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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

March 01, 1998; Volume 284,Issue 3

ANALGESIA AND DRUGS OF ABUSE

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    Pentobarbital Antagonism of Morphine Analgesia Mediated by Spinal Cholecystokinin
    Jodie J. Rady, Wen Lin and James M. Fujimoto
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 878-885;
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    Antinociceptive Responses to Nicotinic Acetylcholine Receptor Ligands after Systemic and Intrathecal Administration in Mice
    M. I. Damaj, M. Fei-Yin, M. Dukat, W. Glassco, R. A. Glennon and B. R. Martin
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1058-1065;
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    Pharmacokinetic-Pharmacodynamic Modeling of the Electroencephalogram Effect of Synthetic Opioids in the Rat: Correlation with the Interaction at the Mu-Opioid Receptor
    Eugène H. Cox, Thomas Kerbusch, Pieter H. Van der Graaf and Meindert Danhof
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1095-1103;
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    Administered and Endogenously Released KappaOpioids Decrease Pilocarpine-Induced Seizures and Seizure-Induced Histopathology
    Suzanne B. Bausch, Tiffany M. Esteb, Gregory W. Terman and Charles Chavkin
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1147-1155;

BEHAVIORAL PHARMACOLOGY

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    Antinociceptive and Antiamnesic Properties of the Presynaptic Cholinergic Amplifier PG-9
    Carla Ghelardini, Nicoletta Galeotti, Fulvio Gualtieri, Vittorio Marchese, Cristina Bellucci and Alessandro Bartolini
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 806-816;
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    Effects of U-50,488H on Scopolamine-, Mecamylamine- and Dizocilpine-Induced Learning and Memory Impairment in Rats
    Masayuki Hiramatsu, Hiroyasu Murasawa, Toshitaka Nabeshima and Tsutomu Kameyama
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 858-867;
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    Reversal of Behavioral Effects of Pentylenetetrazol by the Neuroactive Steroid Ganaxolone
    Marjolein Beekman, Jesse T. Ungard, Maciej Gasior, Richard B. Carter, Durk Dijkstra, Steven R. Goldberg and Jeffrey M. Witkin
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 868-877;
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    High-Affinity Benzodiazepine Antagonists Reduce Responding Maintained by Ethanol Presentation in Ethanol-Preferring Rats
    Harry L. June, Dana Zuccarelli, Lucas Torres, Karen S. Craig, Jana Delong, Angela Allen, Misty R. Braun, Charity R. Cason and James M. Murphy
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1006-1014;
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    Discriminative Stimulus Properties of Cocaine: Enhancement by Monoamine Reuptake Blockers
    Mark S. Kleven and Wouter Koek
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1015-1025;

