Table of Contents

Articles

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  Activation of Human Cytochrome P-450 3A4-Catalyzed Meloxicam 5′-Methylhydroxylation by Quinidine and Hydroquinidine In Vitro

  Eva Ludwig, Jochen Schmid, Klaus Beschke and Thomas Ebner

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 1-8;
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  CNQX but not NBQX Prevents Expression of Amphetamine-Induced Place Preference Conditioning: A Role for the Glycine Site of the NMDA Receptor, but not AMPA Receptors

  Andy N. Mead and David N. Stephens

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 9-15;
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  Inhibition of Phosphodiesterase III with Milrinone Increases Renin Secretion in Human Subjects

  Yeong Jen Chiu, Shu-Hui Hu and Ian A. Reid

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 16-19;
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  N-Methyl-d-Aspartate Receptor Antagonists and the Development of Tolerance to the Discriminative Stimulus Effects of Morphine in Rats

  Anton Yu. Bespalov, Robert L. Balster and Patrick M. Beardsley

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 20-27;
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  α₁-Adrenergic Receptor Stimulation of Mitogenesis in Human Vascular Smooth Muscle Cells: Role of Tyrosine Protein Kinases and Calcium in Activation of Mitogen-Activated Protein Kinase

  Zhuo-Wei Hu, Xiao-You Shi, Richard Z. Lin, Jin Chen and Brian B. Hoffman

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 28-37;
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  Transport of [³H]Losartan across Isolated Perfused Rabbit Proximal Tubule

  Richard M. Edwards, Elwood J. Stack and Walter Trizna

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 38-42;
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  Negative Chronotropic Effects of Fentanyl Attenuate Beneficial Effects of Dobutamine on Oxygen Metabolism: Hemodynamic and Pharmacokinetic Interactions

  Gottfried J. Locker, Robert M. Mader, Blanka Rizovski, Sylvia Knapp, Hans Domanovits, Marcus Muellner, Christoph Hoeller, Guenther G. Steger, Fritz Sterz, Michael Freissmuth, Michael Frass and Anton N. Laggner

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 43-50;
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  Efflux Transport of a New Quinolone Antibacterial Agent, HSR-903, across the Blood-Brain Barrier

  Mitsuo Murata, Ikumi Tamai, Hiroshi Kato, Osamu Nagata, Hideo Kato and Akira Tsuji

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 51-57;
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  Sigmoidal Kinetics of CYP3A Substrates: An Approach for Scaling Dextromethorphan Metabolism in Hepatic Microsomes and Isolated Hepatocytes to Predict In Vivo Clearance in Rat

  Lynn E. Witherow and J. Brian Houston

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 58-65;
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  Pituitary Adenylate Cyclase-Activating Peptide as a Neurotransmitter in the Canine Ileal Circular Muscle

  Jo-Ann E. T. Fox-Threlkeld, Thomas J. McDonald, Zofia Woskowska, Keigo Iesaki and Edwin E. Daniel

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 66-75;
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  Competitive Antagonism of the Mouse 5-Hydroxytryptamine₃ Receptor by Bisindolylmaleimide I, a “Selective” Protein Kinase C Inhibitor

  Steven J. Coultrap, Hongwei Sun, Thomas E. Tenner and Tina K. Machu

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 76-82;
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  F 11356, a Novel 5-Hydroxytryptamine (5-HT) Derivative with Potent, Selective, and Unique High Intrinsic Activity at 5-HT_1B/1D Receptors in Models Relevant to Migraine

  Gareth W. John, Petrus J. Pauwels, Michel Perez, Serge Halazy, Bruno Le Grand, Yvan Verscheure, Jean-Pierre Valentin, Christiane Palmier, Thierry Wurch, Philippe Chopin, Marc Marien, Mark S. Kleven, Wouter Koek, Marie-Bernadette Assié, Elisabeth Carilla-Durand, Jean-Pierre Tarayre and Francis C. Colpaert

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 83-95;
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  Nematode-Induced Jejunal Inflammation in the Ferret Causes Long-Term Changes in Excitatory Neuromuscular Responses

  Kalina Venkova, Jeffrey M. Palmer and Beverley Greenwood-Van Meerveld

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 96-103;
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  Inhibitory Effect of Ondansetron on Glycine Response of Dissociated Rat Hippocampal Neurons

  Jiang Hong Ye, Rebecca Schaefer, Wen-Hsien Wu, Philip L. Liu, Vlasta K. Zbuzek and Joseph J. Mcardle

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 104-111;
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  Group II Metabotropic Glutamate Receptor Activation Attenuates Traumatic Neuronal Injury and Improves Neurological Recovery after Traumatic Brain Injury

  Jason W. Allen, Svetlana A. Ivanova, Lei Fan, Michael G. Espey, Anthony S. Basile and Alan I. Faden

