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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

August 01, 1999; Volume 290,Issue 2

Articles

  • You have access
    NPS R-568: A Type II Calcimimetic Compound that Acts on Parathyroid Cell Calcium Receptor of Rats to Reduce Plasma Levels of Parathyroid Hormone and Calcium
    John Fox, Stacey H. Lowe, Barbara A. Petty and Edward F. Nemeth
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 473-479;
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    Calcimimetic Compound NPS R-568 Stimulates Calcitonin Secretion But Selectively Targets Parathyroid Gland Ca2+ Receptor in Rats
    John Fox, Stacey H. Lowe, Rebecca L. Conklin, Barbara A. Petty and Edward F. Nemeth
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 480-486;
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    Relevance of Aromatic Residues in Transmembrane Segments V to VII for Binding of Peptide and Nonpeptide Antagonists to the Human Tachykinin NK2 Receptor
    A. R. Renzetti, R.-M. Catalioto, M. Criscuoli, P. Cucchi, C. Ferrer, A. Giolitti, M. Guelfi, L. Rotondaro, F. J. Warner and C. A. Maggi
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 487-495;
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    In Vivo Analysis of Amantadine Renal Clearance in the Uninephrectomized Rat: Functional Significance of In Vitro Bicarbonate-Dependent Amantadine Renal Tubule Transport
    Kerry B. Goralski, Donald D. Smyth and Daniel S. Sitar
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 496-504;
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    Levosimendan: Effects of a Calcium Sensitizer on Function and Arrhythmias and Cyclic Nucleotide Levels during Ischemia/Reperfusion in the Langendorff-Perfused Guinea Pig Heart
    E. F. Du Toit, C. A. Muller, J. McCarthy and L. H. Opie
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 505-514;
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    Mechanism of Transient Outward K+ Channel Block by Disopyramide
    Jose A. Sanchez-Chapula
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 515-523;
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    Enhancement of Collagen-Induced Arthritis in Mice by Diesel Exhaust Particles
    Shin Yoshino and Masaru Sagai
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 524-529;
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    Omeprazole Has a Dual Mechanism of Action: It Inhibits Both H+K+ATPase and Gastric Mucosa Carbonic Anhydrase Enzyme in Humans (In Vitro and In Vivo Experiments)
    Ioan Puscas, Marcela Coltau, Michael Baican and Gabriela Domuta
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 530-534;
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    Caffeine, Acting on Adenosine A1 Receptors, Prevents the Extinction of Cocaine-Seeking Behavior in Mice
    A. Kuzmin, B. Johansson, E. E. Zvartau and B. B. Fredholm
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 535-542;
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    The Role of Probenecid-Sensitive Organic Acid Transport in the Pharmacokinetics of N-Methyl-d-Aspartate Receptor Antagonists Acting at the GlycineB-Site: Microdialysis and Maximum Electroshock Seizures Studies
    M. B. Hesselink, H. Smolders, B. Eilbacher, A. G. De Boer, D. D. Breimer and W. Danysz
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 543-550;
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    Rofecoxib [Vioxx, MK-0966; 4-(4′-Methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: A Potent and Orally Active Cyclooxygenase-2 Inhibitor. Pharmacological and Biochemical Profiles
    C.-C. Chan, S. Boyce, C. Brideau, S. Charleson, W. Cromlish, D. Ethier, J. Evans, A. W. Ford-Hutchinson, M. J. Forrest, J. Y. Gauthier, R. Gordon, M. Gresser, J. Guay, S. Kargman, B. Kennedy, Y. Leblanc, S. Leger, J. Mancini, G. P. O’Neill, M. Ouellet, D. Patrick, M. D. Percival, H. Perrier, P. Prasit, I. Rodger, P. Tagari, M. Therien, P. Vickers, D. Visco, Z. Wang, J. Webb, E. Wong, L.-J. Xu, R. N. Young, R. Zamboni and D. Riendeau
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 551-560;
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    In Vivo and In Vitro Evidence of Blood-Brain Barrier Transport of a Novel Cationic Arginine-Vasopressin Fragment 4-9 Analog
