Table of Contents

Articles

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  5-Hydroxytryptamine_1F Receptors Do Not Participate in Vasoconstriction: Lack of Vasoconstriction to LY344864, a Selective Serotonin_1F Receptor Agonist in Rabbit Saphenous Vein

  Marlene L. Cohen and Kathryn Schenck

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 935-939;
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  Cationic Modulation of Human Dopamine Transporter: Dopamine Uptake and Inhibition of Uptake

  Nianhang Chen, Clarence G. Trowbridge and Joseph B. Justice

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 940-949;
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  Glutathione-Dependent Metabolism ofcis-3-(9H-Purin-6-ylthio)acrylic Acid to Yield the Chemotherapeutic Drug 6-Mercaptopurine: Evidence for Two Distinct Mechanisms in Rats

  Sjofn Gunnarsdottir and Adnan A. Elfarra

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 950-957;
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  Mechanism of Intestinal Absorption of an Orally Active β-Lactam Prodrug: Uptake and Transport of Carindacillin in Caco-2 Cells

  Yin-Hua Li, Kiyomi Ito, Yasuyuki Tsuda, Rikako Kohda, Hideo Yamada and Tomoo Itoh

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 958-964;
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  Pharmacological Studies of the Acute and Chronic Effects of (+)-3,4-Methylenedioxymethamphetamine on Locomotor Activity: Role of 5-Hydroxytryptamine_1A and 5-Hydroxytryptamine_1B/1D Receptors

  Andrew C. McCreary, Michael G. Bankson and Kathryn A. Cunningham

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 965-973;
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  Effects of Potassium Channel Blockers on CO₂-Induced Slowly Adapting Pulmonary Stretch Receptor Inhibition

  Shigeji Matsumoto, Toshiaki Takahashi, Takeshi Tanimoto, Chikako Saiki and Mamoru Takeda

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 974-979;
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  Coupling Efficiencies of β₁- and β₂-Adrenergic Receptors Expressed Alone or Together in Transfected GH₃ Pituitary Cells

  Shelly Wood Guerrero and Kenneth P. Minneman

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 980-988;
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  Native γ-Aminobutyric Acid Type A Receptors from Rat Hippocampus, Containing Both α1 and α5 Subunits, Exhibit a Single Benzodiazepine Binding Site with α5 Pharmacological Properties

  Francisco Araujo, Diego Ruano and Javier Vitorica

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 989-997;
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  Ruthenium Red-Mediated Inhibition of Large-Conductance Ca²⁺-Activated K⁺ Channels in Rat Pituitary GH₃ Cells

  Sheng-Nan Wu, Chung-Ren Jan and Hui-Fang Li

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 998-1005;
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  Non-Cyclic AMP-Dependent, Positive Inotropic Cyclodepsipeptides with Negative Chronotropy

  Akinobu Tsunoo and Masayuki Kamijo

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1006-1012;
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  Z-350, A Novel Compound with α₁-Adrenoceptor Antagonistic and Steroid 5α-Reductase Inhibitory Actions: Pharmacological Properties In Vivo

  Yoshihisa Fukuta, Youichi Fukuda, Raita Higashino, Kenji Yoshida, Masayuki Ogishima, Hajime Tamaki and Mineo Takei

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1013-1018;
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  Further Pharmacological Characterization of Bradykinin B₁ Receptor Up-Regulation in Human Umbilical Vein

  Sergio Pablo Sardi, Federico Manuel Daray, Andrea Emilse Errasti, Facundo Germán Pelorosso, Virginia Andrea Pujol-Lereis, Verónica Rey-Ares, María Pía Rogines-Velo and Rodolfo Pedro Rothlin

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1019-1025;
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  Stimulatory and Inhibitory Properties of Aminoglycoside Antibiotics at N-Methyl-d-Aspartate Receptors

  Takashi Masuko, Tomoko Kuno, Keiko Kashiwagi, Tadashi Kusama, Keith Williams and Kazuei Igarashi

