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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

August 01, 1998; Volume 286,Issue 2

Articles

  • You have access
    Cotreatment with Racemic Fenfluramine Inhibits the Development of Tolerance to Morphine Analgesia in Rats
    Rosalin H. Arends, Takahiko G. Hayashi, Thomas J. Luger and Danny D. Shen
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 585-592;
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    Protean Effects of a Natural Peptide Agonist of the G Protein-Coupled Secretin Receptor Demonstrated by Receptor Mutagenesis
    Subhas C. Ganguli, Chan-Guk Park, Martin H. Holtmann, Elizabeth M. Hadac, Terry P. Kenakin and Laurence J. Miller
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 593-598;
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    Changes in Functional Expression of Alpha-1 Adrenoceptors in Hindlimb Vascular Bed of Spontaneously Hypertensive Rats and their Effects on Oxygen Consumption
    Ji-Ming Ye and Eric Q. Colquhoun
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 599-606;
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    Alpha-1 Adrenergic Stimulation of Glucose Uptake in Rat White Adipocytes
    G. Faintrenie and A. Géloën
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 607-610;
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    Cardioprotective Effects of the Novel Adenosine A1/A2 Receptor Agonist AMP 579 in a Porcine Model of Myocardial Infarction
    G. J. Smits, M. McVey, B. F. Cox, M. H. Perrone and K. L. Clark
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 611-618;
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    Two Domains of the Beta Subunit of Neuronal Nicotinic Acetylcholine Receptors Contribute to the Affinity of Substance P
    Grace A. Stafford, Robert E. Oswald, Antonio Figl, Bruce N. Cohen and Gregory A. Weiland
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 619-626;
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    An NR2B Point Mutation Affecting Haloperidol and CP101,606 Sensitivity of Single Recombinant N-Methyl-d-Aspartate Receptors
    Jessica C. Brimecombe, Michael J. Gallagher, David R. Lynch and Elias Aizenman
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 627-634;
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    Endothelin-1-Induced Alterations in Phenylephrine-Induced Contractile Responses Are Largely Additive in Physiologically Diverse Rabbit Vasculature
    Marjorie Gondré and George J. Christ
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 635-642;
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    Pharmacological Profile of T-0201, a Highly Potent and Orally Active Endothelin Receptor Antagonist
    Tomoko Hoshino, Rikako Yamauchi, Kohei Kikkawa, Hideo Yabana and Sakae Murata
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 643-649;
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    Nonpeptide Endothelin Receptor Antagonists. XI. Pharmacological Characterization of SB 234551, a High-Affinity and Selective Nonpeptide ETA Receptor Antagonist
    Eliot H. Ohlstein, Ponnal Nambi, Douglas W. P. Hay, Miklos Gellai, David P. Brooks, Juan Luengo, Jia-Ning Xiang and John D. Elliott
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 650-656;
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    Calcitonin Gene-Related Peptide Mediates the Protective Effect of Sensory Nerves in a Model of Colonic Injury
    Max Reinshagen, Günther Flämig, Sabine Ernst, Irmlind Geerling, Helen Wong, John H. Walsh, Viktor E. Eysselein and Guido Adler
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 657-661;
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    Receptor-Mediated Effects of Endothelin on the l-Type Ca++ Current in Ventricular Cardiomyocytes
    Elizabeth J. Kelso, J. Paul Spiers, Barbara J. McDermott, C. Norman Scholfield and Bernard Silke
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 662-669;
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    Prevention of Thrombosis and Enhancement of Thrombolysis in Rabbits by SR 121787, a Glycoprotein II/III Antagonist
    P. Hoffmann, A. Bernat, P. Savi and J. M. Herbert
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 670-675;
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    Distinct Characteristics of Transcellular Transport between Nicotine and Tetraethylammonium in LLC-PK1Cells