CARDIOVASCULAR PHARMACOLOGY

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    Marked Difference between Angiotensin-Converting Enzyme and Neutral Endopeptidase Inhibition in Vivo by a Dual Inhibitor of Both Enzymes
    Frank Anastasopoulos, Randal Leung, Athena Kladis, Gail M. James, Todd A. Briscoe, Thaddeus P. Gorski and Duncan J. Campbell
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 799-805;
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    Interaction between Alpha-1 Adrenergic and Vagal Effects on Cardiac Rate and Repolarization
    Philippe Chevalier, Francis Ruffy, Peter Danilo and Michael R. Rosen
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 832-837;
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    Coronary Vasorelaxation by Nitroglycerin: Involvement of Plasmalemmal Calcium-Activated K+ Channels and Intracellular Ca++ Stores
    Sajida A. Khan, Nicole R. Higdon and Kaushik D. Meisheri
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 838-846;
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    Antihypertensive and Natriuretic Effects of CGS 30440, a Dual Inhibitor of Angiotensin-Converting Enzyme and Neutral Endopeptidase 24.11
    Ricardo E. Chatelain, Rajendra D. Ghai, Angelo J. Trapani, Lynne M. Odorico, Beatriz N. Dardik, Stephane De Lombaert, Rodney W. Lappe and Cynthia A. Fink
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 974-982;
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    Effect of Magnesium on Calcium Responses to Vasopressin in Vascular Smooth Muscle Cells of Spontaneously Hypertensive Rats
    Rhian M. Touyz, Pascal Laurant and Ernesto L. Schiffrin
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 998-1005;
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    The Enantiomer-Specific Kinetics and Dynamics of Verapamil after Rapid Intravenous Administration to Sheep: Physiological Analysis and Modeling
    Yi Fei Huang, Richard N. Upton, Da Zheng, Colin Mclean, Elke C. Gray and Cliff Grant
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1048-1057;
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    The A2A Adenosine Receptor Mediates Coronary Vasodilation
    Luiz Belardinelli, John C. Shryock, Stephen Snowdy, Yi Zhang, Angela Monopoli, Gianluca Lozza, Ennio Ongini, Ray A. Olsson and Donn M. Dennis
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1066-1073;
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    Mast Cell Chymase-Like Protease(s) Modulates Escherichia coli Lipopolysaccharide-Induced Vasomotor Dysfunction in Skeletal Muscle in Vivo
    Hideyuki Suzuki, George H. Caughey, Xiao-Pei Gao and Israel Rubinstein
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1156-1164;
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    Fos-Like Immunoreactivity in the Medulla after Acute and Chronic Angiotensin II Infusion
    Qian Li, Margaret J. Sullivan, William E. Dale, Eileen M. Hasser, Edward H. Blaine and J. Thomas Cunningham
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1165-1173;
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    Angiotensin I-Converting Enzyme Inhibition but Not Angiotensin II Suppression Alters Angiotensin I-Converting Enzyme Gene Expression in Vessels and Epithelia
    Olivier Costerousse, Jacqueline Allegrini, Jean-Paul Clozel, Joël Ménard and François Alhenc-Gelas
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1180-1187;

CELLULAR AND MOLECULAR PHARMACOLOGY

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    The Heterocyclic Substituted Pyridine Derivative (±)-2-(-3-pyridinyl)-1-Azabicyclo[2.2.2]octane (RJR-2429): A Selective Ligand at Nicotinic Acetylcholine Receptors
    M. Bencherif, J. D. Schmitt, B. S. Bhatti, P. Crooks, W. S. Caldwell, M. E. Lovette, K. Fowler, L. Reeves and P. M. Lippiello
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 886-894;
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    Strychnine: A Potent Competitive Antagonist of α-Bungarotoxin-Sensitive Nicotinic Acetylcholine Receptors In Rat Hippocampal Neurons
    Hiroaki Matsubayashi, Manickavasagom Alkondon, Edna F. R. Pereira, Karen L. Swanson and Edson X. Albuquerque
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 904-913;
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    Trichloroethanol Modulation of Recombinant GABAA, Glycine and GABA ρ1 Receptors
    Matthew D. Krasowski, Suzanne E. Finn, Qing Ye and Neil L. Harrison
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 934-942;
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    Potent Modulation of Tetrodotoxin-Sensitive and Tetrodotoxin-Resistant Sodium Channels by the Type II Pyrethroid Deltamethrin
    Iustin V. Tabarean and Toshio Narahashi
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 958-965;
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    Sensitivity to the Seizure-Inducing Effects of Nicotine is Associated with Strain-Specific Variants of the α5 and α7 Nicotinic Receptor Subunit Genes
    Jerry A. Stitzel, Jennifer M. Blanchette and Allan C. Collins
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1104-1111;
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    Differential Electrophysiological Actions of Endothelin-1 on Cl– and K+ Currents in Myocytes Isolated from Aorta, Basilar and Pulmonary Artery
    Katie J. Salter and Roland Z. Kozlowski
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1122-1131;
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    Effects of Antiarrhythmic Agents on Junctional Resistance of Guinea Pig Ventricular Cell Pairs
    Pascal Daleau
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1174-1179;