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1026-1033;
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  Differing Effects ofN-methyl-d-aspartate Receptor Subtype Selective Antagonists on Dyskinesias in Levodopa-Treated 1-Methyl-4-phenyl-tetrahydropyridine Monkeys

  P. J. Blanchet, S. Konitsiotis, E. R. Whittemore, Z. L. Zhou, R. M. Woodward and T. N. Chase

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1034-1040;
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  Ex Vivo Reversal of Heparin-Mediated Cardioprotection by Heparinase After Ischemia and Reperfusion

  Kenneth S. Kilgore, Elaine J. Tanhehco, Keith B. Naylor and Benedict R. Lucchesi

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1041-1047;
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  Influence of Hypovolemia on the Pharmacokinetics and the Electroencephalographic Effect of Etomidate in the Rat

  Peter De Paepe, Frans M. Belpaire, Gert Van Hoey, Paul A. Boon and Walter A. Buylaert

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1048-1053;
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  Enhancement of Osteogenesis In Vitro and In Vivo by a Novel Osteoblast Differentiation Promoting Compound, TAK-778

  Kohei Notoya, Hirofumi Nagai, Tsuneo Oda, Masayuki Gotoh, Tetsuo Hoshino, Hiroya Muranishi, Shigehisa Taketomi, Takashi Sohda and Haruhiko Makino

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1054-1064;
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  Manipulation of the Tetrahydrocannabinol Side Chain Delineates Agonists, Partial Agonists, and Antagonists

  B. R. Martin, R. Jefferson, R. Winckler, J. L. Wiley, J. W. Huffman, P. J. Crocker, B. Saha and R. K. Razdan

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1065-1079;
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  Troglitazone Inhibits Bicarbonate Secretion in Rat and Human Duodenum

  M. Hosokawa, H. Tsukada, K. Fukuda, M. Oya, M. Onomura, H. Nakamura, M. Kodama, Y. Yamada and Y. Seino

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1080-1084;
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  Pharmacological Profile of ZD1611, a Novel, Orally Active Endothelin ET_A Receptor Antagonist

  Campbell Wilson, Sarah-Jane Hunt, Eric Tang, Nicola Wright, Elizabeth Kelly, Sharon Palmer, Christine Heys, Susan Mellor, Roger James and Russell Bialecki

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1085-1091;
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  Discriminative Stimulus Effects of Morphine in Squirrel Monkeys: Stimulants, Opioids, and Stimulant-Opioid Combinations

  Donna M. Platt, Doreen M. Grech, James K. Rowlett and Roger D. Spealman

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1092-1100;
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  Glutathione Conjugate Interactions with DNA-Dependent Protein Kinase

  Hongxie Shen, Mary P. Schultz and Kenneth D. Tew

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1101-1106;
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  Carrier-Mediated Hepatic Uptake of Peptidic Endothelin Antagonists in Rats

  Sharif Akhteruzzaman, Yukio Kato, Hirokazu Kouzuki, Hiroshi Suzuki, Akihiro Hisaka, Bruno Stieger, Peter J. Meier and Yuichi Sugiyama

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1107-1115;
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  Diltiazem Inhibition of Cytochrome P-450 3A Activity Is Due To Metabolite Intermediate Complex Formation

  David R. Jones, J. Christopher Gorski, Mitchell A. Hamman, Bradley S. Mayhew, Steven Rider and Stephen D. Hall

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1116-1125;
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  Calcium Channels Involved in K⁺- and Veratridine-Induced Increase of Cytosolic Calcium Concentration in Human Cerebral Cortical Synaptosomes

  Wolfgang Meder, Klaus Fink, Josef Zentner and Manfred Göthert

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1126-1131;
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  Opioid Antinociception in Ovariectomized Monkeys: Comparison with Antinociception in Males and Effects of Estradiol Replacement

  S. Stevens Negus and Nancy K. Mello

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1132-1140;
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  Structure-Function Analysis of Human Cytochrome P-450 2B6 Using a Novel Substrate, Site-Directed Mutagenesis, and Molecular Modeling

