Table of Contents

Articles

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  NPS R-568: A Type II Calcimimetic Compound that Acts on Parathyroid Cell Calcium Receptor of Rats to Reduce Plasma Levels of Parathyroid Hormone and Calcium

  John Fox, Stacey H. Lowe, Barbara A. Petty and Edward F. Nemeth

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 473-479;
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  Calcimimetic Compound NPS R-568 Stimulates Calcitonin Secretion But Selectively Targets Parathyroid Gland Ca²⁺ Receptor in Rats

  John Fox, Stacey H. Lowe, Rebecca L. Conklin, Barbara A. Petty and Edward F. Nemeth

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 480-486;
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  Relevance of Aromatic Residues in Transmembrane Segments V to VII for Binding of Peptide and Nonpeptide Antagonists to the Human Tachykinin NK₂ Receptor

  A. R. Renzetti, R.-M. Catalioto, M. Criscuoli, P. Cucchi, C. Ferrer, A. Giolitti, M. Guelfi, L. Rotondaro, F. J. Warner and C. A. Maggi

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 487-495;
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  In Vivo Analysis of Amantadine Renal Clearance in the Uninephrectomized Rat: Functional Significance of In Vitro Bicarbonate-Dependent Amantadine Renal Tubule Transport

  Kerry B. Goralski, Donald D. Smyth and Daniel S. Sitar

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 496-504;
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  Levosimendan: Effects of a Calcium Sensitizer on Function and Arrhythmias and Cyclic Nucleotide Levels during Ischemia/Reperfusion in the Langendorff-Perfused Guinea Pig Heart

  E. F. Du Toit, C. A. Muller, J. McCarthy and L. H. Opie

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 505-514;
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  Mechanism of Transient Outward K⁺ Channel Block by Disopyramide

  Jose A. Sanchez-Chapula

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 515-523;
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  Enhancement of Collagen-Induced Arthritis in Mice by Diesel Exhaust Particles

  Shin Yoshino and Masaru Sagai

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 524-529;
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  Omeprazole Has a Dual Mechanism of Action: It Inhibits Both H⁺K⁺ATPase and Gastric Mucosa Carbonic Anhydrase Enzyme in Humans (In Vitro and In Vivo Experiments)

  Ioan Puscas, Marcela Coltau, Michael Baican and Gabriela Domuta

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 530-534;
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  Caffeine, Acting on Adenosine A₁ Receptors, Prevents the Extinction of Cocaine-Seeking Behavior in Mice

  A. Kuzmin, B. Johansson, E. E. Zvartau and B. B. Fredholm

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 535-542;
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  The Role of Probenecid-Sensitive Organic Acid Transport in the Pharmacokinetics of N-Methyl-d-Aspartate Receptor Antagonists Acting at the Glycine_B-Site: Microdialysis and Maximum Electroshock Seizures Studies

  M. B. Hesselink, H. Smolders, B. Eilbacher, A. G. De Boer, D. D. Breimer and W. Danysz

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 543-550;
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  Rofecoxib [Vioxx, MK-0966; 4-(4′-Methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: A Potent and Orally Active Cyclooxygenase-2 Inhibitor. Pharmacological and Biochemical Profiles

  C.-C. Chan, S. Boyce, C. Brideau, S. Charleson, W. Cromlish, D. Ethier, J. Evans, A. W. Ford-Hutchinson, M. J. Forrest, J. Y. Gauthier, R. Gordon, M. Gresser, J. Guay, S. Kargman, B. Kennedy, Y. Leblanc, S. Leger, J. Mancini, G. P. O’Neill, M. Ouellet, D. Patrick, M. D. Percival, H. Perrier, P. Prasit, I. Rodger, P. Tagari, M. Therien, P. Vickers, D. Visco, Z. Wang, J. Webb, E. Wong, L.-J. Xu, R. N. Young, R. Zamboni and D. Riendeau

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 551-560;
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  In Vivo and In Vitro Evidence of Blood-Brain Barrier Transport of a Novel Cationic Arginine-Vasopressin Fragment 4-9 Analog

  Shuichi Tanabe, Yasuyuki Shimohigashi, Yasuhisa Nakayama, Takashi Makino, Tsugumi Fujita, Takeru Nose, Gozoh Tsujimoto, Teruo Yokokura, Mikihiko Naito, Takashi Tsuruo and Tetsuya Terasaki

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 561-568;
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  Different State Dependencies of 4-Aminopyridine Binding to rKv1.4 and rKv4.2: Role of the Cytoplasmic Halves of the Fifth and Sixth Transmembrane Segments

  Gea-Ny Tseng

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 569-577;
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  Sarcoplasmic Reticulum Ca²⁺ Release by 4-Chloro-m-Cresol (4-CmC) in Intact and Chemically Skinned Ferret Cardiac Ventricular Fibers

