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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

April 01, 1998; Volume 285,Issue 1

ANALGESIA AND DRUGS OF ABUSE

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    Agonist-Induced Desensitization and Down-regulation of the HumanKappa Opioid Receptor Expressed in Chinese Hamster Ovary Cells
    Jinmin Zhu, Lai-Yi Luo, Guan-Fen Mao, Barrie Ashby and Lee-Yuan Liu-Chen
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 28-36;
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    Is the Reduced Efficacy of Morphine in Diabetic Rats Caused by Alterations of Opiate Receptors or of Morphine Pharmacokinetics?
    C. Courteix, P. Bourget, F. Caussade, M. Bardin, F. Coudore, J. Fialip and A. Eschalier
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 63-70;
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    Intravenous and Oral l-α-Acetylmethadol: Pharmacodynamics and Pharmacokinetics in Humans
    Sharon L. Walsh, Rolley E. Johnson, Edward J. Cone and George E. Bigelow
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 71-82;
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    Dopamine Receptor Antagonists in the Nucleus Accumbens Attenuate Analgesia Induced by Ventral Tegmental Area Substance P or Morphine and by Nucleus Accumbens Amphetamine
    Nadège Altier and Jane Stewart
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 208-215;
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    Comparative Receptor Binding Analyses of Cannabinoid Agonists and Antagonists
    Brian F. Thomas, Anne F. Gilliam, David F. Burch, Michael J. Roche and Herbert H. Seltzman
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 285-292;

AUTONOMIC PHARMACOLOGY

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    Role of Spinal Glutamatergic Transmission in the Ascending Limb of the Micturition Reflex Pathway in the Rat
    Hidehiro Kakizaki, Mitsuharu Yoshiyama, James R. Roppolo, August M. Booth and William C. De Groat
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 22-27;
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    Age-Related Decline in Beta Adrenergic and Adenosine A1 Receptor Function in the Heart Are Attenuated by Dietary Restriction
    Erhe Gao, David L. Snyder, Jay Roberts, Eitan Friedman, Guoping Cai, Amir Pelleg and Joel Horwitz
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 186-192;
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    Carrier-Mediated Transport of NG-Nitro-l-Arginine, a Nitric Oxide Synthase Inhibitor, in the Pigmented Rabbit Conjunctiva
    Ken-Ichi Hosoya, Yoshihide Horibe, Kwang-Jin Kim and Vincent H. L. Lee
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 223-227;
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    Effects of Bis(2-chloroethyl)sulfide on ATP Receptor-Mediated Responses of the Rat Vas Deferens: Possible Relationship to Cytotoxicity
    Paul M. Lundy, Thomas W. Sawyer, Brian T. H and and Robert Frew
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 299-306;

BEHAVIORAL PHARMACOLOGY

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    Zolpidem Physical Dependence Assessed Across Increasing Doses Under a Once-Daily Dosing Regimen in Baboons
    Elise M. Weerts, Nancy A. Ator, Doreen M. Grech and Roland R. Griffiths
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 41-53;

CARDIOVASCULAR PHARMACOLOGY

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    RSR13, a Synthetic Modifier of Hemoglobin-Oxygen Affinity, Enhances the Recovery of Stunned Myocardium in Anesthetized Dogs
    Paul S. Pagel, Douglas A. Hettrick, Matthew W. Montgomery, Judy R. Kersten, Robert P. Steffen and David C. Warltier
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 1-8;
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    Cardiovascular Pharmacology of the A2A Adenosine Receptor Antagonist, SCH 58261, in the Rat
    Angela Monopoli, Carlo Casati, Gianluca Lozza, Angelo Forlani and Ennio Ongini
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 9-15;
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    Nitric Oxide Selectively Inhibits Intracellular Ca++Release Elicited by Inositol Trisphosphate but not Caffeine in Rat Vascular Smooth Muscle
    Junzhi Ji, Christina G. Benishin and Peter K. T. Pang
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 16-21;
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    PST2238: A New Antihypertensive Compound That Antagonizes the Long-Term Pressor Effect of Ouabain
    P. Ferrari, L. Torielli, M. Ferrandi, G. Padoani, L. Duzzi, M. Florio, F. Conti, P. Melloni, L. Vesci, N. Corsico and G. Bianchi
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 83-94;
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    Differential Atrial versus Ventricular Activities of Class III Potassium Channel Blockers
    Elizabeth P. Baskin and Joseph J. Lynch
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 135-142;
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    Cotransfection of Second and Third Intracellular Loop Fragments Inhibit Angiotensin AT1a Receptor Activation of Phospholipase C in HEK-293 Cells
    Joseph B. Thompson, Susan M. Wade, Jeffrey K. Harrison, Mina N. Salafranca and Richard R. Neubig
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 216-222;
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    The Effects of Barium, Dofetilide and 4-Aminopyridine (4-AP) on Ventricular Repolarization in Normal and Hypertrophied Rabbit Heart
    Anne M. Gillis, Radzfel A. Geonzon, Heather J. Mathison, Ela Kulisz, Wanda M. Lester and Henry J. Duff
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 262-270;
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    Calcium-Activated Potassium Channels and Nitrate-Induced Vasodilation in Human Coronary Arteries
    Rostislav Bychkov, Maik Gollasch, Tobias Steinke, Christian Ried, Friedrich C. Luft and Hermann Haller
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 293-298;