  Tammy L. Domanski, Kathleen M. Schultz, Fabienne Roussel, Jeffrey C. Stevens and James R. Halpert

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1141-1147;
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  Preclinical Evaluation of Newly Approved and Potential Antiepileptic Drugs Against Cocaine-Induced Seizures

  Maciej Gasior, Jesse T. Ungard and Jeffrey M. Witkin

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1148-1156;
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  Discriminative Stimulus Effects of the Nonpeptidic δ-Opioid Agonist SNC80 in Rhesus Monkeys

  Michael R. Brandt, S. Stevens Negus, Nancy K. Mello, M. Scott Furness, Xiaoyan Zhang and Kenner C. Rice

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1157-1164;
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  Inhibitors of Calmodulin-Dependent Protein Kinase Are Nonspecific Blockers of Voltage-Dependent K⁺ Channels in Vascular Myocytes

  Jonathan Ledoux, Denis Chartier and Normand Leblanc

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1165-1174;
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  Contribution of Nitric Oxide to the Presynaptic Inhibition by Endothelin ET_B Receptor of the Canine Stellate Ganglionic Transmission

  Katsuhiro Yamada, Kazushi Kushiku, Hiromi Yamada, Takeshi Katsuragi, Tatsuo Furukawa, Hidenori Noguchi and Nobufumi Ono

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1175-1181;
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  Age- and Growth Hormone-Induced Alterations in Renal Sulfate Transport

  Kazuko Sagawa, Bing Han, Debra C. DuBois, Heini Murer, Richard R. Almon and Marilyn E. Morris

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1182-1187;
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  Effects of Ifenprodil and Baclofen on Exercise-Induced Increase of Myocardial Oxygen Demand in Normotensive Rats

  Laurent Monassier, Véronique Riehl, Jean-Paul Lienhard, Eduardo Tibiriça, Josiane Feldman and Pascal Bousquet

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1188-1194;
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  5-Hydroxytryptamine_1A Receptor Activation Enhances Norepinephrine Release from Nerves in the Rabbit Saphenous Vein

  Marlene L. Cohen, Kathryn W. Schenck and Susan H. Hemrick-Luecke

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1195-1201;
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  Comparative Pharmacology of the Nonpeptide Neuromedin B Receptor Antagonist PD 168368

  Richard R. Ryan, Tatsuro Katsuno, Samuel A. Mantey, Tapas K. Pradhan, H. Christian Weber, David H. Coy, James F. Battey and Robert T. Jensen

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1202-1211;
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  A Conditionally Immortalized Epithelial Cell Line for Studies of Intestinal Drug Transport

  Staffan Tavelin, Vladan Milovic, Göran Ocklind, Susanne Olsson and Per Artursson

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1212-1221;
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  Apparent pA₂ Values of Benzodiazepine Antagonists and Partial Agonists in Monkeys

  Carol A. Paronis and Jack Bergman

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1222-1229;
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  Bimolecular Glutathione Conjugation Kinetics of Ethacrynic Acid in Rat Liver: In Vitro and Perfusion Studies

  Rommel G. Tirona and K. Sandy Pang

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1230-1241;
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  Development of a Hepatocyte-Specific Prostaglandin E₁Polymeric Prodrug and Its Potential for Preventing Carbon Tetrachloride-Induced Fulminant Hepatitis in Mice

  Ken Akamatsu, Yasuomi Yamasaki, Makiya Nishikawa, Yoshinobu Takakura and Mitsuru Hashida

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1242-1249;
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  Modulation of Cytochrome P-450 Gene Expression in Endotoxemic Mice Is Tissue Specific and Peroxisome Proliferator-Activated Receptor-α Dependent

  Thomas B. Barclay, Jeffrey M. Peters, Marion B. Sewer, Luc Ferrari, Frank J. Gonzalez and Edward T. Morgan

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1250-1257;
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  Effect of Several 5-Hydroxytryptamine_1A Receptor Ligands on the Micturition Reflex in Rats: Comparison with WAY 100635

