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Research ArticleArticle

Magnesium-Dependent Inhibition of N-Methyl-d-Aspartate Receptor-Mediated Synaptic Transmission by Ethanol

Jeffrey L. Calton, Wilkie A. Wilson and Scott D. Moore
Journal of Pharmacology and Experimental Therapeutics December 1998, 287 (3) 1015-1019;
Jeffrey L. Calton
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Wilkie A. Wilson
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Scott D. Moore
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Abstract

Previous studies have indicated that ethanol (EtOH) has a relatively specific effect on excitatory synaptic transmission by inhibiting function of the N-methyl-d-aspartate receptor. We have found that EtOH potently inhibits N-methyl-d-aspartate-mediated synaptic currents in the basolateral amygdala, a brain region associated with actions of anxiolytic agents such as EtOH. This inhibitory effect of EtOH requires the presence of magnesium (Mg++). The dependence of the effect of EtOH on the presence of Mg++ suggests a possible molecular site of the action of EtOH in the vicinity of Mg++ binding sites on the N-methyl-d-aspartate receptor-channel complex. Because EtOH consumption may result in reductions in free brain Mg++, this dynamic interaction between EtOH and Mg++ may have important implications for understanding the behavioral effects of EtOH.

Footnotes

  • Send reprint requests to: Dr. Scott D. Moore, Room 25, Bldg 16, Durham VA Medical Center, Durham, NC 27705.

  • ↵1 This work was supported by VA Merit Review and NIAAA R 29 AA 10994-01.

  • Abbreviations:
    EtOH
    ethanol
    Mg++
    magnesium
    NMDA
    N-methyl-d-aspartate
    ACSF
    artificial cerebrospinal fluid
    BMI
    bicuculline methiodide
    DNQX
    6,7 dinitroquinoxaline
    HEPES
    4-(2-hydroxyethyl)-piperazineethanesulfonic acid
    BAPTA
    1,2-bis(2-aminophenoxy)ethane-N,N,N’,N’,-tetraacetic acid
    APV
    d,1-2-amino-5-phosphonovaleric acid
    GABA
    γ-aminobutyric acid
    EPSP
    excitatory postsynaptic potential
    EPSC
    excitatory postsynaptic current
    • Received March 12, 1998.
    • Accepted June 1, 1998.
  • The American Society for Pharmacology and Experimental Therapeutics
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Journal of Pharmacology and Experimental Therapeutics
Vol. 287, Issue 3
1 Dec 1998
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Research ArticleArticle

Magnesium-Dependent Inhibition of N-Methyl-d-Aspartate Receptor-Mediated Synaptic Transmission by Ethanol

Jeffrey L. Calton, Wilkie A. Wilson and Scott D. Moore
Journal of Pharmacology and Experimental Therapeutics December 1, 1998, 287 (3) 1015-1019;

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Research ArticleArticle

Magnesium-Dependent Inhibition of N-Methyl-d-Aspartate Receptor-Mediated Synaptic Transmission by Ethanol

Jeffrey L. Calton, Wilkie A. Wilson and Scott D. Moore
Journal of Pharmacology and Experimental Therapeutics December 1, 1998, 287 (3) 1015-1019;
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