Table of Contents

Articles

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  Mechanism of Fluoxetine Block of Cloned Voltage-Activated Potassium Channel Kv1.3

  Jin-Sung Choi, Sang June Hahn, Duck-Joo Rhie, Shin-Hee Yoon, Yang-Hyeok Jo and Myung-Suk Kim

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 1-6;
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  Modulation of Norepinephrine Release from Sympathetic Neurons of the Rabbit Aorta by Prejunctional Prostanoid Receptors

  Tenna Juul Jensen and Ove A. Nedergaard

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 7-11;
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  Endomorphin-1 and Endomorphin-2 Show Differences in Their Activation of μ Opioid Receptor-Regulated G Proteins in Supraspinal Antinociception in Mice

  Pilar Sánchez-Blázquez, Marta Rodríguez-Díaz, Isabel DeAntonio and Javier Garzón

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 12-18;
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  Escalating Dose-Binge Treatment with Methylphenidate: Role of Serotonin in the Emergent Behavioral Profile

  David S. Segal and Ronald Kuczenski

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 19-30;
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  1′,1′-Dimethylheptyl-Δ-8-tetrahydrocannabinol-11-oic Acid: A Novel, Orally Effective Cannabinoid with Analgesic and Anti-inflammatory Properties

  Esam Z. Dajani, Kenneth R. Larsen, John Taylor, Noura E. Dajani, Thomas G. Shahwan, Stephen D. Neeleman, Mark S. Taylor, Merril T. Dayton and G. Nabi Mir

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 31-38;
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  Novel Polyamine Derivatives as Neuroprotective Agents

  G. M. Gilad and V. H. Gilad

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 39-43;
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  Decreased [Ca²⁺]_i during Inhibition of Coronary Smooth Muscle Contraction by 17β-Estradiol, Progesterone, and Testosterone

  Jason G. Murphy and Raouf A. Khalil

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 44-52;
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  Nucleotide Stimulation of Cl⁻ Secretion in the Pigmented Rabbit Conjunctiva

  Ken-Ichi Hosoya, Hideo Ueda, Kwang-Jin Kim and Vincent H. L. Lee

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 53-59;
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  Effects of the Long-Acting Monoamine Reuptake Inhibitor Indatraline on Cocaine Self-Administration in Rhesus Monkeys

  S. Stevens Negus, Michael R. Brandt and Nancy K. Mello

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 60-69;
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  Impaired Skeletal Muscle Performance in the Early Stage of Cardiac Pressure Overload in Rabbits: Beneficial Effects of Angiotensin-Converting Enzyme Inhibition

  Catherine Coirault, Olivier Langeron, Francine Lambert, François-Xavier Blanc, Guy Lerebours, Nancy Claude, Bruno Riou, Denis Chemla and Yves Lecarpentier

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 70-75;
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  Role of Adenosine A₁ Receptors in Modulating Extracellular Adenosine Levels

  Bradley T. Andresen, Delbert G. Gillespie, Zaichuan Mi, Raghvendra K. Dubey and Edwin K. Jackson

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 76-80;
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  KMD-3213, a Uroselective and Long-Acting α_1a-Adrenoceptor Antagonist, Tested in a Novel Rat Model

  Katsuyoshi Akiyama, Masachiyo Hora, Satoshi Tatemichi, Naoyuki Masuda, Syunji Nakamura, Ryoichi Yamagishi and Makio Kitazawa

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 81-91;
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  Nerve Terminal Nicotinic Cholinergic Receptors on Excitatory Motoneurons in the Myenteric Plexus of Guinea Pig Intestine

  James J. Galligan

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 92-98;
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  Cognition-Enhancing Drugs Increase Stimulated Hippocampal θ Rhythm Amplitude in the Urethane-Anesthetized Rat

  Gene G. Kinney, Patricia Patino, Yvan Mermet-Bouvier, John E. Starrett and Valentin K. Gribkoff

