Table of Contents

Articles

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  Progression from Homologous to Heterologous Desensitization of Contraction in Gastric Smooth Muscle Cells

  Carola Severi, Veronica Carnicelli, Antonio di Giulio, Giovanna Romano, Argante Bozzi, Arduino Oratore, Roberto Strom and Gianfranco Delle Fave

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 389-398;
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  Characterization of Pardaxin-Induced Dopamine Release from Pheochromocytoma Cells: Role of Calcium and Eicosanoids

  Saleh Abu-Raya, Eugenia Bloch-Shilderman, Peter I. Lelkes, Victoria Trembovler, Esther Shohami, Yehuda Gutman and Philip Lazarovici

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 399-406;
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  Endothelium-Dependent and -Independent Mechanisms of Vasorelaxation by Corticotropin-Releasing Factor in Pregnant Rat Uterine Artery

  Venu Jain, Yurij P. Vedernikov, George R. Saade, Kristof Chwalisz and Robert E. Garfield

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 407-413;
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  Hepatic Disposition of the Acyl Glucuronide1-O-Gemfibrozil-β-d-Glucuronide: Effects of Dibromosulfophthalein on Membrane Transport and Aglycone Formation

  Lucia Sabordo, Benedetta C. Sallustio, Allan M. Evans and Roger L. Nation

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 414-420;
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  CEP-1347/KT-7515, an Inhibitor of c-jun N-Terminal Kinase Activation, Attenuates the 1-Methyl-4-Phenyl Tetrahydropyridine-Mediated Loss of Nigrostriatal Dopaminergic Neurons In Vivo

  Michael S. Saporito, Ellen M. Brown, Matthew S. Miller and Susan Carswell

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 421-427;
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  Pharmacological Inhibition of Protein Kinases in Intact Cells: Antagonism of Beta Adrenergic Receptor Ligand Binding by H-89 Reveals Limitations of Usefulness

  Raymond B. Penn, Jean-Luc Parent, Alexey N. Pronin, Reynold A. Panettieri and Jeffrey L. Benovic

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 428-437;
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  Opioid Receptor Selectivity of Heroin Given Intracerebroventricularly Differs in Six Strains of Inbred Mice

  Jodie J. Rady, Gregory I. Elmer and James M. Fujimoto

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 438-445;
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  Adenosine A₁ Receptor-Dependent and -Independent Effects of the Allosteric Enhancer PD 81,723

  Beth Musser, Ramagopal V. Mudumbi, Jingwen Liu, Richard D. Olson and Robert E. Vestal

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 446-454;
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  Ethanol Counteraction of I₁-Imidazoline but NotAlpha-2 Adrenergic Receptor-Mediated Reduction in Vascular Resistance in Conscious Spontaneously Hypertensive Rats

  Mahmoud M. El-Mas and Abdel A. Abdel-Rahman

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 455-462;
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  Biotransformation of Coumarin by Rodent and Human Cytochromes P-450: Metabolic Basis of Tissue-Selective Toxicity in Olfactory Mucosa of Rats and Mice

  Xiaoliang Zhuo, Jun Gu, Qing-Yu Zhang, David C. Spink, Laurence S. Kaminsky and Xinxin Ding

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 463-471;
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  Effects of Polytherapy Compared With Monotherapy in Antiepileptic Drugs: An Animal Study

  Gerwin Roks, Charles L.P. Deckers, Harry Meinardi, Ris Dirksen, Jan van Egmond and Clementina M. van Rijn

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 472-477;
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  Large Receptor Reserve for Cannabinoid Actions in the Central Nervous System

  Andrew N. Gifford, Magalie Bruneus, S. John Gatley, Ruoxi Lan, Alexandros Makriyannis and Nora D. Volkow

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 478-483;
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  Tetrazepinones Are Equally Cytotoxic to Mer+ and Mer− Human Tumor Cell Lines

  Bertrand J. Jean-Claude, Amir Mustafa, Amanda J. Watson, Zoe Damian, Daniela Vasilescu, Tak Hang Chan and Brian Leyland-Jones