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 112-120;
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  Design and Evaluation of Nitrosylated α-Adrenergic Receptor Antagonists as Potential Agents for the Treatment of Impotence

  I. Sáenz de Tejada, D. S. Garvey, J. D. Schroeder, T. Shelekhin, L. G. Letts, A. Fernández, B. Cuevas, S. Gabancho, V. Martínez, J. Angulo, M. Trocha, P. Marek, P. Cuevas and S. W. Tam

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 121-128;
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  Characterization of Interaction of 3,4,5-Trimethoxybenzoic Acid 8-(Diethylamino)octyl Ester with Torpedo californicaNicotinic Acetylcholine Receptor and 5-Hydroxytryptamine₃Receptor

  Hongwei Sun, Elizabeth A. McCardy, Tina K. Machu and Michael P. Blanton

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 129-135;
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  Cardiovascular and Neuroendocrine Effects and Pharmacokinetics of 3,4-Methylenedioxymethamphetamine in Humans

  Marta Mas, Magí Farré, Rafael de la Torre, Pere N. Roset, Jordi Ortuño, Jordi Segura and Jordi Camí

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 136-145;
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  Electrophysiological Effects of LU111995 on Canine Hearts: In Vivo and In Vitro Studies

  Eugene A. Sosunov, Ravil Z. Gainullin, Peter Danilo, Evgeny P. Anyukhovsky, Michael Kirchengast and Michael R. Rosen

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 146-152;
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  Hepatic Uptake of the Magnetic Resonance Imaging Contrast Agent Gadoxetate by the Organic Anion Transporting Polypeptide Oatp1

  Jessica E. van Montfoort, Bruno Stieger, Dirk K. F. Meijer, Hanns-J. Weinmann, Peter J. Meier and Karin E. Fattinger

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 153-157;
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  Potent Antihyperalgesic Activity without Tolerance Produced by Glycine Site Antagonist of N-Methyl-d-Aspartate Receptor GV196771A

  M. Quartaroli, C. Carignani, G. Dal Forno, M. Mugnaini, A. Ugolini, R. Arban, L. Bettelini, G. Maraia, F. Belardetti, A. Reggiani, D. G. Trist, E. Ratti, R. Di Fabio and M. Corsi

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 158-169;
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  SIB-1757 and SIB-1893: Selective, Noncompetitive Antagonists of Metabotropic Glutamate Receptor Type 5

  Mark A. Varney, Nicholas D. P. Cosford, Christine Jachec, Sara P. Rao, Aida Sacaan, Fen-Fen Lin, Leo Bleicher, Emily M. Santori, Peter J. Flor, Hans Allgeier, Fabrizio Gasparini, Rainer Kuhn, Stephen D. Hess, Gönül Veliçelebi and Edwin C. Johnson

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 170-181;
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  Prostate-Specific Human N-Acetyltransferase 2 (NAT2) Expression in the Mouse

  Matthew A. Leff, Paul N. Epstein, Mark A. Doll, Adrian J. Fretland, Udaya-Sankar Devanaboyina, Timothy D. Rustan and David W. Hein

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 182-187;
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  Preclinical Evaluation of Anti-inflammatory Activities of the Novel Pyrrolopyrimidine PNU-142731A, a Potential Treatment for Asthma

  Jia En Chin, Cheryl A. Hatfield, Greg E. Winterrowd, Raymond F. Krzesicki, Kathy L. Shull, Stephen F. Fidler, Karen P. Kolbasa, John R. Brashler, Robert L. Griffin, William E. Fleming, James M. Justen, Lee S. Banitt, Gordon L. Bundy and Ivan M. Richards

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 188-195;
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  Effect of Chronic Social Stress on δ-Opioid Receptor Function in the Rat

  Larissa A. Pohorecky, Anna Skiandos, Xiaoyan Zhang, Kenner C. Rice and Daniel Benjamin

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 196-206;
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  Biphasic Modulation of Visceral Nociception by Neurotensin in Rat Rostral Ventromedial Medulla

  M. O. Urban, S. V. Coutinho and G. F. Gebhart

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 207-213;
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  Gabapentin Attenuates Nociceptive Behaviors in an Acute Arthritis Model in Rats

  Ying Lu and Karin N. Westlund

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 214-219;
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  AA-2414, an Antioxidant and Thromboxane Receptor Blocker, Completely Inhibits Peroxide-Induced Vasoconstriction in the Human Placenta

  Scott W. Walsh, Yuping Wang and Anthony Killian

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 220-226;
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  Interactions of 6-Gingerol and Ellagic Acid with the Cardiac Sarcoplasmic Reticulum Ca²⁺-ATPase

