Table of Contents

Articles

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  Cotreatment with Racemic Fenfluramine Inhibits the Development of Tolerance to Morphine Analgesia in Rats

  Rosalin H. Arends, Takahiko G. Hayashi, Thomas J. Luger and Danny D. Shen

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 585-592;
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  Protean Effects of a Natural Peptide Agonist of the G Protein-Coupled Secretin Receptor Demonstrated by Receptor Mutagenesis

  Subhas C. Ganguli, Chan-Guk Park, Martin H. Holtmann, Elizabeth M. Hadac, Terry P. Kenakin and Laurence J. Miller

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 593-598;
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  Changes in Functional Expression of Alpha-1 Adrenoceptors in Hindlimb Vascular Bed of Spontaneously Hypertensive Rats and their Effects on Oxygen Consumption

  Ji-Ming Ye and Eric Q. Colquhoun

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 599-606;
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  Alpha-1 Adrenergic Stimulation of Glucose Uptake in Rat White Adipocytes

  G. Faintrenie and A. Géloën

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 607-610;
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  Cardioprotective Effects of the Novel Adenosine A₁/A₂ Receptor Agonist AMP 579 in a Porcine Model of Myocardial Infarction

  G. J. Smits, M. McVey, B. F. Cox, M. H. Perrone and K. L. Clark

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 611-618;
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  Two Domains of the Beta Subunit of Neuronal Nicotinic Acetylcholine Receptors Contribute to the Affinity of Substance P

  Grace A. Stafford, Robert E. Oswald, Antonio Figl, Bruce N. Cohen and Gregory A. Weiland

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 619-626;
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  An NR2B Point Mutation Affecting Haloperidol and CP101,606 Sensitivity of Single Recombinant N-Methyl-d-Aspartate Receptors

  Jessica C. Brimecombe, Michael J. Gallagher, David R. Lynch and Elias Aizenman

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 627-634;
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  Endothelin-1-Induced Alterations in Phenylephrine-Induced Contractile Responses Are Largely Additive in Physiologically Diverse Rabbit Vasculature

  Marjorie Gondré and George J. Christ

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 635-642;
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  Pharmacological Profile of T-0201, a Highly Potent and Orally Active Endothelin Receptor Antagonist

  Tomoko Hoshino, Rikako Yamauchi, Kohei Kikkawa, Hideo Yabana and Sakae Murata

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 643-649;
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  Nonpeptide Endothelin Receptor Antagonists. XI. Pharmacological Characterization of SB 234551, a High-Affinity and Selective Nonpeptide ET_A Receptor Antagonist

  Eliot H. Ohlstein, Ponnal Nambi, Douglas W. P. Hay, Miklos Gellai, David P. Brooks, Juan Luengo, Jia-Ning Xiang and John D. Elliott

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 650-656;
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  Calcitonin Gene-Related Peptide Mediates the Protective Effect of Sensory Nerves in a Model of Colonic Injury

  Max Reinshagen, Günther Flämig, Sabine Ernst, Irmlind Geerling, Helen Wong, John H. Walsh, Viktor E. Eysselein and Guido Adler

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 657-661;
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  Receptor-Mediated Effects of Endothelin on the l-Type Ca⁺⁺ Current in Ventricular Cardiomyocytes

  Elizabeth J. Kelso, J. Paul Spiers, Barbara J. McDermott, C. Norman Scholfield and Bernard Silke

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 662-669;
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  Prevention of Thrombosis and Enhancement of Thrombolysis in Rabbits by SR 121787, a Glycoprotein II/III Antagonist

  P. Hoffmann, A. Bernat, P. Savi and J. M. Herbert

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 670-675;
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  Distinct Characteristics of Transcellular Transport between Nicotine and Tetraethylammonium in LLC-PK₁Cells

  Kenji Takami, Hideyuki Saito, Masahiro Okuda, Mikihisa Takano and Ken-Ichi Inui

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 676-680;
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  Mechanism of Relaxant Effect of Clonidine in Isolated Bovine Tracheal Smooth Muscle

  Masashi Arimitsu, Minori Mitsui-Saito, Koichi Sato, Hiroshi Ozaki, Yoshihisa Koga and Hideaki Karaki

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 681-687;
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  Sensitization to the Rewarding Effects of the Specific Dopamine Uptake Inhibitor GBR12783

  Gwenaelle Le Pen, Dominique Duterte-Boucher and Jean Costentin

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 688-696;
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  Analgesic, Respiratory and Heart Rate Effects of Cannabinoid and Opioid Agonists in Rhesus Monkeys: Antagonist Effects of SR 141716A ,

  Jeffrey A. Vivian, Shiroh Kishioka, Eduardo R. Butelman, Jillian Broadbear, Katherine O. Lee and James H. Woods