    Kenji Takami, Hideyuki Saito, Masahiro Okuda, Mikihisa Takano and Ken-Ichi Inui
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 676-680;
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    Mechanism of Relaxant Effect of Clonidine in Isolated Bovine Tracheal Smooth Muscle
    Masashi Arimitsu, Minori Mitsui-Saito, Koichi Sato, Hiroshi Ozaki, Yoshihisa Koga and Hideaki Karaki
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 681-687;
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    Sensitization to the Rewarding Effects of the Specific Dopamine Uptake Inhibitor GBR12783
    Gwenaelle Le Pen, Dominique Duterte-Boucher and Jean Costentin
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 688-696;
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    Analgesic, Respiratory and Heart Rate Effects of Cannabinoid and Opioid Agonists in Rhesus Monkeys: Antagonist Effects of SR 141716A ,
    Jeffrey A. Vivian, Shiroh Kishioka, Eduardo R. Butelman, Jillian Broadbear, Katherine O. Lee and James H. Woods
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 697-703;
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    Indomethacin Inhibits the Natriuretic Effects of Neuropeptide Y in Anesthetized Rats
    Angela Bischoff, Volker Limmroth and Martin C. Michel
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 704-708;
  • You have access
    Selectivity of Linopirdine (DuP 996), a Neurotransmitter Release Enhancer, in Blocking Voltage-Dependent and Calcium-Activated Potassium Currents in Hippocampal Neurons
    Michael E. Schnee and Barry S. Brown
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 709-717;
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    Cold Exposure Regulates the Renin-Angiotensin System
    Lisa Cassis, Amy Laughter, Mike Fettinger, Scott Akers, Robert Speth, Gerome Burke, Victoria King and Linda Dwoskin
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 718-726;
  • You have access
    Blockade of HERG and Kv1.5 by Ketoconazole
    Robert Dumaine, Mary-Louise Roy and Arthur M. Brown
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 727-735;
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    GABAergic Effects on Nucleus Tractus Solitarius Neurons Receiving Gastric Vagal Inputs
    Chun-Su Yuan, Dong Liu and Anoja S. Attele
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 736-741;
  • You have access
    Holtzman and Harlan Sprague-Dawley Rats: Differences in DRL 72-Sec Performance and 8-Hydroxy-Di-Propylamino Tetralin-Induced Hypothermia
    Mercedes Balcells-Olivero, Michael S. Cousins and Lewis S. Seiden
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 742-752;
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    Identification and Characterization of Muscarinic Receptors Potentiating the Stimulation of Adenylyl Cyclase Activity by Corticotropin-Releasing Hormone in Membranes of Rat Frontal Cortex
    Pierluigi Onali and Maria C. Olianas
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 753-759;
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    Hemodynamic Effects of a Calcium Channel Promoter, BAY y 5959, are Preserved after Chronic Administration in Ischemic Heart Failure in Conscious Dogs
    Geng-Hua Yi, Daniel Burkhoff, Hui Zhang, Shu-Ming Zhu, Donna Zwas and Jie Wang
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 760-766;
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    Oral Administration of l-Arginine Potentiates Allergen-Induced Airway Inflammation and Expression of Interleukin-5 in Mice
    Hirohisa Takano, Heung-Bin Lim, Yuichi Miyabara, Takamichi Ichinose, Toshikazu Yoshikawa and Masaru Sagai
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 767-771;
  • You have access
    Epoxygenase Metabolites of Arachidonic Acid Affect Electrophysiologic Properties of Rat Tracheal Epithelial Cells1
    Jorge M. S. Pascual, Andrew McKenzie, James R. Yankaskas, John R. Falck and Darryl C. Zeldin
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 772-779;
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    Role of Intracellular Calcium in Modification ofMu and Delta Opioid Receptor-Mediated Antinociception by Diabetes in Mice
    Masahiro Ohsawa, Hiroshi Nagase and Junzo Kamei
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 780-787;