  Alexander Y. Antipenko, Andrew I. Spielman and Madeleine A. Kirchberger

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 227-234;
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  Reperfusion Injury in Livers Due To Gentle In Situ Organ Manipulation during Harvest Involves Hypoxia and Free Radicals

  Peter Schemmer, Henry D. Connor, Gavin E. Arteel, James A. Raleigh, Hartwig Bunzendahl, Ronald P. Mason and R. G. Thurman

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 235-240;
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  Differential Cotransmission in Sympathetic Nerves: Role of Frequency of Stimulation and Prejunctional Autoreceptors

  Latchezar D. Todorov, Svetlana T. Mihaylova-Todorova, Richard A. Bjur and David P. Westfall

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 241-246;
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  Topical Opioids in Mice: Analgesia and Reversal of Tolerance by a Topical N-Methyl-d-Aspartate Antagonist

  Yuri Kolesnikov and Gavril W. Pasternak

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 247-252;
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  Modulation of Effect of Dietary Salt on Prehepatic First-Pass Metabolism: Effects of β-Blockade and Intravenous Salt Loading

  Martin F. Fromm, Dawood Darbar, Simonetta Dell’Orto and Dan M. Roden

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 253-258;
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  κ-Opioid Receptor Effects of Butorphanol in Rhesus Monkeys

  Jeffrey A. Vivian, Michael B. DeYoung, Tina L. Sumpter, John R. Traynor, John W. Lewis and James H. Woods

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 259-265;
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  Dual Pharmacological Properties of a Cyclic AMP-Sensitive Potassium Channel

  Juan Carlos Gomora and John J. Enyeart

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 266-275;
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  Dose-Dependent Inhibition of Platelet Cyclooxygenase-1 and Monocyte Cyclooxygenase-2 by Meloxicam in Healthy Subjects

  Maria R. Panara, Giulia Renda, Maria G. Sciulli, Giovanna Santini, Maria Di Giamberardino, Maria T. Rotondo, Stefania Tacconelli, Francesca Seta, Carlo Patrono and Paola Patrignani

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 276-280;
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  Role of Murine Cytochrome P-450 2F2 in Metabolic Activation of Naphthalene and Metabolism of Other Xenobiotics

  Michael A. Shultz, Prabhakara V. Choudary and Alan R. Buckpitt

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 281-288;
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  Transepithelial Transport of Organic Anions across the Choroid Plexus: Possible Involvement of Organic Anion Transporter and Multidrug Resistance-Associated Protein

  Jun-ichi Nishino, Hiroshi Suzuki, Daisuke Sugiyama, Takeo Kitazawa, Kousei Ito, Manabu Hanano and Yuichi Sugiyama

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 289-294;
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  Tetraethylammonium and Amantadine Identify Distinct Organic Cation Transporters in Rat Renal Cortical Proximal and Distal Tubules

  Kerry B. Goralski and Daniel S. Sitar

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 295-302;
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  γ-Hydroxybutyrate Modulates Synthesis and Extracellular Concentration of γ-Aminobutyric Acid in Discrete Rat Brain Regions In Vivo

  Serge Gobaille, Viviane Hechler, Christian Andriamampandry, Véronique Kemmel and Michel Maitre

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 303-309;
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  l-Citrulline, the By-Product of Nitric Oxide Synthesis, Decreases Vascular Smooth Muscle Cell Proliferation

  Emilio Ruiz, Marcela Del Rio, Beatriz Somoza, Patricia Ganado, Mercedes Sanz and Teresa Tejerina

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 310-313;
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  Binding and Hydrolysis of Meperidine by Human Liver Carboxylesterase hCE-1

  Jing Zhang, Joe C. Burnell, Natividad Dumaual and William F. Bosron

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 314-318;
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  Postnatal Ontogeny and Hormonal Regulation of Sulfotransferase SULT1B1 in Male and Female Rats

  Robert T. Dunn, Bruce A. Gleason, Dylan P. Hartley and Curtis D. Klaassen

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 319-324;
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  Pharmacological Reduction of Small Conductance Calcium-Activated Potassium Current (SK) Potentiates the Excitatory Effect of Ethanol on Ventral Tegmental Area Dopamine Neurons

  Mark S. Brodie, Maureen A. McElvain, E. Bradshaw Bunney and Sarah B. Appel

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 325-333;
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  Characterization of 2-[¹²⁵I]Iodomelatonin Binding Sites in Syrian Hamster Peripheral Organs

  Pascal Paul, Chantal Lahaye, Philippe Delagrange, Jean-Paul Nicolas, Emmanuel Canet and Jean A. Boutin

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 334-340;
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  Stimulation of Epithelial Sodium Channel Activity by the Sulfonylurea Glibenclamide

  Ahmed Chraïbi and Jean-Daniel Horisberger

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 341-347;
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  Neuroprotection by a Novel Compound, NS521

