Table of Contents

Articles

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  Carbamazepine-Induced Up-regulation of Voltage-dependent Na⁺ Channels in Bovine Adrenal Medullary Cells in Culture

  Reiji Yoshimura, Nobuyuki Yanagihara, Takeshi Terao, Yasuhito Uezono, Yumiko Toyohira, Susumu Ueno, Kazuhiko Abe and Futoshi Izumi

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 441-447;
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  Pharmacological and Biochemical Characterization of a Recombinant Human Galanin GALR1 Receptor: Agonist Character of Chimeric Galanin Peptides

  Lawrence W. Fitzgerald, John P. Patterson, Deborah S. Conklin, Robert Horlick and Brian L. Largent

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 448-456;
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  Physiologically Based Pharmacokinetics of Cyclosporine A: Extension to Tissue Distribution Kinetics in Rats and Scale-up to Human

  Ryosei Kawai, Diane Mathew, Chiaki Tanaka and Malcolm Rowland

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 457-468;
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  Determinants of Channel Gating Located in the N-Terminal Extracellular Domain of Nicotinic α7 Receptor

  René Anand, Mark E. Nelson, Volodymyr Gerzanich, Gregg B. Wells and Jon Lindstrom

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 469-479;
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  Inhibition of Delayed Rectifier K⁺ Channels by Dexfenfluramine (Redux)

  Shiling Hu, Shuya Wang, Joyce Gibson and Timothy A. Gilbertson

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 480-486;
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  Dopamine Transporter Activity in the Substantia Nigra and Striatum Assessed by High-Speed Chronoamperometric Recordings in Brain Slices

  Alexander F. Hoffman, Carl R. Lupica and Greg A. Gerhardt

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 487-496;
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  Pharmacological Evaluation of an Epoxide as the Putative Hyperpolarizing Factor Mediating the Nitric Oxide-Independent Vasodilator Effect of Bradykinin in the Rat Heart

  D. Fulton, J. C. Mcgiff and J. Quilley

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 497-503;
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  20β-Hydroxysteroid Dehydrogenase Catalyzes Ketone-Reduction of Acetohexamide, an Oral Antidiabetic Drug, in Liver Microsomes of Adult Male Rats

  Hidenori Takada, Masaki Otagiri and Yorishige Imamura

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 504-507;
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  Functional Characterization of the Recombinant Human 5-Hydroxytryptamine_7(a) Receptor Isoform Coupled to Adenylate Cyclase Stimulation

  Nika Adham, John M. Zgombick, Jonathan Bard and Theresa A. Branchek

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 508-514;
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  Inhibition of Buthionine Sulfoximine-Enhanced Doxorubicin Toxicity in Metallothionein Overexpressing Transgenic Mouse Heart

  Hui-Yun Wu and Y. James Kang

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 515-520;
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  Effects of Hibernation and Arousal from Hibernation on Mesenteric Arterial Responses of the Golden Hamster

  Vera Ralevic, Gillian Knight and Geoffrey Burnstock

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 521-526;
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  SP/W-5186, A Cysteine-Containing Nitric Oxide Donor, Attenuates Postischemic Myocardial Injury

  Gao-Lin Liu, Theodore A. Christopher, Bernard L. Lopez, Feng Gao, Yaping Guo, Erhe Gao, Karlheinz Knuettel, Martin Feelisch and Xin L. Ma

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 527-537;
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  Morphine-6β-Glucuronide-Induced Hyperphagia: Characterization of Opioid Action By Selective Antagonists and Antisense Mapping in Rats

  Liza Leventhal, Robert M. Silva, Grace C. Rossi, Gavril W. Pasternak and Richard J. Bodnar

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 538-544;
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  Altered Disposition and Antinociception of [d-Penicillamine^2,5] Enkephalin inmdr1a-Gene-Deficient Mice

  Cuiping Chen and Gary M. Pollack

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 545-552;
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  Lack of Anticonvulsant Tolerance to the Neuroactive Steroid Pregnanolone in Mice

  Tushar G. Kokate, Shun-Ichi Yamaguchi, Lewis K. Pannell, Umamaheswari Rajamani, David M. Carroll, Andrew B. Grossman and Michael A. Rogawski

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 553-558;
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  Neuroprotective Efficacy of YM872, an α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptor Antagonist, after Permanent Middle Cerebral Artery Occlusion in Rats

  Masayasu Takahashi, Jian Wei Ni, Sachiko Kawasaki-Yatsugi, Takashi Toya, Chikako Ichiki, Shin-Ichi Yatsugi, Kazuo Koshiya, Masao Shimizu-Sasamata and Tokio Yamaguchi

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 559-566;
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  Effects of Neutral Endopeptidase Inhibition and Combined Angiotensin Converting Enzyme and Neutral Endopeptidase Inhibition on Angiotensin and Bradykinin Peptides in Rats

  Duncan J. Campbell, Frank Anastasopoulos, Ann-Maree Duncan, Gail M. James, Athena Kladis and Todd A. Briscoe

