Journal of Pharmacology and Experimental Therapeutics: 284 (1)

January 01, 1998; Volume 284,Issue 1

ANALGESIA AND DRUGS OF ABUSE

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Cocaine Blockade of the Acetylcholine-Activated Muscarinic K⁺ Channel in Ferret Cardiac Myocytes
Yong-Fu Xiao and James P. Morgan

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 10-18;
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Dopamine Release in the Nucleus Accumbens during Heroin Self-Administration Is Modulated by Kappa Opioid Receptors: An In Vivo Fast-Cyclic Voltammetry Study
Zheng-Xiong Xi, Scott A. Fuller and Elliot A. Stein

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 151-161;
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The Nitric Oxide/Cyclic GMP System at the Supraspinal Site Is Involved in the Development of Acute Morphine Antinociceptive Tolerance ^,
Jimmy Y. Xu, Kevin P. Hill and Jean M. Bidlack

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 196-201;
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Mutagenesis of the Mouse Delta Opioid Receptor Converts (−)-Buprenorphine from a Partial Agonist to an Antagonist
George Bot, Allan D. Blake, Shuixing Li and Terry Reisine

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 283-290;
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LY320135, a Novel Cannabinoid CB1 Receptor Antagonist, Unmasks Coupling of the CB1 Receptor to Stimulation of cAMP Accumulation
Christian C. Felder, Kelly E. Joyce, Eileen M. Briley, Michelle Glass, Kenneth P. Mackie, Kennan J. Fahey, George J. Cullinan, David C. Hunden, Douglas W. Johnson, Michael O. Chaney, Gary A. Koppel and Michael Brownstein

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 291-297;
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Differential Effects of Intrathecally AdministeredDelta and Mu Opioid Receptor Agonists on Formalin-Evoked Nociception and on the Expression of Fos-like Immunoreactivity in the Spinal Cord of the Rat
Donna L. Hammond, Huilan Wang, Nora Nakashima and Allan I. Basbaum

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 378-387;

AUTONOMIC PHARMACOLOGY

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Contractile Roles of the M₂ and M₃Muscarinic Receptors in the Guinea Pig Colon
Gregory W. Sawyer and Frederick J. Ehlert

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 269-277;
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The Effect of Topical Diltiazem on the Intraocular Pressure in Betamethasone-Induced Ocular Hypertensive Rabbits
José Melena, Juan Santafé and José Segarra

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 278-282;
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A Positive and Reversible Relationship Between Adrenergic Nerves and Alpha-1A Adrenoceptors in Rat Arteries
Frank R. M. Stassen, Roel G. H. T. Maas, Paul M. H. Schiffers, Ger M. J. Janssen and Jo G. R. De Mey

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 399-405;

BEHAVIORAL PHARMACOLOGY

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Discriminative Stimulus Characteristics of BMY 14802 in the Pigeon
Susan A. Vanecek, William D. Essman, Duncan P. Taylor and James H. Woods

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 1-9;
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γ-Aminobutyric Acid_A Agonists Differentially Augment Gnawing Induced by Indirect-Acting Dopamine Agonists in C57BL/6J Mice
Ezio Tirelli, Beth Geter-Douglass and Jeffrey M. Witkin

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 116-124;
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Discriminative Stimulus Effects of 8-Hydroxy-2-(di-n-propylamino)tetralin in Pigeons and Rats: Species Similarities and Differences
Mark S. Kleven and Wouter Koek

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 238-249;

CARDIOVASCULAR PHARMACOLOGY

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Mechanism of Hypocholesterolemic Action of S-8921 in Rats: S-8921 Inhibits Ileal Bile Acid Absorption
Teruhisa Ichihashi, Mariko Izawa, Kenji Miyata, Takuji Mizui, Koichiro Hirano and Yasushi Takagishi

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 43-50;
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Carbachol Increases Contractions and Intracellular Ca⁺⁺ Transients in Guinea Pig Ventricular Myocytes
Lev Protas, Jian-Bing Shen and Achilles J. Pappano

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 66-74;
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Substantially Attenuated Hemodynamic Responses toEscherichia coli-Derived Vascular Endothelial Growth Factor Given by Intravenous Infusion Compared with Bolus Injection
Renhui Yang, Stuart Bunting, Annie Ko, Bruce A. Keyt, Nishit B. Modi, Thomas F. Zioncheck, Napoleone Ferrara and Hongkui Jin