  S. Choisy, C. Huchet-Cadiou and C. Léoty

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 578-586;
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  Inhibition of Interleukin-1-Induced Proteoglycan Degradation and Nitric Oxide Production in Bovine Articular Cartilage/Chondrocyte Cultures by the Natural Product, Hymenialdisine

  Alison M. Badger, Michael N. Cook, Barbara A. Swift, Tonie M. Newman-Tarr, Maxine Gowen and Michael Lark

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 587-593;
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  Use of the Steroid Derivative RPR 106541 in Combination with Site-Directed Mutagenesis for Enhanced Cytochrome P-450 3A4 Structure/Function Analysis

  Jeffrey C. Stevens, Tammy L. Domanski, Greg R. Harlow, Rebecca B. White, Edward Orton and James R. Halpert

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 594-602;
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  Inhibition of β₂-Adrenergic and Muscarinic Cholinergic Receptor Endocytosis after Depletion of Phosphatidylinositol Bisphosphate

  Scott D. Sorensen, Daniel A. Linseman, Edward L. McEwen, Anne M. Heacock and Stephen K. Fisher

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 603-610;
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  Binge Drinking Disturbs Hepatic Microcirculation after Transplantation: Prevention with Free Radical Scavengers

  Zhi Zhong, Gavin E. Arteel, Henry D. Connor, Peter Schemmer, Shu-Chuan Chou, James A. Raleigh, Ronald P. Mason, John J. Lemasters and Ronald G. Thurman

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 611-620;
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  SB 203580, an Inhibitor of p38 Mitogen-Activated Protein Kinase, Enhances Constitutive Apoptosis of Cytokine-Deprived Human Eosinophils

  Hannu Kankaanranta, Patricia M. De Souza, Peter J. Barnes, Michael Salmon, Mark A. Giembycz and Mark A. Lindsay

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 621-628;
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  Peripheral Injection of a New Corticotropin-Releasing Factor (CRF) Antagonist, Astressin, Blocks Peripheral CRF- and Abdominal Surgery-Induced Delayed Gastric Emptying in Rats

  Vicente Martínez, Jean Rivier and Y. Taché

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 629-634;
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  A Novel Transversion in the Intron 5 Donor Splice Junction ofCYP2C19 and a Sequence Polymorphism in Exon 3 Contribute to the Poor Metabolizer Phenotype for the Anticonvulsant DrugS-Mephenytoin

  Gordon C. Ibeanu, Joyce Blaisdell, Ronald J. Ferguson, Burhan I. Ghanayem, Kim Brøsen, Simone Benhamou, Christine Bouchardy, Grant R. Wilkinson, Pierre Dayer and Joyce A. Goldstein

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 635-640;
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  Lack of Effect of McN-A-343 on Membrane Current and Contraction in Guinea Pig Ventricular Myocytes

  Jian-Bing Shen, Bin Jiang and Achilles J. Pappano

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 641-648;
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  Potent and Selective Human β₃-Adrenergic Receptor Antagonists

  Mari Rios Candelore, Liping Deng, Laurie Tota, Xiao-Ming Guan, Angela Amend, Yong Liu, Ron Newbold, Margaret A. Cascieri and Ann E. Weber

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 649-655;
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  Bradykinin Activates a Cross-Signaling Pathway between Sensory and Adrenergic Nerve Endings in the Heart: A Novel Mechanism of Ischemic Norepinephrine Release?

  Nahid Seyedi, Ryushi Maruyama and Roberto Levi

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 656-663;
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  Mechanism-Based Modeling of Rebound Tachycardia after Chronicl-Propranolol Infusion in Spontaneous Hypertensive Rats

  Lena Brynne, Lennart K. Paalzow and Mats O. Karlsson

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 664-671;
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  The Interaction and Transport of β-Lactam Antibiotics with the Cloned Rat Renal Organic Anion Transporter 1

  Surawat Jariyawat, Takashi Sekine, Michio Takeda, Nopporn Apiwattanakul, Yoshikatsu Kanai, Samaisukh Sophasan and Hitoshi Endou

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 672-677;
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  Effects of Systemically Administered Dynorphin A(1–17) in Rhesus Monkeys

  Eduardo R. Butelman, Todd J. Harris, Amarilis Perez and Mary-Jeanne Kreek

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 678-686;
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  Interspecies Differences in the Cardiac Negative Inotropic Effects of β₃-Adrenoceptor Agonists

  Chantal Gauthier, Geneviève Tavernier, Jean-Noël Trochu, Véronique Leblais, Karine Laurent, Dominique Langin, Denis Escande and Hervé Le Marec

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 687-693;
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  The Relationship between the Myocardial Kinetics of Meperidine and Its Effect on Myocardial Contractility: Model-Independent Analysis and Optimal Regional Model

