Table of Contents

Articles

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  Role of 5-HT₄ Receptors in the Mouse Passive Avoidance Test

  Nicoletta Galeotti, Carla Ghelardini and Alessandro Bartolini

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1115-1121;
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  Inhibition of Cholesterol Biosynthesis in Primary Cultured Rat Hepatocytes by Artichoke (Cynara scolymus L.) Extracts

  Rolf Gebhardt

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1122-1128;
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  Pharmacological Characterization of Human m1 Muscarinic Acetylcholine Receptors with Double Mutations at the Junction of TM VI and the Third Extracellular Domain

  X.-P. Huang, F. E. Williams, S. M. Peseckis and W. S. Messer

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1129-1139;
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  Substance P Induction of Itch-Associated Response Mediated by Cutaneous NK₁ Tachykinin Receptors in Mice

  Tsugunobu Andoh, Tetsuro Nagasawa, Masamichi Satoh and Yasushi Kuraishi

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1140-1145;
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  Evidence against Anandamide as the Hyperpolarizing Factor Mediating the Nitric Oxide-Independent Coronary Vasodilator Effect of Bradykinin in the Rat

  David Fulton and John Quilley

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1146-1151;
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  Concentration-Effect Relationship of l-Propranolol and Metoprolol in Spontaneous Hypertensive Rats after Exercise-Induced Tachycardia

  Lena Brynne, Mats O. Karlsson and Lennart K. Paalzow

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1152-1158;
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  The Role of Dopaminergic Systems in the Perinatal Sensitivity to 3,4-Methylenedioxymethamphetamine-Induced Neurotoxicity in Rats

  Norberto Aguirre, Meritxell Barrionuevo, Berta Lasheras and Joaquín Del Río

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1159-1165;
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  Transport of l-Valine-Acyclovir Via the Oligopeptide Transporter In The Human Intestinal Cell Line, Caco-2

  Remco L. A. de Vrueh, Philip L. Smith and Chao-Pin Lee

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1166-1170;
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  Calcium-Mediated Second Messengers Modulate the Expression of Behavioral Sensitization to Cocaine

  R. C. Pierce, E. A. Quick, D. C. Reeder, Z. R. Morgan and P. W. Kalivas

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1171-1176;
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  Multiple Actions of Methohexital on Hippocampal CA1 and Cortical Neurons of Rat Brain Slices

  Liang Zhang, Yu Zhang and Richard Wennberg

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1177-1182;
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  Chronic Administration of Taurine to Aged Rats Improves the Electrical and Contractile Properties of Skeletal Muscle Fibers

  Sabata Pierno, Annamaria De Luca, Claudia Camerino, Ryan J. Huxtable and Diana Conte Camerino

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1183-1190;
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  CVT-124, a Novel Adenosine A₁ Receptor Antagonist with Unique Diuretic Activity

  Miklos Gellai, George F. Schreiner, Robert R. Ruffolo, Tracey Fletcher, Robin DeWolf and David P. Brooks

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1191-1196;
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  Comparing the Subjective, Psychomotor and Physiological Effects of Intravenous Pentazocine and Morphine in Normal Volunteers

  James P. Zacny, Joanna L. Hill, Matthew L. Black and Parvine Sadeghi

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1197-1207;
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  Hydrogen Peroxide-Induced Stimulation of L-Type Calcium Current in Guinea Pig Ventricular Myocytes and Its Inhibition by Adenosine A1 Receptor Activation

  George P. Thomas, Stephen M. Sims, Michael A. Cook and Morris Karmazyn

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1208-1214;
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  Effect of K_ATP Channel Blocker U37883A on Renal Function in Experimental Diabetes Mellitus in Rats

  Volker Vallon, Margitta Albinus and Doreen Blach

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1215-1221;
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  Inhibitory Effects of Nitric Oxide Donors on Nitric Oxide Synthesis in Rat Gastric Myenteric Plexus

  Kenji Hosoda, Toku Takahashi, Masayuki A. Fujino and Chung Owyang

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1222-1230;
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  Characterization of the Effects of the Partial Dopamine Agonist Terguride on Cocaine Self-Administration in the Rat

  Luigi Pulvirenti, Claudia Balducci, Marla Piercy and George F. Koob

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1231-1238;
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  Full Agonistic Properties of Bay x 3702 on Presynaptic and Postsynaptic 5-HT_1A Receptors Electrophysiological Studies in the Rat Hippocampus and Dorsal Raphe.