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 99-106;
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  Capsaicin Inhibits Phospholipase C-Mediated Ca²⁺Increase by Blocking Thapsigargin-Sensitive Store-Operated Ca²⁺ Entry in PC12 Cells

  Se-Young Choi and Kyong-Tai Kim

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 107-114;
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  Low-Dose Angiotensin II Reduces Urinary Cyclic AMP Excretion in Spontaneously Hypertensive, But Not Normotensive, Rats: Independence from Hypertension and Renal Hemodynamic Effects of Angiotensin

  Edwin K. Jackson, William A. Herzer, Zaichuan Mi, Subhash J. Vyas and Curtis K. Kost

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 115-123;
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  Jun N-Terminal Kinase in Rheumatoid Arthritis

  Zuoning Han, David L. Boyle, Karlfried R. Aupperle, Brydon Bennett, Anthony M. Manning and Gary S. Firestein

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 124-130;
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  Small Intestinal Metabolism of the 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase Inhibitor Lovastatin and Comparison with Pravastatin

  Wolfgang Jacobsen, Gabriele Kirchner, Katrin Hallensleben, Laviero Mancinelli, Michael Deters, Ingelore Hackbarth, Karen Baner, Leslie Z. Benet, Karl-Friedrich Sewing and Uwe Christians

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 131-139;
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  Activation of Ca²⁺-Dependent K⁺ Current by Nordihydroguaiaretic Acid in Porcine Coronary Arterial Smooth Muscle Cells

  H. Yamamura, N. Nagano, M. Hirano, K. Muraki, M. Watanabe and Y. Imaizumi

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 140-146;
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  Polyspecific Organic Anion Transporting Polypeptides Mediate Hepatic Uptake of Amphipathic Type II Organic Cations

  Jessica E. van Montfoort, Bruno Hagenbuch, Karin E. Fattinger, Michael Müller, Geny M. M. Groothuis, Dirk K. F. Meijer and Peter J. Meier

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 147-152;
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  Anesthetic Profile of Dexmedetomidine Identified by Stimulus-Response and Continuous Measurements in Rats

  Cornelis J. J. G. Bol, John P. W. Vogelaar and Jaap W. Mandema

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 153-160;
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  The Metabotropic Glutamate 2/3 Receptor Agonists LY354740 and LY379268 Selectively Attenuate Phencyclidine versus d-Amphetamine Motor Behaviors in Rats

  Jayne Cartmell, James A. Monn and Darryle D. Schoepp

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 161-170;
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  Stimulation by Transforming Growth Factor-α of DNA Synthesis and Proliferation of Adult Rat Hepatocytes in Primary Cultures: Modulation by α- and β-Adrenoceptor Agonists

  Mitsutoshi Kimura and Masahiko Ogihara

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 171-180;
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  Modulation by Endogenous Nitric Oxide of Acid Secretion Induced by Gastric Distention in Rats: Enhancement by Nitric Oxide Synthase Inhibitor

  Motohiro Kitamura, Shinichi Sugamoto, Shoji Kawauchi, Shinichi Kato and Koji Takeuchi

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 181-187;
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  Pharmacokinetics and Pharmacodynamics of Nifedipine in Untreated and Atorvastatin-Treated Hyperlipidemic Rats

  Lise A. Eliot and Fakhreddin Jamali

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 188-193;
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  Vascular Peroxynitrite Formation during Organic Nitrate Tolerance

  Michael John Mihm, Christen Marie Coyle, Liang Jing and John Anthony Bauer

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 194-198;
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  Pharmacokinetic-Pharmacodynamic Modeling of the Immunomodulating Agent Susalimod and Experimentally Induced Tumor Necrosis Factor-α Levels in the Mouse

  Peter Gozzi, Ingrid Påhlman, Lena Palmér, Alvar Grönberg and and Stefan Persson

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 199-203;
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  Nonlinear Disposition Kinetics of a Novel Antifolate, MX-68, in Rats