  R. Testa, L. Guarneri, E. Poggesi, P. Angelico, C. Velasco, M. Ibba, A. Cilia, G. Motta, C. Riva and A. Leonardi

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1258-1269;
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  Involvement of Cyclic Nucleotide- and Calcium-Regulated Pathways in Phenobarbital-Induced Cytochrome P-450 3A Expression in Mouse Primary Hepatocytes

  Milagros Galisteo, Nathalie Marc, Alain Fautrel, André Guillouzo, Laurent Corcos and Dominique Lagadic-Gossmann

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1270-1277;
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  AL-8810: A Novel Prostaglandin F_2α Analog with Selective Antagonist Effects at the Prostaglandin F_2α (FP) Receptor

  Brenda W. Griffin, Peter Klimko, Julie Y. Crider and Najam A. Sharif

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1278-1284;
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  Effects of Lipid Mediator Antagonists on Predominant Mediator-Controlled Asthmatic Reactions in Passively Sensitized Guinea Pigs

  Yasuhito Arakida, Keiko Ohga, Kiyomi Suwa, Masaki Yokota, Keiji Miyata, Toshimitsu Yamada and Kazuo Honda

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1285-1291;
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  Sexual Dimorphism in Phencyclidine In Vitro Metabolism and Pharmacokinetics in Rats

  Susan R. Shelnutt, Melinda Gunnell and S. Michael Owens

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1292-1298;
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  In Vivo Formation and Localization of 1,1-Dichloroethylene Epoxide in Murine Liver: Identification of Its Glutathione Conjugate 2-S-Glutathionyl Acetate

  Poh-Gek Forkert

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1299-1306;
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  Modulation of Neurotransmitter Release in the Basal Ganglia of the Rat Brain by Dynorphin Peptides

  Zhi-Bing You, Mario Herrera-Marschitz and Lars Terenius

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1307-1315;
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  Effects of Sex and Gonadectomy on Cocaine Metabolism in the Rat

  Brian P. Bowman, Sharya R. Vaughan, Q. David Walker, Susan L. Davis, Patrick J. Little, Nicole M. Scheffler, Brian F. Thomas and Cynthia M. Kuhn

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1316-1323;
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  Species Differences in the Transport Activity for Organic Anions across the Bile Canalicular Membrane

  Hitoshi Ishizuka, Kumiko Konno, Tetsuo Shiina, Hideo Naganuma, Kenji Nishimura, Kousei Ito, Hiroshi Suzuki and Yuichi Sugiyama

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1324-1330;
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  In Vivo Inhibition of Peptidylglycine-α-Hydroxylating Monooxygenase by 4-Phenyl-3-Butenoic Acid

  Gregory P. Mueller, William J. Driscoll and Betty A. Eipper

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1331-1336;
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  Identification of Quantitative Trait Loci for Haloperidol-Induced Catalepsy on Mouse Chromosome 14

  Erik Rasmussen, Laura Cipp and Robert Hitzemann

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1337-1346;
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  Cocaine-Reinforced Responding in Rhesus Monkeys: Pharmacological Attenuation of the Hypothalamic-Pituitary-Adrenal Axis Response

  Jillian H. Broadbear, Gail Winger and James H. Woods

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1347-1355;
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  Divalent Cations ModulateN-Methyl-d-Aspartate Receptor Function at the Glycine Site

  H. Hashemzadeh-Gargari and Tomás R. Guilarte

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1356-1362;
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  Hyperforin, a Major Antidepressant Constituent of St. John’s Wort, Inhibits Serotonin Uptake by Elevating Free Intracellular Na^+1 1

  A. Singer, M. Wonnemann and W. E. Müller

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1363-1368;
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  Baclofen Inhibits Heroin Self-Administration Behavior and Mesolimbic Dopamine Release

  Zheng-Xiong Xi and Elliot A. Stein

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1369-1374;
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  Stimulatory Effects of Silibinin and Silicristin from the Milk Thistle Silybum marianum on Kidney Cells

  Johann Sonnenbichler, Fortunato Scalera, Isolde Sonnenbichler and Roland Weyhenmeyer

