Table of Contents

Articles

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  (S)-(−)-Cotinine, the Major Brain Metabolite of Nicotine, Stimulates Nicotinic Receptors to Evoke [³H]Dopamine Release from Rat Striatal Slices in a Calcium-Dependent Manner

  Linda P. Dwoskin, Lihong Teng, Susan T. Buxton and Peter A. Crooks

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 905-911;
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  Drug-Protein Binding and Blood-Brain Barrier Permeability

  Hideo Tanaka and Kenji Mizojiri

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 912-918;
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  Bradykinin Promotes Ischemic Norepinephrine Release in Guinea Pig and Human Hearts

  Eiichiro Hatta, Ryushi Maruyama, Stuart J. Marshall, Michiaki Imamura and Roberto Levi

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 919-927;
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  In Vivo Modulation of Alternative Pathways of P-450-Catalyzed Cyclophosphamide Metabolism: Impact on Pharmacokinetics and Antitumor Activity

  Li J. Yu, Pernille Drewes, Katja Gustafsson, Etienne G. C. Brain, Jodi E. D. Hecht and David J. Waxman

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 928-937;
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  Inhibition of Doxorubicin Toxicity in Cultured Neonatal Mouse Cardiomyocytes with Elevated Metallothionein Levels

  Guang-Wu Wang and Y. James Kang

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 938-944;
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  Hepatic Cytochrome P-450 Expression in Tumor Necrosis Factor-α Receptor (p55/p75) Knockout Mice After Endotoxin Administration

  Graham W. Warren, Samuel M. Poloyac, Devin S. Gary, Mark P. Mattson and Robert A. Blouin

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 945-950;
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  Methemoglobin Formation by Hydroxylamine Metabolites of Sulfamethoxazole and Dapsone: Implications for Differences in Adverse Drug Reactions

  Timothy P. Reilly, Patrick M. Woster and Craig K. Svensson

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 951-959;
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  Inhibition of Transient and Persistent Na⁺ Current Fractions by the New Anticonvulsant Topiramate

  S. Taverna, G. Sancini, M. Mantegazza, S. Franceschetti and G. Avanzini

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 960-968;
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  Comparison of Functional Antagonism Between Isoproterenol and M₂ Muscarinic Receptors in Guinea Pig Ileum and Trachea

  Rennolds S. Ostrom and Frederick J. Ehlert

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 969-976;
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  Effect of Chronic Hypoxia on Alpha-1 Adrenoceptor-Mediated Inositol 1,4,5-Trisphosphate Signaling in Ovine Uterine Artery

  Xiang-Qun Hu, Shumei Yang, William J. Pearce, Lawrence D. Longo and Lubo Zhang

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 977-983;
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  Inhibition of Monoamine Oxidase Type A, but Not Type B, Is an Effective Means of Inducing Anticonvulsant Activity in the Kindling Model of Epilepsy

  Wolfgang Löscher, Holger Lehmann, Hans-Jürgen Teschendorf, Martin Traut and Gerhard Gross

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 984-992;
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  Effects of Inhibitors and Substitutes for Chloride in Lumen onp-Aminohippurate Transport by Isolated Perfused Rabbit Renal Proximal Tubules

  Varanuj Chatsudthipong, Promsuk Jutabha, Kristen K. Evans and William H. Dantzler

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 993-1001;
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  S-16924 [(R)-2-{1-[2-(2,3-Dihydro-benzo[1,4]dioxin-5-yloxy)-ethyl]-pyrrolidin-3yl}-1-(4-fluorophenyl)-ethanone], a Novel, Potential Antipsychotic with Marked Serotonin_1AAgonist Properties: III. Anxiolytic Actions in Comparison with Clozapine and Haloperidol

  Mark J. Millan, Mauricette Brocco, Alain Gobert, Rudy Schreiber and Anne Dekeyne

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1002-1014;
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  Comparative Effects of Methylmercury on Parallel-Fiber and Climbing-Fiber Responses of Rat Cerebellar Slices

  Yukun Yuan and William D. Atchison

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1015-1025;
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  Gabapentin Suppresses Ectopic Nerve Discharges and Reverses Allodynia in Neuropathic Rats