  Yong-Hae Han, Yukio Kato and Yuichi Sugiyama

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 204-212;
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  Duration of Cytochrome P-450 2E1 (CYP2E1) Inhibition and Estimation of Functional CYP2E1 Enzyme Half-Life after Single-Dose Disulfiram Administration in Humans

  Maurice G. Emery, Carole Jubert, Kenneth E. Thummel and Evan D. Kharasch

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 213-219;
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  Pindolol, a Putative 5-Hydroxytryptamine_1AAntagonist, Does Not Reverse the Inhibition of Serotonergic Neuronal Activity Induced by Fluoxetine in Awake Cats: Comparison to WAY-100635

  Casimir A. Fornal, Francisco J. Martin, Christine W. Metzler and Barry L. Jacobs

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 220-228;
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  Pindolol Suppresses Serotonergic Neuronal Activity and Does Not Block the Inhibition of Serotonergic Neurons Produced by 8-Hydroxy-2-(di-n-propylamino)tetralin in Awake Cats

  Casimir A. Fornal, Francisco J. Martin, Christine W. Metzler and Barry L. Jacobs

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 229-238;
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  Effects of Various Serotonin Agonists, Antagonists, and Uptake Inhibitors on the Discriminative Stimulus Effects of Methamphetamine in Rats

  Patrik Munzar, Michael D. Laufert, Scott W. Kutkat, Jana Nováková and Steven R. Goldberg

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 239-250;
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  G Protein-Linked Receptors: Pharmacological Evidence for the Formation of Heterodimers

  Roberto Maggio, Pascaline Barbier, Antonella Colelli, Federica Salvadori, Graziella Demontis and Giovanni U. Corsini

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 251-257;
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  Differential Effects of Epinephrine and Norepinephrine on cAMP Response and G_i3α Protein Expression in Cultured Sympathetic Neurons

  Amruthesh C. Shivachar and Douglas C. Eikenburg

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 258-264;
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  Behavioral Effects of Cocaine: Interactions with D1 Dopaminergic Antagonists and Agonists in Mice and Squirrel Monkeys

  Jonathan L. Katz, Theresa A. Kopajtic, Krista A. Myers, Robert J. Mitkus and Michael Chider

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 265-279;
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  Mechanism of Sodium Channel Block by Venlafaxine in Guinea Pig Ventricular Myocytes

  Majed Khalifa, Pascal Daleau and and Jacques Turgeon

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 280-284;
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  Polyamine-Like Actions of Aminoglycosides at RecombinantN-Methyl-d-Aspartate Receptors

  Scott C. Harvey and Phil Skolnick

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 285-291;
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  Metabolism of Trimethoprim to a Reactive Iminoquinone Methide by Activated Human Neutrophils and Hepatic Microsomes

  W. George Lai, Nasir Zahid and Jack P. Uetrecht

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 292-299;
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  Antagonism of 5-Hydroxytryptamine₄ Receptors Attenuates Hyperactivity Induced by Cocaine: Putative Role for 5-Hydroxytryptamine₄ Receptors in the Nucleus Accumbens Shell

  Lance R. McMahon and Kathryn A. Cunningham

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 300-307;
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  Dose-Related Opposite Modulation by Nociceptin/Orphanin FQ of Substance P Nociception in the Nociceptors and Spinal Cord

  Makoto Inoue, Ichiro Shimohira, Akira Yoshida, Andreas Zimmer, Hiroshi Takeshima, Tsukasa Sakurada and Hiroshi Ueda

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 308-313;
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  Inhibition of Activation of Nuclear Factor κB Is Responsible for Inhibition of Inducible Nitric Oxide Synthase Expression by Higenamine, an Active Component of Aconite Root

  Young Jin Kang, Young Soo Lee, Goun Woo Lee, Duck Hyung Lee, Jae Chun Ryu, Hye Sook Yun-Choi and Ki Churl Chang

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 314-320;
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  Bisphosphonate Effects in Rat Unloaded Hindlimb Bone Loss Model: Three-Dimensional Microcomputed Tomographic, Histomorphometric, and Densitometric Analyses