    Shuichi Tanabe, Yasuyuki Shimohigashi, Yasuhisa Nakayama, Takashi Makino, Tsugumi Fujita, Takeru Nose, Gozoh Tsujimoto, Teruo Yokokura, Mikihiko Naito, Takashi Tsuruo and Tetsuya Terasaki
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 561-568;
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    Different State Dependencies of 4-Aminopyridine Binding to rKv1.4 and rKv4.2: Role of the Cytoplasmic Halves of the Fifth and Sixth Transmembrane Segments
    Gea-Ny Tseng
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 569-577;
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    Sarcoplasmic Reticulum Ca2+ Release by 4-Chloro-m-Cresol (4-CmC) in Intact and Chemically Skinned Ferret Cardiac Ventricular Fibers
    S. Choisy, C. Huchet-Cadiou and C. Léoty
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 578-586;
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    Inhibition of Interleukin-1-Induced Proteoglycan Degradation and Nitric Oxide Production in Bovine Articular Cartilage/Chondrocyte Cultures by the Natural Product, Hymenialdisine
    Alison M. Badger, Michael N. Cook, Barbara A. Swift, Tonie M. Newman-Tarr, Maxine Gowen and Michael Lark
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 587-593;
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    Use of the Steroid Derivative RPR 106541 in Combination with Site-Directed Mutagenesis for Enhanced Cytochrome P-450 3A4 Structure/Function Analysis
    Jeffrey C. Stevens, Tammy L. Domanski, Greg R. Harlow, Rebecca B. White, Edward Orton and James R. Halpert
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 594-602;
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    Inhibition of β2-Adrenergic and Muscarinic Cholinergic Receptor Endocytosis after Depletion of Phosphatidylinositol Bisphosphate
    Scott D. Sorensen, Daniel A. Linseman, Edward L. McEwen, Anne M. Heacock and Stephen K. Fisher
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 603-610;
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    Binge Drinking Disturbs Hepatic Microcirculation after Transplantation: Prevention with Free Radical Scavengers
    Zhi Zhong, Gavin E. Arteel, Henry D. Connor, Peter Schemmer, Shu-Chuan Chou, James A. Raleigh, Ronald P. Mason, John J. Lemasters and Ronald G. Thurman
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 611-620;
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    SB 203580, an Inhibitor of p38 Mitogen-Activated Protein Kinase, Enhances Constitutive Apoptosis of Cytokine-Deprived Human Eosinophils
    Hannu Kankaanranta, Patricia M. De Souza, Peter J. Barnes, Michael Salmon, Mark A. Giembycz and Mark A. Lindsay
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 621-628;
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    Peripheral Injection of a New Corticotropin-Releasing Factor (CRF) Antagonist, Astressin, Blocks Peripheral CRF- and Abdominal Surgery-Induced Delayed Gastric Emptying in Rats
    Vicente Martínez, Jean Rivier and Y. Taché
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 629-634;
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    A Novel Transversion in the Intron 5 Donor Splice Junction ofCYP2C19 and a Sequence Polymorphism in Exon 3 Contribute to the Poor Metabolizer Phenotype for the Anticonvulsant DrugS-Mephenytoin
    Gordon C. Ibeanu, Joyce Blaisdell, Ronald J. Ferguson, Burhan I. Ghanayem, Kim Brøsen, Simone Benhamou, Christine Bouchardy, Grant R. Wilkinson, Pierre Dayer and Joyce A. Goldstein
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 635-640;
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    Lack of Effect of McN-A-343 on Membrane Current and Contraction in Guinea Pig Ventricular Myocytes
    Jian-Bing Shen, Bin Jiang and Achilles J. Pappano
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 641-648;
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    Potent and Selective Human β3-Adrenergic Receptor Antagonists
    Mari Rios Candelore, Liping Deng, Laurie Tota, Xiao-Ming Guan, Angela Amend, Yong Liu, Ron Newbold, Margaret A. Cascieri and Ann E. Weber
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 649-655;
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    Bradykinin Activates a Cross-Signaling Pathway between Sensory and Adrenergic Nerve Endings in the Heart: A Novel Mechanism of Ischemic Norepinephrine Release?