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 103-110;
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Characterization of Stress-Induced Sudden Death in Cardiomyopathic Hamsters
Nobuya Matsuoka, Hiroyuki Arakawa, Hiroshi Kodama and Isamu Yamaguchi

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 125-135;
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Differential Distribution of Angiotensin AT₂Receptors in the Normal and Failing Human Heart
John Wharton, Kevin Morgan, Richard A. D. Rutherford, John D. Catravas, Adrian Chester, Bruce F. Whitehead, Marc R. De Leval, Magdi H. Yacoub and Julia M. Polak

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 323-336;
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Integration of Mitogen-Activated Protein Kinase Kinase Activation in Vascular 5-Hydroxytryptamine_2A Receptor Signal Transduction
Jennifer A. Florian and Stephanie W. Watts

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 346-355;
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Reduction of Myocardial Infarct Size In Vivo by Carbohydrate-Based Glycomimetics
Kenneth S. Kilgore, Elaine J. Tanhehco, James L. Park, Keith B. Naylor, Mark B. Anderson and Benedict R. Lucchesi

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 427-435;

CELLULAR AND MOLECULAR PHARMACOLOGY

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Amiodarone Inhibits the Na⁺-K⁺ Pump in Rabbit Cardiac Myocytes after Acute and Chronic Treatment
David F. Gray, Anastasia S. Mihailidou, Peter S. Hansen, Kerrie A. Buhagiar, Nerida L. Bewick, Helge H. Rasmussen and David W. Whalley

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 75-82;
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Colchicine Is a Competitive Antagonist at Human Recombinant γ-Aminobutyric Acid_A Receptors
J. L. Weiner, A. V. Buhler, V. J. Whatley, R. A. Harris and T. V. Dunwiddie

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 95-102;
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Inhibition of Neuronal Na⁺ Channels by Antidepressant Drugs
Joseph J. Pancrazio, Ganesan L. Kamatchi, Amy K. Roscoe and Carl Lynch

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 208-214;
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Ethanol Increases the Activity of Ca⁺⁺-Dependent K⁺ (mslo) Channels: Functional Interaction with Cytosolic Ca⁺⁺
Alejandro M. Dopico, Vellareddy Anantharam and Steven N. Treistman

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 258-268;
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Signal Transduction Mechanisms Involved in Angiotensin-(1–7)-Stimulated Arachidonic Acid Release and Prostanoid Synthesis in Rabbit Aortic Smooth Muscle Cells
Mubarack M. Muthalif, Ibrahim F. Benter, Mohammad R. Uddin, Jason L. Harper and Kafait U. Malik

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 388-398;

DEVELOPMENTAL PHARMACOLOGY

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Opioid-Induced Analgesia in Neonatal Dogs: Pharmacodynamic Differences between Morphine and Fentanyl
Andrew M. Luks, Maurice S. Zwass, Ronald C. Brown, Marie Lau, Gopal Chari and Dennis M. Fisher

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 136-141;

DRUG METABOLISM AND DISPOSITION

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In Vivo Disposition of Dermorphin Analog (DALDA) in Nonpregnant and Pregnant Sheep
Hazel H. Szeto, James F. Clapp, Dominic M. Desiderio, Peter W. Schiller, Olga O. Grigoriants, Yi Soong, Dunli Wu, Niculina Olariu, Jih-Lie Tseng and Robert Becklin

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 61-65;
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Pharmacokinetics of IgG and IgM Anti-Ganglioside Antibodies in Rats and Monkeys after Intrathecal Administration
Ira Bergman, Gilbert J. Burckart, Clifford R. Pohl, Raman Venkataramanan, Mamdouha A. Barmada, Judith A. Griffin and Nai-Kong V. Cheung

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 111-115;
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Relevance of Arteriovenous Concentration Differences in Pharmacokinetic-Pharmacodynamic Modeling of Midazolam
B. Tuk, V. M. M. Herben, J. W. Mandema and M. Danhof

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 202-207;
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A New Genetic Defect in Human CYP2C19: Mutation of the Initiation Codon Is Responsible for Poor Metabolism of S-Mephenytoin
Ronald J. Ferguson, Sonia M.F. De Morais, Simone Benhamou, Christine Bouchardy, Joyce Blaisdell, Gordon Ibeanu, Grant R. Wilkinson, Troy C. Sarich, James M. Wright, Pierre Dayer and Joyce A. Goldstein

