Journal of Pharmacology and Experimental Therapeutics: 285 (1)

April 01, 1998; Volume 285,Issue 1

ANALGESIA AND DRUGS OF ABUSE

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Agonist-Induced Desensitization and Down-regulation of the HumanKappa Opioid Receptor Expressed in Chinese Hamster Ovary Cells
Jinmin Zhu, Lai-Yi Luo, Guan-Fen Mao, Barrie Ashby and Lee-Yuan Liu-Chen

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 28-36;
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Is the Reduced Efficacy of Morphine in Diabetic Rats Caused by Alterations of Opiate Receptors or of Morphine Pharmacokinetics?
C. Courteix, P. Bourget, F. Caussade, M. Bardin, F. Coudore, J. Fialip and A. Eschalier

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 63-70;
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Intravenous and Oral l-α-Acetylmethadol: Pharmacodynamics and Pharmacokinetics in Humans
Sharon L. Walsh, Rolley E. Johnson, Edward J. Cone and George E. Bigelow

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 71-82;
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Dopamine Receptor Antagonists in the Nucleus Accumbens Attenuate Analgesia Induced by Ventral Tegmental Area Substance P or Morphine and by Nucleus Accumbens Amphetamine
Nadège Altier and Jane Stewart

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 208-215;
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Comparative Receptor Binding Analyses of Cannabinoid Agonists and Antagonists
Brian F. Thomas, Anne F. Gilliam, David F. Burch, Michael J. Roche and Herbert H. Seltzman

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 285-292;

AUTONOMIC PHARMACOLOGY

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Role of Spinal Glutamatergic Transmission in the Ascending Limb of the Micturition Reflex Pathway in the Rat
Hidehiro Kakizaki, Mitsuharu Yoshiyama, James R. Roppolo, August M. Booth and William C. De Groat

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 22-27;
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Age-Related Decline in Beta Adrenergic and Adenosine A₁ Receptor Function in the Heart Are Attenuated by Dietary Restriction
Erhe Gao, David L. Snyder, Jay Roberts, Eitan Friedman, Guoping Cai, Amir Pelleg and Joel Horwitz

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 186-192;
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Carrier-Mediated Transport of N^G-Nitro-l-Arginine, a Nitric Oxide Synthase Inhibitor, in the Pigmented Rabbit Conjunctiva
Ken-Ichi Hosoya, Yoshihide Horibe, Kwang-Jin Kim and Vincent H. L. Lee

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 223-227;
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Effects of Bis(2-chloroethyl)sulfide on ATP Receptor-Mediated Responses of the Rat Vas Deferens: Possible Relationship to Cytotoxicity
Paul M. Lundy, Thomas W. Sawyer, Brian T. H and and Robert Frew

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 299-306;

BEHAVIORAL PHARMACOLOGY

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Zolpidem Physical Dependence Assessed Across Increasing Doses Under a Once-Daily Dosing Regimen in Baboons
Elise M. Weerts, Nancy A. Ator, Doreen M. Grech and Roland R. Griffiths

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 41-53;

CARDIOVASCULAR PHARMACOLOGY

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RSR13, a Synthetic Modifier of Hemoglobin-Oxygen Affinity, Enhances the Recovery of Stunned Myocardium in Anesthetized Dogs
Paul S. Pagel, Douglas A. Hettrick, Matthew W. Montgomery, Judy R. Kersten, Robert P. Steffen and David C. Warltier

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 1-8;
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Cardiovascular Pharmacology of the A_2A Adenosine Receptor Antagonist, SCH 58261, in the Rat
Angela Monopoli, Carlo Casati, Gianluca Lozza, Angelo Forlani and Ennio Ongini

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 9-15;
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Nitric Oxide Selectively Inhibits Intracellular Ca⁺⁺Release Elicited by Inositol Trisphosphate but not Caffeine in Rat Vascular Smooth Muscle
Junzhi Ji, Christina G. Benishin and Peter K. T. Pang

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 16-21;
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PST2238: A New Antihypertensive Compound That Antagonizes the Long-Term Pressor Effect of Ouabain
P. Ferrari, L. Torielli, M. Ferrandi, G. Padoani, L. Duzzi, M. Florio, F. Conti, P. Melloni, L. Vesci, N. Corsico and G. Bianchi

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 83-94;
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Differential Atrial versus Ventricular Activities of Class III Potassium Channel Blockers
Elizabeth P. Baskin and Joseph J. Lynch

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 135-142;
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Cotransfection of Second and Third Intracellular Loop Fragments Inhibit Angiotensin AT1a Receptor Activation of Phospholipase C in HEK-293 Cells
Joseph B. Thompson, Susan M. Wade, Jeffrey K. Harrison, Mina N. Salafranca and Richard R. Neubig

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 216-222;
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The Effects of Barium, Dofetilide and 4-Aminopyridine (4-AP) on Ventricular Repolarization in Normal and Hypertrophied Rabbit Heart
Anne M. Gillis, Radzfel A. Geonzon, Heather J. Mathison, Ela Kulisz, Wanda M. Lester and Henry J. Duff

