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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

January 01, 1998; Volume 284,Issue 1

ANALGESIA AND DRUGS OF ABUSE

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    Cocaine Blockade of the Acetylcholine-Activated Muscarinic K+ Channel in Ferret Cardiac Myocytes
    Yong-Fu Xiao and James P. Morgan
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 10-18;
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    Dopamine Release in the Nucleus Accumbens during Heroin Self-Administration Is Modulated by Kappa Opioid Receptors: An In Vivo Fast-Cyclic Voltammetry Study
    Zheng-Xiong Xi, Scott A. Fuller and Elliot A. Stein
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 151-161;
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    The Nitric Oxide/Cyclic GMP System at the Supraspinal Site Is Involved in the Development of Acute Morphine Antinociceptive Tolerance ,
    Jimmy Y. Xu, Kevin P. Hill and Jean M. Bidlack
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 196-201;
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    Mutagenesis of the Mouse Delta Opioid Receptor Converts (−)-Buprenorphine from a Partial Agonist to an Antagonist
    George Bot, Allan D. Blake, Shuixing Li and Terry Reisine
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 283-290;
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    LY320135, a Novel Cannabinoid CB1 Receptor Antagonist, Unmasks Coupling of the CB1 Receptor to Stimulation of cAMP Accumulation
    Christian C. Felder, Kelly E. Joyce, Eileen M. Briley, Michelle Glass, Kenneth P. Mackie, Kennan J. Fahey, George J. Cullinan, David C. Hunden, Douglas W. Johnson, Michael O. Chaney, Gary A. Koppel and Michael Brownstein
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 291-297;
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    Differential Effects of Intrathecally AdministeredDelta and Mu Opioid Receptor Agonists on Formalin-Evoked Nociception and on the Expression of Fos-like Immunoreactivity in the Spinal Cord of the Rat
    Donna L. Hammond, Huilan Wang, Nora Nakashima and Allan I. Basbaum
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 378-387;

AUTONOMIC PHARMACOLOGY

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    Contractile Roles of the M2 and M3Muscarinic Receptors in the Guinea Pig Colon
    Gregory W. Sawyer and Frederick J. Ehlert
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 269-277;
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    The Effect of Topical Diltiazem on the Intraocular Pressure in Betamethasone-Induced Ocular Hypertensive Rabbits
    José Melena, Juan Santafé and José Segarra
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 278-282;
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    A Positive and Reversible Relationship Between Adrenergic Nerves and Alpha-1A Adrenoceptors in Rat Arteries
    Frank R. M. Stassen, Roel G. H. T. Maas, Paul M. H. Schiffers, Ger M. J. Janssen and Jo G. R. De Mey
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 399-405;

BEHAVIORAL PHARMACOLOGY

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    Discriminative Stimulus Characteristics of BMY 14802 in the Pigeon
    Susan A. Vanecek, William D. Essman, Duncan P. Taylor and James H. Woods
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 1-9;
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    γ-Aminobutyric AcidA Agonists Differentially Augment Gnawing Induced by Indirect-Acting Dopamine Agonists in C57BL/6J Mice
    Ezio Tirelli, Beth Geter-Douglass and Jeffrey M. Witkin
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 116-124;
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    Discriminative Stimulus Effects of 8-Hydroxy-2-(di-n-propylamino)tetralin in Pigeons and Rats: Species Similarities and Differences
    Mark S. Kleven and Wouter Koek
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 238-249;

CARDIOVASCULAR PHARMACOLOGY

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    Mechanism of Hypocholesterolemic Action of S-8921 in Rats: S-8921 Inhibits Ileal Bile Acid Absorption
    Teruhisa Ichihashi, Mariko Izawa, Kenji Miyata, Takuji Mizui, Koichiro Hirano and Yasushi Takagishi
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 43-50;
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    Carbachol Increases Contractions and Intracellular Ca++ Transients in Guinea Pig Ventricular Myocytes
    Lev Protas, Jian-Bing Shen and Achilles J. Pappano
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 66-74;
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    Substantially Attenuated Hemodynamic Responses toEscherichia coli-Derived Vascular Endothelial Growth Factor Given by Intravenous Infusion Compared with Bolus Injection
    Renhui Yang, Stuart Bunting, Annie Ko, Bruce A. Keyt, Nishit B. Modi, Thomas F. Zioncheck, Napoleone Ferrara and Hongkui Jin
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 103-110;
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    Characterization of Stress-Induced Sudden Death in Cardiomyopathic Hamsters
    Nobuya Matsuoka, Hiroyuki Arakawa, Hiroshi Kodama and Isamu Yamaguchi
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 125-135;
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    Differential Distribution of Angiotensin AT2Receptors in the Normal and Failing Human Heart
    John Wharton, Kevin Morgan, Richard A. D. Rutherford, John D. Catravas, Adrian Chester, Bruce F. Whitehead, Marc R. De Leval, Magdi H. Yacoub and Julia M. Polak
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 323-336;
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    Integration of Mitogen-Activated Protein Kinase Kinase Activation in Vascular 5-Hydroxytryptamine2A Receptor Signal Transduction
    Jennifer A. Florian and Stephanie W. Watts
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 346-355;
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    Reduction of Myocardial Infarct Size In Vivo by Carbohydrate-Based Glycomimetics
    Kenneth S. Kilgore, Elaine J. Tanhehco, James L. Park, Keith B. Naylor, Mark B. Anderson and Benedict R. Lucchesi
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 427-435;

