Journal of Pharmacology and Experimental Therapeutics: 284 (2)

February 01, 1998; Volume 284,Issue 2

ANALGESIA AND DRUGS OF ABUSE

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Lack of Morphine and Enkephalin Tolerance in 129/SvEv Mice: Evidence for a NMDA Receptor Defect
Yuri Kolesnikov, Subash Jain, Roger Wilson and Gavril W. Pasternak

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 455-459;
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Tyr-W-MIF-1 Attenuates Down-Regulation of Opiate Receptors in SH-SY5Y Human Neuroblastoma Cells
Laura M. Harrison, Abba J. Kastin and James E. Zadina

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 611-617;
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Neuropeptide Y Attenuates Naloxone-Precipitated Morphine Withdrawal via Y5-like Receptors
David P. D. Woldbye, Kristian Klemp and Torsten M. Madsen

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 633-636;
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Repetitive Opioid Abstinence Causes Progressive Hyperalgesia Sensitive to N-Methyl-d-aspartate Receptor Blockade in the Rat
Stuart A. Dunbar and Istvan J. Pulai

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 678-686;

BEHAVIORAL PHARMACOLOGY

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Antiepileptogenic Effects of the Novel Anticonvulsant Levetiracetam (ucb L059) in the Kindling Model of Temporal Lobe Epilepsy
Wolfgang Löscher, Dagmar Hönack and Chris Rundfeldt

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 474-479;
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Fenfluramine and Norfenfluramine Levels in Brain Microdialysate, Brain Tissue and Plasma of Rats Administered Doses ofd-Fenfluramine Known to Deplete 5-Hydroxytryptamine Levels in Brain
Peter Clausing, Glenn D. Newport and John F. Bowyer

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 618-624;
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Anxiolytic and Side-Effect Profile of LY354740: A Potent, Highly Selective, Orally Active Agonist for Group II Metabotropic Glutamate Receptors
David R. Helton, Joseph P. Tizzano, James A. Monn, Darryle D. Schoepp and Mary Jeanne Kallman

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 651-660;

CARDIOVASCULAR PHARMACOLOGY

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Angiotensin Inhibits Neurotransmission of Calcitonin Gene-Related Peptide-Containing Vasodilator Nerves in Mesenteric Artery of Spontaneously Hypertensive Rats
Hiromu Kawasaki, Makoto Takenaga, Hiroaki Araki, Kojirou Futagami and Yutaka Gomita

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 508-515;
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S-Transnitrosation Reactions Are Involved in the Metabolic Fate and Biological Actions of Nitric Oxide
Zhenguo Liu, M. Audrey Rudd, Jane E. Freedman and Joseph Loscalzo

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 526-534;
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Differential Effects of Paclitaxel and Derivatives on Guinea Pig Isolated Heart and Papillary Muscle
Giuseppe Alloatti, Claudia Penna, Maria Pia Gallo, Renzo C. Levi, Ezio Bombardelli and Giovanni Appendino

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 561-567;
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Ovariectomy and Estrogen-Induced Alterations in Myocardial Contractility in Female Rabbits: Role of the L-Type Calcium Channel
Eugene Patterson, Lianmin Ma, Bela Szabo, Casey P. Robinson and Udho Thadani

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 586-591;
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Lipid Transfer Protein I Facilitated Transfer of Cyclosporine from Low- to High-Density Lipoproteins is Only Partially Dependent on its Cholesteryl Ester Transfer Activity
Kishor M. Wasan, Manisha Ramaswamy, Wesley Wong and P. Haydn Pritchard

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 599-605;
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Oxidized Low-Density Lipoprotein Inhibits Acetylcholine-Induced Vasorelaxation and Increases 5-HT-Induced Vasoconstriction in Isolated Human Saphenous Vein
Lifan Zhao and Randall L. Tackett