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 262-270;
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Calcium-Activated Potassium Channels and Nitrate-Induced Vasodilation in Human Coronary Arteries
Rostislav Bychkov, Maik Gollasch, Tobias Steinke, Christian Ried, Friedrich C. Luft and Hermann Haller

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 293-298;

CELLULAR AND MOLECULAR PHARMACOLOGY

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Glutamate Receptor-Mediated Hyperexcitability after Ethanol Exposure in Isolated Neonatal Rat Spinal Cord
Shirley M. E. Wong, David L. Tauck, Eileen G. Fong and Joan J. Kendig

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 201-207;
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Binding of [³H]-SK&F 107260 and [³H]-SB 214857 to Purified Integrin α_IIbβ₃: Evidence for a Common Binding Site for Cyclic Arginyl-Glycinyl-Aspartic Acid Peptides and Nonpeptides
Angela Wong, Shing Mei Hwang, Kyung Johanson, James Samanen, Donald Bennett, Scott W. Landvatter, Wenting Chen, J. Richard Heys, Fadia E. Ali, Thomas W. Ku, William Bondinell, Andrew J. Nichols, David A. Powers and Jeffrey M. Stadel

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 228-235;
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Increases in Acetylcholine Release Produced by Phorbol Esters Are Not Mediated by Protein Kinase C at Motor Nerve Endings
T. J. Searl and E. M. Silinsky

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 247-251;
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Tyramine and Vanadate Synergistically Stimulate Glucose Transport in Rat Adipocytes by Amine Oxidase-Dependent Generation of Hydrogen Peroxide
Luc Marti, Nathalie Morin, Gemma Enrique-Tarancon, Danielle Prevot, Max Lafontan, Xavier Testar, Antonio Zorzano and Christian Carpéné

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 342-349;
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Pharmacological Characterization of the Human Ionotropic Glutamate Receptor Subtype GluR3 Stably Expressed in Mammalian Cells
M. A. Varney, S. P. Rao, C. Jachec, C. Deal, S. D. Hess, L. P. Daggett, F.-F. Lin, E. C. Johnson and G. Veliçelebi

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 358-370;
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Differential Agonist Inhibition Identifies Multiple Epibatidine Binding Sites in Mouse Brain
Michael J. Marks, Kimberly W. Smith and Allan C. Collins

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 377-386;

CHEMOTHERAPY/GENE THERAPY

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Chronopharmacology of Granulocyte Colony-Stimulating Factor in Mice
Shigehiro Ohdo, Naoko Arata, Taku Furukubo, Eiji Yukawa, Shun Higuchi, Shigeyuki Nakano and Nobuya Ogawa

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 242-246;

DEVELOPMENTAL PHARMACOLOGY

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In Vivo Maternal-Fetal-Amniotic Fluid Pharmacokinetics of Zidovudine in the Pigtailed Macaque: Comparison of Steady-State and Single-Dose Regimens
Tove Tuntland, Aleksandrs Odinecs, Connie Nosbisch and Jashvant D. Unadkat

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 54-62;

DRUG METABOLISM AND DISPOSITION

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Novel Somatostatin Analogs for the Treatment of Acromegaly and Cancer Exhibit Improved In Vivo Stability and Distribution
T. J. Gillespie, A. Erenberg, S. Kim, J. Dong, J. E. Taylor, V. Hau and T. P. Davis

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 95-104;
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Oncostatin M Down-regulates Basal and Induced Cytochromes P450 in Human Hepatocytes
M. Isabel Guillén, M. Teresa Donato, Ramiro Jover, JoséV. Castell, R. Fabra, R. Trullenque and M. José Gómez-Lechón

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 127-134;

GASTROINTESTINAL PHARMACOLOGY

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Dose-Related Effects of N-Demethyl-N-Isopropyl-8,9-anhydroerythromycin A 6,9-hemiacetal on Gastric Emptying of Solids in Healthy Human Volunteers
Myung-Gyu Choi, Michael Camilleri, Duane D. Burton, Steven Johnson and Anthony Edmonds

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 37-40;
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Characterization of I₂ Imidazoline and ς Binding Sites in the Rat and Human Stomach
Gerhard J. Molderings, Kurt Donecker, Maria Burian, W. Alexander Simon, Detlev W. Schröder and Manfred Göthert

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 170-177;
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Parallel Contractile Signal Transduction Pathways Activated by Receptors for Thrombin and Epidermal Growth Factor-Urogastrone in Guinea Pig Gastric Smooth Muscle: Blockade by Inhibitors of Mitogen-Activated Protein Kinase-Kinase and Phosphatidyl Inositol 3′-Kinase
Xi-Long Zheng, Bernard Renaux and Morley D. Hollenberg

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 325-334;

IMMUNOPHARMACOLOGY

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Thapsigargin-Induced Secretion Is Dependent on Activation of a Cholera Toxin-Sensitive and Phosphatidylinositol-3-kinase-Regulated Phospholipase D in a Mast Cell Line
David S. Cissel, Paul F. Fraundorfer and Michael A. Beaven

