Journal of Pharmacology and Experimental Therapeutics: 284 (3)

March 01, 1998; Volume 284,Issue 3

ANALGESIA AND DRUGS OF ABUSE

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Pentobarbital Antagonism of Morphine Analgesia Mediated by Spinal Cholecystokinin
Jodie J. Rady, Wen Lin and James M. Fujimoto

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 878-885;
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Antinociceptive Responses to Nicotinic Acetylcholine Receptor Ligands after Systemic and Intrathecal Administration in Mice
M. I. Damaj, M. Fei-Yin, M. Dukat, W. Glassco, R. A. Glennon and B. R. Martin

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1058-1065;
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Pharmacokinetic-Pharmacodynamic Modeling of the Electroencephalogram Effect of Synthetic Opioids in the Rat: Correlation with the Interaction at the Mu-Opioid Receptor
Eugène H. Cox, Thomas Kerbusch, Pieter H. Van der Graaf and Meindert Danhof

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1095-1103;
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Administered and Endogenously Released KappaOpioids Decrease Pilocarpine-Induced Seizures and Seizure-Induced Histopathology
Suzanne B. Bausch, Tiffany M. Esteb, Gregory W. Terman and Charles Chavkin

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1147-1155;

BEHAVIORAL PHARMACOLOGY

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Antinociceptive and Antiamnesic Properties of the Presynaptic Cholinergic Amplifier PG-9
Carla Ghelardini, Nicoletta Galeotti, Fulvio Gualtieri, Vittorio Marchese, Cristina Bellucci and Alessandro Bartolini

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 806-816;
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Effects of U-50,488H on Scopolamine-, Mecamylamine- and Dizocilpine-Induced Learning and Memory Impairment in Rats
Masayuki Hiramatsu, Hiroyasu Murasawa, Toshitaka Nabeshima and Tsutomu Kameyama

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 858-867;
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Reversal of Behavioral Effects of Pentylenetetrazol by the Neuroactive Steroid Ganaxolone
Marjolein Beekman, Jesse T. Ungard, Maciej Gasior, Richard B. Carter, Durk Dijkstra, Steven R. Goldberg and Jeffrey M. Witkin

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 868-877;
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High-Affinity Benzodiazepine Antagonists Reduce Responding Maintained by Ethanol Presentation in Ethanol-Preferring Rats
Harry L. June, Dana Zuccarelli, Lucas Torres, Karen S. Craig, Jana Delong, Angela Allen, Misty R. Braun, Charity R. Cason and James M. Murphy

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1006-1014;
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Discriminative Stimulus Properties of Cocaine: Enhancement by Monoamine Reuptake Blockers
Mark S. Kleven and Wouter Koek

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1015-1025;

CARDIOVASCULAR PHARMACOLOGY

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Marked Difference between Angiotensin-Converting Enzyme and Neutral Endopeptidase Inhibition in Vivo by a Dual Inhibitor of Both Enzymes
Frank Anastasopoulos, Randal Leung, Athena Kladis, Gail M. James, Todd A. Briscoe, Thaddeus P. Gorski and Duncan J. Campbell

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 799-805;
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Interaction between Alpha-1 Adrenergic and Vagal Effects on Cardiac Rate and Repolarization
Philippe Chevalier, Francis Ruffy, Peter Danilo and Michael R. Rosen

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 832-837;
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Coronary Vasorelaxation by Nitroglycerin: Involvement of Plasmalemmal Calcium-Activated K⁺ Channels and Intracellular Ca⁺⁺ Stores
Sajida A. Khan, Nicole R. Higdon and Kaushik D. Meisheri

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 838-846;
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Antihypertensive and Natriuretic Effects of CGS 30440, a Dual Inhibitor of Angiotensin-Converting Enzyme and Neutral Endopeptidase 24.11
Ricardo E. Chatelain, Rajendra D. Ghai, Angelo J. Trapani, Lynne M. Odorico, Beatriz N. Dardik, Stephane De Lombaert, Rodney W. Lappe and Cynthia A. Fink