  Odile Barou, Marie-Hélène Lafage-Proust, Catherine Martel, Thierry Thomas, Fabrice Tirode, Norbert Laroche, Alain Barbier, Christian Alexandre and Laurence Vico

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 321-328;
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  Angiotensin II-Induced Renal Vasoconstriction in Genetic Hypertension

  Edwin K. Jackson, William A. Herzer, Subhash J. Vyas and Curtis K. Kost

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 329-334;
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  Hypoxia and Alkalinization Inhibit Endothelium-Derived Nitric Oxide But Not Endothelium-Derived Hyperpolarizing Factor Responses in Porcine Coronary Artery

  Shunichi Shimizu and Richard J. Paul

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 335-344;
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  Polaprezinc Down-Regulates Proinflammatory Cytokine-Induced Nuclear Factor-κB Activiation and Interleukin-8 Expression in Gastric Epithelial Cells

  Tadahito Shimada, Naomi Watanabe, Yukio Ohtsuka, Motoya Endoh, Kazuo Kojima, Hideyuki Hiraishi and Akira Terano

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 345-352;
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  Effects of Dopamine D_1-like and D_2-likeAgonists in Rats that Self-Administer Cocaine

  S. Barak Caine, S. Stevens Negus, Nancy K. Mello and Jack Bergman

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 353-360;
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  Zinc Inhibition of γ-Aminobutyric Acid_A Receptor Function Is Decreased in the Cerebral Cortex during Pilocarpine-Induced Status Epilepticus

  Pradeep K. Banerjee, Richard W. Olsen and O. Carter Snead

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 361-366;
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  Effects of Pirfenidone on Transforming Growth Factor-β Gene Expression at the Transcriptional Level in Bleomycin Hamster Model of Lung Fibrosis

  S. N. Iyer, G. Gurujeyalakshmi and S. N. Giri

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 367-373;
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  Inward Currents in Neurons from Newborn Guinea Pig Intestine: Mediation by 5-Hydroxytryptamine Type 3 Receptors

  Jin Zhai, Michael D. Gershon, John H. Walsh, Helen C. Wong and Annette L. Kirchgessner

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 374-382;
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  Stimulatory Effect of Taurine on Calcium Ion Uptake in Rod Outer Segments of the Rat Retina Is Independent of Taurine Uptake

  Julius D. Militante and John B. Lombardini

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 383-389;
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  Antinociceptive and Pharmacological Effects of Metanicotine, a Selective Nicotinic Agonist

  M. I. Damaj, W. Glassco, M. D. Aceto and B. R. Martin

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 390-398;
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  Neuroprotection (Focal Ischemia) and Neurotoxicity (Electroencephalographic) Studies in Rats with AHN649, a 3-Amino Analog of Dextromethorphan and Low-Affinity N-Methyl-d-Aspartate Antagonist

  Frank C. Tortella, Paul Britton, Anthony Williams, Xi Chung May Lu and Amy H. Newman

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 399-408;
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  Reinforcing Effects of Psychostimulants in Humans Are Associated with Increases in Brain Dopamine and Occupancy of D₂Receptors

  Nora D. Volkow, Gene-Jack Wang, Joanna S. Fowler, Jean Logan, S. John Gatley, Cristopher Wong, Robert Hitzemann and Naomi R. Pappas

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 409-415;
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  Differential Effects of Heme Oxygenase Isoforms on Heme Mediation of Endothelial Intracellular Adhesion Molecule 1 Expression

  Frank A. D. T. G. Wagener, Jean-Louis da Silva, Tim Farley, Theo de Witte, Attallah Kappas and Nader G. Abraham

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 416-423;
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  Three-Dimensional-Quantitative Structure Activity Relationship Analysis of Cytochrome P-450 3A4 Substrates

  Sean Ekins, Gianpaolo Bravi, James H. Wikel and Steven A. Wrighton

  Journal of Pharmacology and Experimental Therapeutics October 1999, 291 (1) 424-433;