mediated Norepinephrine Release in Protracted Myocardial Ischemia
    Neil C. E. Smith and Roberto Levi
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 456-463;
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    Selectivities of Dihydropyridine Derivatives in Blocking Ca2+ Channel Subtypes Expressed in XenopusOocytes
    Taiji Furukawa, Takeshi Yamakawa, Takayuki Midera, Toshio Sagawa, Yasuo Mori and Toshihide Nukada
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 464-473;
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    ATP-Sensitive Potassium Channel Blocker HMR 1883 Reduces Mortality and Ischemia-Associated Electrocardiographic Changes in Pigs with Coronary Occlusion
    Klaus J. Wirth, Björn Rosenstein, Jörg Uhde, Heinrich C. Englert, Andreas E. Busch and Bernward A. Schölkens
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 474-481;
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    Effects of Regulators of G Protein-Signaling Proteins on the Functional Response of the μ-Opioid Receptor in a Melanophore-Based Assay
    Marc N. Potenza, Stephen J. Gold, Alison Roby-Shemkowitz, Michael R. Lerner and Eric J. Nestler
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 482-491;
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    Influence of Exogenous Thiols on Inorganic Mercury-Induced Injury in Renal Proximal and Distal Tubular Cells from Normal and Uninephrectomized Rats
    Lawrence H. Lash, David A. Putt and Rudolfs K. Zalups
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 492-502;
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    Agonist-Induced Sensitization of β-Adrenoceptor Signaling in Neonatal Rat Heart: Expression and Catalytic Activity of Adenylyl Cyclase
    J. L. Zeiders, F. J. Seidler and T. A. Slotkin
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 503-510;
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    5-Oxo-6,8,11,14-eicosatetraenoic Acid Stimulates Isotonic Volume Reduction of Guinea Pig Jejunal Crypt Epithelial Cells
    R. John MacLeod, P. Lembessis, J. R. Hamilton and William S. Powell
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 511-516;
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    Inhibitors of Chymase as Mast Cell-Stabilizing Agents: Contribution of Chymase in the Activation of Human Mast Cells
    Shaoheng He, Marianna D. A. Gaça, Alan R. McEuen and Andrew F. Walls
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 517-523;
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    Estrogen Alters Relative Contributions of Nitric Oxide and Cyclooxygenase Products to Endothelium-Dependent Vasodilation
    Jennifer Case and Cathy A. Davison
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 524-530;
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    Role of Adenosine andN-Methyl-d-aspartate Receptors in Mediating Haloperidol-Induced Gene Expression and Catalepsy
    Elena H. Chartoff, Raymond P. Ward and Daniel M. Dorsa
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 531-537;
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    Effects of Delphinium Alkaloids on Neuromuscular Transmission
    Peter Dobelis, James E. Madl, James A. Pfister, Gary D. Manners and John P. Walrond
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 538-546;
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    Pharmacokinetic-Pharmacodynamic Modeling of Tolerance to the Prolactin-Secreting Effect of Chlorprothixene after Different Modes of Drug Administration
    Metin Bagli, Richard Süverkrüp, Ralph Quadflieg, Gereon Höflich, Siegfried Kasper, Hans-Jürgen Möller, Michael Langer, Uwe Barlage and Marie Luise Rao
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 547-554;
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    Chlorotrifluoroethylcysteine Interaction with Rabbit Proximal Tubule Cell Basolateral Membrane Organic Anion Transport and Apical Membrane Amino Acid Transport
    Carlotta E. Groves and Mark N. Morales
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 555-561;
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    Bepridil Blunts the Shortening of Action Potential Duration Caused by Metabolic Inhibition via Blockade of ATP-Sensitive K+ Channels and Na+-Activated K+Channels
    Yulong Li, Toshiaki Sato and Makoto Arita
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 562-568;
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    Effect of Poststroke Captopril Treatment on Mortality Associated with Hemorrhagic Stroke in Stroke-Prone Rats
    John Smeda, Sudesh Vasdev and Shelley R. King
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 569-575;
  • You have access
    Sex Differences in the Pentylenetetrazol-Like Stimulus Induced by Ethanol Withdrawal
    Marianna E. Jung, Cleatus J. Wallis, Michael B. Gatch and Harbans Lal
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 576-582;
