Table of Contents

Articles

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  Dithiocarbamate Pesticides Affect Glutamate Transport in Brain Synaptic Vesicles

  Andrea Vaccari, Pierluigi Saba, Ignazia Mocci and Stefania Ruiu

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 1-5;
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  ONO-1603, a Potential Antidementia Drug, Delays Age-Induced Apoptosis and Suppresses Overexpression of Glyceraldehyde-3-Phosphate Dehydrogenase in Cultured Central Nervous System Neurons

  Nobuo Katsube, Katsuyoshi Sunaga, Hideki Aishita, De-Maw Chuang and Ryoichi Ishitani

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 6-13;
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  Blockade of Striatal Dopamine Transporters by Intravenous Methylphenidate Is Not Sufficient to Induce Self-Reports of “High”

  Nora D. Volkow, Gene-Jack Wang, Joanna S. Fowler, S. John Gatley, Jean Logan, Yu-Shin Ding, Stephen L. Dewey, Robert Hitzemann, Andrew N. Gifford and Naomi R. Pappas

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 14-20;
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  Three-Dimensional Quantitative Structure Activity Relationship Analyses of Substrates for CYP2B6

  Sean Ekins, Gianpaolo Bravi, Barbara J. Ring, Todd A. Gillespie, Jennifer S. Gillespie, Mark Vandenbranden, Steven A. Wrighton and James H. Wikel

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 21-29;
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  Chronic Morphine Treatment Selectively Augments Metabotropic Glutamate Receptor-Induced Inhibition of N-Methyl-d-Aspartate Receptor-Mediated Neurotransmission in Nucleus Accumbens

  Gilles Martin, Riszard Przewlocki and George R. Siggins

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 30-35;
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  RhoA-Sensitive Trafficking of Muscarinic Acetylcholine Receptors

  Oliver Vögler, Patrick Krummenerl, Martina Schmidt, Karl H. Jakobs and Chris J. Van Koppen

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 36-42;
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  Effect of Overproduction of Interleukin 5 on Dinitrofluorobenzene-Induced Allergic Cutaneous Response in Mice

  Hiroichi Nagai, Yoshifumi Ueda, Hiroyuki Tanaka, Yousuke Hirano, Nobuaki Nakamura, Naoki Inagaki, Kiyoshi Takatsu and Kenji Kawada

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 43-50;
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  Detection of 2-Hydroxyiminostilbene in the Urine of Patients Taking Carbamazepine and Its Oxidation to a Reactive Iminoquinone Intermediate

  C. Ju and J. P. Uetrecht

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 51-56;
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  Renal Drug Targeting Using a Vector “Alkylglycoside”

  Kokichi Suzuki, Hiroshi Susaki, Satoshi Okuno and Yuichi Sugiyama

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 57-64;
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  Diclofenac Toxicity to Hepatocytes: A Role for Drug Metabolism in Cell Toxicity

  Roque Bort, Xavier Ponsoda, Ramiro Jover, M. José Gómez-Lechón and José V. Castell

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 65-72;
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  Neomycin Inhibits Catecholamine Secretion by Blocking Nicotinic Acetylcholine Receptors in Bovine Adrenal Chromaffin Cells

  Kyong-Tai Kim, Se-Young Choi and Tae-Ju Park

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 73-80;
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  Chronic Clomipramine and Triiodothyronine Increase Serotonin Levels in Rat Frontal Cortex In Vivo: Relationship to Serotonin Autoreceptor Activity

  Eitan Gur, Bernard Lerer and Michael E. Newman

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 81-87;
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  Noncompetitive Functional Inhibition at Diverse, Human Nicotinic Acetylcholine Receptor Subtypes by Bupropion, Phencyclidine, and Ibogaine

  John D. Fryer and Ronald J. Lukas

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 88-92;
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  Propulsion in Guinea Pig Colon Induced by 5-Hydroxytryptamine (HT) via 5-HT₄ and 5-HT₃ Receptors

  J.-G. Jin, A. E. Foxx-Orenstein and J. R. Grider

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 93-97;
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  Daily Injections of Fluoxetine Induce Dose-Dependent Desensitization of Hypothalamic 5-HT_1A Receptors: Reductions in Neuroendocrine Responses to 8-OH-DPAT and in Levels of G_z and G_i Proteins

  D. K. Raap, S. Evans, F. Garcia, Q. Li, N. A. Muma, W. A. Wolf, G. Battaglia and L. D. Van De Kar

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 98-106;
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  Increasing Doses of Pentoxifylline as a Continuous Infusion in Canine Septic Shock

  Zenaide M. N. Quezado, William D. Hoffman, Steven M. Banks, Robert L. Danner, Peter Q. Eichacker, Gregory M. Susla and Charles Natanson