DRUG METABOLISM AND DISPOSITION

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    Pharmacokinetic and Pharmacodynamic Study of a New Nonsteroidal 5α-Reductase Inhibitor, 4-[3-[3-[Bis(4-Isobutylphenyl)Methylamino]Benzoyl]-1H-Indol-1-yl]-Butyric Acid, in Rats
    Masataka Katashima, Koujirou Yamamoto, Yoji Tokuma, Takehisa Hata, Yasufumi Sawada and Tatsuji Iga
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 914-920;
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    Kinetic Study of the Hepatobiliary Transport of a New Prostaglandin Receptor Agonist
    Haruo Imawaka and Yuichi Sugiyama
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 949-957;
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    Carrier-Mediated Mechanism for the Biliary Excretion of the Quinolone Antibiotic Grepafloxacin and Its Glucuronide in Rats
    Hiroyuki Sasabe, Akira Tsuji and Yuichi Sugiyama
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1033-1039;
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    Effect of Clofibrate on the Chiral Disposition of Ibuprofen in Rats
    Stefan Scheuerer, Kenneth M. Williams, Roland Brugger, Andrew J. McLachlan, Kay Brune, Richard O. Day and Gerd Geisslinger
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1132-1138;
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    Estrogen Sulfotransferase Expression in the Human Liver: Marked Interindividual Variation and Lack of Gender Specificity
    Wen-Chao Song, Yueming Qian and Albert P. Li
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1197-1202;

GASTROINTESTINAL PHARMACOLOGY

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    The Role of Cyclic Guanylate Monophosphate in Nitric Oxide-Induced Injury to Rat Small Intestinal Epithelial Cells
    B. L. Tepperman, T. D. Abrahamson and B. D. Soper
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 929-933;

IMMUNOPHARMACOLOGY

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    In Vitro Immunosuppressive Activity, Isolation from Pig Liver Microsomes and Identification by Electrospray ms-ms of a New FK-506 C19-C20 Epoxide Metabolite
    G. Lhoëst, R. Dieden, R.K. Verbeeck, N. Maton, A. Ingendoh and D. Latinne
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1074-1081;

NEUROPHARMACOLOGY

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    Dynorphin Block of N-Methyl-d-Aspartate Channels Increases with the Peptide Length
    Li Chen and Li-Yen Mae Huang
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 826-831;
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    In Vivo Characterization of T-794, a Novel Reversible Inhibitor of Monoamine Oxidase-A, as an Antidepressant with a Wide Safety Margin
    Masaya Kato, Taiichi Katayama, Hiroshi Iwata, Michio Yamamura, Yuzo Matsuoka and Hiroshi Narita
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 983-990;
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    Dexfenfluramine Enhances Striatal Dopamine Release in Conscious Rats via a Serotoninergic Mechanism
    Aygul Balcioglu and Richard J. Wurtman
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 991-997;
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    Neuroprotective and Memory-Related Actions of NovelAlpha-7 Nicotinic Agents with Different Mixed Agonist/Antagonist Properties
    Edwin M. Meyer, Ee Tein Tay, John A. Zoltewicz, Craig Meyers, Michael A. King, Roger L. Papke and Christopher M. De Fiebre
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1026-1032;
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    Resistance of Neuronal Nitric Oxide Synthase-Deficient Mice to Methamphetamine-Induced Dopaminergic Neurotoxicity
    Yossef Itzhak, Carlos Gandia, Paul L. Huang and Syed F. Ali
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1040-1047;
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    Characterization of the Aminomethylchroman Derivative BAY × 3702 as a Highly Potent 5-Hydroxytryptamine1A Receptor Agonist
    Jean De Vry, Rudolf Schohe-Loop, Hans-Georg Heine, Joachim M. Greuel, Frank Mauler, Bernard Schmidt, Henning Sommermeyer and Thomas Glaser
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1082-1094;
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    Nicotine-Induced Norepinephrine Release in the Rat Amygdala and Hippocampus is Mediated through Brainstem Nicotinic Cholinergic Receptors
    Yitong Fu, Shannon G. Matta, Tressa J. James and Burt M. Sharp
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1188-1196;
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    Assessment of Anandamide Interaction with the Cannabinoid Brain Receptor: SR 141716A Antagonism Studies in Mice and Autoradiographic Analysis of Receptor Binding in Rat Brain
    I. B. Adams, D. R. Compton and B. R. Martin
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1209-1217;
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    Sequestration of Human Muscarinic Acetylcholine Receptor hm1—hm5 Subtypes: Effect of G Protein-Coupled Receptor Kinases GRK2, GRK4, GRK5 and GRK6
    Hirofumi Tsuga, Eriko Okuno, Kimihiko Kameyama and Tatsuya Haga
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1218-1226;
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    Corticosteroids Alter 5-Hydroxytryptamine1AReceptor-effector Pathway in Hippocampal Subfield CA3 Pyramidal Cells
    Dayne Y. Okuhara and Sheryl G. Beck
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1227-1233;

