Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleArticle

Aldosterone Receptor Blockade Inhibits Increased Furosemide-Sensitive Sodium Reabsorption in Rats with Liver Cirrhosis

Thomas E. N. Jonassen, Jørgen Søberg Petersen, Anne-Mette Sørensen, Frederik Andreasen and Sten Christensen
Journal of Pharmacology and Experimental Therapeutics December 1998, 287 (3) 931-936;
Thomas E. N. Jonassen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jørgen Søberg Petersen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anne-Mette Sørensen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Frederik Andreasen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sten Christensen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

We examined the role of chronic aldosterone receptor blockade on the altered furosemide-sensitive sodium reabsorption in rats with liver cirrhosis induced by common bile duct ligation. CBL and sham-operated control animals were treated with the aldosterone receptor antagonist canrenoate (20 mg/day i.v.) for 4 weeks. Untreated CBL and sham-CBL served as control groups. The plasma concentration of aldosterone was within the normal range in all groups. Sodium balance studies showed that aldosterone receptor blockade prevented sodium retention in cirrhotic rats. Clearance studies showed that the glomerular filtration rate was unchanged, whereas the renal plasma flow was increased in CBL rats. A test dose of furosemide (7.5 mg/kg b.wt. i.v.) produced significantly greater diuretic (+59%) and natriuretic (+56%) responses in CBL rats than in sham-operated controls. The urinary furosemide excretion rate (UFURV) reflects delivery of furosemide to the thick ascending limb. When the natriuresis was expressed relative to UFURV (i.e., the natriuretic efficiency), we found that natriuretic efficiency of furosemide was significantly increased in untreated CBL rats (+59%). However, the natriuretic efficiency of furosemide was normalized in CBL rats treated with canrenoate. The urinary excretion of furosemide was unchanged in untreated CBL rats, but it was significantly increased in cirrhotic rats treated with canrenoate (+43%). This suggests that in CBL rats, chronic canrenoate treatment increases the renal elimination of furosemide as a consequence of reduced metabolism. These data suggest that chronic aldosterone receptor blockade with canrenoate prevents sodium retention in cirrhotic rats partly by inhibition of increased sodium reabsorption in the thick ascending limb.

Footnotes

  • Send reprint requests to: Thomas E. N. Jonassen, M.D., Department of Pharmacology, The Panum Institute, University of Copenhagen, 3 Blegdamsvej, Building 18.6, DK-2200 Copenhagen N, Denmark. E-mail: fitj{at}farmakol.ku.dk

  • ↵1 This work received financial support from the Danish Medical Research Council, The Eva and Robert Voss Hansen Foundation, The Ruth Kønig-Petersen Foundation, The Knud Øster-Jørgensen Foundation and The Helen and Ejnar Bjørnow Foundation.

  • Abbreviations:
    TAL
    thick ascending limb of Henle’s loop
    CD
    collecting duct
    CBL
    common bile duct ligation
    GFR
    glomerular filtration rate
    ERPF
    effective renal plasma flow
    EFF
    effective filtration fraction
    ERVR
    effective renal vascular resistance
    MAP
    mean arterial pressure
    HR
    heart rate
    C
    renal clearance
    FE
    fractional excretion
    V
    urine flow rate
    UNaV
    urinary sodium excretion rate
    UFURV
    urinary furosemide excretion rate
    ALAT
    alanine aminotransaminase
    • Received November 4, 1997.
    • Accepted June 25, 1998.
  • The American Society for Pharmacology and Experimental Therapeutics
View Full Text

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 287, Issue 3
1 Dec 1998
  • Table of Contents
  • Index by author
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Aldosterone Receptor Blockade Inhibits Increased Furosemide-Sensitive Sodium Reabsorption in Rats with Liver Cirrhosis
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

Aldosterone Receptor Blockade Inhibits Increased Furosemide-Sensitive Sodium Reabsorption in Rats with Liver Cirrhosis

Thomas E. N. Jonassen, Jørgen Søberg Petersen, Anne-Mette Sørensen, Frederik Andreasen and Sten Christensen
Journal of Pharmacology and Experimental Therapeutics December 1, 1998, 287 (3) 931-936;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

Aldosterone Receptor Blockade Inhibits Increased Furosemide-Sensitive Sodium Reabsorption in Rats with Liver Cirrhosis

Thomas E. N. Jonassen, Jørgen Søberg Petersen, Anne-Mette Sørensen, Frederik Andreasen and Sten Christensen
Journal of Pharmacology and Experimental Therapeutics December 1, 1998, 287 (3) 931-936;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • CRV431 Decreases Liver Fibrosis and Tumor Development
  • Mechanisms of 5-Hydroxytryptamine2A Receptor Activation of the Mitogen-Activated Protein Kinase Pathway in Vascular Smooth Muscle
  • Interactive Role for Neurosteroids in Ethanol Enhancement of γ-Aminobutyric Acid-Gated Currents from Dissociated Substantia Nigra Reticulata Neurons
Show more Article

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2022 by the American Society for Pharmacology and Experimental Therapeutics