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 356-361;

ENDOCRINE PHARMACOLOGY

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The Effect of Orally Administered Clodronate on Bone Mineral Density and Bone Geometry in Ovariectomized Rats
T. Österman, L. Laurén, P. Kuurtamo, R. Hannuniemi, P. Isaksson, K. Kippo, Z. Peng, H. K. Väänänen and R. Sellman

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 312-316;

GASTROINTESTINAL PHARMACOLOGY

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Roles of Extracellular Ca⁺⁺ and Calmodulin in Roxatidine-Stimulated Secretion and Synthesis of Mucus by Cultured Rabbit Gastric Mucosal Cells
Satoru Takahashi and Susumu Okabe

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 37-42;
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Absorption Enhancement through Intracellular Regulation of Tight Junction Permeability by Medium Chain Fatty Acids in Caco-2 Cells
Tuulikki Lindmark, Yukitaka Kimura and Per Artursson

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 362-369;

IMMUNOPHARMACOLOGY

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Differential Effects of Salbutamol and Salmeterol on Human Eosinophil Responses
Charles I. Ezeamuzie and Mary Al-Hage

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 25-31;
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The Role of Platelet-Activating Factor (PAF) and the Efficacy of ABT-491, a Highly Potent and Selective PAF Antagonist, in Experimental Allergic Rhinitis
Daniel H. Albert, Peter E. Malo, Paul Tapang, Thomas K. Shaughnessy, Douglas W. Morgan, Craig D. Wegner, Michael L. Curtin, George S. Sheppard, Lianhong Xu, Steven K. Davidsen, James B. Summers and George W. Carter

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 83-88;
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ONO-4007, an Antitumor Lipid A Analog, Induces Tumor Necrosis Factor-α Production by Human Monocytes Only under Primed State: Different Effects of ONO-4007 and Lipopolysaccharide on Cytokine Production
Norihito Matsumoto, Yoshiya Aze, Akira Akimoto and Tsuneo Fujita

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 189-195;
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Detection of Kappa Opioid Receptors on Mouse Thymocyte Phenotypic Subpopulations as Assessed by Flow Cytometry
Tracey A. Ignatowski and Jean M. Bidlack

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 298-306;
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SB 207499 (Ariflo), a Potent and Selective Second-Generation Phosphodiesterase 4 Inhibitor: In VitroAnti-inflammatory Actions
Mary S. Barnette, Siegfried B. Christensen, David M. Essayan, Marilyn Grous, Uma Prabhakar, Julia A. Rush, Anne Kagey-Sobotka and Theodore J. Torphy

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 420-426;

NEUROPHARMACOLOGY

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Selective Actions of a Detergent on Ligand-Gated Ion Channels Expressed in Xenopus Oocytes
Tina K. Machu, S. John Mihic and J. E. Dildy-Mayfield

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 32-36;
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Corticotropin-Releasing Factor Increases Dihydropyridine- and Neurotoxin-Resistant Calcium Currents in Neurons of the Central Amygdala
Baojian Yu and Patricia Shinnick-Gallagher

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 170-179;
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Adaptation of γ-Aminobutyric Acid Type A Receptors to Alcohol Exposure: Studies with Stably Transfected Cells
R. Adron Harris, C. Fernando Valenzuela, Susan Brozowski, Luminita Chuang, Karen Hadingham and Paul J. Whiting

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 180-188;
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Synthetic Combined Superoxide Dismutase/Catalase Mimetics Are Protective as a Delayed Treatment in a Rat Stroke Model: A Key Role for Reactive Oxygen Species in Ischemic Brain Injury
Keith Baker, Catherine Bucay Marcus, Karl Huffman, Henry Kruk, Bernard Malfroy and Susan R. Doctrow

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 215-221;
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Reduction of Cortical Pyramidal Neuron Excitability by the Action of Phenytoin on Persistent Na⁺ Current
Ilan Lampl, Peter Schwindt and Wayne Crill

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 228-237;
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Prenatal Ethanol Exposure Alters the Modulation of the γ-Aminobutyric Acid_A Receptor-Gated Chloride Ion Channel in Adult Rat Offspring
Andrea M. Allan, Hua Wu, Linda L. Paxton and Daniel D. Savage

