Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleArticle

The In Vivo Unidirectional Conversion of Nitro-d-arginine to Nitro-l-arginine

Qiong Wang, Michael Cwik, Catherine J. Wright, Francesca Cunningham and Dale A. Pelligrino
Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 270-273;
Qiong Wang
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael Cwik
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Catherine J. Wright
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Francesca Cunningham
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dale A. Pelligrino
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

We recently reported that nitric oxide synthase in the brain can be inhibited not only by nitro-l-arginine (l-NA) but also by its D-enantiomer nitro-d-arginine (d-NA). In the present study, we found that d-NA, when tested in vitro, was 400 times less potent than l-NA. However, when d-NA was injected in vivo, its l-enantiomer, l-NA, was found to rapidly appear in plasma samples (∼1 min), rose to a maximum concentration at 30 min (∼40% conversion), and remained at this plateau for about 5 h. This was consistent with the changes in blood pressure. There was no conversion of l- tod-NA. The results suggested that d-NA has very weak biological actions by itself, but when administered in vivo,d-NA can be converted to l-NA.

Footnotes

  • Send reprint requests to: Qiong Wang, M.D., Doctor of Philosophy, Department of Anesthesiology, University of Illinois at Chicago, 1740 W. Taylor Street., Chicago, Illinois.

  • 1 This work was supported by the National Institutes of Health (HL 52595) and a grant-in-aid from the American Heart Association (National).

  • Abbreviations:
    NO
    nitric oxide
    NOS
    NO synthase
    d-NA
    nitro-d-arginine
    l-NA
    nitro-l-arginine
    • Received November 26, 1997.
    • Accepted August 13, 1998.
  • The American Society for Pharmacology and Experimental Therapeutics
View Full Text

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics: 288 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 288, Issue 1
1 Jan 1999
  • Table of Contents
  • About the Cover
  • Index by author
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
The In Vivo Unidirectional Conversion of Nitro-d-arginine to Nitro-l-arginine
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

The In Vivo Unidirectional Conversion of Nitro-d-arginine to Nitro-l-arginine

Qiong Wang, Michael Cwik, Catherine J. Wright, Francesca Cunningham and Dale A. Pelligrino
Journal of Pharmacology and Experimental Therapeutics January 1, 1999, 288 (1) 270-273;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

The In Vivo Unidirectional Conversion of Nitro-d-arginine to Nitro-l-arginine

Qiong Wang, Michael Cwik, Catherine J. Wright, Francesca Cunningham and Dale A. Pelligrino
Journal of Pharmacology and Experimental Therapeutics January 1, 1999, 288 (1) 270-273;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • CRV431 Decreases Liver Fibrosis and Tumor Development
  • Mechanisms of 5-Hydroxytryptamine2A Receptor Activation of the Mitogen-Activated Protein Kinase Pathway in Vascular Smooth Muscle
  • Interactive Role for Neurosteroids in Ethanol Enhancement of γ-Aminobutyric Acid-Gated Currents from Dissociated Substantia Nigra Reticulata Neurons
Show more Article

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2022 by the American Society for Pharmacology and Experimental Therapeutics