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Research ArticleArticle

Effects of Hibernation and Arousal from Hibernation on Mesenteric Arterial Responses of the Golden Hamster

Vera Ralevic, Gillian Knight and Geoffrey Burnstock
Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 521-526;
Vera Ralevic
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Gillian Knight
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Geoffrey Burnstock
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Abstract

The aim of our study was to investigate the changes that occur in functional responses of the golden hamster mesenteric arterial bed after: 1) 8 wk of hibernation and 2) 2 hr after arousal from hibernation. Age-matched and cold-exposed hamsters were used as controls. At 8 wk after hibernation there was an increase in sensitivity of vasoconstrictor responses to sympathetic nerve stimulation but no significant difference in constrictor responses to norepinephrine, α,β-methylene ATP, uridine 5′-triphosphate or KCl (studied in unconstricted preparations), or in endothelium-dependent vasodilatation to acetylcholine and uridine 5′-triphosphate (in methoxamine-preconstricted preparations) compared with the control groups. In contrast, in the arousal from hibernation group, sympathetic vasoconstriction was similar to that in the control groups, and the maximal response to exogenous norepinephrine, and responses to α,β-methylene ATP were augmented. These results suggest that there is an augmentation of sympathetic neurotransmission of golden hamster mesenteric arteries at 8 wk after hibernation, which appears to be due to pre- rather than postjunctional changes. This is reversed with arousal from hibernation, when the sensitivity of sympathetic contractile responses is not different from that of the controls. However, an increase in maximal constrictor responses to norepinephrine suggests that postjunctional changes may occur in sympathetic neurotransmission during arousal.

Footnotes

  • Send reprint requests to: Dr. V. Ralevic, School of Biomedical Sciences, Queen’s Medical Centre, The University of Nottingham, Nottingham NG7 2UH, England.

  • ↵1 This work was supported by the Royal Society.

  • ↵2 Current address: School of Biomedical Sciences, Queen’s Medical Centre, The University of Nottingham, Nottingham NG7 2UH

  • Abbreviations:
    α
    β-meATP, α,β-methylene ATP
    ACh
    acetylcholine
    ATP
    adenosine 5′-triphosphate
    EFS
    electrical field stimulation
    KCl
    potassium chloride
    NE
    norepinephrine
    UTP
    uridine 5′-triphosphate
    ANOVA
    analysis of variance
    • Received February 25, 1998.
    • Accepted June 3, 1998.
  • The American Society for Pharmacology and Experimental Therapeutics
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Journal of Pharmacology and Experimental Therapeutics
Vol. 287, Issue 2
1 Nov 1998
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Research ArticleArticle

Effects of Hibernation and Arousal from Hibernation on Mesenteric Arterial Responses of the Golden Hamster

Vera Ralevic, Gillian Knight and Geoffrey Burnstock
Journal of Pharmacology and Experimental Therapeutics November 1, 1998, 287 (2) 521-526;

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Research ArticleArticle

Effects of Hibernation and Arousal from Hibernation on Mesenteric Arterial Responses of the Golden Hamster

Vera Ralevic, Gillian Knight and Geoffrey Burnstock
Journal of Pharmacology and Experimental Therapeutics November 1, 1998, 287 (2) 521-526;
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