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 107-113;
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  Treatment with Liposome-Bound Recombinant Human Tumor Necrosis Factor-α Suppresses Parasitemia and Protects againstPlasmodium berghei k173-Induced Experimental Cerebral Malaria in Mice

  N. S. Postma, D. J. A. Crommelin, W. M. C. Eling and J. Zuidema

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 114-120;
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  [S]-AR-R 15896AR—A Novel Anticonvulsant: Acute Safety, Pharmacokinetic and Pharmacodynamic Properties

  Gene C. Palmer, Robert J. Murray, Carrie L. Cramer, Mary L. Stagnitto, Marilyn K. Knowles, Lou R. Freedman, Mark S. Eismann, Nik Mahmood, Mike Balestra, Alfonso R. Borrelli, Thomas J. Hudzik and Dennis J. McCarthy

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 121-132;
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  Inhibitory Effect of Rebamipide on the Neutrophil Adherence Stimulated by Conditioned Media from Helicobacter pylori-Infected Gastric Epithelial Cells

  Chi Dae Kim, Hyun Hee Kim and Ki Whan Hong

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 133-138;
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  Mechanisms of Antihyperglycemic Effects of Moxonidine in the Obese Spontaneously Hypertensive Koletsky Rat (SHROB)

  Paul Ernsberger, Tatsuya Ishizuka, Sha Liu, Craig J. Farrell, David Bedol, Richard J. Koletsky and Jacob E. Friedman

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 139-147;
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  Insights Into the Unusual Alpha Adrenoceptor Subtype in Dog Saphenous Vein Using Phenoxybenzamine

  A. M. Low, H. Lu-Chao, J. C. P. Loke, C. Y. Kwan and E. E. Daniel

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 148-156;
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  Uptake of Fentanyl in Pulmonary Endothelium

  Christopher M. Waters, Michael J. Avram, Tom C. Krejcie and Thomas K. Henthorn

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 157-163;
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  Selectivity Profile of Muscarinic Toxin 3 in Functional Assays of Cloned and Native Receptors

  Maria C. Olianas, Angela Ingianni, Carlo Maullu, Abdu Adem, Evert Karlsson and Pierluigi Onali

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 164-170;
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  Modulation of the Permeability of H₂ Receptor Antagonists Cimetidine and Ranitidine by P-Glycoprotein in Rat Intestine and the Human Colonic Cell Line Caco-2

  A. Collett, N. B. Higgs, E. Sims, M. Rowland and G. Warhurst

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 171-178;
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  Altered Plasma and Brain Disposition and Pharmacodynamics of Methadone in Abstinent Rats

  María J. Garrido, Marta Valle, Rosario Calvo and Iñaki F. Trocóniz

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 179-187;
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  Subjective and Physiological Effects of Intravenous Nicotine and Cocaine in Cigarette Smoking Cocaine Abusers

  Hendrée E. Jones, Bridgette E. Garrett and Roland R. Griffiths

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 188-197;
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  High-Affinity Efflux Transport System for Glutathione Conjugates on the Luminal Membrane of a Mouse Brain Capillary Endothelial Cell Line (MBEC4)

  Masashi Homma, Hiroshi Suzuki, Hiroyuki Kusuhara, Mikihiko Naito, Takashi Tsuruo and Yuichi Sugiyama

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 198-203;
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  Differences in Degree of Trapping of Low-Affinity UncompetitiveN-Methyl-d-aspartic Acid Receptor Antagonists with Similar Kinetics of Block

  G. A. R. Mealing, T. H. Lanthorn, C. L. Murray, D. L. Small and P. Morley

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 204-210;
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  Potentiation of Ethanol Effects in Cerebellum by Activation of Endogenous Noradrenergic Inputs

  Yun Wang, Ronald K. Freund and Michael R. Palmer

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 211-220;
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  Characterization of (S)-Des-4-amino-3-[¹²⁵I]iodozacopride ([¹²⁵I]DAIZAC), a Selective High-Affinity Radioligand for 5-Hydroxytryptamine₃ Receptors

  William A. Hewlett, Bakula L. Trivedi, Zhang-Jin Zhang, Tomas de Paulis, Dennis E. Schmidt, David M. Lovinger, M. Sib Ansari and Michael H. Ebert

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 221-231;
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  Gα_L1 (Gα₁₄) Couples the Opioid Receptor-Like₁ Receptor to Stimulation of Phospholipase C

  Lisa Y. Yung, Sushma A. Joshi, Robbie Y.K. Chan, Joy S.C. Chan, Gang Pei and Yung H. Wong

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 232-238;
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  Mechanisms and Sites of Action of Endothelins 1 and 2 on the Opossum Internal Anal Sphincter Smooth Muscle Tone In Vitro

