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SB 207499 (Ariflo), a Second Generation Phosphodiesterase 4 Inhibitor, Reduces Tumor Necrosis Factor α and Interleukin-4 Production in vivo

Don E. Griswold, Edward F. Webb, Alison M. Badger, Peter D. Gorycki, Patricia A. Levandoski, Mary A. Barnette, Marilyn Grous, Siegfried Christensen and Theodore J. Torphy
Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 705-711;

Article Information

vol. 287 no. 2 705-711
PubMed 
9808700
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Received February 18, 1998
  • Accepted June 26, 1998
  • Published online November 1, 1998.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Don E. Griswold1,
  2. Edward F. Webb1,
  3. Alison M. Badger2,
  4. Peter D. Gorycki3,
  5. Patricia A. Levandoski3,
  6. Mary A. Barnette1,
  7. Marilyn Grous1,
  8. Siegfried Christensen4 and
  9. Theodore J. Torphy1
  1. Departments of 1Pulmonary Pharmacology (D.E.G., E.F.W., M.A.B., M.G., T.J.T.), 2Bone and Cartilage Biology (A.M.B.), 3Drug Metabolism and Pharmacokinetics (P.D.G., P.A.L.) and 4Medicinal Chemistry (S.C.), SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania
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    SB 207499 (Ariflo), a Second Generation Phosphodiesterase 4 Inhibitor, Reduces Tumor Necrosis Factor α and Interleukin-4 Production in vivo

    Don E. Griswold, Edward F. Webb, Alison M. Badger, Peter D. Gorycki, Patricia A. Levandoski, Mary A. Barnette, Marilyn Grous, Siegfried Christensen and Theodore J. Torphy
    Journal of Pharmacology and Experimental Therapeutics November 1, 1998, 287 (2) 705-711;
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