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Research ArticleArticle

Modifications by Superoxide-Generating Agent, Neurotransmitters and Neuromodulators of Nitroxidergic Nerve Function in Monkey Cerebral Arteries

Tomio Okamura, Hideyuki Fujioka, Kazuhide Ayajiki and Noboru Toda
Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1321-1325;
Tomio Okamura
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Hideyuki Fujioka
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Kazuhide Ayajiki
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Noboru Toda
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Abstract

Isolated monkey cerebral arteries denuded of the endothelium responded to transmural electrical stimulation (5 Hz for 40 sec) with relaxations that are mediated by nitric oxide (NO) synthesized froml-arginine. The relaxant response was slightly inhibited by duroquinone, a superoxide anion-generating agent. The agent markedly inhibited the response after treatment with diethylthiocarbamic acid, an inhibitor of copper/zinc superoxide dismutase. The inhibition was partially reversed by superoxide dismutase. The neurogenic relaxation was reduced by acetylcholine acting on prejunctional muscarinic receptors. Neuropeptide Y, morphine, ATP, clonidine and pituitary adenylate cyclase-activating polypeptide did not change the response to nerve stimulation. Sodium nitroprusside in a dose sufficient to produce relaxation attenuated the neurogenic response. It is concluded that the neurotransmitter liberated from vasodilator nerves in monkey cerebral arteries is free NO rather than a stable analog of NO, like S-nitrosocysteine. Substances other than acetylcholine released as neuromodulators do not seem to regulate the NO-mediated nerve function.

Footnotes

  • Send reprint requests to: Dr. Noboru Toda, Department of Pharmacology, Shiga University of Medical Science, Seta, Ohtsu 520-2192, Japan. E-mail:toda{at}belle.shiga-med.ac.jp

  • ↵1 This work was supported in part by Grant-in-Aid for Scientific Research (B) and (C) from the Ministry of Education, Science, Sports and Culture, Japan.

  • Abbreviations:
    NO
    nitric oxide
    R-SNO
    S-nitrosothiol
    NPY
    neuropeptide Y
    PACAP
    pituitary adenylate cyclase-activating polypeptide
    DQ
    duroquinone
    DETCA
    diethylthiocarbamic acid
    SOD
    superoxide dismutase
    PG
    prostaglandin
    ACh
    acetylcholine
    • Received January 21, 1998.
    • Accepted May 6, 1998.
  • The American Society for Pharmacology and Experimental Therapeutics
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Journal of Pharmacology and Experimental Therapeutics
Vol. 286, Issue 3
1 Sep 1998
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Research ArticleArticle

Modifications by Superoxide-Generating Agent, Neurotransmitters and Neuromodulators of Nitroxidergic Nerve Function in Monkey Cerebral Arteries

Tomio Okamura, Hideyuki Fujioka, Kazuhide Ayajiki and Noboru Toda
Journal of Pharmacology and Experimental Therapeutics September 1, 1998, 286 (3) 1321-1325;

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Research ArticleArticle

Modifications by Superoxide-Generating Agent, Neurotransmitters and Neuromodulators of Nitroxidergic Nerve Function in Monkey Cerebral Arteries

Tomio Okamura, Hideyuki Fujioka, Kazuhide Ayajiki and Noboru Toda
Journal of Pharmacology and Experimental Therapeutics September 1, 1998, 286 (3) 1321-1325;
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