  Hui-Lin Pan, James C. Eisenach and Shao-Rui Chen

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1026-1030;
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  Neurogenic Vasodilatation of Canine Isolated Small Labial Arteries

  Tomio Okamura, Kazuhide Ayajiki, Masami Uchiyama, Masami Uehara and Noboru Toda

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1031-1036;
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  Neural Modulation of Cephalexin Intestinal Absorption Through the Di- and Tripeptide Brush Border Transporter of Rat Jejunum In Vivo

  Françoise Berlioz, Stéphanie Julien, Annick Tsocas, Jacques Chariot, Claude Carbon, Robert Farinotti and Claude Rozé

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1037-1044;
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  Intestinal Prokinesia by Two Esters of 4-Amino-5-Chloro-2-Methoxybenzoic Acid: Involvement of 5-Hydroxytryptamine-4 Receptors and Dissociation from Cardiac Effects In Vivo

  Francesca Crema, Chiara Modini, Tiziano Croci, Michel Langlois and Fabrizio de Ponti

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1045-1052;
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  Acquisition of Nicotine Discrimination and Discriminative Stimulus Effects of Nicotine in Rats Chronically Exposed to Caffeine ,

  Maciej Gasior, Mohammed Shoaib, Sevil Yasar, Maria Jaszyna and Steven R. Goldberg

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1053-1073;
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  PST 2238: A New Antihypertensive Compound that Modulates Na,K-ATPase in Genetic Hypertension

  P. Ferrari, M. Ferrandi, G. Tripodi, L. Torielli, G. Padoani, E. Minotti, P. Melloni and G. Bianchi

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1074-1083;
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  Kinetic Analysis of Drug-Receptor Interactions of Long-Acting β₂ Sympathomimetics in Isolated Receptor Membranes: Evidence against Prolonged Effects of Salmeterol and Formoterol on Receptor-Coupled Adenylyl Cyclase

  Andrea Teschemacher and Horst Lemoine

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1084-1092;
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  Ergoline Derivative LEK-8829-Induced Turning Behavior in Rats with Unilateral Striatal Ibotenic Acid Lesions: Interaction with Bromocriptine

  Lilijana Šprah, Marko Živin and Dušan Sket

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1093-1100;
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  Mechanisms of Prostaglandin E₂ Release by Intact Cells Expressing Cyclooxygenase-2: Evidence for a ‘Two-Component’ Model

  Michael A. Saunders, Maria G. Belvisi, Guiseppe Cirino, P. J. Barnes, Timothy D. Warner and Jane A. Mitchell

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1101-1106;
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  Spinal Antinociceptive Synergism between Morphine and Clonidine Persists in Mice Made Acutely or Chronically Tolerant to Morphine

  Carolyn A. Fairbanks and George L. Wilcox

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1107-1116;
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  Pharmacology of LY315920/S-5920,[[3-(Aminooxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetate, a Potent and Selective Secretory Phospholipase A₂Inhibitor: A New Class of Anti-Inflammatory Drugs, SPI

  David W. Snyder, Nicholas J. Bach, Robert D. Dillard, Susan E. Draheim, Donald G. Carlson, Niles Fox, Neal W. Roehm, Christopher T. Armstrong, Chan H. Chang, Lawrence W. Hartley, Lea M. Johnson, Carlos R. Roman, Amy C. Smith, Min Song and Jerome H. Fleisch

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1117-1124;
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  Selective Antiaggressive Effects of Alnespirone in Resident-Intruder Test Are Mediated via 5-Hydroxytryptamine_1A Receptors: A Comparative Pharmacological Study with 8-Hydroxy-2-Dipropylaminotetralin, Ipsapirone, Buspirone, Eltoprazine, and WAY-100635

  S. F. de Boer, M. Lesourd, E. Mocaer and J. M. Koolhaas

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1125-1133;
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  Alpha-2 Adrenergic Receptor Functional Coupling to G Proteins in Rat Brain During Postnatal Development

  H. Kevin Happe, David B. Bylund and L. Charles Murrin

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1134-1142;
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  Development of Muscarinic Analgesics Derived from Epibatidine: Role of the M₄ Receptor Subtype