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 637-643;
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Anti-inflammatory Mystixin Peptides Inhibit Plasma Leakage Without Blocking Endothelial Gap Formation
Peter Baluk, Natasha W. Fine, Holly A. Thomas, Edward T. Wei and Donald M. Mcdonald

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 693-699;
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Mechanism of Nicotine-Induced Relaxation in the Porcine Basilar Artery
W. Zhang, L. Edvinsson and Tony J-F. Lee

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 790-797;

CELLULAR AND MOLECULAR PHARMACOLOGY

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Pharmacological Comparison of the Cloned Human and Rat M2 Muscarinic Receptor Genes Expressed in the Murine Fibroblast (B82) Cell Line
Ildiko Kovacs, Henry I. Yamamura, Sue L. Waite, Eva V. Varga and William R. Roeske

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 500-507;
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Brevetoxin-3 (PbTx-3) and Its Derivatives Modulate Single Tetrodotoxin-Sensitive Sodium Channels in Rat Sensory Neurons
G. Jeglitsch, K. Rein, D. G. Baden and D. J. Adams

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 516-525;
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Alpha-1A Adrenergic Receptor Stimulation with Phenylephrine Promotes Arachidonic Acid Release by Activation of Phospholipase D in Rat-1 Fibroblasts: Inhibition by Protein Kinase A
Ying Ruan, Hong Kan, Jean-Hugues Parmentier, Soghra Fatima, Lee F. Allen and Kafait U. Malik

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 576-585;
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Regulation of K⁺ and Ca⁺⁺ Channels by a Family of Neuropeptide Y Receptors
Lihjen Sun, Louis H. Philipson and Richard J. Miller

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 625-632;
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SR 144528, the First Potent and Selective Antagonist of the CB2 Cannabinoid Receptor
Murielle Rinaldi-Carmona, Francis Barth, José Millan, Jean-Marie Derocq, Pierre Casellas, Christian Congy, Didier Oustric, Martine Sarran, Monsif Bouaboula, Bernard Calandra, Marielle Portier, David Shire, Jean-Claude Brelière and Gérard Le Fur

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 644-650;
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Use of Antimuscarinic Toxins To Facilitate Studies of Striatal m4 Muscarinic Receptors
Sherry L. Purkerson and Lincoln T. Potter

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 707-713;
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Identification of High-Affinity Binding Sites for the Insulin Sensitizer Rosiglitazone (BRL-49653) in Rodent and Human Adipocytes Using a Radioiodinated Ligand for Peroxisomal Proliferator-Activated Receptor γ
Paul W. Young, Derek R. Buckle, Barrie C. C. Cantello, Helen Chapman, John C. Clapham, Paul J. Coyle, David Haigh, Richard M. Hindley, Julie C. Holder, Howard Kallender, Alison J. Latter, Kenneth W. M. Lawrie, Danuta Mossakowska, Gregory J. Murphy, Lynne Roxbee Cox and Stephen A. Smith

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 751-759;
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Ethanol-GABA_A Receptor Interactions: A Comparison between Cell Lines and Cerebellar Purkinje Cells
Douglas W. Sapp and Hermes H. Yeh

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 768-776;
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Characterization of Human Recombinant Neuronal Nicotinic Acetylcholine Receptor Subunit Combinations α2β4, α3β4 and α4β4 Stably Expressed in HEK293 Cells
Kenneth A. Stauderman, L. Scott Mahaffy, Michael Akong, Gönül Veliçelebi, Laura E. Chavez-Noriega, James H. Crona, Edwin C. Johnson, Kathryn J. Elliott, Alison Gillespie, Richard T. Reid, Pamala Adams, Michael M. Harpold and Janis Corey-Naeve

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 777-789;

CHEMOTHERAPY/GENE THERAPY

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Purification and Characterization of Eugeniin as an Anti-herpesvirus Compound from Geum japonicum andSyzygium aromaticum
Masahiko Kurokawa, Toyoharu Hozumi, Purusotam Basnet, Michio Nakano, Shigetoshi Kadota, Tuneo Namba, Takashi Kawana and Kimiyasu Shiraki