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    The Antipsychotic Agent Sertindole is a High Affinity Antagonist of the Human Cardiac Potassium Channel HERG
    David Rampe, Michael K. Murawsky, Jessica Grau and Eric W. Lewis
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 788-793;
  • You have access
    Nucleus Accumbens Dopaminergic Medication of Fixed Interval Schedule-Controlled Behavior and Its Modulation by Low-Level Lead Exposure
    D. A. Cory-Slechta, D. J. O’Mara and B. J. Brockel
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 794-805;
  • You have access
    Dose-Dependent Effects of Adenosine on Interstitial Fluid Adenosine and Postischemic Function in the Isolated Rat Heart
    Robert D. Lasley and Robert M. Mentzer
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 806-811;
  • You have access
    Effects of Kappa Opioid Agonists on Cocaine- and Food-Maintained Responding by Rhesus Monkeys
    Nancy K. Mello and S. Stevens Negus
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 812-824;
  • You have access
    Effects of Chronic Nicotine Treatment on Expression of Diverse Nicotinic Acetylcholine Receptor Subtypes. I. Dose- and Time-Dependent Effects of Nicotine Treatment
    Lei Ke, Cynthia M. Eisenhour, Merouane Bencherif and Ronald J. Lukas
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 825-840;
  • You have access
    Murine Alpha 1-Adrenoceptor Subtypes. I. Radioligand Binding Studies
    Ming Yang, Jens Reese, Susanna Cotecchia and Martin C. Michel
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 841-847;
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    Regulation of Tyrosine Hydroxylase Activity by Muscarinic Agonists in Rat Adrenal Medulla
    A. William Tank, Cheryl A. Osterhout and Carol R. Sterling
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 848-854;
  • You have access
    Adenylyl Cyclase Supersensitivity in Opioid-Withdrawn NG108–15 Hybrid Cells Requires Gs but Is Not Mediated by the Gsα Subunit
    Hermann Ammer and Rüdiger Schulz
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 855-862;
  • You have access
    Protection against Dynorphin-(1–8) Hydrolysis in Membrane Preparations by the Combination of Amastatin, Captopril and Phosphoramidon
    Toyokazu Hiranuma, Ken Kitamura, Takao Taniguchi, Masayuki Kanai, Yoshiharu Arai, Kayoko Iwao and Tetsuo Oka
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 863-869;
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    Influence of Two Commercial Fibers in the Pharmacokinetics of Ethinylestradiol in Rabbits
    N. Fernández, M. J. Diez, M. T. Terán, J. J. García, A. P. Calle and M. Sierra
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 870-874;
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    Chronic Exposure to Morphine Decreases Physiologically Active Corticosterone in Both Male and Female Rats but by Different Mechanisms
    Bruce Nock, Theodore J. Cicero and Michele Wich
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 875-882;
  • You have access
    Alterations of Immune Functions in Heroin Addicts and Heroin Withdrawal Subjects
    Piyarat Govitrapong, Tunda Suttitum, Naiphinich Kotchabhakdi and Thongchai Uneklabh
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 883-889;
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    Efflux of Taurocholic Acid Across the Blood-Brain Barrier: Interaction with Cyclic Peptides
    Takeo Kitazawa, Tetsuya Terasaki, Hiroshi Suzuki, Atsuyuki Kakee and Yuichi Sugiyama
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 890-895;
  • You have access
    Nociceptin (Orphanin FQ): High-Affinity and High-Capacity Binding Site Coupled to Low-Potency Stimulation of Guanylyl-5′-O-(γ-thio)-triphosphate Binding in Rat Brain Membranes
    Erika Albrecht, Nelya N. Samovilova, Stephan Oswald, Ingo Baeger and Hartmut Berger
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 896-902;
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    Partial Recovery of Skeletal Muscle Sodium Channel Properties in Aged Rats Chronically Treated with Growth Hormone or the GH-Secretagogue Hexarelin
    Jean-François Desaphy, Annamaria De Luca, Sabata Pierno, Paola Imbrici and Diana Conte Camerino
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 903-912;