CELLULAR AND MOLECULAR PHARMACOLOGY

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    Glutamate Receptor-Mediated Hyperexcitability after Ethanol Exposure in Isolated Neonatal Rat Spinal Cord
    Shirley M. E. Wong, David L. Tauck, Eileen G. Fong and Joan J. Kendig
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 201-207;
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    Binding of [3H]-SK&F 107260 and [3H]-SB 214857 to Purified Integrin αIIbβ3: Evidence for a Common Binding Site for Cyclic Arginyl-Glycinyl-Aspartic Acid Peptides and Nonpeptides
    Angela Wong, Shing Mei Hwang, Kyung Johanson, James Samanen, Donald Bennett, Scott W. Landvatter, Wenting Chen, J. Richard Heys, Fadia E. Ali, Thomas W. Ku, William Bondinell, Andrew J. Nichols, David A. Powers and Jeffrey M. Stadel
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 228-235;
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    Increases in Acetylcholine Release Produced by Phorbol Esters Are Not Mediated by Protein Kinase C at Motor Nerve Endings
    T. J. Searl and E. M. Silinsky
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 247-251;
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    Tyramine and Vanadate Synergistically Stimulate Glucose Transport in Rat Adipocytes by Amine Oxidase-Dependent Generation of Hydrogen Peroxide
    Luc Marti, Nathalie Morin, Gemma Enrique-Tarancon, Danielle Prevot, Max Lafontan, Xavier Testar, Antonio Zorzano and Christian Carpéné
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 342-349;
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    Pharmacological Characterization of the Human Ionotropic Glutamate Receptor Subtype GluR3 Stably Expressed in Mammalian Cells
    M. A. Varney, S. P. Rao, C. Jachec, C. Deal, S. D. Hess, L. P. Daggett, F.-F. Lin, E. C. Johnson and G. Veliçelebi
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 358-370;
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    Differential Agonist Inhibition Identifies Multiple Epibatidine Binding Sites in Mouse Brain
    Michael J. Marks, Kimberly W. Smith and Allan C. Collins
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 377-386;

CHEMOTHERAPY/GENE THERAPY

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    Chronopharmacology of Granulocyte Colony-Stimulating Factor in Mice
    Shigehiro Ohdo, Naoko Arata, Taku Furukubo, Eiji Yukawa, Shun Higuchi, Shigeyuki Nakano and Nobuya Ogawa
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 242-246;

DEVELOPMENTAL PHARMACOLOGY

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    In Vivo Maternal-Fetal-Amniotic Fluid Pharmacokinetics of Zidovudine in the Pigtailed Macaque: Comparison of Steady-State and Single-Dose Regimens
    Tove Tuntland, Aleksandrs Odinecs, Connie Nosbisch and Jashvant D. Unadkat
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 54-62;

DRUG METABOLISM AND DISPOSITION

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    Novel Somatostatin Analogs for the Treatment of Acromegaly and Cancer Exhibit Improved In Vivo Stability and Distribution
    T. J. Gillespie, A. Erenberg, S. Kim, J. Dong, J. E. Taylor, V. Hau and T. P. Davis
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 95-104;
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    Oncostatin M Down-regulates Basal and Induced Cytochromes P450 in Human Hepatocytes
    M. Isabel Guillén, M. Teresa Donato, Ramiro Jover, JoséV. Castell, R. Fabra, R. Trullenque and M. José Gómez-Lechón
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 127-134;

GASTROINTESTINAL PHARMACOLOGY

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    Dose-Related Effects of N-Demethyl-N-Isopropyl-8,9-anhydroerythromycin A 6,9-hemiacetal on Gastric Emptying of Solids in Healthy Human Volunteers
    Myung-Gyu Choi, Michael Camilleri, Duane D. Burton, Steven Johnson and Anthony Edmonds
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 37-40;
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    Characterization of I2 Imidazoline and ς Binding Sites in the Rat and Human Stomach
    Gerhard J. Molderings, Kurt Donecker, Maria Burian, W. Alexander Simon, Detlev W. Schröder and Manfred Göthert
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 170-177;
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    Parallel Contractile Signal Transduction Pathways Activated by Receptors for Thrombin and Epidermal Growth Factor-Urogastrone in Guinea Pig Gastric Smooth Muscle: Blockade by Inhibitors of Mitogen-Activated Protein Kinase-Kinase and Phosphatidyl Inositol 3′-Kinase
    Xi-Long Zheng, Bernard Renaux and Morley D. Hollenberg
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 325-334;

IMMUNOPHARMACOLOGY

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    Thapsigargin-Induced Secretion Is Dependent on Activation of a Cholera Toxin-Sensitive and Phosphatidylinositol-3-kinase-Regulated Phospholipase D in a Mast Cell Line
    David S. Cissel, Paul F. Fraundorfer and Michael A. Beaven
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 110-118;
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    Diaminic Carbonates, a New Class of Anti-inflammatory Compounds: Their Biological Characterization and Mode of Action
    Giuliana Porro, Giorgio Bertolini, M. Antonietta Bonardi, Elena Giovanetti, Paola Lento, Flavio Leoni, Daniela Modena, Gianfranco Pavich and Fabrizio Marcucci
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 193-200;