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 110-118;
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Diaminic Carbonates, a New Class of Anti-inflammatory Compounds: Their Biological Characterization and Mode of Action
Giuliana Porro, Giorgio Bertolini, M. Antonietta Bonardi, Elena Giovanetti, Paola Lento, Flavio Leoni, Daniela Modena, Gianfranco Pavich and Fabrizio Marcucci

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 193-200;

NEUROPHARMACOLOGY

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Effect of Protein Kinase C Activation on N-Methyl-d-Aspartate-Evoked Release of Adenosine and [³H]Norepinephrine from Rat Cortical Slices
Yushan Wang and Thomas D. White

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 105-109;
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Agonist and Inverse Agonist Activity at the Dopamine D₃ Receptor Measured by Guanosine 5′-[γ-Thio]Triphosphate-[³⁵S] Binding
Åsa Malmberg, Åsa Mikaels and Nina Mohell

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 119-126;
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The Pharmacology of Mesocortical Dopamine Neurons: A Dual-Probe Microdialysis Study in the Ventral Tegmental Area and Prefrontal Cortex of the Rat Brain
B.H.C. Westerink, P. Enrico, J. Feimann and J.B. De Vries

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 143-154;
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Role of Glutamate Receptors and Voltage-Dependent Calcium and Sodium Channels in the Extracellular Glutamate/Aspartate Accumulation and Subsequent Neuronal Injury Induced by Oxygen/Glucose Deprivation in Cultured Hippocampal Neurons
Manami Kimura, Kohei Sawada, Takehiko Miyagawa, Manabu Kuwada, Kouichi Katayama and Yukio Nishizawa

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 178-185;
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Effects of Ketoconazole on Triazolam Pharmacokinetics, Pharmacodynamics and Benzodiazepine Receptor Binding in Mice
Jeanne M. Fahey, Gary A. Pritchard, Lisa L. von Moltke, John S. Pratt, Jeffrey M. Grassi, Richard I. Shader and David J. Greenblatt

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 271-276;
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Alterations in Locomotor Activity during Chronic Cocaine Administration: Effect on Dopamine Receptors and Interaction with Opioids
Paul M. Kunko, Dawn French and Sari Izenwasser

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 277-284;
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Sodium Valproate Down-regulates the Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) in Immortalized Hippocampal Cells: A Property of Protein Kinase C-Mediated Mood Stabilizers
David G. Watson, Jeannette M. Watterson and Robert H. Lenox

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 307-316;
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Dopaminergic Regulation of Extracellular γ-Aminobutyric Acid Levels in the Prefrontal Cortex of the Rat
A. Chistina Grobin and Ariel Y. Deutch

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 350-357;
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Quantitative Autoradiography of Halothane Binding in Rat Brain
Maryellen Fazen Eckenhoff and Roderic G. Eckenhoff

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 371-376;

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

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The Effects of Ethanol and Acetaldehyde on the Metabolism of Prostaglandin E₂ and Leukotriene B₄ in Isolated Rat Hepatocytes
Joseph A. Hankin, Carl E. Clay and Robert C. Murphy

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 155-161;
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Characterization of Human Neutrophil and Endothelial Cell Ligand-Operated Extracellular Acidification Rate by Microphysiometry: Impact of Reoxygenation
Karsten Gronert, Sean P. Colgan and Charles N. Serhan

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 252-261;

RENAL PHARMACOLOGY

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Na-Dependent Transport ofS-(1,2-Dichlorovinyl)-l-Cysteine by Renal Brush-Border Membrane Vesicles
Stephen H. Wright, Theresa M. Wunz, J. North and James L. Stevens

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 162-169;
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Strain Difference in Sensitivity of Mice to Renal Toxicity of Inorganic Mercury
Toshiko Tanaka-Kagawa, Mieko Suzuki, Akira Naganuma, Nobuaki Yamanaka and Nobumasa Imura

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 335-341;

TOXICOLOGY

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Cyanide-Induced Generation of Oxidative Species: Involvement of Nitric Oxide Synthase and Cyclooxygenase-2
P. G. Gunasekar, J. L. Borowitz and G. E. Isom

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 236-241;
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Tumor Necrosis Factor-α as a Contributor in Fumonisin B₁ Toxicity
Raviprakash R. Dugyala, Raghubir P. Sharma, Masashi Tsunoda and Ronald T. Riley

Journal of Pharmacology and Experimental Therapeutics April 1998, 285 (1) 317-324;

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Table of Contents

ANALGESIA AND DRUGS OF ABUSE

AUTONOMIC PHARMACOLOGY

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR PHARMACOLOGY

CELLULAR AND MOLECULAR PHARMACOLOGY

CHEMOTHERAPY/GENE THERAPY

DEVELOPMENTAL PHARMACOLOGY

DRUG METABOLISM AND DISPOSITION

GASTROINTESTINAL PHARMACOLOGY

IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

RENAL PHARMACOLOGY

TOXICOLOGY

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