    Nahid Seyedi, Ryushi Maruyama and Roberto Levi
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 656-663;
  • You have access
    Mechanism-Based Modeling of Rebound Tachycardia after Chronicl-Propranolol Infusion in Spontaneous Hypertensive Rats
    Lena Brynne, Lennart K. Paalzow and Mats O. Karlsson
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 664-671;
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    The Interaction and Transport of β-Lactam Antibiotics with the Cloned Rat Renal Organic Anion Transporter 1
    Surawat Jariyawat, Takashi Sekine, Michio Takeda, Nopporn Apiwattanakul, Yoshikatsu Kanai, Samaisukh Sophasan and Hitoshi Endou
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 672-677;
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    Effects of Systemically Administered Dynorphin A(1–17) in Rhesus Monkeys
    Eduardo R. Butelman, Todd J. Harris, Amarilis Perez and Mary-Jeanne Kreek
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 678-686;
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    Interspecies Differences in the Cardiac Negative Inotropic Effects of β3-Adrenoceptor Agonists
    Chantal Gauthier, Geneviève Tavernier, Jean-Noël Trochu, Véronique Leblais, Karine Laurent, Dominique Langin, Denis Escande and Hervé Le Marec
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 687-693;
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    The Relationship between the Myocardial Kinetics of Meperidine and Its Effect on Myocardial Contractility: Model-Independent Analysis and Optimal Regional Model
    Richard N. Upton, Yi Fei Huang, Laurence E. Mather and David J. Doolette
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 694-701;
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    Mechanism-Based Pharmacokinetic-Pharmacodynamic Modeling of Antilipolytic Effects of Adenosine A1 Receptor Agonists in Rats: Prediction of Tissue-Dependent Efficacy In Vivo
    P. H. Van der Graaf, E. A. Van Schaick, S. A. G. Visser, H. J. M. M. De Greef, A. P. Ijzerman and M. Danhof
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 702-709;
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    Evidence for Differential Regulation of Renal Proximal Tubularp-Aminohippurate and Sodium-Dependent Dicarboxylate Transport
    G. Gabriëls, A. Werners, S. Mauss and J. Greven
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 710-715;
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    Effects of LU-111995 in Three Models of Disrupted Prepulse Inhibition in Rats
    Mark A. Geyer, Neal R. Swerdlow, Virginia Lehmann-Masten, Hans-Jürgen Teschendorf, Martin Traut and Gerhard Gross
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 716-724;
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    Studies on Maitotoxin-Induced Intracellular Ca2+Elevation in Chinese Hamster Ovary Cells Stably Transfected with cDNAs Encoding for L-Type Ca2+ Channel Subunits ,
    Mauro Cataldi, Agnese Secondo, Angela D’Alessio, Maurizio Taglialatela, Franz Hofmann, Norbert Klugbauer, Gianfranco Di Renzo and Lucio Annunziato
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 725-730;
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    Nicotinic Acetylcholine Receptor Agonist SIB-1508Y Improves Cognitive Functioning in Chronic Low-Dose MPTP-Treated Monkeys
    J. S. Schneider, John P. Tinker, Maria Van Velson, Frederique Menzaghi and G. Kenneth Lloyd
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 731-739;
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    Synthetic Estrogen 17α-Ethinyl Estradiol Induces Pattern of Uterine Gene Expression Similar to Endogenous Estrogen 17β-Estradiol
    Salman M. Hyder, Constance Chiappetta and George M. Stancel
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 740-747;
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    Improvement of Mortality by Long-Term E4010 Treatment in Monocrotaline-Induced Pulmonary Hypertensive Rats
    Kohtarou Kodama and Hideyuki Adachi
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 748-752;
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    Proteinase-Activated Receptor 2 (PAR2): Development of a Ligand-Binding Assay Correlating with Activation of PAR2 by PAR1- and PAR2-Derived Peptide Ligands
    Bahjat Al-Ani, Mahmoud Saifeddine, Atsufumi Kawabata, Bernard Renaux, Shalini Mokashi and Morley D. Hollenberg
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 753-760;
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    Comparison of the Pharmacological Properties of Cloned Rat, Human, and Bovine Norepinephrine Transporters
    Filip A. Paczkowski, Lesley J. Bryan-Lluka, Peter Pörzgen, Michael Brüss and Heinz Bönisch
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 761-767;
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    Depletion and Restoration of the Putative Photosensitive Materials Store Yielding Nitric Oxide in the Isolated Mouse Gastric Fundus
    Kansu Büyükafşar, Emi˙ne Demi˙rel-Yilmaz, Cemi˙l Göçmen and Ati˙lla Di˙kmen
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 768-773;
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    S-Adenosylmethionine Protects Against Cyclosporin A-Induced Alterations in Rat Liver Plasma Membrane Fluidity and Functions
    Ana I. Galán, M. Eugenia Muñoz and Rafael Jiménez
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 774-781;
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    Inhibition of Neutrophil Proteinases by Recombinant Serpin Lex032 Reduces Capillary No-Reflow in Ischemia/Reperfusion-Induced Acute Pancreatitis
    E. von Dobschuetz, T. Hoffmann and K. Messmer
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 782-788;
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    Association of Heparin with Basic Fibroblast Growth Factor, Epidermal Growth Factor, and Constitutive Nitric Oxide Synthase on Healing of Gastric Ulcer in Rats
    Y. Li, H. Y. Wang and C. H. Cho
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 789-796;
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    The Irreversible γ-Aminobutyric Acid (GABA) Transaminase Inhibitor γ-Vinyl-GABA Blocks Cocaine Self-Administration in Rats