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 974-982;
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Effect of Magnesium on Calcium Responses to Vasopressin in Vascular Smooth Muscle Cells of Spontaneously Hypertensive Rats
Rhian M. Touyz, Pascal Laurant and Ernesto L. Schiffrin

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 998-1005;
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The Enantiomer-Specific Kinetics and Dynamics of Verapamil after Rapid Intravenous Administration to Sheep: Physiological Analysis and Modeling
Yi Fei Huang, Richard N. Upton, Da Zheng, Colin Mclean, Elke C. Gray and Cliff Grant

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1048-1057;
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The A_2A Adenosine Receptor Mediates Coronary Vasodilation
Luiz Belardinelli, John C. Shryock, Stephen Snowdy, Yi Zhang, Angela Monopoli, Gianluca Lozza, Ennio Ongini, Ray A. Olsson and Donn M. Dennis

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1066-1073;
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Mast Cell Chymase-Like Protease(s) Modulates Escherichia coli Lipopolysaccharide-Induced Vasomotor Dysfunction in Skeletal Muscle in Vivo
Hideyuki Suzuki, George H. Caughey, Xiao-Pei Gao and Israel Rubinstein

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1156-1164;
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Fos-Like Immunoreactivity in the Medulla after Acute and Chronic Angiotensin II Infusion
Qian Li, Margaret J. Sullivan, William E. Dale, Eileen M. Hasser, Edward H. Blaine and J. Thomas Cunningham

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1165-1173;
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Angiotensin I-Converting Enzyme Inhibition but Not Angiotensin II Suppression Alters Angiotensin I-Converting Enzyme Gene Expression in Vessels and Epithelia
Olivier Costerousse, Jacqueline Allegrini, Jean-Paul Clozel, Joël Ménard and François Alhenc-Gelas

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1180-1187;

CELLULAR AND MOLECULAR PHARMACOLOGY

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The Heterocyclic Substituted Pyridine Derivative (±)-2-(-3-pyridinyl)-1-Azabicyclo[2.2.2]octane (RJR-2429): A Selective Ligand at Nicotinic Acetylcholine Receptors
M. Bencherif, J. D. Schmitt, B. S. Bhatti, P. Crooks, W. S. Caldwell, M. E. Lovette, K. Fowler, L. Reeves and P. M. Lippiello

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 886-894;
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Strychnine: A Potent Competitive Antagonist of α-Bungarotoxin-Sensitive Nicotinic Acetylcholine Receptors In Rat Hippocampal Neurons
Hiroaki Matsubayashi, Manickavasagom Alkondon, Edna F. R. Pereira, Karen L. Swanson and Edson X. Albuquerque

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 904-913;
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Trichloroethanol Modulation of Recombinant GABA_A, Glycine and GABA ρ₁ Receptors
Matthew D. Krasowski, Suzanne E. Finn, Qing Ye and Neil L. Harrison

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 934-942;
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Potent Modulation of Tetrodotoxin-Sensitive and Tetrodotoxin-Resistant Sodium Channels by the Type II Pyrethroid Deltamethrin
Iustin V. Tabarean and Toshio Narahashi

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 958-965;
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Sensitivity to the Seizure-Inducing Effects of Nicotine is Associated with Strain-Specific Variants of the α5 and α7 Nicotinic Receptor Subunit Genes
Jerry A. Stitzel, Jennifer M. Blanchette and Allan C. Collins

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1104-1111;
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Differential Electrophysiological Actions of Endothelin-1 on Cl^– and K⁺ Currents in Myocytes Isolated from Aorta, Basilar and Pulmonary Artery
Katie J. Salter and Roland Z. Kozlowski

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1122-1131;
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Effects of Antiarrhythmic Agents on Junctional Resistance of Guinea Pig Ventricular Cell Pairs
Pascal Daleau

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1174-1179;