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 697-703;
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  Indomethacin Inhibits the Natriuretic Effects of Neuropeptide Y in Anesthetized Rats

  Angela Bischoff, Volker Limmroth and Martin C. Michel

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 704-708;
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  Selectivity of Linopirdine (DuP 996), a Neurotransmitter Release Enhancer, in Blocking Voltage-Dependent and Calcium-Activated Potassium Currents in Hippocampal Neurons

  Michael E. Schnee and Barry S. Brown

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 709-717;
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  Cold Exposure Regulates the Renin-Angiotensin System

  Lisa Cassis, Amy Laughter, Mike Fettinger, Scott Akers, Robert Speth, Gerome Burke, Victoria King and Linda Dwoskin

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 718-726;
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  Blockade of HERG and Kv1.5 by Ketoconazole

  Robert Dumaine, Mary-Louise Roy and Arthur M. Brown

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 727-735;
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  GABAergic Effects on Nucleus Tractus Solitarius Neurons Receiving Gastric Vagal Inputs

  Chun-Su Yuan, Dong Liu and Anoja S. Attele

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 736-741;
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  Holtzman and Harlan Sprague-Dawley Rats: Differences in DRL 72-Sec Performance and 8-Hydroxy-Di-Propylamino Tetralin-Induced Hypothermia

  Mercedes Balcells-Olivero, Michael S. Cousins and Lewis S. Seiden

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 742-752;
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  Identification and Characterization of Muscarinic Receptors Potentiating the Stimulation of Adenylyl Cyclase Activity by Corticotropin-Releasing Hormone in Membranes of Rat Frontal Cortex

  Pierluigi Onali and Maria C. Olianas

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 753-759;
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  Hemodynamic Effects of a Calcium Channel Promoter, BAY y 5959, are Preserved after Chronic Administration in Ischemic Heart Failure in Conscious Dogs

  Geng-Hua Yi, Daniel Burkhoff, Hui Zhang, Shu-Ming Zhu, Donna Zwas and Jie Wang

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 760-766;
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  Oral Administration of l-Arginine Potentiates Allergen-Induced Airway Inflammation and Expression of Interleukin-5 in Mice

  Hirohisa Takano, Heung-Bin Lim, Yuichi Miyabara, Takamichi Ichinose, Toshikazu Yoshikawa and Masaru Sagai

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 767-771;
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  Epoxygenase Metabolites of Arachidonic Acid Affect Electrophysiologic Properties of Rat Tracheal Epithelial Cells¹

  Jorge M. S. Pascual, Andrew McKenzie, James R. Yankaskas, John R. Falck and Darryl C. Zeldin

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 772-779;
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  Role of Intracellular Calcium in Modification ofMu and Delta Opioid Receptor-Mediated Antinociception by Diabetes in Mice

  Masahiro Ohsawa, Hiroshi Nagase and Junzo Kamei

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 780-787;
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  The Antipsychotic Agent Sertindole is a High Affinity Antagonist of the Human Cardiac Potassium Channel HERG

  David Rampe, Michael K. Murawsky, Jessica Grau and Eric W. Lewis

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 788-793;
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  Nucleus Accumbens Dopaminergic Medication of Fixed Interval Schedule-Controlled Behavior and Its Modulation by Low-Level Lead Exposure

  D. A. Cory-Slechta, D. J. O’Mara and B. J. Brockel

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 794-805;
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  Dose-Dependent Effects of Adenosine on Interstitial Fluid Adenosine and Postischemic Function in the Isolated Rat Heart

  Robert D. Lasley and Robert M. Mentzer

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 806-811;
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  Effects of Kappa Opioid Agonists on Cocaine- and Food-Maintained Responding by Rhesus Monkeys

  Nancy K. Mello and S. Stevens Negus

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 812-824;
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  Effects of Chronic Nicotine Treatment on Expression of Diverse Nicotinic Acetylcholine Receptor Subtypes. I. Dose- and Time-Dependent Effects of Nicotine Treatment

  Lei Ke, Cynthia M. Eisenhour, Merouane Bencherif and Ronald J. Lukas

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 825-840;
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  Murine Alpha ₁-Adrenoceptor Subtypes. I. Radioligand Binding Studies

  Ming Yang, Jens Reese, Susanna Cotecchia and Martin C. Michel

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 841-847;
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  Regulation of Tyrosine Hydroxylase Activity by Muscarinic Agonists in Rat Adrenal Medulla

  A. William Tank, Cheryl A. Osterhout and Carol R. Sterling

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 848-854;
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  Adenylyl Cyclase Supersensitivity in Opioid-Withdrawn NG108–15 Hybrid Cells Requires G_s but Is Not Mediated by the G_sα Subunit

  Hermann Ammer and Rüdiger Schulz

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 855-862;
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  Protection against Dynorphin-(1–8) Hydrolysis in Membrane Preparations by the Combination of Amastatin, Captopril and Phosphoramidon

