Table of Contents

Articles

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  LY353381.HCl: A Novel Raloxifene Analog with Improved SERM Potency and Efficacy In Vivo

  Masahiko Sato, Charles H. Turner, Tongyu Wang, M. Dee Adrian, Ellen Rowley and Henry U. Bryant

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 1-7;
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  DMPS (2,3-Dimercaptopropane-1-sulfonate, Dimaval) Decreases the Body Burden of Mercury in Humans Exposed to Mercurous Chloride

  Diego Gonzalez-Ramirez, Miguel Zuniga-Charles, Antonio Narro-Juarez, Yolanda Molina-Recio, Katherine M. Hurlbut, Richard C. Dart and H. Vasken Aposhian

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 8-12;
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  Exposure to Ochratoxin A Impairs Organic Anion Transport in Proximal-Tubule-Derived Opossum Kidney Cells

  Christoph Sauvant, Stefan Silbernagl and Michael Gekle

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 13-20;
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  Metabolic and Cardiovascular Effects of the Adenosine A₁ Receptor Agonist N⁶-(p-Sulfophenyl)Adenosine in Diabetic Zucker Rats: Influence of the Disease on the Selectivity of Action

  E. A. van Schaick, K. P. Zuideveld, H. E. Tukker, M. W. E. Langemeijer, A. P. Ijzerman and M. Danhof

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 21-30;
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  Excretion of Ofloxacin into Saliva in Rats with Renal Failure

  Guohua Ding, Kohji Naora, Sadao Nagasako, Hidenari Hirano and Kikuo Iwamoto

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 31-36;
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  Transport of Temocaprilat into Rat Hepatocytes: Role of Organic Anion Transporting Polypeptide ,

  Hitoshi Ishizuka, Kumiko Konno, Hideo Naganuma, Kenji Nishimura, Hirokazu Kouzuki, Hiroshi Suzuki, Bruno Stieger, Peter J. Meier and Yuichi Sugiyama

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 37-42;
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  Sch 50971, an Orally Active Histamine H₃ Receptor Agonist, Inhibits Central Neurogenic Vascular Inflammation and Produces Sedation in the Guinea Pig

  R. L. McLeod, R. Aslanian, M. del Prado, R. Duffy, R. W. Egan, W. Kreutner, R. McQuade and J. A. Hey

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 43-50;
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  Effects of Acute and Repeated Administration of Amisulpride, a Dopamine D₂/D₃ Receptor Antagonist, on the Electrical Activity of Midbrain Dopaminergic Neurons

  Giuseppe Di Giovanni, Michele Di Mascio, Vincenzo Di Matteo and Ennio Esposito

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 51-57;
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  Imidazenil, a Positive Allosteric GABA_A Receptor Modulator, Inhibits the Effects of Cocaine on Locomotor Activity and Extracellular Dopamine in the Nucleus Accumbens Shell Without Tolerance Liability

  Marco Giorgetti, Javaid I. Javaid, John M. Davis, Erminio Costa, Alessandro Guidotti, Sarah B. Appel and Mark S. Brodie

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 58-66;
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  Pharmacokinetics and Biological Actions of Subcutaneously Administered Human Brain Natriuretic Peptide

  L. Edward Clemens, Ramona G. Almirez, Karine A. Baudouin, Ronald P. Mischak, Elliott B. Grossbard and Andrew A. Protter

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 67-71;
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  Corticosterone Facilitates the Acquisition of Cocaine Self-Administration in Rats: Opposite Effects of the Type II Glucocorticoid Receptor Agonist Dexamethasone

  John R. Mantsch, David Saphier and Nick E. Goeders

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 72-80;
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  Antagonism by Class I Antiarrhythmic Drugs of Levcromakalim-Induced Relaxation in Isolated Rat Aorta

  Angel L. Cogolludo, Francisco Perez-Vizcaino and Juan Tamargo

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 81-86;
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  Evidence for a Causative Role of N-Methyl-d-aspartate Receptors in an In Vitro Model of Alcohol Withdrawal Hyperexcitability

  Mark P. Thomas, Daniel T. Monaghan and Richard A. Morrisett

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 87-97;
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  Calcium Source Diversity in Canine Lower Esophageal Sphincter Muscle

  Anne Marie F. Salapatek, Annette Lam and Edwin E. Daniel

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 98-106;
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  The Effects of Methamphetamine on the Production of Free Radicals and Oxidative Stress