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 484-489;
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  Probing the “Active Site” of Diamine Oxidase: Structure-Activity Relations for Histamine Potentiation byO-Alkylhydroxylamines on Colonic Epithelium

  A. High, T. Prior, R. A. Bell and P. K. Rangachari

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 490-501;
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  Endogenous Opioids Regulate the Expression of Inducible Nitric Oxide Synthase by Splenocytes

  Donald T. Lysle and Tam How

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 502-508;
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  Effects of Ethanol Treatment on Epididymal Secretory Products and Sperm Maturation in Albino Rats

  V. Srikanth, T. Malini, J. Arunakaran, P. Govindarajulu and K. Balasubramanian

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 509-515;
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  Anticoagulant and Antithrombotic Activity of Maltodapoh, a Novel Sulfated Tetrasaccharide

  Daniel J. Martin, Joseph A. Toce, Phillip J. Anevski, Douglas M. Tollefsen and Dana R. Abendschein

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 516-521;
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  Inhibitory Effects of Proadrenomedullin N-terminal 20 Peptide on Antidiuresis and Norepinephrine Overflow Induced by Stimulation of Renal Nerves in Anesthetized Dogs

  Kiyoshi Tadano, Tomoyuki Yamasaki and Yasuo Matsumura

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 522-528;
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  Novel Terpenoid-Type Quinones Isolated fromPycnanthus angolensis of Potential Utility in the Treatment of Type 2 Diabetes

  Jian Luo, Jeanne Cheung, Eileen M. Yevich, John P. Clark, Joyce Tsai, Priscilla Lapresca, Rosa P. Ubillas, Diana M. Fort, Thomas J, Carlson, Richard F. Hector, Steven R. King, Christopher D. Mendez, S. D. Jolad and Gerald M. Reaven

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 529-534;
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  Pharmacokinetic-Pharmacodynamic Modeling of the Psychomotor Stimulant Effect of Cocaine after Intravenous Administration: Timing Performance Deficits

  Chyan E. Lau, Fang Ma, David M. Foster and John L. Falk

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 535-543;
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  Agmatine Selectively Blocks theN-Methyl-d-Aspartate Subclass of Glutamate Receptor Channels in Rat Hippocampal Neurons

  Xian-Cheng Yang and Donald J. Reis

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 544-549;
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  Effects of Phentermine on Responding Maintained under Multiple Fixed-Ratio Schedules of Food and Cocaine Presentation in the Rhesus Monkey

  Francis H. E. Wojnicki, Richard B. Rothman, Kenner C. Rice and John R. Glowa

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 550-560;
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  Sustained Desensitization of Hypothalamic 5-Hydroxytryptamine_1A Receptors after Discontinuation of Fluoxetine: Inhibited Neuroendocrine Responses to 8-Hydroxy-2-(Dipropylamino)Tetralin in the Absence of Changes in G_i/o/z Proteins

  D. K. Raap, F. Garcia, N. A. Muma, W. A. Wolf, G. Battaglia and L. D. van de Kar

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 561-567;
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  Hepatobiliary Transport Governs Overall Elimination of Peptidic Endothelin Antagonists in Rats

  Yukio Kato, Sharif Akhteruzzaman, Akihiro Hisaka and Yuichi Sugiyama

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 568-574;
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  Primary Active Transport of Peptidic Endothelin Antagonists by Rat Hepatic Canalicular Membrane

  Sharif Akhteruzzaman, Yukio Kato, Akihiro Hisaka and Yuichi Sugiyama

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 575-581;
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  SR 144528, an Antagonist for the Peripheral Cannabinoid Receptor that Behaves as an Inverse Agonist

  Marielle Portier, Murielle Rinaldi-Carmona, Florence Pecceu, Thérèse Combes, Caroline Poinot-Chazel, Bernard Calandra, Francis Barth, Gérard Le Fur and Pierre Casellas

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 582-589;
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  Atypical Neuroleptics Enhance Histamine Turnover in Brain Via 5-Hydroxytryptamine_2A Receptor Blockade

