Activation of Human Cytochrome P-450 3A4-Catalyzed Meloxicam 5′-Methylhydroxylation by Quinidine and Hydroquinidine In Vitro

Eva Ludwig; Jochen Schmid; Klaus Beschke; Thomas Ebner

Article Information

vol. 290 no. 1 1-8

PubMed

10381752

Published By

American Society for Pharmacology and Experimental Therapeutics

Print ISSN

0022-3565

Online ISSN

1521-0103

History

Received August 5, 1998
Accepted February 16, 1999
Published online July 1, 1999.

The American Society for Pharmacology and Experimental Therapeutics

Author Information

Eva Ludwig,
Jochen Schmid,
Klaus Beschke and
Thomas Ebner

Department of Pharmacokinetics and Drug Metabolism, Boehringer Ingelheim Pharma KG, Biberach an der Riss, Germany

View Full Text

Statistics from Altmetric.com

Article usage

Article usage: June 1999 to June 2023

	Abstract	Full	Pdf
Jun 1999	26	72	22
Jul 1999	45	206	73
Aug 1999	8	26	17
Sep 1999	6	21	4
Oct 1999	4	17	7
Nov 1999	1	6	0
Dec 1999	1	3	1
Jan 2000	0	6	8
Feb 2000	0	8	7
Mar 2000	2	6	2
Apr 2000	0	5	5
May 2000	1	2	1
Jun 2000	3	9	10
Jul 2000	1	14	19
Aug 2000	0	4	4
Sep 2000	1	10	7
Oct 2000	0	4	9
Nov 2000	0	12	15
Dec 2000	0	6	8
Jan 2001	2	12	4
Feb 2001	1	11	11
Mar 2001	1	8	12
Apr 2001	2	9	5
May 2001	5	6	4
Jun 2001	1	14	17
Jul 2001	0	2	9
Aug 2001	0	7	9
Sep 2001	1	6	7
Oct 2001	1	5	5
Nov 2001	1	8	14
Dec 2001	1	6	6
Jan 2002	1	9	10
Feb 2002	2	6	8
Mar 2002	2	5	3
Apr 2002	1	6	14
May 2002	0	4	9
Jun 2002	0	9	9
Jul 2002	1	2	4
Aug 2002	0	2	7
Sep 2002	1	4	8
Oct 2002	0	3	6
Nov 2002	1	5	2
Dec 2002	2	1	5
Jan 2003	1	7	5
Feb 2003	0	6	8
Mar 2003	2	11	10
Apr 2003	0	3	2
May 2003	1	7	10
Jun 2003	3	5	4
Jul 2003	8	17	19
Aug 2003	13	32	6
Sep 2003	11	35	9
Oct 2003	14	29	12
Nov 2003	24	47	10
Dec 2003	18	38	10
Jan 2004	18	46	9
Feb 2004	8	45	21
Mar 2004	22	99	21
Apr 2004	21	53	16
May 2004	25	43	7
Jun 2004	26	49	22
Jul 2004	24	42	7
Aug 2004	14	32	4
Sep 2004	13	48	7
Oct 2004	12	56	12
Nov 2004	16	58	13
Dec 2004	6	41	8
Jan 2005	19	31	10
Feb 2005	6	33	4
Mar 2005	18	34	9
Apr 2005	9	56	18
May 2005	9	41	9
Jun 2005	17	39	5
Jul 2005	9	38	12
Aug 2005	9	17	7
Sep 2005	4	19	6
Oct 2005	13	25	6
Nov 2005	8	32	8
Dec 2005	8	32	8
Jan 2006	6	30	7
Feb 2006	5	40	12
Mar 2006	3	36	5
Apr 2006	6	37	10
May 2006	3	30	16
Jun 2006	6	15	8
Jul 2006	6	19	4
Aug 2006	4	25	12
Sep 2006	7	16	9
Oct 2006	10	28	11
Nov 2006	14	21	14
Dec 2006	9	9	5
Jan 2007	6	26	17
Feb 2007	17	18	20
Mar 2007	16	29	21
Apr 2007	15	29	18
May 2007	15	33	18
Jun 2007	5	20	14
Jul 2007	23	36	10
Aug 2007	21	40	13
Sep 2007	16	30	13
Oct 2007	15	31	16
Nov 2007	14	45	11
Dec 2007	2	32	7
Jan 2008	5	30	7
Feb 2008	7	39	11
Mar 2008	4	31	15
Apr 2008	8	39	9
May 2008	8	40	12
Jun 2008	14	37	11
Jul 2008	7	27	14
Aug 2008	7	18	10
Sep 2008	17	19	9
Oct 2008	11	12	6
Nov 2008	11	26	13
Dec 2008	14	7	5
Jan 2009	3	15	7
Feb 2009	9	11	6
Mar 2009	13	18	12
Apr 2009	14	21	10