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 567-577;
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  Selective Cyclooxygenase-2 Inhibition by Nimesulide in Man

  Louise Cullen, Linda Kelly, Shane O. Connor and Desmond J. Fitzgerald

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 578-582;
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  Biotransformation of Tirilazad in Human: 3. Tirilazad A-Ring Reduction by Human Liver Microsomal 5α-Reductase Type 1 and Type 2

  Larry C. Wienkers, Rick C. Steenwyk, Michael J. Hauer, Joseph C. Fleishaker and Paul G. Pearson

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 583-590;
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  Biotransformation of Tirilazad in Human: 4. Effect of Finasteride on Tirilazad Clearance and Reduced Metabolite Formation

  Joseph C. Fleishaker, Paul G. Pearson, Larry C. Wienkers, Laura K. Pearson, Theresa A. Moore and Gary R. Peters

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 591-597;
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  Anandamide, an Endogenous Cannabinoid, Has a Very Low Physical Dependence Potential

  Mario D. Aceto, Susan M. Scates, Raj K. Razdan and Billy R. Martin

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 598-605;
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  Seizure Sensitivity and GABAergic Modulation of Ethanol Sensitivity in Selectively Bred FAST and SLOW Mouse Lines

  Elaine H. Shen, Janet Dorow, Richard Harland, Sue Burkhart-Kasch and Tamara J. Phillips

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 606-615;
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  Pharmacokinetic Mechanisms for Obtaining High Renal Coelimination of Phencyclidine and a Monoclonal Antiphencyclidine Antigen-Binding Fragment of Immunoglobulin G in the Rat

  Joel W. Proksch, W. Brooks Gentry and S. Michael Owens

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 616-624;
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  Delta Opioid Receptor Down-Regulation Is Independent of Functional G Protein yet Is Dependent on Agonist Efficacy

  Ann E. Remmers, Mary J. Clark, Xiang Yang Liu and Fedor Medzihradsky

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 625-632;
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  In Vitro Pharmacologic Profile of YM158, a New Dual Antagonist for LTD₄ and TXA₂ receptors

  Yasuhito Arakida, Kiyomi Suwa, Keiko Ohga, Masaki Yokota, Keiji Miyata, Toshimitsu Yamada and Kazuo Honda

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 633-639;
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  Characterization of the Polymorphonuclear Leukocyte-Induced Vasoconstriction in Isolated Human Umbilical Veins

  Steven W. Kerr, Rebecca Yu, Carol D. Stearns, Nancy A. Haynes and Raymond J. Winquist

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 640-647;
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  Pharmacological Characterization of Nicotinic Receptor-stimulated GABA Release From Mouse Brain Synaptosomes

  Ying Lu, Sharon Grady, Michael J. Marks, Marina Picciotto, Jean-Pierre Changeux and Allan C. Collins

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 648-657;
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  Neurochemical and Behavioral Effects of Ciproxifan, A Potent Histamine H₃-Receptor Antagonist

  X. Ligneau, J.-S. Lin, G. Vanni-Mercier, M. Jouvet, J. L. Muir, C. R. Ganellin, H. Stark, S. Elz, W. Schunack and J.-C. Schwartz

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 658-666;
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  Ligand- and Subtype-Selective Coupling of HumanAlpha-2 Adrenoceptors to Ca⁺⁺ elevation in Chinese Hamster Ovary Cells

  Jyrki P. Kukkonen, Annika Renvaktar, Ramin Shariatmadari and Karl E. O. Åkerman

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 667-671;
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  Transport of Quinolone Antibacterial Drugs in a Kidney Epithelial Cell Line, LLC-PK₁

  Yumiko Matsuo, Ikuko Yano, Tatsuya Ito, Yukiya Hashimoto and Ken-Ichi Inui

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 672-678;
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  Diesel Exhaust Particles Block Induction of Oral Tolerance in Mice

  Shin Yoshino, Motoyasu Ohsawa and Masaru Sagai

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 679-683;
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  Noncompetitive Inhibition of Glycylsarcosine Transport by Quinapril in Rabbit Renal Brush Border Membrane Vesicles: Effect on High-Affinity Peptide Transporter

  Wiyada Akarawut, Chun-Jung Lin and David E. Smith

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 684-690;
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  Effect of YNS-15P, a New Alpha-2 Adrenoceptor Antagonist, on Stress-Stimulated Colonic Propulsion in Rats

  Osamu Yamamoto, Hiromichi Niida, Koyuki Tajima, Yoshiaki Shirouchi, Yousuke Kyotani, Fusao Ueda, Masahiro Kise and Kiyoshi Kimura

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 691-696;
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  Acute and Chronic Effects of Capsaicin in Perfused Rat Muscle: The Role of Tachykinins and Calcitonin Gene-Related Peptide

  Cory D. Griffiths, Dominic P. Geraghty, Tristram P.D. Eldershaw and Eric Q. Colquhoun