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    5-HT2C Receptor Agonists: Pharmacological Characteristics and Therapeutic Potential
    J. R. Martin, M. Bös, F. Jenck, J.-L. Moreau, V. Mutel, A. J. Sleight, J. Wichmann, J. S. Andrews, H. H. G. Berendsen, C. L. E. Broekkamp, G. S. F. Ruigt, C. Köhler and A. M. L. van Delft
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 913-924;
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    Pharmacokinetics/Dynamics of 5c8, a Monoclonal Antibody to CD154 (CD40 Ligand) Suppression of an Immune Response in Monkeys
    Jogarao V.S. Gobburu, Christopher Tenhoor, Mark C. Rogge, Donald E. Frazier, David Thomas, Chris Benjamin, Donna M. Hess and William J. Jusko
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 925-930;
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    Rat Natural Killer Cell, T Cell and Macrophage Functions after Intracerebroventricular Injection of SNC 80
    Jason E. Nowak, Ricardo Gomez-Flores, Silvia N. Calderon, Kenner C. Rice and Richard J. Weber
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 931-937;
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    Formation of Reactive Oxygen Species by Pentaerithrityltetranitrate and Glyceryl Trinitrate In Vitro and Development of Nitrate Tolerance
    S. Dikalov, B. Fink, M. Skatchkov, D. Stalleicken and E. Bassenge
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 938-944;
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    Functional Relevance of the Expression of Ligand-Induced Binding Sites in the Response to Platelet GP IIb/IIIa Antagonists In Vivo.
    Natalie P. Murphy, Domenico Pratico and Desmond J. Fitzgerald
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 945-951;
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    Inhibition of Cholinergic Neurotransmission in Guinea Pig Trachea by NS1619, a Putative Activator of Large-Conductance, Calcium-Activated Potassium Channels ,
    Hema J. Patel, Mark A. Giembycz, Joelle E. Keeling, Peter J. Barnes and Maria G. Belvisi
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 952-958;
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    Comparative Pharmacokinetic and Pharmacodynamic Studies of Human Insulin and Analogues in Chronic Diabetic Yucatan Minipigs
    Senshang Lin, Li-Lan H. Chen and Yie W. Chien
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 959-966;
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    In Vivo Chronoamperometric Measures of Extracellular Serotonin Clearance in Rat Dorsal Hippocampus: Contribution of Serotonin and Norepinephrine Transporters
    Lynette C. Daws, Glenn M. Toney, Greg A. Gerhardt and Alan Frazer
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 967-976;
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    Potential Contribution of Endothelin to Renal Abnormalities in Glycerol-Induced Acute Renal Failure in Rats
    Toshikatsu Shimizu, Takayuki Kuroda, Minoru Ikeda, Satoshi Hata and Masafumi Fujimoto
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 977-983;
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    Cellular Localization and Pharmacological Characterization of Functioning Alpha-1 Adrenoceptors by Fluorescent Ligand Binding and Image Analysis Reveals Identical Binding Properties of Clustered and Diffuse Populations of Receptors
    C. J. Daly, C. M. Milligan, G. Milligan, J. F. Mackenzie and J. C. Mcgrath
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 984-990;
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    Felbamate Increases [3H]Glycine Binding in Rat Brain and Sections of Human Postmortem Brain
    R. Tyler McCabe, R. Duane Sofia, Richard T. Layer, Kevin A. Leiner, Richard L. M. Faull, Neelam Narang and James K. Wamsley
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 991-999;
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    Contribution of Opioid Receptors on Primary Afferent Versus Sympathetic Neurons to Peripheral Opioid Analgesia
    Li Zhou, Qin Zhang, Christoph Stein and Michael Schäfer
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1000-1006;
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    Pharmacological characterization of Endomorphin-1 and Endomorphin-2 in Mouse Brain
    Ira E. Goldberg, Grace C. Rossi, Sharon R. Letchworth, John P. Mathis, Jennifer Ryan-Moro, Liza Leventhal, Wendy Su, David Emmel, Elizabeth A. Bolan and Gavril W. Pasternak