  Bryan K. Yamamoto and Wenjun Zhu

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 107-114;
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  Stimulation of Cholesterol Release from Rabbit Foam Cells by the Action of a New Inhibitor for Acyl CoA:Cholesterol Acyltransferase (ACAT), HL-004

  Itsuko Ishii, Noriko Yokoyama, Mamoru Yanagimachi, Naoya Ashikawa, Masayuki Hata, Shigeru Murakami, Yumiko Asami, Nobuhiro Morisaki, Yasushi Saito, Shigeru Ohmori and Mitsukazu Kitada

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 115-121;
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  The Selective Norepinephrine Reuptake Inhibitor, LY368975, Reduces Food Consumption in Animal Models of Feeding

  Donald R. Gehlert, Laura Dreshfield, Frank Tinsley, Mark J. Benvenga, Scott Gleason, Ray W. Fuller, David T. Wong and Susan K. Hemrick-Luecke

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 122-127;
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  Epithelial Ion Transport and Barrier Abnormalities Evoked by Superantigen-Activated Immune Cells Are Inhibited by Interleukin-10 but Not Interleukin-4

  Jun Lu, Dana J. Philpott, Paul R. Saunders, Mary H. Perdue, Ping-Chang Yang and Derek M. McKay

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 128-136;
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  Inflammation Modifies the Role of Cyclooxygenases in the Contractile Responses of the Rat Detrusor Smooth Muscle to Kinin Agonists

  Stefania Meini, Alessandro Lecci, Paola Cucchi, Rose-Marie Catalioto, Marco Criscuoli and Carlo A. Maggi

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 137-143;
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  Central GABA_A and GABA_B Receptor Modulation of Basal and Stress-Induced Plasma Interleukin-6 Levels in Mice

  Dong-Keun Song, Hong-Won Suh, Sung-Oh Huh, Jun-Sub Jung, Bong-Moo Ihn, Ihn-Geun Choi and Yung-Hi Kim

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 144-149;
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  Exogenous Leukotriene B₄ (LTB₄) Inhibits Human Neutrophil Generation of LTB₄ from Endogenous Arachidonic Acid During Opsonized Zymosan Phagocytosis

  Jessica Fiedler, Pat Wheelan, Peter M. Henson and Robert C. Murphy

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 150-156;
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  Novel, Selective Δ6 or Δ5 Fatty Acid Desaturase Inhibitors as Antiinflammatory Agents in Mice

  Mark G. Obukowicz, Dean J. Welsch, William J. Salsgiver, Cynthia L. Martin-Berger, Kevin S. Chinn, Kevin L. Duffin, Amiram Raz and Philip Needleman

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 157-166;
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  S 18126 ({2-[4-(2,3-dihydrobenzo[1,4]dioxin-6-yl)piperazin-1-yl methyl]indan-2-yl}), a Potent, Selective and Competitive Antagonist at Dopamine D₄ Receptors: An In Vitro andIn Vivo Comparison with L 745,870 (3-(4-[4-chlorophenyl]piperazin-1-yl)methyl-1H-pyrrolo[2,3b]pyridine) and Raclopride

  Mark J. Millan, Adrian Newman-Tancredi, Mauricette Brocco, Alain Gobert, Françoise Lejeune, Valérie Audinot, Jean-Michel Rivet, Rudy Schreiber, Anne Dekeyne, Michael Spedding, Jean-Paul Nicolas and Jean-Louis Peglion

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 167-186;
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  A Comparative In Vitro and In VivoPharmacological Characterization of the Novel Dopamine D₃Receptor Antagonists (+)-S 14297, Nafadotride, GR 103,691 and U 99194

  Valérie Audinot, Adrian Newman-Tancredi, Alain Gobert, Jean-Michel Rivet, Mauricette Brocco, Françoise Lejeune, Laurence Gluck, Isabelle Desposte, Karin Bervoets, Anne Dekeyne and Mark J. Millan

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 187-197;
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  Substituted 3β-Phenylethynyl Derivatives of 3α-Hydroxy-5α-pregnan-20-one: Remarkably Potent Neuroactive Steroid Modulators of γ-Aminobutyric Acid_A Receptors

  Jon E. Hawkinson, Manuel Acosta-Burruel, Kevin C. Yang, Derk J. Hogenkamp, Jie-Sheng Chen, Nancy C. Lan, John A. Drewe, Edward R. Whittemore, Richard M. Woodward, Richard B. Carter and Ravindra B. Upasani

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 198-207;
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  Structural Requirements for the Hepatotoxicity of Nonsteroidal Anti-inflammatory Drugs in Isolated Rat Hepatocytes

