OPC-41061, a Highly Potent Human Vasopressin V2-Receptor Antagonist: Pharmacological Profile and Aquaretic Effect by Single and Multiple Oral Dosing in Rats

	Abstract	Full	Pdf
Jan 1999	2	20	10
Feb 1999	1	9	4
Mar 1999	3	2	2
Apr 1999	1	7	1
Jun 1999	1	0	0
Jul 1999	0	5	0
Aug 1999	2	3	0
Sep 1999	2	1	0
Oct 1999	0	3	2
Nov 1999	0	3	3
Dec 1999	0	2	3
Jan 2000	2	6	1
Feb 2000	2	4	1
Mar 2000	0	1	1
Apr 2000	0	7	10
May 2000	0	0	3
Jun 2000	1	12	9
Jul 2000	0	2	4
Aug 2000	0	3	2
Sep 2000	0	1	8
Oct 2000	0	8	3
Nov 2000	0	1	3
Dec 2000	0	11	5
Jan 2001	1	4	1
Feb 2001	0	4	1
Mar 2001	2	9	5
Apr 2001	1	6	3
May 2001	2	7	2
Jun 2001	0	1	3
Jul 2001	0	2	5
Aug 2001	1	2	2
Sep 2001	0	3	2
Oct 2001	0	4	2
Nov 2001	0	4	10
Dec 2001	1	2	4
Jan 2002	1	5	6
Feb 2002	0	7	4
Mar 2002	2	4	9
Apr 2002	0	8	7
May 2002	1	8	8
Jun 2002	0	1	4
Jul 2002	1	11	14
Aug 2002	1	7	13
Sep 2002	0	12	7
Oct 2002	1	4	4
Nov 2002	0	9	8
Dec 2002	0	2	1
Jan 2003	2	5	10
Feb 2003	1	7	5
Mar 2003	1	2	4
Apr 2003	0	8	8
May 2003	0	2	4
Jun 2003	0	4	8
Jul 2003	8	14	5
Aug 2003	25	27	7
Sep 2003	21	26	12
Oct 2003	27	18	7
Nov 2003	30	53	11
Dec 2003	20	34	12
Jan 2004	38	47	13
Feb 2004	22	39	6
Mar 2004	16	41	18
Apr 2004	16	65	32
May 2004	28	46	25
Jun 2004	25	34	19
Jul 2004	27	35	10
Aug 2004	28	56	20
Sep 2004	27	67	19
Oct 2004	26	81	34
Nov 2004	21	81	22
Dec 2004	18	37	14
Jan 2005	25	33	11
Feb 2005	33	40	15
Mar 2005	18	34	18
Apr 2005	25	22	11
May 2005	21	73	17
Jun 2005	33	29	19
Jul 2005	31	17	6
Aug 2005	15	30	6
Sep 2005	17	28	8
Oct 2005	25	15	7
Nov 2005	28	23	17
Dec 2005	16	30	10
Jan 2006	21	54	20
Feb 2006	18	36	18
Mar 2006	29	39	16
Apr 2006	19	49	19
May 2006	15	26	12
Jun 2006	15	50	18
Jul 2006	12	25	11
Aug 2006	10	16	8
Sep 2006	24	29	10
Oct 2006	12	26	12
Nov 2006	24	28	12
Dec 2006	10	16	11
Jan 2007	10	21	9
Feb 2007	6	19	12
Mar 2007	20	22	10
Apr 2007	22	19	11
May 2007	17	33	16
Jun 2007	20	26	7
Jul 2007	16	32	14
Aug 2007	20	16	8
Sep 2007	5	15	8
Oct 2007	20	29	25
Nov 2007	12	15	10
Dec 2007	11	12	1
Jan 2008	12	16	9
Feb 2008	9	7	8
Mar 2008	4	15	7
Apr 2008	10	10	7
May 2008	13	11	7
Jun 2008	13	12	6
Jul 2008	6	17	6
Aug 2008	8	10	6
Sep 2008	16	28	19
Oct 2008	20	10	2
Nov 2008	20	16	5
Dec 2008	22	8	4
Jan 2009	20	17	15
Feb 2009	9	11	12
Mar 2009	17	10	2
Apr 2009	9	19	9
May 2009	14	9	11
Jun 2009	13	22	19
Jul 2009	7	12	15
Aug 2009	22	6	9
Sep 2009	14	13	13
Oct 2009	26	22	14
Nov 2009	15	19	11
Dec 2009	13	11	10
Jan 2010	22	13	11
Feb 2010	30	30	21
Mar 2010	18	15	9
Apr 2010	12	16	10
May 2010	10	8	8
Jun 2010	14	13	15
Jul 2010	17	17	7
Aug 2010	17	20	28
Sep 2010	8	23	20
Oct 2010	12	26	12
Nov 2010	8	25	13
Dec 2010	11	21	17
Jan 2011	13	13	13
Feb 2011	13	17	13
Mar 2011	15	17	19
Apr 2011	23	24	23
May 2011	22	22	17
Jun 2011	18	17	12
Jul 2011	21	27	20