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    Functional Evidence for an Angiotensin IV Receptor in Rat Resistance Arteries
    Laurent Loufrani, Daniel Henrion, Dominique Chansel, Raymond Ardaillou and Bernard I. Levy
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 583-588;
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    Effects of Atrial Natriuretic Peptide on Left Ventricular Performance in Conscious Dogs Before and After Pacing-Induced Heart Failure
    Nobuyuki Ohte, Che-Ping Cheng, Makoto Suzuki and William C. Little
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 589-595;
  • You have access
    Molecular Cloning and Functional Characterization of a Polyspecific Organic Anion Transporter from Caenorhabditis elegans
    Ronald L. George, Xiang Wu, Wei Huang, You-Jun Fei, Frederick H. Leibach and Vadivel Ganapathy
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 596-603;
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    Mechanisms of Action of OPC-28326, a Selective Hindlimb Vasodilator
    Kensuke Orito, Takashi Imaizumi, Kenji Yoshida, Hiroyuki Fujiki, Masami Kishi, Shuji Teramoto, Michinori Tanaka, Hiroshi Shimizu, Michiaki Tominaga, Yukio Kimura, Junichi Kambayashi and Toyoki Mori
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 604-611;
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    Design and Characterization of Orally Active Arg-Gly-Asp Peptidomimetic Vitronectin Receptor Antagonist SB 265123 for Prevention of Bone Loss in Osteoporosis
    Michael W. Lark, George B. Stroup, Shing Mei Hwang, Ian E. James, David J. Rieman, Fred H. Drake, Jeremy N. Bradbeer, Ashwini Mathur, Karl F. Erhard, Kenneth A. Newlander, Stephen T. Ross, Kevin L. Salyers, Brian R. Smith, William H. Miller, William F. Huffman and Maxine Gowen
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 612-617;
  • You have access
    Cannabinoid Receptors Can Activate and Inhibit G Protein-Coupled Inwardly Rectifying Potassium Channels in a Xenopus Oocyte Expression System
    Sean D. McAllister, Graeme Griffin, Leslie S. Satin and Mary E. Abood
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 618-626;
  • You have access
    Developmental Regulation of Endothelial Nitric Oxide Synthase in Cerebral Vessels of Newborn Pig by Prostaglandin E2
    Isabelle Dumont, Xin Hou, Pierre Hardy, Krishna G. Peri, Martin Beauchamp, Taline Najarian, Stéphane Molotchnikoff, Daya R. Varma and Sylvain Chemtob
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 627-633;
  • You have access
    Regulation by Endogenous Interleukin-1 of mRNA Expression of Healing-Related Factors in Gastric Ulcers in Rats
    Satoru Takahashi, Norihiro Kobayashi and Susumu Okabe
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 634-641;
  • You have access
    Beneficial Effects of Ropivacaine in Rat Experimental Colitis
    Titti Martinsson, Tryggve Ljung, Carlos Rubio and Per M. Hellström
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 642-647;
  • You have access
    Pharmacological Characterization of (E)-N-(3-iodoprop-2-enyl)-2β-Carbomethoxy-3β-(4′-methylphenyl)nortropane as a Selective and Potent Inhibitor of the Neuronal Dopamine Transporter
    Sylvie Chalon, Lucette Garreau, Patrick Emond, Luc Zimmer, Marie-Paule Vilar, Jean-Claude Besnard and Denis Guilloteau
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 648-654;
  • You have access
    Adenosine A2A Receptors Mediate Coronary Microvascular Dilation to Adenosine: Role of Nitric Oxide and ATP-Sensitive Potassium Channels
    Travis W. Hein, Luiz Belardinelli and Lih Kuo
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 655-664;
  • You have access
    Characterization of Interleukin-1α Binding to Mouse Brain Endothelial Cells
    William A. Banks
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 665-670;
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    α-Adrenoceptors in Canine Mesenteric Artery Are Predominantly 1A Subtype: Pharmacological and Immunochemical Evidence
    E. E. Daniel, R. Dale Brown, Y. F. Wang, A. M. Low, H. Lu-Chao and C.-Y. Kwan
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 671-679;
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    RWJ 67657, a Potent, Orally Active Inhibitor of p38 Mitogen-Activated Protein Kinase
    Scott A. Wadsworth, Druie E. Cavender, Scott A. Beers, Praful Lalan, Peter H. Schafer, Elizabeth A. Malloy, Wei Wu, Bohumila Fahmy, Gilbert C. Olini, Janet E. Davis, J. Lee Pellegrino-Gensey, Michael P. Wachter and John J. Siekierka
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 680-687;
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    Effects of Treatment with Haloperidol, Chlorpromazine, and Clozapine on Protein Kinase C (PKC) and Phosphoinositide-Specific Phospholipase C (PI-PLC) Activity and on mRNA and Protein Expression of PKC and PLC Isozymes in Rat Brain
    Yogesh Dwivedi and Ghanshyam N. Pandey
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 688-704;
  • You have access