  Yasuhiro Masubuchi, Haruka Saito and Toshiharu Horie

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 208-213;
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  A Novel Cardiotonic Agent SCH00013 Acts as a Ca⁺⁺Sensitizer with No Chronotropic Activity in Mammalian Cardiac Muscle ,

  Hiromi Sugawara and Masao Endoh

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 214-222;
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  Modulation by Angiotensin II of Isoproterenol-Induced cAMP Production in Preglomerular Microvascular Smooth Muscle Cells from Normotensive and Genetically Hypertensive Rats

  Rupa Mokkapatti, Subhash J. Vyas, Guillermo G. Romero, Zaichuan Mi, Tomoo Inoue, Raghvendra K. Dubey, Delbert G. Gillespie, Amy K. Stout and Edwin K. Jackson

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 223-231;
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  Blockade of N- and P/Q-Type Calcium Channels Reduces the Secondary Heat Hyperalgesia Induced by Acute Inflammation

  K. A. Sluka

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 232-237;
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  Renal Excretory Responses Produced by theDelta Opioid Agonist, BW373U86, in Conscious Rats

  Sena F. Sezen, Velga A. Kenigs and Daniel R. Kapusta

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 238-245;
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  Effects of Ketoconazole on the Intestinal Metabolism, Transport and Oral Bioavailability of K02, a Novel Vinylsulfone Peptidomimetic Cysteine Protease Inhibitor and a P450 3A, P-Glycoprotein Dual Substrate, in Male Sprague-Dawley Rats

  Yuanchao Zhang, Yunsheng Hsieh, Takashi Izumi, Emil T. Lin and Leslie Z. Benet

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 246-252;
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  Characterization of Cembranoid Interaction with the Nicotinic Acetylcholine Receptor

  Richard M. Hann, Oné R. Pagán, Liza Gregory, Tomas Jácome, Abimael D. Rodríguez, P. A. Ferchmin, Ruiliang Lu and Vesna A. Eterovic

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 253-260;
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  Gamma-Hydroxybutyrate is a GABA_B Receptor Agonist that Increases a Potassium Conductance in Rat Ventral Tegmental Dopamine Neurons

  Theresa E. Madden and Steven W. Johnson

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 261-265;
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  F 11440, a Potent, Selective, High Efficacy 5-HT_1AReceptor Agonist with Marked Anxiolytic and Antidepressant Potential

  W. Koek, J.-F. Patoiseau, M.-B. Assié, C. Cosi, M. S. Kleven, E. Dupont-Passelaigue, E. Carilla-Durand, C. Palmier, J.-P. Valentin, G. John, P. J. Pauwels, J.-P. Tarayre and F. C. Colpaert

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 266-283;
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  Contribution of the Opioid System to Alcohol Aversion and Alcohol Drinking Behavior

  J. C. Froehlich, N. E. Badia-Elder, R. W. Zink, D. E. McCullough and P. S. Portoghese

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 284-292;
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  Blockage by Terfenadine of the Adenosine Triphosphate (ATP)-Sensitive K⁺ Current in Rabbit Ventricular Myocytes

  Manabu Nishio, Yoshizumi Habuchi, Hideo Tanaka, Junichiro Morikawa, Taku Yamamoto and Kei Kashima

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 293-300;
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  Effects of Novel Anti-Inflammatory Compounds on Healing of Acetic Acid-Induced Gastric Ulcer in Rats

  C.A. Lesch, R.B. Gilbertsen, Y. Song, R.D. Dyer, D. Schrier, E.R. Kraus, B. Sanchez and A. Guglietta

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 301-306;
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  A Neurotensin Receptor Antagonist Inhibits Acute Immobilization Stress-Induced Cardiac Mast Cell Degranulation, a Corticotropin-Releasing Hormone-Dependent Process

  Xinzhu Pang, Nicholas Alexacos, Richard Letourneau, Dimitri Seretakis, Wei Gao, William Boucher, David E. Cochrane and Theoharis C. Theoharides

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 307-314;
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  The Antiproliferative and Cell Cycle Effects of 5,6,7,8-Tetrahydro-N⁵,N¹⁰-Carbonylfolic Acid, an Inhibitor of Methylenetetrahydrofolate Dehydrogenase, Are Potentiated by Hypoxanthine

  John L. Tonkinson, Lillian L. Habeck, John E. Toth, Laurane G. Mendelsohn, Jesse Bewley, Katherine A. Shackelford, Susan B. Gates, James Ray and Victor J. Chen