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1375-1383;
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  Evidence That the Apoptotic Actions of Etoposide Are Independent of c-Jun/Activating Protein-1-Mediated Transregulation

  W. David Jarvis, Charlene R. Johnson, Frank A. Fornari, Jong Sung Park, Paul Dent and Steven Grant

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1384-1392;
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  Characterization of MK-801-Induced Behavior as a Putative Rat Model of Psychosis

  Peter Andiné, Nina Widermark, Rolf Axelsson, Gösta Nyberg, Ulla Olofsson, Erik Mårtensson and Mats Sandberg

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1393-1408;
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  Biochemical and Functional Profile of a Newly Developed Potent and Isozyme-Selective Arginase Inhibitor

  Ricky Baggio, Frances A. Emig, David W. Christianson, David E. Ash, Sushanta Chakder and Satish Rattan

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1409-1416;
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  Action Potentials, Contraction, and Membrane Currents in Guinea Pig Ventricular Preparations Treated with the Antispasmodic Agent Terodiline

  Lesya M. Shuba, Yuji Kasamaki, Stephen E. Jones, Toshitsugu Ogura, John R. McCullough and Terence F. McDonald

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1417-1426;
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  Differential Effect of Histamine 3 Receptor-Active Agents on Brain, but not Peritoneal, Mast Cell Activation ,

  Jacek J. Rozniecki, Richard Letourneau, Miltiades Sugiultzoglu, Constantinos Spanos, Jonathan Gorbach and Theoharis C. Theoharides

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1427-1435;
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  Effect of Calcium Channel Antagonists Nifedipine and Nicardipine on Rat Cytochrome P-450 2B and 3A Forms

  Richard C. Zangar, Janice Rice Okita, Hyesook Kim, Paul E. Thomas, Alan Anderson, Robert J. Edwards, David L. Springer and Richard T. Okita

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1436-1441;
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  Tyrphostins That Suppress the Growth of Human Papilloma Virus 16-Immortalized Human Keratinocytes

  H. Ben-Bassat, S. Rosenbaum-Mitrani, Z. Hartzstark, R. Levitzki, M. Chaouat, Z. Shlomai, B. Y. Klein, N. Kleinberger-Doron, A. Gazit, R. Tsvieli and A. Levitzki

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1442-1457;
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  The Human and Rat Recombinant Receptors for Advanced Glycation End Products Have a High Degree of Homology but Different Pharmacokinetic Properties in Rats

  C. Renard, O. Chappey, M. P. Wautier, M. Nagashima, J. Morser, J. M. Scherrmann and J. L. Wautier

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1458-1466;
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  Retroviral-Mediated Expression of the P140A, but not P140A/G156A, Mutant Form of O ⁶-Methylguanine DNA Methyltransferase Protects Hematopoietic Cells against O ⁶-Benzylguanine Sensitization to Chloroethylnitrosourea Treatment

  Rodney Maze, Chandrika Kurpad, Anthony E. Pegg, Leonard C. Erickson and David A. Williams

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1467-1474;
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  Inhibition of Serotonin-Induced Vascular Smooth Muscle Cell Proliferation by Sarpogrelate

  Sushil K. Sharma, Peter Zahradka, Donald Chapman, Hideo Kumamoto, Nobuakira Takeda and Naranjan S. Dhalla

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1475-1481;
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  Functional Characteristics and Tissue Distribution Pattern of Organic Cation Transporter 2 (OCTN2), an Organic Cation/Carnitine Transporter

  Xiang Wu, Wei Huang, Puttur D. Prasad, Pankaj Seth, Deva P. Rajan, Frederick H. Leibach, Jinwen Chen, Simon J. Conway and Vadivel Ganapathy

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1482-1492;
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  Multisecond Oscillations in Firing Rate in the Globus Pallidus: Synergistic Modulation by D1 and D2 Dopamine Receptors

  David N. Ruskin, Debra A. Bergstrom and Judith R. Walters

  Journal of Pharmacology and Experimental Therapeutics September 1999, 290 (3) 1493-1501;