    Recognition of l-Amino Acid Ester Compounds by Rat Peptide Transporters PEPT1 and PEPT2
    Kyoko Sawada, Tomohiro Terada, Hideyuki Saito, Yukiya Hashimoto and Ken-Ichi Inui
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 705-709;
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    Role of an ATP-Sensitive Potassium Channel Opener, YM934, in Mitochondrial Energy Production in Ischemic/Reperfused Heart
    Kouichi Tanonaka, Taku Taguchi, Miki Koshimizu, Tsuyoshi Ando, Tomohiro Morinaka, Tomoya Yogo, Fusako Konishi and Satoshi Takeo
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 710-716;
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    K+-Induced Neurogenic Relaxation of Rat Distal Colon
    Lars Börjesson, Svante Nordgren and Dick S. Delbro
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 717-724;
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    Canine Cardiac Muscarinic Receptors, G Proteins, and Adenylate Cyclase after Long-Term Morphine
    Leslie D. Napier, Sandra C. Roerig, Darice A. Yoshishige, Barbara A. Barron and James L. Caffrey
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 725-732;
  • You have access
    Hypoxia-Reoxygenation-Induced Apoptosis in Cultured Adult Rat Myocytes and the Protective Effect of Platelets and Transforming Growth Factor-β1
    B. C. Yang, D. S. Zander and J. L. Mehta
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 733-738;
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    Inhibition of Epidermal Growth Factor Receptor-Associated Tyrosine Phosphorylation in Human Carcinomas with CP-358,774: Dynamics of Receptor Inhibition In Situ and Antitumor Effects in Athymic Mice
    Vincent A. Pollack, Douglas M. Savage, Deborah A. Baker, Konstantinos E. Tsaparikos, Donald E. Sloan, James D. Moyer, Elsa G. Barbacci, Leslie R. Pustilnik, Teresa A. Smolarek, John A. Davis, Madhur P. Vaidya, Lee D. Arnold, John L. Doty, Kenneth K. Iwata and Michael J. Morin
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 739-748;
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    Role of a Potent Inhibitory Monoclonal Antibody to Cytochrome P-450 3A4 in Assessment of Human Drug Metabolism
    Qin Mei, Cuyue Tang, Carol Assang, Yuh Lin, Donald Slaughter, A. David Rodrigues, Thomas A. Baillie, Thomas H. Rushmore and Magang Shou
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 749-759;
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    High-Affinity Interaction of (des-Tyrosyl)Dynorphin A(2-17) with NMDA Receptors
    Qingbo Tang, Ronnie Gandhoke, Andrew Burritt, Victor J. Hruby, Frank Porreca and Josephine Lai
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 760-765;
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    A Transgenic Model of Acetaldehyde Overproduction Accelerates Alcohol Cardiomyopathy
    Qiangrong Liang, Edward C. Carlson, Anthony J. Borgerding and Paul N. Epstein
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 766-772;
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    Combined Effects of Buffer and Adrenergic Agents on Postresuscitation Myocardial Function
    Shijie Sun, Max Harry Weil, Wanchun Tang, Heitor P. Povoas and Earl Mason
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 773-777;
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    Na+-Dependent Carnitine Transport by Organic Cation Transporter (OCTN2): Its Pharmacological and Toxicological Relevance
    Rikiya Ohashi, Ikumi Tamai, Hikaru Yabuuchi, Jun-Ichi Nezu, Asuka Oku, Yoshimichi Sai, Miyuki Shimane and Akira Tsuji
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 778-784;
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    A Critical Role of theN-Methyl-d-aspartate (NMDA) Receptor Subunit (NR) 2A in the Expression of Redox Sensitivity of NR1/NR2A Recombinant NMDA Receptors
    Jessica C. Brimecombe, William K. Potthoff and Elias Aizenman
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 785-792;
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    Variability in Phenylephrine Response and Essential Hypertension: A Search for Human α1B-Adrenergic Receptor Polymorphisms
    Rainer Büscher, Volker Herrmann, Kevin M. Ring, Mala T. Kailasam, Daniel T. O’Connor, Robert J. Parmer and Paul A. Insel
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 793-798;
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    Angiotensin-Converting Enzyme and Matrix Metalloproteinase Inhibition with Developing Heart Failure: Comparative Effects on Left Ventricular Function and Geometry
    James H. McElmurray, Rupak Mukherjee, R. Brent New, Angela C. Sampson, Mary K. King, Jennifer W. Hendrick, Aron Goldberg, Thomas J. Peterson, Hussein Hallak, Michael R. Zile and Francis G. Spinale
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 799-811;
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    Milameline (CI-979/RU35926): A Muscarinic Receptor Agonist with Cognition-Activating Properties: Biochemical and In Vivo Characterization