NEUROPHARMACOLOGY

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    Effect of Protein Kinase C Activation on N-Methyl-d-Aspartate-Evoked Release of Adenosine and [3H]Norepinephrine from Rat Cortical Slices
    Yushan Wang and Thomas D. White
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 105-109;
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    Agonist and Inverse Agonist Activity at the Dopamine D3 Receptor Measured by Guanosine 5′-[γ-Thio]Triphosphate-[35S] Binding
    Åsa Malmberg, Åsa Mikaels and Nina Mohell
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 119-126;
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    The Pharmacology of Mesocortical Dopamine Neurons: A Dual-Probe Microdialysis Study in the Ventral Tegmental Area and Prefrontal Cortex of the Rat Brain
    B.H.C. Westerink, P. Enrico, J. Feimann and J.B. De Vries
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 143-154;
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    Role of Glutamate Receptors and Voltage-Dependent Calcium and Sodium Channels in the Extracellular Glutamate/Aspartate Accumulation and Subsequent Neuronal Injury Induced by Oxygen/Glucose Deprivation in Cultured Hippocampal Neurons
    Manami Kimura, Kohei Sawada, Takehiko Miyagawa, Manabu Kuwada, Kouichi Katayama and Yukio Nishizawa
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 178-185;
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    Effects of Ketoconazole on Triazolam Pharmacokinetics, Pharmacodynamics and Benzodiazepine Receptor Binding in Mice
    Jeanne M. Fahey, Gary A. Pritchard, Lisa L. von Moltke, John S. Pratt, Jeffrey M. Grassi, Richard I. Shader and David J. Greenblatt
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 271-276;
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    Alterations in Locomotor Activity during Chronic Cocaine Administration: Effect on Dopamine Receptors and Interaction with Opioids
    Paul M. Kunko, Dawn French and Sari Izenwasser
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 277-284;
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    Sodium Valproate Down-regulates the Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) in Immortalized Hippocampal Cells: A Property of Protein Kinase C-Mediated Mood Stabilizers
    David G. Watson, Jeannette M. Watterson and Robert H. Lenox
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 307-316;
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    Dopaminergic Regulation of Extracellular γ-Aminobutyric Acid Levels in the Prefrontal Cortex of the Rat
    A. Chistina Grobin and Ariel Y. Deutch
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 350-357;
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    Quantitative Autoradiography of Halothane Binding in Rat Brain
    Maryellen Fazen Eckenhoff and Roderic G. Eckenhoff
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 371-376;

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

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    The Effects of Ethanol and Acetaldehyde on the Metabolism of Prostaglandin E2 and Leukotriene B4 in Isolated Rat Hepatocytes
    Joseph A. Hankin, Carl E. Clay and Robert C. Murphy
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 155-161;
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    Characterization of Human Neutrophil and Endothelial Cell Ligand-Operated Extracellular Acidification Rate by Microphysiometry: Impact of Reoxygenation
    Karsten Gronert, Sean P. Colgan and Charles N. Serhan
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 252-261;

RENAL PHARMACOLOGY

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    Na-Dependent Transport ofS-(1,2-Dichlorovinyl)-l-Cysteine by Renal Brush-Border Membrane Vesicles
    Stephen H. Wright, Theresa M. Wunz, J. North and James L. Stevens
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 162-169;
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    Strain Difference in Sensitivity of Mice to Renal Toxicity of Inorganic Mercury
    Toshiko Tanaka-Kagawa, Mieko Suzuki, Akira Naganuma, Nobuaki Yamanaka and Nobumasa Imura
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 335-341;

TOXICOLOGY

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    Cyanide-Induced Generation of Oxidative Species: Involvement of Nitric Oxide Synthase and Cyclooxygenase-2
    P. G. Gunasekar, J. L. Borowitz and G. E. Isom
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 236-241;
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    Tumor Necrosis Factor-α as a Contributor in Fumonisin B1 Toxicity
    Raviprakash R. Dugyala, Raghubir P. Sharma, Masashi Tsunoda and Ronald T. Riley
    Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 317-324;
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Journal of Pharmacology and Experimental Therapeutics
Vol. 285, Issue 1
1 Apr 1998
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  • ANALGESIA AND DRUGS OF ABUSE
  • AUTONOMIC PHARMACOLOGY
  • BEHAVIORAL PHARMACOLOGY
  • CARDIOVASCULAR PHARMACOLOGY
  • CELLULAR AND MOLECULAR PHARMACOLOGY
  • CHEMOTHERAPY/GENE THERAPY
  • DEVELOPMENTAL PHARMACOLOGY
  • DRUG METABOLISM AND DISPOSITION
  • GASTROINTESTINAL PHARMACOLOGY
  • IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS
  • RENAL PHARMACOLOGY
  • TOXICOLOGY
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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