  S. Morisset, U. G. Sahm, E. Traiffort, J. Tardivel-Lacombe, J. M. Arrang and J.-C. Schwartz

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 590-596;
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  Differences in Excretion of Hippurate, as a Metabolite of Benzoate and as an Administered Species, in the Single-Pass Isolated Perfused Rat Kidney Explained

  Wanping Geng and K. Sandy Pang

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 597-606;
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  Contribution of Cytochrome P-4502D6 Phenotype to the Neuromodulatory Effects of Dextromethorphan

  Jules A. Desmeules, Mitsuko Kondo Oestreicher, Valérie Piguet, Anne-Françoise Allaz and Pierre Dayer

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 607-612;
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  Acetyl-11-Keto-β-Boswellic Acid Induces Apoptosis in HL-60 and CCRF-CEM Cells and Inhibits Topoisomerase I

  R. F. Hoernlein, Th. Orlikowsky, C. Zehrer, D. Niethammer, E. R. Sailer, Th. Simmet, G. E. Dannecker and H. P. T. Ammon

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 613-619;
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  Epidermal Growth Factor Protects Rat Epithelial Cells Against Acid-Induced Damage Through the Activation of Na⁺/H⁺ Exchangers

  Osamu Furukawa, Hiroshi Matsui, Noriko Suzuki and Susumu Okabe

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 620-626;
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  Contribution of Organic Anion Transporting Polypeptide to Uptake of Its Possible Substrates into Rat Hepatocytes

  Hirokazu Kouzuki, Hiroshi Suzuki, Kousei Ito, Rui Ohashi and Yuichi Sugiyama

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 627-634;
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  The Effects of Morphine, Nicotine and Epibatidine on Lymphocyte Activity and Hypothalamic-Pituitary-Adrenal Axis Responses

  R. Daniel Mellon and Barbara M. Bayer

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 635-642;
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  Disruption of Prepulse Inhibition and Increases in Locomotor Activity by Competitive N-Methyl-d-aspartate Receptor Antagonists in Rats

  Vaishali P. Bakshi, Mark Tricklebank, Hans C. Neijt, Virginia Lehmann-Masten and Mark A. Geyer

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 643-652;
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  Calcineurin Inhibitors FK506 and SDZ ASM 981 Alleviate the Outcome of Focal Cerebral Ischemic/Reperfusion Injury

  D. Bochelen, M. Rudin and A. Sauter

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 653-659;
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  Ropivacaine Inhibits Serum-Induced Proliferation of Colon Adenocarcinoma Cells In Vitro

  Titti Martinsson

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 660-664;
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  Polyethylene Glycol-Modified Liposome-Encapsulated Hemoglobin: A Long Circulating Red Cell Substitute

  W. T. Phillips, R. W. Klipper, V. D. Awasthi, A. S. Rudolph, R. Cliff, V. Kwasiborski and B. A. Goins

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 665-670;
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  Cardiovascular Responses Mediated by Protease-Activated Receptor-2 (PAR-2) and Thrombin Receptor (PAR-1) are Distinguished in Mice Deficient in PAR-2 or PAR-1

  Bruce P. Damiano, Wai-Man Cheung, Rosemary J. Santulli, Wai-Ping Fung-Leung, Karen Ngo, Richard D. Ye, Andrew L. Darrow, Claudia K. Derian, Lawrence de Garavilla and Patricia Andrade-Gordon

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 671-678;
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  Finasteride, a 5α-Reductase Inhibitor, Blocks the Anticonvulsant Activity of Progesterone in Mice

  Tushar G. Kokate, Melissa K. Banks, Tamika Magee, Shun-Ichi Yamaguchi and Michael A. Rogawski

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 679-684;
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  Two Genetically Selected Strains of Rats Exhibit Hypersensitivity or Resistance to Cocaine-Induced Fatal Arrhythmias

  Bing Shi, James E. Heavner, Jian Liu, Martin J. Wang, Lorenz O. Lutherer, Dan C. McIntyre and Charles E. Reigel