DRUG METABOLISM AND DISPOSITION

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Pharmacokinetic and Pharmacodynamic Study of a New Nonsteroidal 5α-Reductase Inhibitor, 4-[3-[3-[Bis(4-Isobutylphenyl)Methylamino]Benzoyl]-1H-Indol-1-yl]-Butyric Acid, in Rats
Masataka Katashima, Koujirou Yamamoto, Yoji Tokuma, Takehisa Hata, Yasufumi Sawada and Tatsuji Iga

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 914-920;
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Kinetic Study of the Hepatobiliary Transport of a New Prostaglandin Receptor Agonist
Haruo Imawaka and Yuichi Sugiyama

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 949-957;
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Carrier-Mediated Mechanism for the Biliary Excretion of the Quinolone Antibiotic Grepafloxacin and Its Glucuronide in Rats
Hiroyuki Sasabe, Akira Tsuji and Yuichi Sugiyama

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1033-1039;
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Effect of Clofibrate on the Chiral Disposition of Ibuprofen in Rats
Stefan Scheuerer, Kenneth M. Williams, Roland Brugger, Andrew J. McLachlan, Kay Brune, Richard O. Day and Gerd Geisslinger

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1132-1138;
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Estrogen Sulfotransferase Expression in the Human Liver: Marked Interindividual Variation and Lack of Gender Specificity
Wen-Chao Song, Yueming Qian and Albert P. Li

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1197-1202;

GASTROINTESTINAL PHARMACOLOGY

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The Role of Cyclic Guanylate Monophosphate in Nitric Oxide-Induced Injury to Rat Small Intestinal Epithelial Cells
B. L. Tepperman, T. D. Abrahamson and B. D. Soper

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 929-933;

IMMUNOPHARMACOLOGY

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In Vitro Immunosuppressive Activity, Isolation from Pig Liver Microsomes and Identification by Electrospray ms-ms of a New FK-506 C₁₉-C₂₀ Epoxide Metabolite
G. Lhoëst, R. Dieden, R.K. Verbeeck, N. Maton, A. Ingendoh and D. Latinne

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1074-1081;

NEUROPHARMACOLOGY

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Dynorphin Block of N-Methyl-d-Aspartate Channels Increases with the Peptide Length
Li Chen and Li-Yen Mae Huang

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 826-831;
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In Vivo Characterization of T-794, a Novel Reversible Inhibitor of Monoamine Oxidase-A, as an Antidepressant with a Wide Safety Margin
Masaya Kato, Taiichi Katayama, Hiroshi Iwata, Michio Yamamura, Yuzo Matsuoka and Hiroshi Narita

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 983-990;
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Dexfenfluramine Enhances Striatal Dopamine Release in Conscious Rats via a Serotoninergic Mechanism
Aygul Balcioglu and Richard J. Wurtman

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 991-997;
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Neuroprotective and Memory-Related Actions of NovelAlpha-7 Nicotinic Agents with Different Mixed Agonist/Antagonist Properties
Edwin M. Meyer, Ee Tein Tay, John A. Zoltewicz, Craig Meyers, Michael A. King, Roger L. Papke and Christopher M. De Fiebre

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1026-1032;
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Resistance of Neuronal Nitric Oxide Synthase-Deficient Mice to Methamphetamine-Induced Dopaminergic Neurotoxicity
Yossef Itzhak, Carlos Gandia, Paul L. Huang and Syed F. Ali

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1040-1047;
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Characterization of the Aminomethylchroman Derivative BAY × 3702 as a Highly Potent 5-Hydroxytryptamine_1A Receptor Agonist
Jean De Vry, Rudolf Schohe-Loop, Hans-Georg Heine, Joachim M. Greuel, Frank Mauler, Bernard Schmidt, Henning Sommermeyer and Thomas Glaser

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1082-1094;
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Nicotine-Induced Norepinephrine Release in the Rat Amygdala and Hippocampus is Mediated through Brainstem Nicotinic Cholinergic Receptors
Yitong Fu, Shannon G. Matta, Tressa J. James and Burt M. Sharp