  Jianming Dong, Claude de Montigny and Pierre Blier

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1239-1247;
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  Dopamine D₂ Receptors Mediate Glomerular Hyperfiltration Due To Amino Acids

  Gerd Luippold and Bernd Mühlbauer

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1248-1252;
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  Further Characterization of the Expression in Liver and Catalytic Activity of CYP2B6

  Sean Ekins, Mark Vandenbranden, Barbara J. Ring, Jennifer S. Gillespie, Tian J. Yang, Harry V. Gelboin and Steven A. Wrighton

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1253-1259;
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  Effects of N-Methyl-d-Aspartate Receptor Antagonists on Discriminative Stimulus Effects of Naloxone in Morphine-Dependent Rats Using the Y-Maze Drug Discrimination Paradigm ,

  Ivan O. Medvedev, Olga A. Dravolina and Anton Y. Bespalov

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1260-1268;
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  Potentiation and Inhibition of Nicotinic Acetylcholine Receptors by Spermine in the TE671 Human Muscle Cell Line

  Zuoyi Shao, Ian R. Mellor, Matthew J. Brierley, John Harris and Peter N. R. Usherwood

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1269-1276;
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  Antiplatelet Efficacy of XV459, A Novel Nonpeptide Platelet GPIIb/IIIa Antagonist: Comparative Platelet Binding Profiles with c7E3

  Shaker A. Mousa, Jeffrey M. Bozarth, William Lorelli, Mark S. Forsythe, Martin J. M. C. Thoolen, Andrew M. Slee, Thomas M. Reilly and Paul A. Friedman

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1277-1284;
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  Application of Liquid Chromatography/Mass Spectrometry in Accelerating the Identification of Human Liver Cytochrome P450 Isoforms Involved in the Metabolism of Iloperidone

  A. E. Mutlib and J. T. Klein

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1285-1293;
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  A Study on the Metabolism of Etoposide and Possible Interactions with Antitumor or Supporting Agents by Human Liver Microsomes

  Takashi Kawashiro, Kouwa Yamashita, Xue-Jun Zhao, Eriko Koyama, Masayoshi Tani, Kan Chiba and Takashi Ishizaki

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1294-1300;
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  Differential Blockade of the Antinociceptive Effects of Centrally Administered Cannabinoids by SR141716A

  Sandra P. Welch, John W. Huffman and John Lowe

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1301-1308;
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  Vasoregulatory Prostanoid Generation Proceeds Via Cyclooxygenase-2 in Noninflamed Rat Lungs

  L. Ermert, M. Ermert, A. Althoff, M. Merkle, F. Grimminger and W. Seeger

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1309-1314;
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  Role of Vasopressin on Adrenergic Neurotransmission in Human Penile Blood Vessels

  Gloria Segarra, Pascual Medina, Cristina Domenech, José M. Vila, Juan B. Martínez-León, Martín Aldasoro and Salvador Lluch

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1315-1320;
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  Modifications by Superoxide-Generating Agent, Neurotransmitters and Neuromodulators of Nitroxidergic Nerve Function in Monkey Cerebral Arteries

  Tomio Okamura, Hideyuki Fujioka, Kazuhide Ayajiki and Noboru Toda

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1321-1325;
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  Apparent Insensitivity of the Hotplate Latency Test for Detection of Antinociception Following Intraperitoneal, Intravenous or Intracerebroventricular M6G Administration to Rats

  Samantha M. South and Maree T. Smith

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1326-1332;
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  Interaction of 2′,2′-Difluorodeoxycytidine (Gemcitabine) and Formycin B with the Na⁺-Dependent and -Independent Nucleoside Transporters of Ehrlich Ascites Tumor Cells

  Trisha Burke, Stephanie Lee, Peter J. Ferguson and James R. Hammond

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1333-1340;
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  S 16924 ((R)-2-{1-[2-(2,3-Dihydro-Benzo[1,4] Dioxin-5-Yloxy)-Ethyl]-Pyrrolidin-3yl}-1-(4-Fluoro-Phenyl)-Ethanone), a Novel, Potential Antipsychotic with Marked Serotonin (5-HT)_1A Agonist Properties: I. Receptorial and Neurochemical Profile in Comparison with Clozapine and Haloperidol

  Mark J. Millan, Alain Gobert, Adrian Newman-Tancredi, Valérie Audinot, Françoise Lejeune, Jean-Michel Rivet, Didier Cussac, Jean-Paul Nicolas, Olivier Muller and Gilbert Lavielle

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1341-1355;
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  S 16924 ((R)-2-{1-[2-(2,3-Dihydro-Benzo[1,4] Dioxin-5-Yloxy)-Ethyl]-Pyrrolidin-3yl}-1-(4-Fluoro-Phenyl)-Ethanone), a Novel, Potential Antipsychotic with Marked Serotonin (5-HT)_1A Agonist Properties: II. Functional Profile in Comparison to Clozapine and Haloperidol