  Toyokazu Hiranuma, Ken Kitamura, Takao Taniguchi, Masayuki Kanai, Yoshiharu Arai, Kayoko Iwao and Tetsuo Oka

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 863-869;
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  Influence of Two Commercial Fibers in the Pharmacokinetics of Ethinylestradiol in Rabbits

  N. Fernández, M. J. Diez, M. T. Terán, J. J. García, A. P. Calle and M. Sierra

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 870-874;
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  Chronic Exposure to Morphine Decreases Physiologically Active Corticosterone in Both Male and Female Rats but by Different Mechanisms

  Bruce Nock, Theodore J. Cicero and Michele Wich

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 875-882;
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  Alterations of Immune Functions in Heroin Addicts and Heroin Withdrawal Subjects

  Piyarat Govitrapong, Tunda Suttitum, Naiphinich Kotchabhakdi and Thongchai Uneklabh

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 883-889;
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  Efflux of Taurocholic Acid Across the Blood-Brain Barrier: Interaction with Cyclic Peptides

  Takeo Kitazawa, Tetsuya Terasaki, Hiroshi Suzuki, Atsuyuki Kakee and Yuichi Sugiyama

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 890-895;
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  Nociceptin (Orphanin FQ): High-Affinity and High-Capacity Binding Site Coupled to Low-Potency Stimulation of Guanylyl-5′-O-(γ-thio)-triphosphate Binding in Rat Brain Membranes

  Erika Albrecht, Nelya N. Samovilova, Stephan Oswald, Ingo Baeger and Hartmut Berger

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 896-902;
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  Partial Recovery of Skeletal Muscle Sodium Channel Properties in Aged Rats Chronically Treated with Growth Hormone or the GH-Secretagogue Hexarelin

  Jean-François Desaphy, Annamaria De Luca, Sabata Pierno, Paola Imbrici and Diana Conte Camerino

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 903-912;
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  5-HT_2C Receptor Agonists: Pharmacological Characteristics and Therapeutic Potential

  J. R. Martin, M. Bös, F. Jenck, J.-L. Moreau, V. Mutel, A. J. Sleight, J. Wichmann, J. S. Andrews, H. H. G. Berendsen, C. L. E. Broekkamp, G. S. F. Ruigt, C. Köhler and A. M. L. van Delft

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 913-924;
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  Pharmacokinetics/Dynamics of 5c8, a Monoclonal Antibody to CD154 (CD40 Ligand) Suppression of an Immune Response in Monkeys

  Jogarao V.S. Gobburu, Christopher Tenhoor, Mark C. Rogge, Donald E. Frazier, David Thomas, Chris Benjamin, Donna M. Hess and William J. Jusko

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 925-930;
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  Rat Natural Killer Cell, T Cell and Macrophage Functions after Intracerebroventricular Injection of SNC 80

  Jason E. Nowak, Ricardo Gomez-Flores, Silvia N. Calderon, Kenner C. Rice and Richard J. Weber

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 931-937;
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  Formation of Reactive Oxygen Species by Pentaerithrityltetranitrate and Glyceryl Trinitrate In Vitro and Development of Nitrate Tolerance

  S. Dikalov, B. Fink, M. Skatchkov, D. Stalleicken and E. Bassenge

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 938-944;
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  Functional Relevance of the Expression of Ligand-Induced Binding Sites in the Response to Platelet GP IIb/IIIa Antagonists In Vivo.

  Natalie P. Murphy, Domenico Pratico and Desmond J. Fitzgerald

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 945-951;
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  Inhibition of Cholinergic Neurotransmission in Guinea Pig Trachea by NS1619, a Putative Activator of Large-Conductance, Calcium-Activated Potassium Channels ,

  Hema J. Patel, Mark A. Giembycz, Joelle E. Keeling, Peter J. Barnes and Maria G. Belvisi

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 952-958;
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  Comparative Pharmacokinetic and Pharmacodynamic Studies of Human Insulin and Analogues in Chronic Diabetic Yucatan Minipigs

  Senshang Lin, Li-Lan H. Chen and Yie W. Chien

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 959-966;
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  In Vivo Chronoamperometric Measures of Extracellular Serotonin Clearance in Rat Dorsal Hippocampus: Contribution of Serotonin and Norepinephrine Transporters

  Lynette C. Daws, Glenn M. Toney, Greg A. Gerhardt and Alan Frazer

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 967-976;
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  Potential Contribution of Endothelin to Renal Abnormalities in Glycerol-Induced Acute Renal Failure in Rats

  Toshikatsu Shimizu, Takayuki Kuroda, Minoru Ikeda, Satoshi Hata and Masafumi Fujimoto

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 977-983;
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  Cellular Localization and Pharmacological Characterization of Functioning Alpha-1 Adrenoceptors by Fluorescent Ligand Binding and Image Analysis Reveals Identical Binding Properties of Clustered and Diffuse Populations of Receptors

