Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleArticle

Diesel Exhaust Particles Block Induction of Oral Tolerance in Mice

Shin Yoshino, Motoyasu Ohsawa and Masaru Sagai
Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 679-683;
Shin Yoshino
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Motoyasu Ohsawa
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Masaru Sagai
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

We investigated the effect of diesel exhaust particles (DEP) on oral tolerance. Oral tolerance was induced by feeding mice with 10 mg of hen egg lysozyme (HEL) daily over a period of 5 days before immunization with the antigen. Varying doses of DEP were orally administered immediately before each feeding of HEL. The results showed that oral administration of HEL significantly suppressed production of anti-HEL IgG, IgG1 and IgG2a antibodies, delayed-type hypersensitivity and proliferative responses of lymph node cells to the antigen. The suppression of these immune responses to HEL by the oral antigen was associated with a marked decrease in secretion of interferon-γ and interleukin-4 from the lymphoid cells. Administration of DEP dose-dependently blocked suppression by oral HEL of antigen-specific IgG, IgG1 and IgG2a antibody production, delayed-type hypersensitivity and lymphoid cell proliferation. The suppression by the fed antigen of secretion of interferon-γ and interleukin-4 was also markedly diminished by the particles. Thus, DEP appear to be effective in blocking induction of oral tolerance.

Footnotes

  • Send reprint requests to: Dr. Shin Yoshino, Department of Microbiology, Saga Medical School, Nabeshima 5-1-1, Saga 849-8501, Japan.

  • 1 This work was supported by a Grant-in-Aid for Scientific Research (C) from the Ministry of Education, Science, Sports, and Culture of Japan.

  • Abbreviations:
    DEP
    diesel exhaust particles
    HEL
    hen egg lysozyme
    DTH
    delayed-type hypersensitivity
    IFN-γ
    interferon-γ
    IL-4
    interleukin-4
    PBS
    phosphate-buffered saline
    ELISA
    enzyme-linked immunosorbent assay
    • Received April 2, 1998.
    • Accepted July 2, 1998.
  • The American Society for Pharmacology and Experimental Therapeutics
View Full Text

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 287, Issue 2
1 Nov 1998
  • Table of Contents
  • Index by author
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Diesel Exhaust Particles Block Induction of Oral Tolerance in Mice
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

Diesel Exhaust Particles Block Induction of Oral Tolerance in Mice

Shin Yoshino, Motoyasu Ohsawa and Masaru Sagai
Journal of Pharmacology and Experimental Therapeutics November 1, 1998, 287 (2) 679-683;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Research ArticleArticle

Diesel Exhaust Particles Block Induction of Oral Tolerance in Mice

Shin Yoshino, Motoyasu Ohsawa and Masaru Sagai
Journal of Pharmacology and Experimental Therapeutics November 1, 1998, 287 (2) 679-683;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • CRV431 Decreases Liver Fibrosis and Tumor Development
  • Mechanisms of 5-Hydroxytryptamine2A Receptor Activation of the Mitogen-Activated Protein Kinase Pathway in Vascular Smooth Muscle
  • Interactive Role for Neurosteroids in Ethanol Enhancement of γ-Aminobutyric Acid-Gated Currents from Dissociated Substantia Nigra Reticulata Neurons
Show more Article

Similar Articles

  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2021 by the American Society for Pharmacology and Experimental Therapeutics