  Mark J. Millan, Rudy Schreiber, Anne Dekeyne, Jean-Michel Rivet, Karin Bervoets, Michaelis Mavridis, Claude Sebban, Sophie Maurel-Remy, Adrian Newman-Tancredi, Michael Spedding, Olivier Muller, Gilbert Lavielle and Mauricette Brocco

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1356-1373;
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  Potentiation of CD95L-Induced Apoptosis of Human Malignant Glioma Cells by Topotecan Involves Inhibition of RNA Synthesis but Not Changes in CD95 or CD95L Protein Expression

  Stephan Winter and Michael Weller

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1374-1382;
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  Role of Cyclooxygenase-2 in the Healing of Gastric Ulcers in Rats

  Jun-Ichi Shigeta, Satoru Takahashi and Susumu Okabe

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1383-1390;
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  Hepatic Sinusoidal Membrane Transport of Anionic Drugs Mediated by Anion Transporter Npt1

  Hikaru Yabuuchi, Ikumi Tamai, Kyoko Morita, Tomoko Kouda, Ken-Ichi Miyamoto, Eiji Takeda and Akira Tsuji

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1391-1396;
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  The Effects of Stress on Homeostasis in JCR-LA-cp Rats: The Role of Nitric Oxide

  Juan C. Leza, Eduardo Salas, Grzegorz Sawicki, James C. Russell and Marek W. Radomski

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1397-1403;
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  Purification of Two Rat Hepatic Proteins with A-Esterase Activity Toward Chlorpyrifos-Oxon and Paraoxon

  Amber L. Pond, Howard W. Chambers, Cody P. Coyne and Janice E. Chambers

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1404-1411;
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  Modulation of Epileptiform Activity by Adenosine A1 Receptor-Mediated Mechanisms in the Juvenile Rat Hippocampus

  Virginia Tancredi, Margherita D’Antuono, Astrid Nehlig and Massimo Avoli

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1412-1419;
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  EP₄/EP₂ Receptor-Specific Prostaglandin E₂ Regulation of Interleukin-6 Generation by Human HSB.2 Early T Cells

  Li Zeng, Songzhu An and Edward J. Goetzl

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1420-1426;
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  Protective Effect of Bismuth Nitrate Against Injury to the Bone Marrow by γ-Irradiation in Mice: Possible Involvement of Induction of Metallothionein Synthesis

  Nobuhiko Miura, Masahiko Satoh, Nobumasa Imura and Akira Naganuma

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1427-1430;
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  Dissociation of Angiotensin II-Stimulated Activation of Mitogen-Activated Protein Kinase Kinase from Vascular Contraction

  Stephanie W. Watts, Jennifer A. Florian and Kimberly M. Monroe

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1431-1438;
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  Saquinavir, an HIV Protease Inhibitor, Is Transported by P-Glycoprotein

  Annice E. Kim, Jay M. Dintaman, David S. Waddell and Jeffrey A. Silverman

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1439-1445;
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  M2 Muscarinic Autoreceptors Modulate Acetylcholine Release in the Medial Pontine Reticular Formation

  H. A. Baghdoyan, R. Lydic and M. A. Fleegal

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1446-1452;
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  HMR 1883, a Novel Cardioselective Inhibitor of the ATP-Sensitive Potassium Channel. Part I: Effects on Cardiomyocytes, Coronary Flow and Pancreatic β-Cells

  Heinz Gögelein, Jens Hartung, Heinrich C. Englert and Bernward A. Schölkens

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1453-1464;
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  HMR 1883, a Novel Cardioselective Inhibitor of the ATP-Sensitive Potassium Channel. Part II: Effects on Susceptibility to Ventricular Fibrillation Induced by Myocardial Ischemia in Conscious Dogs

  George E. Billman, Heinrich C. Englert and Bernward A. Schölkens

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1465-1473;
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  Prenatal Exposure to Fluoxetine (Prozac) Produces Site-Specific and Age-Dependent Alterations in Brain Serotonin Transporters in Rat Progeny: Evidence from Autoradiographic Studies

  Theresa M. Cabrera-Vera and George Battaglia

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1474-1481;
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  Serotonin-Mediated Palmitoylation and Depalmitoylation of GAlpha Proteins in Rat Brain Cortical Membranes

  Shubhada Bhamre, Hoau-Yan Wang and Eitan Friedman

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1482-1489;
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  Identification of New Human CYP2C19 Alleles (CYP2C19*6 and CYP2C19*2B) in a Caucasian Poor Metabolizer of Mephenytoin

  Gordon C. Ibeanu, Joyce A. Goldstein, Urs Meyer, Simone Benhamou, Christine Bouchardy, Pierre Dayer, Burhan I. Ghanayem and Joyce Blaisdell

  Journal of Pharmacology and Experimental Therapeutics September 1998, 286 (3) 1490-1495;