  Mette Grønborg, Teit E. Johansen, Dan Peters, Philip K. Ahring, Jørgen Drejer, Arne Møller and Leif H. Jensen

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 348-353;
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  Peripheral Effects of the κ-Opioid Agonist EMD 61753 on Pain and Inflammation in Rats and Humans

  Halina Machelska, Martina Pflüger, Werner Weber, Mojgan Piranvisseh-Völk, Jeffrey D. Daubert, Robert DeHaven and Christoph Stein

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 354-361;
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  Ethanol Directly Depresses AMPA and NMDA Glutamate Currents in Spinal Cord Motor Neurons Independent of Actions on GABA_A or Glycine Receptors

  Meng-Ya Wang, Ira J. Rampil and Joan J. Kendig

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 362-367;
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  Enhanced Antitumor Potency of Polyethylene Glycolylated Tumor Necrosis Factor-α: A Novel Polymer-Conjugation Technique with a Reversible Amino-Protective Reagent

  Shinichi Tsunoda, Tomoyoshi Ishikawa, Yoko Yamamoto, Haruhiko Kamada, Keiichi Koizumi, Junji Matsui, Yasuo Tsutsumi, Takashi Hirano and Tadanori Mayumi

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 368-372;
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  Efficient Extraction by the Liver Governs Overall Elimination of Hepatocyte Growth Factor in Rats

  Motohiro Kato, Yukio Kato, Toshikazu Nakamura and Yuichi Sugiyama

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 373-379;
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  Long-Lasting Changes of Rat Blood Pressure to Vasoconstrictors and Vasodilators Induced by Nitric Oxide Donor Infusion: Involvement of Potassium Channels

  José Eduardo da Silva-Santos and Jamil Assreuy

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 380-387;
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  Transport Characteristics of Diphenhydramine in Human Intestinal Epithelial Caco-2 Cells: Contribution of pH-Dependent Transport System

  Hiroshi Mizuuchi, Toshiya Katsura, Hideyuki Saito, Yukiya Hashimoto and Ken-Ichi Inui

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 388-392;
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  Effects of Response Contingent and Noncontingent Cocaine Injection on Hypothalamic-Pituitary-Adrenal Activity in Rhesus Monkeys

  Jillian H. Broadbear, Gail Winger, Theodore J. Cicero and James H. Woods

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 393-402;
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  Moxonidine, a Selective α₂-Adrenergic and Imidazoline Receptor Agonist, Produces Spinal Antinociception in Mice

  Carolyn A. Fairbanks and George L. Wilcox

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 403-412;
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  Impact of Ethnic Origin and Quinidine Coadministration on Codeine’s Disposition and Pharmacodynamic Effects

  Yoseph Caraco, James Sheller and Alastair J. J. Wood

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 413-422;
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  Activity of Putative Cognition Enhancers in Kynurenate Test Performed with Human Neocortex Slices

  Anna Pittaluga, Roberto Pattarini, Gian Carlo Andrioli, Concetta Viola, Claudio Munari and Maurizio Raiteri

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 423-428;
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  Three- and Four-Dimensional Quantitative Structure Activity Relationship Analyses of Cytochrome P-450 3A4 Inhibitors

  Sean Ekins, Gianpaolo Bravi, Shelly Binkley, Jennifer S. Gillespie, Barbara J. Ring, James H. Wikel and Steven A Wrighton

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 429-438;
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  Brevetoxins Cause Acute Excitotoxicity in Primary Cultures of Rat Cerebellar Granule Neurons

  Frederick W. Berman and Thomas F. Murray

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 439-444;
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  Identification of Selective Mechanism-Based Inactivators of Cytochromes P-450 2B4 and 2B5, and Determination of the Molecular Basis for Differential Susceptibility

  Sharon M. Strobel, Grazyna D. Szklarz, You qun He, Maryam Foroozesh, William L. Alworth, Elizabeth S. Roberts, Paul F. Hollenberg and James R. Halpert

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 445-451;
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  Expression of Multiple α₁-Adrenoceptors on Vascular Smooth Muscle: Correlation with the Regulation of Contraction

  Sandra L. Hrometz, Stephanie E. Edelmann, Dan F. McCune, Jennifer R. Olges, Robert W. Hadley, Dianne M. Perez and Michael T. Piascik

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 452-463;
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  Efficacy of Keratinocyte Growth Factor-2 in Dextran Sulfate Sodium-Induced Murine Colitis

  Renée Miceli, Melissa Hubert, Gemma Santiago, Da-Lin Yao, Timothy A. Coleman, Kathleen A. Huddleston and Kevin Connolly

  Journal of Pharmacology and Experimental Therapeutics July 1999, 290 (1) 464-471;