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1007-1013;
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    Glycine Accelerates Recovery from Alcohol-Induced Liver Injury
    Ming Yin, Kenichi Ikejima, Gavin E. Arteel, Vitor Seabra, Blair U. Bradford, Hiroshi Kono, Ivan Rusyn and Ronald G. Thurman
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1014-1019;
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    Molecular Characterization of Human Brain N-Acetylated α-Linked Acidic Dipeptidase (NAALADase)
    Ruth Luthi-Carter, Amy K. Barczak, Henry Speno and Joseph T. Coyle
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1020-1025;
  • You have access
    Characterization of the Role of N-Linked Glycosylation on the Cell Signaling and Expression of the Human Thromboxane A2Receptor Alpha and BetaIsoforms
    Marie T. Walsh, John F. Foley and B. Therese Kinsella
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1026-1036;
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    Interaction of β-Lactam Antibiotics with H+/Peptide Cotransporters in Rat Renal Brush-Border Membranes
    Kazushige Takahashi, Nobuhiko Nakamura, Tomohiro Terada, Tomonobu Okano, Takahiro Futami, Hideyuki Saito and Ken-Ichi Inui
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1037-1042;
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    Contribution of Sodium Taurocholate Co-Transporting Polypeptide to the Uptake of Its Possible Substrates Into Rat Hepatocytes
    Hirokazu Kouzuki, Hiroshi Suzuki, Kousei Ito, Rui Ohashi and Yuichi Sugiyama
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1043-1050;
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    Immunological Characterization of Adenosine A2AReceptors in Human and Porcine Cardiovascular Tissues
    Ravi B. Marala and S. Jamal Mustafa
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1051-1057;
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    Regulation of cAMP-Dependent Protein Kinase Subunit Expression in CATH.a and SH-SY5Y Cells
    Virginia A. Boundy, Jingshan Chen and Eric J. Nestler
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1058-1065;
  • You have access
    Rhabdomyosarcoma-Specific Expression of the Herpes Simplex Virus Thymidine Kinase Gene Confers Sensitivity to Ganciclovir
    Christopher L. Morton and Philip M. Potter
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1066-1073;
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    Long-term Effects of Amphetamine Neurotoxicity on Tyrosine Hydroxylase mRNA and Protein in Aged Rats
    John F. Bowyer, Lynn T. Frame, Peter Clausing, Kumi Nagamoto-Combs, Cheryl A. Osterhout, Carol R. Sterling and A. William Tank
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1074-1085;
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    Effects of Nitric Oxide in Cultured Prevertebral Sympathetic Ganglion Neurons
    K. N. Browning, Z. L. Zheng, D. L. Kreulen and R. A. Travagli
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1086-1093;
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    Pharmacology of [3H]Prostaglandin E1/[3H]Prostaglandin E2 and [3H]Prostaglandin F2 α Binding to EP3 and FP Prostaglandin Receptor Binding Sites in Bovine Corpus Luteum: Characterization and Correlation with Functional Data
    N. A. Sharif, S. X. Xu, G. W. Williams, J. Y. Crider, B. W. Griffin and T. L. Davis
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1094-1102;
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    Δ9-Tetrahydrocannabinol Induces Apoptosis in Macrophages and Lymphocytes: Involvement of Bcl-2 and Caspase-1
    Weigang Zhu, Herman Friedman and Thomas W. Klein
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1103-1109;
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    Binding of Nonsteroidal Antiinflammatory Drugs to the α-Subunit of the Trifunctional Protein of Long Chain Fatty Acid Oxidation
    Graham S. Baldwin, Vincent J. Murphy, Zhiyu Yang and Takashi Hashimoto
    Journal of Pharmacology and Experimental Therapeutics August 1998, 286 (2) 1110-1114;
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Journal of Pharmacology and Experimental Therapeutics
Vol. 286, Issue 2
1 Aug 1998
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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