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 250-257;
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Trihexyphenidyl Interactions with the Dopamine D₁-Selective Receptor Agonist SKF-82958 and the D₂-Selective Receptor Agonist N-0923 in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Hemiparkinsonian Monkeys
Edward F. Domino and Lisong Ni

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 307-311;
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Metabotropic Glutamate Receptors in the Rat Nucleus Accumbens Contribute to Amphetamine-Induced Locomotion
Jeong-Hoon Kim and Paul Vezina

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 317-322;

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

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Cytochromes P450 with Bisallylic Hydroxylation Activity on Arachidonic and Linoleic Acids Studied with Human Recombinant Enzymes and with Human and Rat Liver Microsomes
Johan Bylund, Tina Kunz, Karin Valmsen and Ernst H. Oliw

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 51-60;
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Lisofylline Causes Rapid and Prolonged Suppression of Serum Levels of Free Fatty Acids
Stuart L. Bursten, David Federighi, Jeffrey Wald, Brent Meengs, William Spickler and Edward Nudelman

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 337-345;

PULMONARY PHARMACOLOGY

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Differential Susceptibility of Tracheal Contraction to Nonadrenergic Noncholinergic Relaxation
David C. Thompson and Ralph J. Altiere

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 19-24;
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Novel Phosphodiesterase 4 Inhibitor T-440 Reverses and Prevents Human Bronchial Contraction Induced by Allergen
Kazuhiko Fujii, Hirotsugu Kohrogi, Hajime Iwagoe, Junji Hamamoto, Naomi Hirata, Eisuke Goto, Osamu Kawano, Kazuteru Wada, Shinsuke Yamagata and Masayuki Ando

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 162-169;
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Fluticasone Propionate and Pentamidine Isethionate Reduce Airway Hyperreactivity, Pulmonary Eosinophilia and Pulmonary Dendritic Cell Response in a Guinea Pig Model of Asthma
Tracey E. Lawrence, Lyndell L. Millecchia and Jeffrey S. Fedan

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 222-227;
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Pharmacological Analysis of the Tachykinin Receptors that Mediate Activation of Nonadrenergic, Noncholinergic Relaxant Nerves that Innervate Guinea Pig Trachealis
Brendan J. Canning, Axel Fischer and Bradley J. Undem

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 370-377;

RENAL PHARMACOLOGY

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Probenecid Alters Topotecan Systemic and Renal Disposition by Inhibiting Renal Tubular Secretion
William C. Zamboni, Peter J. Houghton, Randall K. Johnson, Jeff L. Hulstein, William R. Crom, Pam J. Cheshire, Suzan K. Hanna, Lois B. Richmond, Xiaolong Luo and Clinton F. Stewart

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 89-94;
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Role of Protein Thiols in Inhibition of Sodium-Coupled Glucose Uptake by Cisplatin in Renal Brush-Border Membrane Vesicles
Sophie Potdevin, Françoise Courjault-Gautier, Bertrand Monegier Du Sorbier, Pierre Ripoche and Hervé J. Toutain

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 142-150;

TOXICOLOGY

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The 21-Aminosteroid 16-Desmethyl Tirilazad Mesylate Prevents Necroinflammatory Changes in Experimental Alcoholic Liver Disease
S. M. Hossein Sadrzadeh and Amin A. Nanji

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 406-412;
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Liver Toxicity from Norcocaine Nitroxide, an N-Oxidative Metabolite of Cocaine
Florence M. Ndikum-Moffor, Trenton R. Schoeb and Stephen M. Roberts

Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 413-419;

Erratum

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Correction for vol. 282, p. 1064
Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 435;

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Table of Contents

ANALGESIA AND DRUGS OF ABUSE

AUTONOMIC PHARMACOLOGY

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR PHARMACOLOGY

CELLULAR AND MOLECULAR PHARMACOLOGY

DEVELOPMENTAL PHARMACOLOGY

DRUG METABOLISM AND DISPOSITION

ENDOCRINE PHARMACOLOGY

GASTROINTESTINAL PHARMACOLOGY

IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

PULMONARY PHARMACOLOGY

RENAL PHARMACOLOGY

TOXICOLOGY

Erratum

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