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OtherANALGESIA AND DRUGS OF ABUSE

S-(+)-3-Isobutylgaba and Its Stereoisomer Reduces the Amount of Inflammation and Hyperalgesia in an Acute Arthritis Model in the Rat

Andrea K. Houghton, Ying Lu and Karin N. Westlund
Journal of Pharmacology and Experimental Therapeutics May 1998, 285 (2) 533-538;
Andrea K. Houghton
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Ying Lu
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Karin N. Westlund
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Abstract

The present study investigated whether spinal administration ofS-(+)-3-isobutylgaba (S-(+)-3-IBG) or its stereoisomer, R-(−)-3-isobutylgaba (R-(−)-3-IBG), are effective in reducing the hyperalgesia and swelling observed after injection of kaolin and carrageenan into the knee joint of the rat. The effects of pretreatment and post-treatment of S-(+)-3-IBG,R-(−)-3-IBG and artificial cerebrospinal fluid (aCSF) on the swelling, pain-related behavior scores and the heat hyperalgesia induced by knee joint inflammation were compared. Infusion of eitherS-(+)-3-IBG or R-(−)-3-IBG through a microdialysis fiber, implanted in the dorsal horn of the spinal cord, for 1.5 h before injection of kaolin and carrageenan resulted in a 20 to 30% reduction in joint swelling compared with aCSF-treated controls, and prevented the development of heat hyperalgesia and spontaneous pain. In contrast, infusion of either stereoisomer after the development of inflammation reduced the hyperalgesia but did not reduce the amount of joint swelling compared with aCSF-treated animals. In summary, S-(+)-3-IBG and R-(−)-3-IBG are effective antihyperalgesic agents when administered both before and after joint inflammation. In addition, if administered before injection of kaolin and carrageenan into the knee joint this drug can attenuate joint inflammation. Both the antihyperalgesic and anti-inflammatory properties of this drug probably are mediated through a central neurogenic mechanism.

Footnotes

  • Send reprint requests to: Karin N. Westlund High, Department of Anatomy and Neurosciences, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-1069.

  • ↵1 This work was supported by National Institutes of Health grant NS 32778.

  • Abbreviations:
    PWL
    paw withdrawal latency
    S-(+)-3-IBG
    S-(+)-3-isobutylgaba
    R-(−)-3-IBG
    R-(−)-3-isobutylgaba
    S.E.M.
    standard error of the mean
    aCSF
    artificial cerebrospinal fluid
    DRR
    dorsal root reflex
    NMDA
    N-methyl-d-aspartate
    GABA
    γ-aminobutyric acid
    • Received June 4, 1997.
    • Accepted January 20, 1998.
  • The American Society for Pharmacology and Experimental Therapeutics
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Journal of Pharmacology and Experimental Therapeutics
Vol. 285, Issue 2
1 May 1998
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OtherANALGESIA AND DRUGS OF ABUSE

S-(+)-3-Isobutylgaba and Its Stereoisomer Reduces the Amount of Inflammation and Hyperalgesia in an Acute Arthritis Model in the Rat

Andrea K. Houghton, Ying Lu and Karin N. Westlund
Journal of Pharmacology and Experimental Therapeutics May 1, 1998, 285 (2) 533-538;

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OtherANALGESIA AND DRUGS OF ABUSE

S-(+)-3-Isobutylgaba and Its Stereoisomer Reduces the Amount of Inflammation and Hyperalgesia in an Acute Arthritis Model in the Rat

Andrea K. Houghton, Ying Lu and Karin N. Westlund
Journal of Pharmacology and Experimental Therapeutics May 1, 1998, 285 (2) 533-538;
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