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 685-692;
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  Pressor and Renal Vasoconstrictor Responses to Acute Systemic Nitric Oxide Synthesis Inhibition Are Independent of the Sympathetic Nervous System and Angiotensin II

  Chris Baylis, Jeff Harvey, Beth R. Santmyire and Kevin Engels

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 693-698;
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  Sensitization of Amphetamine-Induced Stereotyped Behaviors During the Acute Response

  Ronald Kuczenski and David S. Segal

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 699-709;
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  Novel Antipsychotic-Like Effects on Prepulse Inhibition of Startle Produced by a Neurotensin Agonist

  David Feifel, Tammi L. Reza, David J. Wustrow and M. Duff Davis

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 710-713;
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  Lead Stimulates Lymphocyte Proliferation Through Enhanced T Cell-B Cell Interaction

  Seddigheh Razani-Boroujerdi, Bruce Edwards and Mohan L. Sopori

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 714-719;
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  Pharmacokinetic/Pharmacodynamic Models for Corticosteroid Receptor Down-Regulation and Glutamine Synthetase Induction in Rat Skeletal Muscle by a Receptor/Gene-Mediated Mechanism

  Yu-Nien Sun, Lorraine I. McKay, Debra C. DuBois, William J. Jusko and Richard R. Almon

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 720-728;
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  Comparison of an Agonist, Urocortin, and an Antagonist, Astressin, as Radioligands for Characterization of Corticotropin-Releasing Factor Receptors

  Marilyn H. Perrin, Steve W. Sutton, Laura A. Cervini, Jean E. Rivier and Wylie W. Vale

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 729-734;
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  Active Efflux of CPT-11 and Its Metabolites in Human KB-Derived Cell Lines

  Xiao-Yan Chu, Hiroshi Suzuki, Kaoru Ueda, Yukio Kato, Shin-Ichi Akiyama and Yuichi Sugiyama

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 735-741;
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  Kinin-Mediated Coronary Nitric Oxide Production Contributes to the Therapeutic Action of Angiotensin-Converting Enzyme and Neutral Endopeptidase Inhibitors and Amlodipine in the Treatment in Heart Failure

  Xiaoping Zhang, Fabio A. Recchia, Robert Bernstein, Xiaobin Xu, Alberto Nasjletti and Thomas H. Hintze

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 742-751;
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  l-Methamphetamine Pharmacokinetics and Pharmacodynamics for Assessment of In Vivo Deprenyl-Derivedl-Methamphetamine

  William P. Melega, Arthur K. Cho, Debra Schmitz, Ronald Kuczenski and David S. Segal

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 752-758;
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  Chelation of Zinc in the Extracellular Area of the Spinal Cord, Using Ethylenediaminetetraacetic Acid Disodium-Calcium Salt or Dipicolinic Acid, Inhibits the Antinociceptive Effect of Capsaicin in Adult Mice

  Alice A. Larson and Kelley F. Kitto

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 759-765;
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  Trauma Decreases Leucine Enkephalin Hydrolysis in Human Plasma

  Reto Babst, Lucilla Bongiorno, Mario Marini, L. Giorgio Roda, Giulio Spagnoli and Alessandra Urbani

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 766-773;
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  Effects of Antipsychotic Drugs on Extracellular Dopamine Levels in Rat Medial Prefrontal Cortex and Nucleus Accumbens

  Toshihide Kuroki, Herbert Y. Meltzer and Junji Ichikawa

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 774-781;
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  Chronic Ethanol Differentially Alters Susceptibility to Chemically Induced Convulsions in Withdrawal Seizure-Prone and -Resistant Mice

  Deborah A. Finn and John C. Crabbe

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 782-790;
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  Mechanism-Based Inactivation of Cytochrome P-450-3A4 by Mifepristone (RU486)

  Kan He, Thomas F. Woolf and Paul F. Hollenberg

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 791-797;
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  Effects of Alpha-2 Adrenoceptor Agonists and Antagonists on Circling Behavior in Rats with Unilateral 6-Hydroxydopamine Lesions of the Nigrostriatal Pathway

