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Research ArticleArticle

Dopamine D2 Receptors Mediate Glomerular Hyperfiltration Due To Amino Acids

Gerd Luippold and Bernd Mühlbauer
Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1248-1252;
Gerd Luippold
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Bernd Mühlbauer
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Abstract

Renal dopamine has been proposed to be involved in the regulation of glomerular filtration rate (GFR). Because inhibition of dopamine D2 receptors abolishes the renal hyperfiltration due to amino acid load, we tested the hypothesis that pharmacological activation of D2-like receptors mimicked this renal response. In anesthetized rats, quinpirole (0.3 μg · 100 g−1 · min−1), an agonist for receptors of the D2-like family, caused an increase in GFR by 20 ± 2%, which corresponded to that provoked by infusion of an 10% amino acid solution. The D2 receptor antagonist S(−)-sulpiride that acts both centrally and peripherally completely abolished the renal hemodynamic response to quinpirole and to amino acids whereas domperidone, a peripherally acting D2receptor antagonist, inhibited this hyperfiltration only in part. Urinary dopamine excretion increased in response to amino acid infusion whether GFR increased or not. We conclude that, in anesthetized rats, dopamine D2 receptors contribute to the amino acid-induced hyperfiltration and that both central and peripheral receptors might be involved, whereas dopamine excreted into the urine does not appear to play a functional role in this renal hemodynamic response.

Footnotes

  • Send reprint requests to: Dr. G. Luippold, Department of Pharmacology, University of Tübingen, Wilhelmstrasse 56, D-72074 Tübingen, Germany.

  • ↵1 This study was supported by grants from the Federal Ministry of Education and Research (BMBF 01EC0405) and by the Deutsche Forschungsgemeinschaft (DFG Mu 1297/1-1). G. L. is a fellow of the Interdisciplinary Clinical Research Center (IKFZ 01KS 9602) Tübingen.

  • Abbreviations:
    AA
    amino acid
    CON
    time controls
    CP
    clearance period
    DOM
    domperidone
    FENa
    fractional urinary sodium excretion
    HR
    heart rate
    Hct
    hematocrit
    L-DOPA
    L-3,4-dihydroxyphenylalanine
    MAP
    mean arterial blood pressure
    NaPlasma
    sodium plasma concentration
    QP
    quinpirole
    SUL
    S(−)-sulpiride
    UNaV
    total urinary sodium excretion
    UV
    urinary flow rate
    UDAV
    urinary dopamine excretion
    VHC
    vehicle controls
    PE
    polyethylene
    • Received January 2, 1998.
    • Accepted May 1, 1998.
  • The American Society for Pharmacology and Experimental Therapeutics
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Journal of Pharmacology and Experimental Therapeutics
Vol. 286, Issue 3
1 Sep 1998
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Research ArticleArticle

Dopamine D2 Receptors Mediate Glomerular Hyperfiltration Due To Amino Acids

Gerd Luippold and Bernd Mühlbauer
Journal of Pharmacology and Experimental Therapeutics September 1, 1998, 286 (3) 1248-1252;

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Research ArticleArticle

Dopamine D2 Receptors Mediate Glomerular Hyperfiltration Due To Amino Acids

Gerd Luippold and Bernd Mühlbauer
Journal of Pharmacology and Experimental Therapeutics September 1, 1998, 286 (3) 1248-1252;
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