  C. J. Daly, C. M. Milligan, G. Milligan, J. F. Mackenzie and J. C. Mcgrath

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 984-990;
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  Felbamate Increases [³H]Glycine Binding in Rat Brain and Sections of Human Postmortem Brain

  R. Tyler McCabe, R. Duane Sofia, Richard T. Layer, Kevin A. Leiner, Richard L. M. Faull, Neelam Narang and James K. Wamsley

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 991-999;
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  Contribution of Opioid Receptors on Primary Afferent Versus Sympathetic Neurons to Peripheral Opioid Analgesia

  Li Zhou, Qin Zhang, Christoph Stein and Michael Schäfer

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1000-1006;
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  Pharmacological characterization of Endomorphin-1 and Endomorphin-2 in Mouse Brain

  Ira E. Goldberg, Grace C. Rossi, Sharon R. Letchworth, John P. Mathis, Jennifer Ryan-Moro, Liza Leventhal, Wendy Su, David Emmel, Elizabeth A. Bolan and Gavril W. Pasternak

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1007-1013;
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  Glycine Accelerates Recovery from Alcohol-Induced Liver Injury

  Ming Yin, Kenichi Ikejima, Gavin E. Arteel, Vitor Seabra, Blair U. Bradford, Hiroshi Kono, Ivan Rusyn and Ronald G. Thurman

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1014-1019;
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  Molecular Characterization of Human Brain N-Acetylated α-Linked Acidic Dipeptidase (NAALADase)

  Ruth Luthi-Carter, Amy K. Barczak, Henry Speno and Joseph T. Coyle

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1020-1025;
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  Characterization of the Role of N-Linked Glycosylation on the Cell Signaling and Expression of the Human Thromboxane A₂Receptor Alpha and BetaIsoforms

  Marie T. Walsh, John F. Foley and B. Therese Kinsella

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1026-1036;
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  Interaction of β-Lactam Antibiotics with H⁺/Peptide Cotransporters in Rat Renal Brush-Border Membranes

  Kazushige Takahashi, Nobuhiko Nakamura, Tomohiro Terada, Tomonobu Okano, Takahiro Futami, Hideyuki Saito and Ken-Ichi Inui

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1037-1042;
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  Contribution of Sodium Taurocholate Co-Transporting Polypeptide to the Uptake of Its Possible Substrates Into Rat Hepatocytes

  Hirokazu Kouzuki, Hiroshi Suzuki, Kousei Ito, Rui Ohashi and Yuichi Sugiyama

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1043-1050;
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  Immunological Characterization of Adenosine A_2AReceptors in Human and Porcine Cardiovascular Tissues

  Ravi B. Marala and S. Jamal Mustafa

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1051-1057;
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  Regulation of cAMP-Dependent Protein Kinase Subunit Expression in CATH.a and SH-SY5Y Cells

  Virginia A. Boundy, Jingshan Chen and Eric J. Nestler

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1058-1065;
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  Rhabdomyosarcoma-Specific Expression of the Herpes Simplex Virus Thymidine Kinase Gene Confers Sensitivity to Ganciclovir

  Christopher L. Morton and Philip M. Potter

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1066-1073;
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  Long-term Effects of Amphetamine Neurotoxicity on Tyrosine Hydroxylase mRNA and Protein in Aged Rats

  John F. Bowyer, Lynn T. Frame, Peter Clausing, Kumi Nagamoto-Combs, Cheryl A. Osterhout, Carol R. Sterling and A. William Tank

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1074-1085;
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  Effects of Nitric Oxide in Cultured Prevertebral Sympathetic Ganglion Neurons

  K. N. Browning, Z. L. Zheng, D. L. Kreulen and R. A. Travagli

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1086-1093;
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  Pharmacology of [³H]Prostaglandin E₁/[³H]Prostaglandin E₂ and [³H]Prostaglandin F_{2 α} Binding to EP₃ and FP Prostaglandin Receptor Binding Sites in Bovine Corpus Luteum: Characterization and Correlation with Functional Data

  N. A. Sharif, S. X. Xu, G. W. Williams, J. Y. Crider, B. W. Griffin and T. L. Davis

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1094-1102;
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  Δ⁹-Tetrahydrocannabinol Induces Apoptosis in Macrophages and Lymphocytes: Involvement of Bcl-2 and Caspase-1

  Weigang Zhu, Herman Friedman and Thomas W. Klein

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1103-1109;
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  Binding of Nonsteroidal Antiinflammatory Drugs to the α-Subunit of the Trifunctional Protein of Long Chain Fatty Acid Oxidation

  Graham S. Baldwin, Vincent J. Murphy, Zhiyu Yang and Takashi Hashimoto

  Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1110-1114;