Aug 2011	17	9	13
Sep 2011	18	20	14
Oct 2011	22	18	22
Nov 2011	37	19	16
Dec 2011	13	13	16
Jan 2012	11	11	20
Feb 2012	19	15	16
Mar 2012	15	14	9
Apr 2012	14	11	11
May 2012	19	16	15
Jun 2012	11	24	12
Jul 2012	14	21	20
Aug 2012	3	8	8
Sep 2012	8	11	19
Oct 2012	22	20	23
Nov 2012	4	17	19
Dec 2012	5	10	18
Jan 2013	14	31	21
Feb 2013	8	17	20
Mar 2013	19	19	18
Apr 2013	15	13	19
May 2013	11	30	31
Jun 2013	14	17	24
Jul 2013	13	11	14
Aug 2013	12	8	14
Sep 2013	12	23	28
Oct 2013	20	23	29
Nov 2013	8	12	12
Dec 2013	21	24	19
Jan 2014	11	17	36
Feb 2014	9	28	33
Mar 2014	32	17	13
Apr 2014	9	12	19
May 2014	10	14	16
Jun 2014	6	8	12
Jul 2014	24	26	24
Aug 2014	7	19	14
Sep 2014	8	27	16
Oct 2014	23	21	20
Nov 2014	11	19	15
Dec 2014	8	8	41
Jan 2015	15	12	28
Feb 2015	57	26	23
Mar 2015	16	8	19
Apr 2015	6	18	15
May 2015	6	12	13
Jun 2015	1	12	16
Jul 2015	14	20	23
Aug 2015	14	8	6
Sep 2015	13	15	14
Oct 2015	8	7	8
Nov 2015	14	14	13
Dec 2015	11	16	11
Jan 2016	23	22	18
Feb 2016	8	10	9
Mar 2016	15	8	17
Apr 2016	17	15	12
May 2016	20	19	26
Jun 2016	17	14	18
Jul 2016	6	16	17
Aug 2016	11	15	24
Sep 2016	9	14	13
Oct 2016	13	24	28
Nov 2016	9	19	16
Dec 2016	2	15	13
Jan 2017	4	17	7
Feb 2017	5	31	16
Mar 2017	2	28	20
Apr 2017	5	12	10
May 2017	11	30	18
Jun 2017	3	14	13
Jul 2017	5	25	15
Aug 2017	5	31	15
Sep 2017	2	19	15
Oct 2017	3	21	17
Nov 2017	4	45	17
Dec 2017	8	14	8
Jan 2018	6	23	15
Feb 2018	3	17	11
Mar 2018	5	22	16
Apr 2018	2	25	15
May 2018	4	22	25
Jun 2018	2	24	17
Jul 2018	4	28	32
Aug 2018	4	7	9
Sep 2018	0	21	15
Oct 2018	4	21	9
Nov 2018	1	28	18
Dec 2018	49	9	5
Jan 2019	29	4	3
Feb 2019	25	10	12
Mar 2019	40	15	6
Apr 2019	25	5	2
May 2019	36	9	8
Jun 2019	25	5	6
Jul 2019	27	3	1
Aug 2019	40	7	6
Sep 2019	64	10	6
Oct 2019	17	3	2
Nov 2019	49	4	3
Dec 2019	43	3	4
Jan 2020	34	8	7
Feb 2020	24	9	3
Mar 2020	36	6	6
Apr 2020	27	8	5
May 2020	58	8	5
Jun 2020	7	4	2
Jul 2020	49	7	3
Aug 2020	14	5	3
Sep 2020	34	6	7
Oct 2020	46	4	4
Nov 2020	22	2	0
Dec 2020	20	9	7
Jan 2021	45	13	6
Feb 2021	54	9	6
Mar 2021	54	4	3
Apr 2021	51	4	2
May 2021	35	11	5
Jun 2021	37	11	3
Jul 2021	45	3	2
Aug 2021	36	10	8
Sep 2021	31	3	2
Oct 2021	40	4	2
Nov 2021	68	8	3
Dec 2021	29	5	7
Jan 2022	64	9	5
Feb 2022	62	9	6
Mar 2022	57	5	4
Apr 2022	105	4	6
May 2022	29	2	1
Jun 2022	28	5	3
Jul 2022	34	3	0
Aug 2022	52	5	1
Sep 2022	47	12	6
Oct 2022	32	6	5
Nov 2022	44	9	3
Dec 2022	37	2	1
Jan 2023	66	13	5
Feb 2023	56	6	2
Mar 2023	47	4	2
Apr 2023	27	6	1
May 2023	46	4	3
Jun 2023	4	0	0

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OPC-41061, a Highly Potent Human Vasopressin V₂-Receptor Antagonist: Pharmacological Profile and Aquaretic Effect by Single and Multiple Oral Dosing in Rats

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