  Philippe Chopin, Francis C. Colpaert and Marc Marien

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 798-804;
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  Inotropic Effects of Diadenosine Tetraphosphate (AP₄A) in Human and Animal Cardiac Preparations

  U. Vahlensieck, P. Bokník, I. Gombosová, S. Huke, J. Knapp, B. Linck, H. Lüβ, F. U. Müller, J. Neumann, M. C. Deng, H. H. Scheld, H. Jankowski, H. Schlüter, W. Zidek, N. Zimmermann and W. Schmitz

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 805-813;
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  Improving Effects of Huperzine A on Spatial Working Memory in Aged Monkeys and Young Adult Monkeys with Experimental Cognitive Impairment

  Jia Wei Ye, Jing Xia Cai, Li Ming Wang and Xi Can Tang

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 814-819;
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  Electrophysiological Comparison of 5-Hydroxytryptamine_1A Receptor Antagonists on Dorsal Raphe Cell Firing

  Lynn P. Martin, David M. Jackson, Carin Wallsten and Barbara L. Waszczak

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 820-826;
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  Opioid Efficacy in a C6 Glioma Cell Line Stably Expressing the Human Kappa Opioid Receptor

  Ann E. Remmers, Mary J. Clark, Alfred Mansour, Huda Akil, James H. Woods and Fedor Medzihradsky

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 827-833;
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  Identification of a Novel, Inhibitory Action of Amiodarone on Vesicular Monoamine Transport

  Deepak Haikerwal, Anthony M. Dart, Peter J. Little and David M. Kaye

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 834-837;
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  Timolol Effects on Aqueous Humor Dynamics in Eyes of Anesthetized Rats

  Robin V. Searles, Vladimir Shikher, Carey D. Balaban and Walter B. Severs

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 838-842;
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  Anxiolytic 5-Hydroxytryptamine_1A Agonists Suppress Firing Activity of Dorsal Hippocampus CA1 Pyramidal Neurons through a Postsynaptic Mechanism: Single-Unit Study in Unanesthetized, Unrestrained Rats

  Koji Tada, Kimihiro Kasamo, Naoki Ueda, Tadashi Suzuki, Takuya Kojima and Koichi Ishikawa

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 843-848;
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  Oral Administration of Leflunomide (HWA486) Results in Prominent Suppression of Immunoglobulin E Formation in a Rat Type 1 Allergy Model

  Yuko Mizushima, Yukio Amano, Hiroshi Kitagawa and Kenji Ogata

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 849-857;
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  Block of Potassium Currents in Guinea Pig Ventricular Myocytes and Lengthening of Cardiac Repolarization in Man by the Histamine H1 Receptor Antagonist Diphenhydramine

  Majed Khalifa, Benoit Drolet, Pascal Daleau, Christophe Lefez, Marcel Gilbert, Sylvain Plante, Gilles E. O’Hara, Onil Gleeton, Bettina A. Hamelin and Jacques Turgeon

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 858-865;
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  Potential Role of the Gene Transcription Factor Cyclic AMP-Responsive Element Binding Protein in Ethanol Withdrawal-Related Anxiety

  Subhash C. Pandey, Daolong Zhang, Navdha Mittal and Deepak Nayyar

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 866-878;
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  Age-Related Changes in the Capacity, Rate, and Modulation of Dopamine Uptake within the Striatum and Nucleus Accumbens of Fischer 344 Rats: An In Vivo Electrochemical Study

  Meleik A. Hebert and Greg A. Gerhardt

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 879-887;
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  Specific Renal Delivery of Sugar-Modified Low-Molecular-Weight Peptides

  Kokichi Suzuki, Hiroshi Susaki, Satoshi Okuno, Harutami Yamada, Hiroshi K. Watanabe and Yuichi Sugiyama

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 888-897;
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  Angiotensin II Type 1 Receptor Blockade Prevents Up-Regulation of Angiotensin II Type 1A Receptors in Rat Injured Artery

  Shigeki Tazawa, Tokio Nakane and Shigetoshi Chiba

  Journal of Pharmacology and Experimental Therapeutics February 1999, 288 (2) 898-904;