  Sushanta Chakder and Satish Rattan

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 239-246;
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  Long-Term Sequential Determination of Behavioral Ontogeny of 5-HT_1A and 5-HT₂ Receptor Functions in the Rat

  Nissar A. Darmani and Bashir Ahmad

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 247-253;
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  Peroxisomes Are Involved in the Swift Increase in Alcohol Metabolism

  Blair U. Bradford, Nobuyuki Enomoto, Kenichi Ikejima, Michelle L. Rose, Heidi K. Bojes, Donald T. Forman and Ronald G. Thurman

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 254-259;
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  Dynorphin A_1–13 Causes Elevation of Serum Levels of Prolactin Through an Opioid Receptor Mechanism in Humans: Gender Differences and Implications for Modulation of Dopaminergic Tone in the Treatment of Addictions

  M. J. Kreek, J. Schluger, L. Borg, M. Gunduz and A. Ho

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 260-269;
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  The In Vivo Unidirectional Conversion of Nitro-d-arginine to Nitro-l-arginine

  Qiong Wang, Michael Cwik, Catherine J. Wright, Francesca Cunningham and Dale A. Pelligrino

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 270-273;
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  Synergistic Elevations in Nucleus Accumbens Extracellular Dopamine Concentrations during Self-Administration of Cocaine/Heroin Combinations (Speedball) in Rats

  Scott E. Hemby, Conchita Co, Steven I. Dworkin and James E. Smith

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 274-280;
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  Specific Delivery of Captopril to the Kidney with the Prodrug Captopril-Lysozyme

  R. J. Kok, F. Grijpstra, R. B. Walthuis, F. Moolenaar, D. de Zeeuw and D. K. F. Meijer

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 281-285;
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  Pharmacologic Actions of the Second-Generation Leukotriene B₄ Receptor Antagonist LY293111: In Vitro Studies

  William T. Jackson, Larry L. Froelich, Robert J. Boyd, James P. Schrementi, David L. Saussy, Richard M. Schultz, J. Scott Sawyer, Michael J. Sofia, David K. Herron, Theodore Goodson, David W. Snyder, Penni A. Pechous, Stephen M. Spaethe, Carlos R. Roman and Jerome H. Fleisch

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 286-294;
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  Effects of α- and β-Adrenoceptor Blockade on Purine Secretion Induced by Sympathetic Nerve Stimulation in the Rat Kidney

  Zaichuan Mi and Edwin K. Jackson

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 295-301;
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  Novel 3α-Diphenylmethoxytropane Analogs: Selective Dopamine Uptake Inhibitors with Behavioral Effects Distinct from Those of Cocaine

  Jonathan L. Katz, Sari Izenwasser, Richard H. Kline, Andrew C. Allen and Amy Hauck Newman

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 302-315;
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  Levosimendan, a Calcium Sensitizer in Cardiac Muscle, Induces Relaxation in Coronary Smooth Muscle Through Calcium Desensitization

  Peggy Bowman, Heimo Haikala and Richard J. Paul

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 316-325;
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  Metabolic Transformations of Leukotriene B₄ in Primary Cultures of Human Hepatocytes

  Pat Wheelan, Joseph A. Hankin, Bahri Bilir, Denis Guenette and Robert C. Murphy

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 326-334;
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  Full and Partial 5-HT_1A Receptor Agonists Disrupt Learning and Performance in Rats

  P. J. Winsauer, F. H. Rodriguez, A. E. Cha and J. M. Moerschbaecher

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 335-347;
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  Characterization of Binding Properties to Human P-Glycoprotein: Development of a [³H]Verapamil Radioligand-Binding Assay

  Stephan Döppenschmitt, Peter Langguth, Carl Gunnar Regårdh, Tommy B. Andersson, Constanze Hilgendorf and Hildegard Spahn-Langguth

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 348-357;
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  Evaluation of Proteinase-Activated Receptor-1 (PAR₁) Agonists and Antagonists Using a Cultured Cell Receptor Desensitization Assay: Activation of PAR₂ by PAR₁-Targeted Ligands

  Atsufumi Kawabata, Mahmoud Saifeddine, Bahjat Al-Ani, Lorraine Leblond and Morley D. Hollenberg

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 358-370;
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  Preclinical Pharmacokinetics, Interspecies Scaling, and Tissue Distribution of a Humanized Monoclonal Antibody against Vascular Endothelial Growth Factor

  Yvonne S. Lin, Cindy Nguyen, Jose-Luis Mendoza, Enrique Escandon, David Fei, Y. Gloria Meng and Nishit B. Modi

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 371-378;
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  Differential Actions of Pacific Ciguatoxin-1 on Sodium Channel Subtypes in Mammalian Sensory Neurons

  Liesl C. Strachan, Richard J. Lewis and Graham M. Nicholson

  Journal of Pharmacology and Experimental Therapeutics January 1999, 288 (1) 379-388;