  James L. Ellis, Dean Harman, Javier Gonzalez, Michael L. Spera, Ronggang Liu, T. Y. Shen, Donna M. Wypij and Fangming Zuo

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1143-1150;
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  Biochemical and Electrophysiological Studies on the Mechanism of Action of PNU-151774E, A Novel Antiepileptic Compound

  P. Salvati, R. Maj, C. Caccia, M. A. Cervini, M. G. Fornaretto, E. Lamberti, P. Pevarello, G. A. Skeen, H. S. White, H. H. Wolf, L. Faravelli, M. Mazzanti, E. Mancinelli, M. Varasi and R. G. Fariello

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1151-1159;
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  Effects of Stimulants of Abuse on Extrapyramidal and Limbic Neuropeptide Y Systems

  Scot C. Westwood and Glen R. Hanson

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1160-1166;
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  The Mechanism of the Increasing Action of TA-993, a New 1,5-Benzothiazepine Derivative, on Limb Blood Flow in Anesthetized Dogs: Selective Suppression of Sympathetic Nerve Activity

  Minako Kaburaki, Hideo Yabana, Hisayoshi Doi, Koichi Nagata, Hiroshi Narita and Sakae Murata

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1167-1173;
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  N,N′-Diacetyl-l-cystine—the Disulfide Dimer of N-acetylcysteine—Is a Potent Modulator of Contact Sensitivity/Delayed Type Hypersensitivity Reactions in Rodents

  Bengt Särnstrand, Anne-Helene Jansson, Giedre Matuseviciene, Annika Scheynius, Stefan Pierrou and Håkan Bergstrand

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1174-1184;
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  [³H]Gemcitabine Uptake by Nucleoside Transporters in a Human Head and Neck Squamous Carcinoma Cell Line

  James R. Hammond, Stephanie Lee and Peter J. Ferguson

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1185-1191;
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  The Interaction of n-Tetraalkylammonium Compounds with a Human Organic Cation Transporter, hOCT1

  Lei Zhang, Wenche Gorset, Mark J. Dresser and Kathleen M. Giacomini

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1192-1198;
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  Acute Effects of Ethanol on Kainate Receptors with Different Subunit Compositions

  C. Fernando Valenzuela and Rita A. Cardoso

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1199-1206;
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  Neuroprotection of the Developing Brain by Systemic Administration of Vasoactive Intestinal Peptide Derivatives

  Pierre Gressens, Leslie Besse, Patrick Robberecht, Illana Gozes, Mati Fridkin and Philippe Evrard

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1207-1213;
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  Endogenous Endothelin-1 Depresses Left Ventricular Systolic and Diastolic Performance in Congestive Heart Failure

  Katsuya Onishi, Michiya Ohno, William C. Little and Che-Ping Cheng

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1214-1222;
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  Ethanol Exposure Differentially Alters Central Monoamine Neurotransmission in Alcohol-Preferring versus -Nonpreferring Rats

  Amanda D. Smith and Friedbert Weiss

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1223-1228;
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  Angiotensin Receptor Subtype 1 Mediates Angiotensin II Enhancement of Isoproterenol-Induced Cyclic AMP Production in Preglomerular Microvascular Smooth Muscle Cells

  Tomoo Inoue, Zaichuan Mi, Delbert G. Gillespie, Raghvendra K. Dubey and Edwin K. Jackson

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1229-1234;
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  Inhibition of Prostaglandin Synthesis Up-Regulates Cyclooxygenase-2 Induced by Lipopolysaccharide and Peroxisomal Proliferators

  Nuria A. Callejas, Antonio Castrillo, Lisardo Boscá and Paloma Martı́n-Sanz

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1235-1241;
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  Relaxation of Endothelin-1-Induced Pulmonary Arterial Constriction by Niflumic Acid and NPPB: Mechanism(s) Independent of Chloride Channel Block

  Kenichi Kato, A. Mark Evans and Roland Z. Kozlowski

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1242-1250;
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  N-Oxygenation of Amphetamine and Methamphetamine by the Human Flavin-Containing Monooxygenase (Form 3): Role in Bioactivation and Detoxication

  John R. Cashman, Yeng N. Xiong, Lifen Xu and Aaron Janowsky

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1251-1260;
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  Thioridazine Lengthens Repolarization of Cardiac Ventricular Myocytes by Blocking the Delayed Rectifier Potassium Current