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 315-321;
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  Delta Opioid Peptide [d-Ala²,d-leu⁵]Enkephalin Blocks the Long-term Loss of Dopamine Transporters Induced by Multiple Administrations of Methamphetamine: Involvement of Opioid Receptors and Reactive Oxygen Species

  Li-I Tsao, Bruce Ladenheim, Anne M. Andrews, Chuang C. Chiueh, Jean Lud Cadet and Tsung-Ping Su

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 322-331;
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  Differential Effects of S6 Mutations on Binding of Quinidine and 4-Aminopyridine to Rat Isoform of Kv1.4: Common Site but Different Factors in Determining Blockers’ Binding Affinity

  Hailing Zhang, Bing Zhu, Jian-An Yao and Gea-Ny Tseng

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 332-343;
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  Protection from Cadmium Cytotoxicity by N-Acetylcysteine in LLC-PK₁ Cells

  Bambang Wispriyono, Masato Matsuoka, Hideki Igisu and Koji Matsuno

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 344-351;
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  Down-Regulation of the Expression of Three Major Rat Liver Cytochrome P450S by Endotoxin In Vivo Occurs Independently of Nitric Oxide Production

  Marion B. Sewer and Edward T. Morgan

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 352-358;
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  Differential Effect of Ethanol on PC12 Cell Death

  Jan Oberdoerster, Angela R. Kamer and Richard A. Rabin

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 359-365;
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  Pharmacology and Intracellular Signaling Mechanisms of the Native Human Orphan Receptor BRS-3 in Lung Cancer Cells

  Richard R. Ryan, H. Christian Weber, Samuel A. Mantey, Wei Hou, Mary E. Hilburger, Tapas K. Pradhan, David H. Coy and Robert T. Jensen

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 366-380;
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  Microsomal Metabolism of Delavirdine: Evidence for Mechanism-Based Inactivation of Human Cytochrome P450 3A

  Richard L. Voorman, Stephen M. Maio, N. Ann Payne, Zhiyang Zhao, Kenneth A. Koeplinger and Xiaohong Wang

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 381-388;
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  Oxytocin Inhibits the Uptake of Serotonin into Uterine Mast Cells

  María Isolde Rudolph, Claudia Oviedo, Edgardo Vega, Lorena Martínez, Karin Reinicke, María Villar and Leonor Villán

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 389-394;
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  Absorption Enhancement, Structural Changes in Tight Junctions and Cytotoxicity Caused by Palmitoyl Carnitine in Caco-2 and IEC-18 Cells

  Erwin Duizer, Cees Van Der Wulp, Carolien H. M. Versantvoort and John P. Groten

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 395-402;
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  Participation of Nitric Oxide in the Mucosal Injury of Rat Intestine Induced by Ischemia-Reperfusion

  Kohei Takada, Kimihiro Yamashita, Yasuko Sakurai-Yamashita, Kazuto Shigematsu, Yoshinori Hamada, Kohshiro Hioki and Kohtaro Taniyama

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 403-407;
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  Targeted Delivery of Plasmid DNA to Hepatocytes In Vivo: Optimization of the Pharmacokinetics of Plasmid DNA/Galactosylated Poly(l-Lysine) Complexes by Controlling their Physicochemical Properties

  Makiya Nishikawa, Shigeo Takemura, Yoshinobu Takakura and Mitsuru Hashida

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 408-415;
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  Characterization and Purification of the Bovine Adrenal Angiotensin IV Receptor (AT₄) Using [¹²⁵I]Benzoylphenylalanine-Angiotensin IV as a Specific Photolabel

  Jian-Hua Zhang, Jeffery W. Stobb, Jodie M. Hanesworth, Michael F. Sardinia and Joseph W. Harding

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 416-424;
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  Depletion of Protein Kinase C-α by Antisense Oligonucleotides Alters Beta-Adrenergic Function and Reverses the Phorbol Ester-Induced Reduction of Isoproterenol-Induced Adenosine 3′-5′-Cyclic Monophosphate Accumulation in Murine Swiss 3T3 Fibroblasts.

  Luc Levesque and Stanley T. Crooke

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 425-434;
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  Human Vascular Endothelial Cells Express Functional Nicotinic Acetylcholine Receptors

  Kevin D. Macklin, Arno D. J. Maus, Edna F. R. Pereira, Edson X. Albuquerque and Bianca M. Conti-Fine

  Journal of Pharmacology and Experimental Therapeutics October 1998, 287 (1) 435-439;