May 2009	13	34	19
Jun 2009	12	16	11
Jul 2009	6	20	8
Aug 2009	9	13	7
Sep 2009	10	17	10
Oct 2009	14	16	12
Nov 2009	21	28	8
Dec 2009	28	18	9
Jan 2010	14	11	3
Feb 2010	7	10	2
Mar 2010	15	11	15
Apr 2010	18	22	8
May 2010	19	14	8
Jun 2010	12	9	6
Jul 2010	23	9	4
Aug 2010	22	18	6
Sep 2010	16	11	7
Oct 2010	14	16	5
Nov 2010	26	30	5
Dec 2010	16	12	3
Jan 2011	23	21	8
Feb 2011	17	16	4
Mar 2011	21	20	8
Apr 2011	11	24	5
May 2011	16	19	14
Jun 2011	26	24	20
Jul 2011	11	17	15
Aug 2011	11	14	15
Sep 2011	5	17	5
Oct 2011	15	23	16
Nov 2011	15	27	19
Dec 2011	17	17	28
Jan 2012	9	14	12
Feb 2012	16	28	28
Mar 2012	20	21	13
Apr 2012	16	12	15
May 2012	20	14	11
Jun 2012	16	21	20
Jul 2012	12	20	19
Aug 2012	21	19	18
Sep 2012	25	12	13
Oct 2012	18	18	30
Nov 2012	13	16	18
Dec 2012	26	20	17
Jan 2013	22	12	14
Feb 2013	14	16	10
Mar 2013	15	13	21
Apr 2013	20	9	8
May 2013	23	19	18
Jun 2013	7	4	10
Jul 2013	5	3	5
Aug 2013	13	4	10
Sep 2013	16	7	7
Oct 2013	5	8	6
Nov 2013	6	1	5
Dec 2013	7	4	2
Jan 2014	8	6	7
Feb 2014	19	7	10
Mar 2014	8	2	2
Apr 2014	13	7	10
May 2014	12	7	7
Jun 2014	6	6	11
Jul 2014	18	19	6
Aug 2014	7	9	3
Sep 2014	9	13	5
Oct 2014	9	8	6
Nov 2014	17	6	3
Dec 2014	8	3	1
Jan 2015	12	10	4
Feb 2015	9	12	7
Mar 2015	8	15	11
Apr 2015	9	17	11
May 2015	10	5	5
Jun 2015	7	16	15
Jul 2015	8	11	9
Aug 2015	11	16	11
Sep 2015	7	7	4
Oct 2015	4	12	8
Nov 2015	5	3	7
Dec 2015	11	13	10
Jan 2016	12	12	9
Feb 2016	9	9	11
Mar 2016	17	12	13
Apr 2016	4	2	15
May 2016	10	8	5
Jun 2016	6	14	7
Jul 2016	8	18	16
Aug 2016	3	13	10
Sep 2016	8	4	13
Oct 2016	5	20	17
Nov 2016	9	19	7
Dec 2016	5	20	9
Jan 2017	3	8	8
Feb 2017	3	10	4
Mar 2017	1	8	2
Apr 2017	0	18	8
May 2017	1	12	9
Jun 2017	1	9	4
Jul 2017	0	7	9
Aug 2017	5	14	13
Sep 2017	1	15	3
Oct 2017	0	21	10
Nov 2017	0	24	15
Dec 2017	2	11	3
Jan 2018	0	20	11
Feb 2018	0	13	10
Mar 2018	0	20	15
Apr 2018	1	51	21
May 2018	0	13	10
Jun 2018	0	29	19
Jul 2018	3	22	17
Aug 2018	0	16	12
Sep 2018	0	32	17
Oct 2018	1	20	18
Nov 2018	2	11	18
Dec 2018	33	0	3
Jan 2019	33	5	5
Feb 2019	20	2	4
Mar 2019	27	4	6
Apr 2019	24	0	0
May 2019	17	6	2
Jun 2019	12	4	4
Jul 2019	15	2	5
Aug 2019	20	1	2
Sep 2019	27	7	1
Oct 2019	24	0	0
Nov 2019	31	3	6
Dec 2019	21	7	5
Jan 2020	16	3	4
Feb 2020	17	8	9
Mar 2020	41	12	9
Apr 2020	16	4	3
May 2020	18	5	3
Jun 2020	11	0	0
Jul 2020	13	1	2
Aug 2020	5	1	2
Sep 2020	10	3	1
Oct 2020	16	2	4
Nov 2020	17	0	5
Dec 2020	12	9	4
Jan 2021	15	18	4
Feb 2021	9	13	1
Mar 2021	13	8	5
Apr 2021	23	3	3
May 2021	22	6	0
Jun 2021	19	12	3
Jul 2021	17	2	1
Aug 2021	18	15	3
Sep 2021	8	4	3
Oct 2021	17	4	3
Nov 2021	23	2	2
Dec 2021	20	7	2
Jan 2022	5	3	1
Feb 2022	13	4	3
Mar 2022	10	4	3
Apr 2022	15	5	2
May 2022	7	1	1
Jun 2022	10	2	1
Jul 2022	18	4	1
Aug 2022	12	3	1
Sep 2022	26	5	2
Oct 2022	17	9	0
Nov 2022	15	1	0
Dec 2022	8	1	0
Jan 2023	15	2	2
Feb 2023	10	5	0
Mar 2023	4	3	0
Apr 2023	14	6	1
May 2023	3	11	2
Jun 2023	1	0	0