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 697-704;
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  SB 207499 (Ariflo), a Second Generation Phosphodiesterase 4 Inhibitor, Reduces Tumor Necrosis Factor α and Interleukin-4 Production in vivo

  Don E. Griswold, Edward F. Webb, Alison M. Badger, Peter D. Gorycki, Patricia A. Levandoski, Mary A. Barnette, Marilyn Grous, Siegfried Christensen and Theodore J. Torphy

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 705-711;
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  Effects of EM574 and Cisapride on Gastric Contractile and Emptying Activity in Normal and Drug-Induced Gastroparesis in Dogs

  Toshiyuki Tanaka, Akiyoshi Mizumoto, Erito Mochiki, Hideki Suzuki, Zen Itoh and Satoshi Omura

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 712-719;
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  Beta-3 Adrenergic Receptor Agonists Cause an Increase in Gastrointestinal Transit Time in Wild-type Mice, But Not in Mice Lacking the Beta-3 Adrenergic Receptor

  Daniel S. Fletcher, Mari Rios Candelore, Danica Grujic, Bradford B. Lowell, Silvi Luell, Vedrana S. Susulic and D. Euan Macintyre

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 720-724;
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  Prediction of Catalepsies Induced by Amiodarone, Aprindine and Procaine: Similarity in Conformation of Diethylaminoethyl Side Chain

  Akiko Matsui, Hirotami Matsuo, Hitomi Takanaga, Shigeki Sasaki, Minoru Maeda and Yasufumi Sawada

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 725-732;
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  Acute Regulation of Norepinephrine Transport: I. Protein Kinase C-Linked Muscarinic Receptors Influence Transport Capacity and Transporter Density in SK-N-SH Cells

  Subramaniam Apparsundaram, Aurelio Galli, Louis J. DeFelice, H. Criss Hartzell and Randy D. Blakely

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 733-743;
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  Acute Regulation of Norepinephrine Transport: II. PKC-Modulated Surface Expression of Human Norepinephrine Transporter Proteins

  Subramaniam Apparsundaram, Sally Schroeter, Elena Giovanetti and Randy D. Blakely

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 744-751;
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  Decreased Benzodiazepine Binding with Little Effect on γ-Aminobutyric Acid Binding in Rat Brain After Treatment with Antisense Oligodeoxynucleotide to the γ-Aminobutyric Acid_A Receptor Gamma-2 Subunit ,

  Tai-Jun Zhao, Ming Li, Ted H. Chiu and Howard C. Rosenberg

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 752-759;
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  Inhibition of Nitric Oxide Synthase Disrupts Inhibitory Gating of Auditory Responses in Rat Hippocampus

  Catherine E. Adams and Karen E. Stevens

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 760-765;
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  Absence Seizures Decrease Steroid Modulation of t-[³⁵S]Butylbicyclophosphorothionate Binding in Thalamic Relay Nuclei

  Pradeep K. Banerjee, Richard W. Olsen, Niranjala J. K. Tillakaratne, Simon Brailowsky, Allan J. Tobin and O. Carter Snead

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 766-772;
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  The Expression of Heme Oxygenase-1 Gene Responded to Oxidative Stress Produced by Phorone, a Glutathione Depletor, in the Rat Liver; The Relevance to Activation of c-Jun N-Terminal Kinase

  Takiko Oguro, Moyuru Hayashi, Shigeo Nakajo, Satoshi Numazawa and Takemi Yoshida

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 773-778;
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  Aspirin-Triggered 15-epi-Lipoxin A₄ (ATL) Generation by Human Leukocytes and Murine Peritonitis Exudates: Development of a Specific 15-epi-LXA₄ ELISA

  Nan Chiang, Tomoko Takano, Clary B. Clish, Nicos A. Petasis, Hsin-Hsiung Tai and Charles N. Serhan

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 779-790;
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  A Possible Mechanism of Eighteen Patient Deaths Caused by Interactions of Sorivudine, a New Antiviral Drug, with Oral 5-Fluorouracil Prodrugs

  Haruhiro Okuda, Kenichiro Ogura, Atsushi Kato, Hiroaki Takubo and Tadashi Watabe

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 791-799;
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  Functional Characteristics and Membrane Localization of Rat Multispecific Organic Cation Transporters, OCT1 and OCT2, Mediating Tubular Secretion of Cationic Drugs

  Yumiko Urakami, Masahiro Okuda, Satohiro Masuda, Hideyuki Saito and Ken-Ichi Inui

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 800-805;
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  Disruption of Insulin-Like Growth Factor-1 Signaling and Down-Regulation of Cdc2 by SC-ααδ9, a Novel Small Molecule Antisignaling Agent Identified in a Targeted Array Library

  Andreas Vogt, Robert L. Rice, Catherine E. Settineri, Fumiaki Yokokawa, Shiho Yokokawa, Peter Wipf and John S. Lazo

  Journal of Pharmacology and Experimental Therapeutics November 1998, 287 (2) 806-813;