  Benoit Drolet, Frédérick Vincent, Jimmy Rail, Mohamed Chahine, Dominic Deschênes, Sylvie Nadeau, Majed Khalifa, Bettina A. Hamelin and Jacques Turgeon

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1261-1268;
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  Discriminative Stimulus Effects of Naltrexone After a Single Dose of Morphine in the Rat

  Keith W. Easterling and Stephen G. Holtzman

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1269-1277;
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  O-Raffinose Cross-Linking Markedly Reduces Systemic and Renal Vasoconstrictor Effects of Unmodified Human Hemoglobin

  Wilfred Lieberthal, Robert Fuhro, Jane E. Freedman, George Toolan, Joseph Loscalzo and C. Robert Valeri

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1278-1287;
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  Characterization of the Analgesic and Anti-Inflammatory Activities of Ketorolac and Its Enantiomers in the Rat

  Mary-Frances Jett, Chakk S. Ramesha, Carl D. Brown, Sophie Chiu, Caroline Emmett, Tatyana Voronin, Thomas Sun, Counde O’Yang, John C. Hunter, Richard M. Eglen and Randolph M. Johnson

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1288-1297;
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  Behavioral, Toxic, and Neurochemical Effects of Sydnocarb, a Novel Psychomotor Stimulant: Comparisons with Methamphetamine

  J. M. Witkin, N. Savtchenko, M. Mashkovsky, M. Beekman, P. Munzar, M. Gasior, S. R. Goldberg, J. T. Ungard, J. Kim, T. Shippenberg and V. Chefer

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1298-1310;
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  Optimization of Magnesium Therapy after Severe Diffuse Axonal Brain Injury in Rats

  Deanne L. Heath and Robert Vink

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1311-1316;
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  Increased Lipophilicity and Subsequent Cell Partitioning Decrease Passive Transcellular Diffusion of Novel, Highly Lipophilic Antioxidants

  Geri A. Sawada, Craig L. Barsuhn, Barry S. Lutzke, Michael E. Houghton, Guy E. Padbury, Norman F. H. Ho and Thomas J. Raub

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1317-1326;
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  Novel, Highly Lipophilic Antioxidants Readily Diffuse Across the Blood-Brain Barrier and Access Intracellular Sites

  Geri A. Sawada, Lawrence R. Williams, Barry S. Lutzke and Thomas J. Raub

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1327-1333;
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  Age-Related Reductions in [³H]WIN 35,428 Binding to the Dopamine Transporter in Nigrostriatal and Mesolimbic Brain Regions of the Fischer 344 Rat

  Meleik A. Hebert, Gaynor A. Larson, Nancy R. Zahniser and Greg A. Gerhardt

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1334-1339;
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  Effect of Riluzole on the Neurological and Neuropathological Changes in an Animal Model of Cardiac Arrest-Induced Movement Disorder

  Anumantha G. Kanthasamy, Richard J. Yun, Bang Nguyen and Daniel D. Truong

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1340-1348;
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  Potent Mast Cell Degranulation and Vascular Permeability Triggered by Urocortin Through Activation of Corticotropin-Releasing Hormone Receptors

  Leena K. Singh, William Boucher, Xinzhu Pang, Richard Letourneau, Dimitri Seretakis, Marlon Green and Theoharis C. Theoharides

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1349-1356;
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  The Central Cannabinoid Receptor (CB1) Mediates Inhibition of Nitric Oxide Production by Rat Microglial Cells

  Yaakov Waksman, John M. Olson, Steven J. Carlisle and Guy A. Cabral

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1357-1366;
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  Evidence for β₃-Adrenoceptor Subtypes in Relaxation of the Human Urinary Bladder Detrusor: Analysis by Molecular Biological and Pharmacological Methods

  Masayuki Takeda, Kenji Obara, Takaki Mizusawa, Yoshihiko Tomita, Kei Arai, Toshiki Tsutsui, Akihiko Hatano, Kota Takahashi and Shintaro Nomura

  Journal of Pharmacology and Experimental Therapeutics March 1999, 288 (3) 1367-1373;