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1188-1196;
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Assessment of Anandamide Interaction with the Cannabinoid Brain Receptor: SR 141716A Antagonism Studies in Mice and Autoradiographic Analysis of Receptor Binding in Rat Brain
I. B. Adams, D. R. Compton and B. R. Martin

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1209-1217;
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Sequestration of Human Muscarinic Acetylcholine Receptor hm1—hm5 Subtypes: Effect of G Protein-Coupled Receptor Kinases GRK2, GRK4, GRK5 and GRK6
Hirofumi Tsuga, Eriko Okuno, Kimihiko Kameyama and Tatsuya Haga

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1218-1226;
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Corticosteroids Alter 5-Hydroxytryptamine_1AReceptor-effector Pathway in Hippocampal Subfield CA3 Pyramidal Cells
Dayne Y. Okuhara and Sheryl G. Beck

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1227-1233;

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

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Characteristics of Arachidonic Acid Generation in Human Basophils: Relationship Between the Effects of Inhibitors of Secretory Phospholipase A₂ Activity and Leukotriene C₄Release
T. R. Hundley, L. A. Marshall, W. C. Hubbard and D. W. Macglashan

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 847-857;
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Role of Extracellular Ca⁺⁺ Influx viaL-Type and Non-L-Type Ca⁺⁺ Channels in Thromboxane A₂ Receptor-Mediated Contraction in Rat Aorta
Metiner Tosun, Richard J. Paul and Robert M. Rapoport

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 921-928;
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Cytochrome P450-Derived Arachidonic Acid Metabolism in the Rat Kidney: Characterization of Selective Inhibitors
Mong-Heng Wang, Elimor Brand-Schieber, Barbara A. Zand, Xuandai Nguyen, John R. Falck, Narayanan Balu and Michal Laniado Schwartzman

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 966-973;
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Inhibition of Nitric Oxide Synthase Attenuates Peroxynitrite Generation, but Augments Neutrophil Accumulation in Hepatic Ischemia-Reperfusion in Rats
Peitan Liu, Kingsley Yin, Robert Nagele and Patrick Y-K Wong

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1139-1146;

PULMONARY PHARMACOLOGY

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Endothelin_B Receptors in Rabbit Pulmonary Resistance Arteries: Effect of Left Ventricular Dysfunction
Cheryl C. Docherty and Margaret R. Maclean

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 895-903;

RENAL PHARMACOLOGY

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Peritubular Transport of Ochratoxin A in Rabbit Renal Proximal Tubules
Carlotta E. Groves, Mark Morales and Stephen H. Wright

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 943-948;
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Bladder Instillation and Intraperitoneal Injection ofEscherichia coli Lipopolysaccharide Up-regulate Cytokines and iNOS in Rat Urinary Bladder
Lief Eric Olsson, Marcia A. Wheeler, William C. Sessa and Robert M. Weiss

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1203-1208;

TOXICOLOGY

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Hepatocellular Effects of Cyclosporine A and its Derivative SDZ IMM 125 in Vitro
Armin Wolf, Ursula Schramm, Alfred Fahr, Lothar Aicher, André Cordier, Wolfgang E. Trommer and Gert Fricker

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 817-825;
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Electron Transport-Mediated Wasteful Consumption of NADH Promotes the Lethal Response of U937 Cells to Tert-Butylhydroperoxide
Liliana Brambilla, Piero Sestili, Andrea Guidarelli, Letizia Palomba and Orazio Cantoni

Journal of Pharmacology and Experimental Therapeutics March 1998, 284 (3) 1112-1121;

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Table of Contents

ANALGESIA AND DRUGS OF ABUSE

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR PHARMACOLOGY

CELLULAR AND MOLECULAR PHARMACOLOGY

DRUG METABOLISM AND DISPOSITION

GASTROINTESTINAL PHARMACOLOGY

IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

PULMONARY PHARMACOLOGY

RENAL PHARMACOLOGY

TOXICOLOGY

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