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Research ArticleArticle

Excretion of Ofloxacin into Saliva in Rats with Renal Failure

Guohua Ding, Kohji Naora, Sadao Nagasako, Hidenari Hirano and Kikuo Iwamoto
Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 31-36;
Guohua Ding
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Kohji Naora
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Sadao Nagasako
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Hidenari Hirano
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Kikuo Iwamoto
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Abstract

To clarify effects of renal failure on salivary distribution of ofloxacin (OFLX), a quinolone antibiotics, blood, parotid and mandibular saliva were collected from the single-step 5/6th-nephrectomized and sham-operated (control) rats after bolus i.v. administration of OFLX (5 mg/kg). The concentrations of OFLX in these samples were determined by high-performance liquid chromatography. Renal failure induced by the partial nephrectomy significantly elevated plasma levels and cumulative salivary excretion of OFLX when compared to control rats. Total body clearance was significantly decreased by the renal failure, although salivary clearance of the partially nephrectomized rats was about three times larger than that of the control. At the terminal phase, the saliva/plasma concentration ratios of OFLX for parotid and mandibular saliva in control rats was 0.249 ± 0.180 and 0.136 ± 0.024, respectively, and there was a significant difference between both salivary glands. The saliva/plasma concentration ratios in the rats with renal failure were significantly greater than those in the control group in both parotid (about 3.2 times) and mandibular (about 2.5 times) saliva. The results of this study suggest that the salivary excretion of OFLX is significantly increased by renal failure and a glandular difference in the salivary excretion of OFLX exists in both rats with normal and impaired renal function.

Footnotes

  • Send reprint requests to: Dr. K. Iwamoto, Department of Pharmacy, Shimane Medical University Hospital, 89–1 Enya-cho, Izumo, Shimane 693-8501, Japan.

  • ↵1 Current address: Department of Pharmacy, Heilongjiang Provincial 2nd Hospital, 159 Diduan Street, Harbin 150010, Heilongjiang, China.

  • Abbreviations:
    OFLX
    ofloxacin
    t1/2β
    elimination half-life
    CLtot
    total body clearance
    Vss
    distribution volume at the steady state
    CLsal
    salivary clearance
    HPLC
    high-performance liquid chromatography
    S/P ratio
    saliva-to-plasma concentration ratio
    • Received October 2, 1997.
    • Accepted May 11, 1998.
  • The American Society for Pharmacology and Experimental Therapeutics
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Journal of Pharmacology and Experimental Therapeutics
Vol. 287, Issue 1
1 Oct 1998
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Research ArticleArticle

Excretion of Ofloxacin into Saliva in Rats with Renal Failure

Guohua Ding, Kohji Naora, Sadao Nagasako, Hidenari Hirano and Kikuo Iwamoto
Journal of Pharmacology and Experimental Therapeutics October 1, 1998, 287 (1) 31-36;

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Research ArticleArticle

Excretion of Ofloxacin into Saliva in Rats with Renal Failure

Guohua Ding, Kohji Naora, Sadao Nagasako, Hidenari Hirano and Kikuo Iwamoto
Journal of Pharmacology and Experimental Therapeutics October 1, 1998, 287 (1) 31-36;
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