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

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    Characteristics of Arachidonic Acid Generation in Human Basophils: Relationship Between the Effects of Inhibitors of Secretory Phospholipase A2 Activity and Leukotriene C4Release
    T. R. Hundley, L. A. Marshall, W. C. Hubbard and D. W. Macglashan
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 847-857;
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    Role of Extracellular Ca++ Influx viaL-Type and Non-L-Type Ca++ Channels in Thromboxane A2 Receptor-Mediated Contraction in Rat Aorta
    Metiner Tosun, Richard J. Paul and Robert M. Rapoport
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 921-928;
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    Cytochrome P450-Derived Arachidonic Acid Metabolism in the Rat Kidney: Characterization of Selective Inhibitors
    Mong-Heng Wang, Elimor Brand-Schieber, Barbara A. Zand, Xuandai Nguyen, John R. Falck, Narayanan Balu and Michal Laniado Schwartzman
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 966-973;
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    Inhibition of Nitric Oxide Synthase Attenuates Peroxynitrite Generation, but Augments Neutrophil Accumulation in Hepatic Ischemia-Reperfusion in Rats
    Peitan Liu, Kingsley Yin, Robert Nagele and Patrick Y-K Wong
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1139-1146;

PULMONARY PHARMACOLOGY

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    EndothelinB Receptors in Rabbit Pulmonary Resistance Arteries: Effect of Left Ventricular Dysfunction
    Cheryl C. Docherty and Margaret R. Maclean
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 895-903;

RENAL PHARMACOLOGY

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    Peritubular Transport of Ochratoxin A in Rabbit Renal Proximal Tubules
    Carlotta E. Groves, Mark Morales and Stephen H. Wright
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 943-948;
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    Bladder Instillation and Intraperitoneal Injection ofEscherichia coli Lipopolysaccharide Up-regulate Cytokines and iNOS in Rat Urinary Bladder
    Lief Eric Olsson, Marcia A. Wheeler, William C. Sessa and Robert M. Weiss
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1203-1208;

TOXICOLOGY

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    Hepatocellular Effects of Cyclosporine A and its Derivative SDZ IMM 125 in Vitro
    Armin Wolf, Ursula Schramm, Alfred Fahr, Lothar Aicher, André Cordier, Wolfgang E. Trommer and Gert Fricker
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 817-825;
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    Electron Transport-Mediated Wasteful Consumption of NADH Promotes the Lethal Response of U937 Cells to Tert-Butylhydroperoxide
    Liliana Brambilla, Piero Sestili, Andrea Guidarelli, Letizia Palomba and Orazio Cantoni
    Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1112-1121;
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Journal of Pharmacology and Experimental Therapeutics
Vol. 284, Issue 3
1 Mar 1998
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  • ANALGESIA AND DRUGS OF ABUSE
  • BEHAVIORAL PHARMACOLOGY
  • CARDIOVASCULAR PHARMACOLOGY
  • CELLULAR AND MOLECULAR PHARMACOLOGY
  • DRUG METABOLISM AND DISPOSITION
  • GASTROINTESTINAL PHARMACOLOGY
  • IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS
  • PULMONARY PHARMACOLOGY
  • RENAL PHARMACOLOGY
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