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 728-735;

DEVELOPMENTAL PHARMACOLOGY

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Propranolol Elimination by Right and Left Fetal Liver: Studies in the Intact Isolated Perfused Fetal Sheep Liver
John A. Ring, Hany Ghabrial, Michael S. Ching, Arthur Shulkes, Richard A. Smallwood and Denis J. Morgan

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 535-541;

DRUG METABOLISM AND DISPOSITION

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Oxidation of Histamine H1 Antagonist Mequitazine is Catalyzed by Cytochrome P450 2D6 in Human Liver Microsomes
Katsunori Nakamura, Tsuyoshi Yokoi, Takao Kodama, Kazuaki Inoue, Kazuo Nagashima, Noriaki Shimada, Toshiaki Shimizu and Tetsuya Kamataki

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 437-442;
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Pharmacokinetic-Pharmacodynamic Modeling of the Anticonvulsant and Electroencephalogram Effects of Phenytoin in Rats
O. E. Della Paschoa, J. W. Mandema, R. A. Voskuyl and M. Danhof

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 460-466;
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Hepatic Uptake of Bromosulfophthalein-Glutathione in Perfused Eisai Hyperbilirubinemic Mutant Rat Liver: A Multiple-Indicator Dilution Study
Wanping Geng, Andreas J. Schwab, Tohru Horie, Carl A. Goresky and K. Sandy Pang

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 480-492;
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In Vivo Cimetidine Inhibits Hepatic CYP2C6 and CYP2C11 but Not CYP1A1 in Adult Male Rats ^,
Marc Levine, Eva Y. W. Law, Stelvio M. Bandiera, Thomas K. H. Chang and Gail D. Bellward

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 493-499;
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Stereoselective Hepatobiliary Transport of the Quinolone Antibiotic Grepafloxacin and Its Glucuronide in the Rat
Hiroyuki Sasabe, Yukio Kato, Akira Tsuji and Yuichi Sugiyama

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 661-668;
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Human Hepatocyte Growth Factor Down-regulates the Expression of Cytochrome P450 Isozymes in Human Hepatocytes in Primary Culture
M. Teresa Donato, M. José Gómez-Lechón, Ramiro Jover, Toshikazu Nakamura and José V. Castell

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 760-767;

ENDOCRINE PHARMACOLOGY

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Efficacy of an Insulin-Like Growth Factor-Interleukin-3 Fusion Protein in Reversing the Hematopoietic Toxicity Associated with Azidothymidine in Mice
Marcos R. Difalco, Line Dufresne and Luis Fernando Congote

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 449-454;

GASTROINTESTINAL PHARMACOLOGY

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Hypoxia Inhibits Cyclic Nucleotide-Stimulated Epithelial Ion Transport: Role for Nucleotide Cyclases as Oxygen Sensors
Cormac T. Taylor, Steven J. Lisco, Christopher S. Awtrey and Sean P. Colgan

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 568-575;
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Effects of Nitric Oxide Synthase Inhibition or Sulfasalazine on the Spontaneous Colitis Observed in HLA-B27 Transgenic Rats
Satoshi Aiko, John Fuseler and Matthew B. Grisham

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 722-727;
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Site-Directed Mutagenesis of Human Vasoactive Intestinal Peptide Receptor Subtypes VIP1 and VIP2: Evidence for Difference in the Structure-Function Relationship
Pascal Nicole, Kai Du, Alain Couvineau and Marc Laburthe

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 744-750;

IMMUNOPHARMACOLOGY

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Pharmacological Effects of SB 220025, a Selective Inhibitor of P38 Mitogen-Activated Protein Kinase, in Angiogenesis and Chronic Inflammatory Disease Models
Jeffrey R. Jackson, Brian Bolognese, Leonard Hillegass, Shouki Kassis, Jerry Adams, Don E. Griswold and James D. Winkler

