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Research ArticleArticle

Differential Effects of N-Methyl-d-Aspartate Receptor Blockade on Eticlopride-Induced Immediate Early Gene Expression in the Medial and Lateral Striatum

Kristen A. Keefe and Amy C. Adams
Journal of Pharmacology and Experimental Therapeutics December 1998, 287 (3) 1076-1083;
Kristen A. Keefe
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Amy C. Adams
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Abstract

The function of striatopallidal neurons is regulated by N-methyl-d-aspartate (NMDA) and dopamine D2 receptors. Previous studies show that immediate early gene induction by D2 receptor blockade is suppressed by NMDA receptor antagonists. Because the pharmacology of NMDA receptors depends on the incorporation of different NR2 subunits and NR2 subunits show regional and cellular differences in their expression in striatum, our study examined whether different NMDA receptor antagonists would have differential effects on eticlopride-induced immediate early gene expression in striatum. Male Sprague-Dawley rats were pretreated with vehicle, CGS 19755, MK-801 or ifenprodil. Rats then received injections of eticlopride and were killed 40 min later. In situ hybridization histochemistry was used to determine the expression of c-fos andzif268 in the striatum. Eticlopride increased immediate early gene expression in striatum, with the increase generally being greater in lateral than in medial striatum. Pretreatment with each of the NMDA receptor antagonists dose-dependently decreased the expression of the immediate early genes. This suppression of eticlopride-induced gene expression was significant only in the medial-central aspect of striatum. Although there was a trend toward suppression of the gene induction in lateral striatum, it did not reach statistical significance and was not typically dose dependent. The data suggest that different types of NMDA receptor antagonists do not exert differential effects on D2 dopamine receptor-mediated function in the striatum. In addition, the data indicate that eticlopride-induced gene expression in the striatum is not uniformly dependent on NMDA receptor activation.

Footnotes

  • Send reprint requests to: Dr. Kristen A. Keefe, Department of Pharmacology and Toxicology, University of Utah, 30 S 2000 E, Room 211, Salt Lake City, UT 84112.

  • ↵1 This work was supported by Grant NS 335579 (K.A.K.) and 5 P30 CA42014 (University of Utah DNA/Peptide facility).

  • Abbreviations:
    NMDA
    N-methyl-d-aspartate
    SSC
    saline-sodium citrate
    EDTA
    ethylenediaminetetraacetic acid
    • Received February 9, 1998.
    • Accepted June 1, 1998.
  • The American Society for Pharmacology and Experimental Therapeutics
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Journal of Pharmacology and Experimental Therapeutics
Vol. 287, Issue 3
1 Dec 1998
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Research ArticleArticle

Differential Effects of N-Methyl-d-Aspartate Receptor Blockade on Eticlopride-Induced Immediate Early Gene Expression in the Medial and Lateral Striatum

Kristen A. Keefe and Amy C. Adams
Journal of Pharmacology and Experimental Therapeutics December 1, 1998, 287 (3) 1076-1083;

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Research ArticleArticle

Differential Effects of N-Methyl-d-Aspartate Receptor Blockade on Eticlopride-Induced Immediate Early Gene Expression in the Medial and Lateral Striatum

Kristen A. Keefe and Amy C. Adams
Journal of Pharmacology and Experimental Therapeutics December 1, 1998, 287 (3) 1076-1083;
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