  Richard N. Upton, Yi Fei Huang, Laurence E. Mather and David J. Doolette

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 694-701;
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  Mechanism-Based Pharmacokinetic-Pharmacodynamic Modeling of Antilipolytic Effects of Adenosine A₁ Receptor Agonists in Rats: Prediction of Tissue-Dependent Efficacy In Vivo

  P. H. Van der Graaf, E. A. Van Schaick, S. A. G. Visser, H. J. M. M. De Greef, A. P. Ijzerman and M. Danhof

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 702-709;
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  Evidence for Differential Regulation of Renal Proximal Tubularp-Aminohippurate and Sodium-Dependent Dicarboxylate Transport

  G. Gabriëls, A. Werners, S. Mauss and J. Greven

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 710-715;
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  Effects of LU-111995 in Three Models of Disrupted Prepulse Inhibition in Rats

  Mark A. Geyer, Neal R. Swerdlow, Virginia Lehmann-Masten, Hans-Jürgen Teschendorf, Martin Traut and Gerhard Gross

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 716-724;
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  Studies on Maitotoxin-Induced Intracellular Ca²⁺Elevation in Chinese Hamster Ovary Cells Stably Transfected with cDNAs Encoding for L-Type Ca²⁺ Channel Subunits ,

  Mauro Cataldi, Agnese Secondo, Angela D’Alessio, Maurizio Taglialatela, Franz Hofmann, Norbert Klugbauer, Gianfranco Di Renzo and Lucio Annunziato

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 725-730;
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  Nicotinic Acetylcholine Receptor Agonist SIB-1508Y Improves Cognitive Functioning in Chronic Low-Dose MPTP-Treated Monkeys

  J. S. Schneider, John P. Tinker, Maria Van Velson, Frederique Menzaghi and G. Kenneth Lloyd

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 731-739;
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  Synthetic Estrogen 17α-Ethinyl Estradiol Induces Pattern of Uterine Gene Expression Similar to Endogenous Estrogen 17β-Estradiol

  Salman M. Hyder, Constance Chiappetta and George M. Stancel

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 740-747;
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  Improvement of Mortality by Long-Term E4010 Treatment in Monocrotaline-Induced Pulmonary Hypertensive Rats

  Kohtarou Kodama and Hideyuki Adachi

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 748-752;
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  Proteinase-Activated Receptor 2 (PAR₂): Development of a Ligand-Binding Assay Correlating with Activation of PAR₂ by PAR₁- and PAR₂-Derived Peptide Ligands

  Bahjat Al-Ani, Mahmoud Saifeddine, Atsufumi Kawabata, Bernard Renaux, Shalini Mokashi and Morley D. Hollenberg

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 753-760;
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  Comparison of the Pharmacological Properties of Cloned Rat, Human, and Bovine Norepinephrine Transporters

  Filip A. Paczkowski, Lesley J. Bryan-Lluka, Peter Pörzgen, Michael Brüss and Heinz Bönisch

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 761-767;
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  Depletion and Restoration of the Putative Photosensitive Materials Store Yielding Nitric Oxide in the Isolated Mouse Gastric Fundus

  Kansu Büyükafşar, Emi˙ne Demi˙rel-Yilmaz, Cemi˙l Göçmen and Ati˙lla Di˙kmen

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 768-773;
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  S-Adenosylmethionine Protects Against Cyclosporin A-Induced Alterations in Rat Liver Plasma Membrane Fluidity and Functions

  Ana I. Galán, M. Eugenia Muñoz and Rafael Jiménez

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 774-781;
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  Inhibition of Neutrophil Proteinases by Recombinant Serpin Lex032 Reduces Capillary No-Reflow in Ischemia/Reperfusion-Induced Acute Pancreatitis

  E. von Dobschuetz, T. Hoffmann and K. Messmer

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 782-788;
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  Association of Heparin with Basic Fibroblast Growth Factor, Epidermal Growth Factor, and Constitutive Nitric Oxide Synthase on Healing of Gastric Ulcer in Rats

  Y. Li, H. Y. Wang and C. H. Cho

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 789-796;
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  The Irreversible γ-Aminobutyric Acid (GABA) Transaminase Inhibitor γ-Vinyl-GABA Blocks Cocaine Self-Administration in Rats

  Stephanie A. Kushner, Stephen L. Dewey and Conan Kornetsky

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 797-802;
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  Synaptic Activation and Properties of 5-Hydroxytryptamine₃ Receptors in Myenteric Neurons of Guinea Pig Intestine

  Xiaoping Zhou and James J. Galligan

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 803-810;
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  Attenuation of Cortical Neuronal Apoptosis by Gangliosides

  Bo Rum Ryu, Dennis W. Choi, Dean M. Hartley, Erminio Costa, Ilo Jou and Byoung Joo Gwag

