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Research ArticleARTICLE

Glucocorticoid Enhances Interleukin-1-Induced Pressor Response in Freely Moving Rats Through Its Effect on Nitric Oxide Release

Tatsuo Watanabe, Yoshiyuki Sakata, Takashi Fujioka, Daikai Sadamitsu and Tsuyoshi Maekawa
Journal of Pharmacology and Experimental Therapeutics April 1999, 289 (1) 24-30;
Tatsuo Watanabe
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Yoshiyuki Sakata
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Takashi Fujioka
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Daikai Sadamitsu
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Tsuyoshi Maekawa
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Abstract

We investigated whether changes in nitric oxide (NO) release might be responsible for the modulation by glucocorticoids of the pressor response to i.p. injection of interleukin-1β (IL-1β) in freely moving rats. In such rats, IL-1β (10 μg/kg) induced a biphasic pressor response, with a rise in the plasma concentration of NOx (NO2− andNO3− : metabolites of NO) during the second phase. Systemic pretreatment with an exogenous glucocorticoid, dexamethasone (0.5 mg/kg), enhanced the second phase of the pressor response and completely suppressed the increase in plasma NOx. Treatment withNω-nitro-l-arginine methyl ester (l-NAME, a nonspecific NO synthase inhibitor), enhanced the pressor response while attenuating the increase in plasma NOx. After bilateral adrenalectomy, IL-1β induced a smaller pressor response, but a larger increase in plasma NOx; dexamethasone reversed these changes. Our results suggest that endogenous NO moderates the pressor response to IL-1β in freely moving rats, and that glucocorticoids enhance the IL-1β-induced pressor response at least in part by reducing endogenous NO release.

Footnotes

  • Send reprint requests to: Tatsuo Watanabe, M.D., Ph.D., Department of Physiology, Yamaguchi University School of Medicine, Ube, Yamaguchi 755 Japan. E-mail: tatsuo{at}po.cc.yamaguchi-u.ac.jp

  • ↵1 This work was partly supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan.

  • ↵2 Current address: Department of Critical Care and Emergency Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi 755, Japan.

  • Abbreviations:
    IL-1
    interleukin-1
    DEX
    dexamethasone
    ADX
    adrenalectomized
    NO
    nitric oxide
    NO2−
    nitrite
    NO3−
    nitrate
    NOx
    NO2− and NO3−
    L-NAME
    Nω-nitro-l-arginine methyl ester
    LPS
    lipopolysaccharide
    cNOS
    constitutive NO synthase
    iNOS
    inducible NO synthase
    • Received December 30, 1997.
    • Accepted October 21, 1998.
  • The American Society for Pharmacology and Experimental Therapeutics
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Journal of Pharmacology and Experimental Therapeutics: 289 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 289, Issue 1
1 Apr 1999
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Research ArticleARTICLE

Glucocorticoid Enhances Interleukin-1-Induced Pressor Response in Freely Moving Rats Through Its Effect on Nitric Oxide Release

Tatsuo Watanabe, Yoshiyuki Sakata, Takashi Fujioka, Daikai Sadamitsu and Tsuyoshi Maekawa
Journal of Pharmacology and Experimental Therapeutics April 1, 1999, 289 (1) 24-30;

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Research ArticleARTICLE

Glucocorticoid Enhances Interleukin-1-Induced Pressor Response in Freely Moving Rats Through Its Effect on Nitric Oxide Release

Tatsuo Watanabe, Yoshiyuki Sakata, Takashi Fujioka, Daikai Sadamitsu and Tsuyoshi Maekawa
Journal of Pharmacology and Experimental Therapeutics April 1, 1999, 289 (1) 24-30;
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