    Stephanie A. Kushner, Stephen L. Dewey and Conan Kornetsky
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 797-802;
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    Synaptic Activation and Properties of 5-Hydroxytryptamine3 Receptors in Myenteric Neurons of Guinea Pig Intestine
    Xiaoping Zhou and James J. Galligan
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 803-810;
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    Attenuation of Cortical Neuronal Apoptosis by Gangliosides
    Bo Rum Ryu, Dennis W. Choi, Dean M. Hartley, Erminio Costa, Ilo Jou and Byoung Joo Gwag
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 811-816;
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    Amplification of the Cyclic AMP Response to Forskolin in Pheochromocytoma PC12 Cells through Adenosine A2APurinoceptors
    Chiara Florio, Fabiana Frausin, Rodolfo Vertua and Rosa Maria Gaion
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 817-824;
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    Effects of ZD6169, a KATP Channel Opener, on the Micturition Reflex in the Rat
    Yongbei Yu and William C. de Groat
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 825-831;
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    Heterogeneity of Endothelium-Dependent Vasodilation in Pressurized Cerebral and Small Mesenteric Resistance Arteries of the Rat
    Guy J. L. Lagaud, Peter L. Skarsgard, Ismail Laher and Cornelis van Breemen
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 832-839;
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    Pharmacology of Tezosentan, New Endothelin Receptor Antagonist Designed for Parenteral Use
    Martine Clozel, Henri Ramuz, Jean-Paul Clozel, Volker Breu, Patrick Hess, Bernd-Michael Löffler, Philippe Coassolo and Sébastien Roux
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 840-846;
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    N-Type Ca2+ Channels Trigger Release of Excitatory and Inhibitory Neurotransmitter from Nerve Endings in Canine Bronchi
    Amer M. Johri and Luke J. Janssen
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 847-853;
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    Selectivity of the Multidrug Resistance Modulator, LY335979, for P-Glycoprotein and Effect on Cytochrome P-450 Activities
    A. H. Dantzig, R. L. Shepard, K. L. Law, L. Tabas, S. Pratt, J. S. Gillespie, S. N. Binkley, M. T. Kuhfeld, J. J. Starling and S. A. Wrighton
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 854-862;
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    Differential κ-Opioid Receptor Expression on Mouse Lymphocytes at Varying Stages of Maturation and on Mouse Macrophages after Selective Elicitation
    Tracey A. Ignatowski and Jean M. Bidlack
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 863-870;
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    Determinants of Paclitaxel Penetration and Accumulation in Human Solid Tumor
    Hyo-Jeong Kuh, Seong H. Jang, M. Guillaume Wientjes, Jean R. Weaver and Jessie L.-S. Au
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 871-880;
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    Total Neurochemical Lesion of Noradrenergic Neurons of the Locus Ceruleus Does Not Alter Either Naloxone-Precipitated or Spontaneous Opiate Withdrawal nor Does It Influence Ability of Clonidine To Reverse Opiate Withdrawal
    Stéphanie Caillé, Emilio F. Espejo, Jean-Philippe Reneric, Martine Cador, George F. Koob and Luis Stinus
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 881-892;
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    Characterization of Prejunctional and Postjunctional Muscarinic Receptors of the Ascending Reflex Contraction in Rat Ileum
    M. Kurjak, D. Sattler, V. Schusdziarra and H. D. Allescher
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 893-900;
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    Muscarinic Receptor Agonists, Like Dopamine Receptor Antagonist Antipsychotics, Inhibit Conditioned Avoidance Response in Rats
    Harlan E. Shannon, John C. Hart, Frank P. Bymaster, David O. Calligaro, Neil W. DeLapp, Charles H. Mitch, John S. Ward, Anders Fink-Jensen, Per Sauerberg, Lone Jeppesen, Malcolm J. Sheardown and Michael D.B. Swedberg
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 901-907;
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    Comparison of the Ligand Binding and Signaling Properties of Human Dopamine D2 and D3 Receptors in Chinese Hamster Ovary Cells
    Jurgen F. M. Vanhauwe, Norbert Fraeyman, Bart J. B. Francken, Walter H. M. L. Luyten and Josée E. Leysen
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 908-916;
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    Quantitative Autoradiography with Short-Lived Positron Emission Tomography Tracers: A Study on Muscarinic Acetylcholine Receptors withN-[11C]methyl-4-piperidylbenzilate
    Sven Sihver, Wiebke Sihver, Mats Bergström, A. Urban Höglund, Pernilla Sjöberg, Bengt Långström and Yasuyoshi Watanabe
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 917-922;
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    Zinc Stimulates DNA Synthesis during Its Antiapoptotic Action Independently with Increments of an Antiapoptotic Protein, Bcl-2, in Porcine Kidney LLC-PK1 Cells
    Masami Ishido, Tsuguyoshi Suzuki, Tatsumi Adachi and Manabu Kunimoto
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 923-928;
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    Cerebral Blood Flow Responses to Somatosensory Stimulation Are Unaffected by Scopolamine in Unanesthetized Rat
    Yasuaki Nakao, Jun Gotoh, Tang-Yong Kuang, David M. Cohen, Karen D. Pettigrew and Louis Sokoloff
    Journal of Pharmacology and Experimental Therapeutics August 1999, 290 (2) 929-934;
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Journal of Pharmacology and Experimental Therapeutics: 290 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 290, Issue 2
1 Aug 1999
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
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