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 811-816;
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  Amplification of the Cyclic AMP Response to Forskolin in Pheochromocytoma PC12 Cells through Adenosine A_2APurinoceptors

  Chiara Florio, Fabiana Frausin, Rodolfo Vertua and Rosa Maria Gaion

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 817-824;
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  Effects of ZD6169, a K_ATP Channel Opener, on the Micturition Reflex in the Rat

  Yongbei Yu and William C. de Groat

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 825-831;
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  Heterogeneity of Endothelium-Dependent Vasodilation in Pressurized Cerebral and Small Mesenteric Resistance Arteries of the Rat

  Guy J. L. Lagaud, Peter L. Skarsgard, Ismail Laher and Cornelis van Breemen

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 832-839;
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  Pharmacology of Tezosentan, New Endothelin Receptor Antagonist Designed for Parenteral Use

  Martine Clozel, Henri Ramuz, Jean-Paul Clozel, Volker Breu, Patrick Hess, Bernd-Michael Löffler, Philippe Coassolo and Sébastien Roux

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 840-846;
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  N-Type Ca²⁺ Channels Trigger Release of Excitatory and Inhibitory Neurotransmitter from Nerve Endings in Canine Bronchi

  Amer M. Johri and Luke J. Janssen

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 847-853;
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  Selectivity of the Multidrug Resistance Modulator, LY335979, for P-Glycoprotein and Effect on Cytochrome P-450 Activities

  A. H. Dantzig, R. L. Shepard, K. L. Law, L. Tabas, S. Pratt, J. S. Gillespie, S. N. Binkley, M. T. Kuhfeld, J. J. Starling and S. A. Wrighton

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 854-862;
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  Differential κ-Opioid Receptor Expression on Mouse Lymphocytes at Varying Stages of Maturation and on Mouse Macrophages after Selective Elicitation

  Tracey A. Ignatowski and Jean M. Bidlack

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 863-870;
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  Determinants of Paclitaxel Penetration and Accumulation in Human Solid Tumor

  Hyo-Jeong Kuh, Seong H. Jang, M. Guillaume Wientjes, Jean R. Weaver and Jessie L.-S. Au

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 871-880;
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  Total Neurochemical Lesion of Noradrenergic Neurons of the Locus Ceruleus Does Not Alter Either Naloxone-Precipitated or Spontaneous Opiate Withdrawal nor Does It Influence Ability of Clonidine To Reverse Opiate Withdrawal

  Stéphanie Caillé, Emilio F. Espejo, Jean-Philippe Reneric, Martine Cador, George F. Koob and Luis Stinus

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 881-892;
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  Characterization of Prejunctional and Postjunctional Muscarinic Receptors of the Ascending Reflex Contraction in Rat Ileum

  M. Kurjak, D. Sattler, V. Schusdziarra and H. D. Allescher

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 893-900;
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  Muscarinic Receptor Agonists, Like Dopamine Receptor Antagonist Antipsychotics, Inhibit Conditioned Avoidance Response in Rats

  Harlan E. Shannon, John C. Hart, Frank P. Bymaster, David O. Calligaro, Neil W. DeLapp, Charles H. Mitch, John S. Ward, Anders Fink-Jensen, Per Sauerberg, Lone Jeppesen, Malcolm J. Sheardown and Michael D.B. Swedberg

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 901-907;
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  Comparison of the Ligand Binding and Signaling Properties of Human Dopamine D₂ and D₃ Receptors in Chinese Hamster Ovary Cells

  Jurgen F. M. Vanhauwe, Norbert Fraeyman, Bart J. B. Francken, Walter H. M. L. Luyten and Josée E. Leysen

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 908-916;
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  Quantitative Autoradiography with Short-Lived Positron Emission Tomography Tracers: A Study on Muscarinic Acetylcholine Receptors withN-[¹¹C]methyl-4-piperidylbenzilate

  Sven Sihver, Wiebke Sihver, Mats Bergström, A. Urban Höglund, Pernilla Sjöberg, Bengt Långström and Yasuyoshi Watanabe

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 917-922;
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  Zinc Stimulates DNA Synthesis during Its Antiapoptotic Action Independently with Increments of an Antiapoptotic Protein, Bcl-2, in Porcine Kidney LLC-PK₁ Cells

  Masami Ishido, Tsuguyoshi Suzuki, Tatsumi Adachi and Manabu Kunimoto

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 923-928;
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  Cerebral Blood Flow Responses to Somatosensory Stimulation Are Unaffected by Scopolamine in Unanesthetized Rat

  Yasuaki Nakao, Jun Gotoh, Tang-Yong Kuang, David M. Cohen, Karen D. Pettigrew and Louis Sokoloff

  Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 929-934;