    Roy D. Schwarz, Michael J. Callahan, Linda L. Coughenour, Melvin R. Dickerson, Jack J. Kinsora, William J. Lipinski, Charlotte A. Raby, Carolyn J. Spencer and Haile Tecle
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 812-822;
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    An Unusual Ca2+ Entry Pathway Activated by Protein Kinase C in Dog Splenic Artery
    Mohammad A. Khoyi, Lisa G. Gregory, Andrew D. Smith, Kathleen D. Keef and David P. Westfall
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 823-828;
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    α1-Adrenoceptor Subtypes Mediating Inotropic Responses in Rat Heart
    You-Yi Zhang, Kai-Ming Xu and Chide Han
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 829-836;
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    The Third Transmembrane Helix of the Cannabinoid Receptor Plays a Role in the Selectivity of Aminoalkylindoles for CB2, Peripheral Cannabinoid Receptor
    Chen-ni Chin, James W. Murphy, John W. Huffman and Debra A. Kendall
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 837-844;
  • You have access
    Modification of Cardiac Na+ Current by RWJ 24517 and Its Enantiomers in Guinea Pig Ventricular Myocytes
    Robert G. Tsushima, James E. Kelly, Joseph J. Salata, Kristine N. Liberty and J. Andrew Wasserstrom
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 845-855;
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    Species-Dependent Differences in Monoamine Oxidase A and B-Catalyzed Oxidation of Various C4 Substituted 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridinyl Derivatives
    Hiroyuki Inoue, Kay Castagnoli, Cornelis Van der Schyf, Stéphane Mabic, Kazuo Igarashi and Neal Castagnoli
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 856-864;
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    Safety, Pharmacokinetics, and Tissue Distribution of Liposomal P-Ethoxy Antisense Oligonucleotides Targeted to Bcl-2
    Yolanda Gutiérrez-Puente, Ana M. Tari, Clifton Stephens, Michael Rosenblum, Reyes Tamez Guerra and Gabriel Lopez-Berestein
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 865-869;
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    Thioguanine Administered as a Continuous Intravenous Infusion to Pediatric Patients Is Metabolized to the Novel Metabolite 8-Hydroxy-Thioguanine
    Brenda J. Kitchen, Asher Moser, Elizabeth Lowe, Frank M. Balis, Brigitte Widemann, Lawrence Anderson, John Strong, Susan M. Blaney, Stacey L. Berg, Michelle O’Brien and Peter C. Adamson
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 870-874;
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    β-Adrenoceptor Subtype Activities of Trimetoquinol Derivatives: Biochemical Studies on Human β-Adrenoceptors Expressed in Chinese Hamster Ovary Cells
    Anish A. Konkar, Sandeep S. Vansal, Gamal Shams, Paul F. Fraundorfer, Wei-Ping Zheng, Victor I. Nikulin, Joseph De Los Angeles, Richard H. Fertel, Duane D. Miller and Dennis R. Feller
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 875-883;
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    Nicotine Infusion Modulates Immobilization Stress-Triggered Induction of Gene Expression of Rat Catecholamine Biosynthetic Enzymes
    Lidia Serova, Emil Danailov, Firas Chamas and Esther L. Sabban
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 884-892;
  • You have access
    Cannabinoid Receptors Differentially Modulate Potassium A and D Currents in Hippocampal Neurons in Culture
    Jian Mu, Shou-yuan Zhuang, M. Todd Kirby, Robert E. Hampson and Sam A. Deadwyler
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 893-902;
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    Repeated Measurement of Intestinal Permeability as an Assessment of Colitis Severity in HLA-B27 Transgenic Rats
    Steven W. Kerr, Walter W. Wolyniec, Zoran Filipovic, Suzanne G. Nodop, Frank Braza, Raymond J. Winquist and Thomas C. Noonan
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 903-910;
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    Spin Trap (N-t-butyl-α-phenylnitrone)-Mediated Suprainduction of Heme Oxygenase-1 in Kidney Ischemia/Reperfusion Model: Role of the Oxygenase in Protection against Oxidative Injury
    Mahin D. Maines, Vulapali S. Raju and Nariman Panahian
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 911-919;
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    Regulation of Aquaporin-2 Expression by the α2-Adrenoceptor Agonist Clonidine in the Rat
    Asad Junaid, Li Cui, S. Brian Penner and Donald D. Smyth
    Journal of Pharmacology and Experimental Therapeutics November 1999, 291 (2) 920-923;
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Journal of Pharmacology and Experimental Therapeutics: 291 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 291, Issue 2
1 Nov 1999
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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