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 687-692;

NEUROPHARMACOLOGY

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YM872, a Novel Selective α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor Antagonist, Reduces Brain Damage after Permanent Focal Cerebral Ischemia in Cats
Masayasu Takahashi, Jian Wei Ni, Sachiko Kawasaki-Yatsugi, Takashi Toya, Sin-Ichi Yatsugi, Masao Shimizu-Sasamata, Kazuo Koshiya, Jun-Ichi Shishikura, Shuichi Sakamoto and Tokio Yamaguchi

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 467-473;
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Dopamine D₄ Receptor Mediated Inhibition of Potassium Current in Neurohypophysial Nerve Terminals
Russell A. Wilke, Shyue-Fang Hsu and Meyer B. Jackson

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 542-548;
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Modulation of [³H]Dopamine Release from Rat Nucleus Accumbens by Neuropeptide Y May Involve a Sigma ₁-like Receptor
David T. Ault, Julie M. Radeff and Linda L. Werling

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 553-560;
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Protein Kinase C Inhibitors Block Amphetamine-Mediated Dopamine Release in Rat Striatal Slices
L. Kantor and M. E. Gnegy

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 592-598;
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Deprenyl and Desmethylselegiline Protect Mesencephalic Neurons from Toxicity Induced by Glutathione Depletion
Catherine Mytilineou, Efthimia Kototos Leonardi, Pheona Radcliffe, Esa H. Heinonen, Shan-Kuo Han, Peter Werner, Gerald Cohen and C. Warren Olanow

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 700-706;
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Norepinephrine Transporters in Rat Placenta Labeled with [³H]Nisoxetine
Lauren P. Shearman and Jerrold S. Meyer

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 736-743;

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

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Therapeutic Administration of a Selective Inhibitor of Nitric Oxide Synthase Does Not Ameliorate the Chronic Inflammation and Tissue Damage Associated with Adjuvant-Induced Arthritis in Rats
Daniel S. Fletcher, W. Richard Widmer, Silvi Luell, Amy Christen, Chad Orevillo, Shrenik Shah and Denise Visco

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 714-721;

PULMONARY PHARMACOLOGY

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Nitric Oxide Opposes Phorbol Ester-Induced Increases in Pulmonary Microvascular Permeability in Dogs
Randy S. Sprague, Alan H. Stephenson, Lorraine Mcmurdo and Andrew J. Lonigro

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 443-448;
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Leukotriene D₄ Contractions in Human Airways are Blocked by SK&F 96365, an Inhibitor of Receptor-Mediated Calcium Entry
Isabelle Gorenne, Carlos Labat, Jean-Pierre Gascard, Xavier Norel, Nabila Nashashibi and Charles Brink

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 549-552;
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Functional and Binding Characterization of Endothelin Receptors in Human Bronchus: Evidence for a Novel Endothelin B Receptor Subtype?
Douglas W. P. Hay, Mark A. Luttmann, Mark A. Pullen and Ponnal Nambi

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 669-677;

RENAL PHARMACOLOGY

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Probenecid Protects against In VivoAcetaminophen-Induced Nephrotoxicity in Male Wistar Rats
Laura Trumper, Liliana A. Monasterolo and M. Mónica Elías

Journal of Pharmacology and Experimental Therapeutics February 1998, 284 (2) 606-610;

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Table of Contents

ANALGESIA AND DRUGS OF ABUSE

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR PHARMACOLOGY

CELLULAR AND MOLECULAR PHARMACOLOGY

CHEMOTHERAPY/GENE THERAPY

DEVELOPMENTAL PHARMACOLOGY

DRUG METABOLISM AND DISPOSITION

ENDOCRINE PHARMACOLOGY

GASTROINTESTINAL PHARMACOLOGY

IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

PULMONARY PHARMACOLOGY

RENAL PHARMACOLOGY

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