CELLULAR AND MOLECULAR PHARMACOLOGY

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    Amiodarone Inhibits the Na+-K+ Pump in Rabbit Cardiac Myocytes after Acute and Chronic Treatment
    David F. Gray, Anastasia S. Mihailidou, Peter S. Hansen, Kerrie A. Buhagiar, Nerida L. Bewick, Helge H. Rasmussen and David W. Whalley
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 75-82;
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    Colchicine Is a Competitive Antagonist at Human Recombinant γ-Aminobutyric AcidA Receptors
    J. L. Weiner, A. V. Buhler, V. J. Whatley, R. A. Harris and T. V. Dunwiddie
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 95-102;
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    Inhibition of Neuronal Na+ Channels by Antidepressant Drugs
    Joseph J. Pancrazio, Ganesan L. Kamatchi, Amy K. Roscoe and Carl Lynch
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 208-214;
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    Ethanol Increases the Activity of Ca++-Dependent K+ (mslo) Channels: Functional Interaction with Cytosolic Ca++ 
    Alejandro M. Dopico, Vellareddy Anantharam and Steven N. Treistman
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 258-268;
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    Signal Transduction Mechanisms Involved in Angiotensin-(1–7)-Stimulated Arachidonic Acid Release and Prostanoid Synthesis in Rabbit Aortic Smooth Muscle Cells
    Mubarack M. Muthalif, Ibrahim F. Benter, Mohammad R. Uddin, Jason L. Harper and Kafait U. Malik
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 388-398;

DEVELOPMENTAL PHARMACOLOGY

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    Opioid-Induced Analgesia in Neonatal Dogs: Pharmacodynamic Differences between Morphine and Fentanyl
    Andrew M. Luks, Maurice S. Zwass, Ronald C. Brown, Marie Lau, Gopal Chari and Dennis M. Fisher
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 136-141;

DRUG METABOLISM AND DISPOSITION

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    In Vivo Disposition of Dermorphin Analog (DALDA) in Nonpregnant and Pregnant Sheep
    Hazel H. Szeto, James F. Clapp, Dominic M. Desiderio, Peter W. Schiller, Olga O. Grigoriants, Yi Soong, Dunli Wu, Niculina Olariu, Jih-Lie Tseng and Robert Becklin
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 61-65;
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    Pharmacokinetics of IgG and IgM Anti-Ganglioside Antibodies in Rats and Monkeys after Intrathecal Administration
    Ira Bergman, Gilbert J. Burckart, Clifford R. Pohl, Raman Venkataramanan, Mamdouha A. Barmada, Judith A. Griffin and Nai-Kong V. Cheung
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 111-115;
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    Relevance of Arteriovenous Concentration Differences in Pharmacokinetic-Pharmacodynamic Modeling of Midazolam
    B. Tuk, V. M. M. Herben, J. W. Mandema and M. Danhof
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 202-207;
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    A New Genetic Defect in Human CYP2C19: Mutation of the Initiation Codon Is Responsible for Poor Metabolism of S-Mephenytoin
    Ronald J. Ferguson, Sonia M.F. De Morais, Simone Benhamou, Christine Bouchardy, Joyce Blaisdell, Gordon Ibeanu, Grant R. Wilkinson, Troy C. Sarich, James M. Wright, Pierre Dayer and Joyce A. Goldstein
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 356-361;

ENDOCRINE PHARMACOLOGY

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    The Effect of Orally Administered Clodronate on Bone Mineral Density and Bone Geometry in Ovariectomized Rats
    T. Österman, L. Laurén, P. Kuurtamo, R. Hannuniemi, P. Isaksson, K. Kippo, Z. Peng, H. K. Väänänen and R. Sellman
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 312-316;

GASTROINTESTINAL PHARMACOLOGY

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    Roles of Extracellular Ca++ and Calmodulin in Roxatidine-Stimulated Secretion and Synthesis of Mucus by Cultured Rabbit Gastric Mucosal Cells
    Satoru Takahashi and Susumu Okabe
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 37-42;
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    Absorption Enhancement through Intracellular Regulation of Tight Junction Permeability by Medium Chain Fatty Acids in Caco-2 Cells
    Tuulikki Lindmark, Yukitaka Kimura and Per Artursson
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 362-369;

IMMUNOPHARMACOLOGY

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    Differential Effects of Salbutamol and Salmeterol on Human Eosinophil Responses
    Charles I. Ezeamuzie and Mary Al-Hage
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 25-31;
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    The Role of Platelet-Activating Factor (PAF) and the Efficacy of ABT-491, a Highly Potent and Selective PAF Antagonist, in Experimental Allergic Rhinitis
    Daniel H. Albert, Peter E. Malo, Paul Tapang, Thomas K. Shaughnessy, Douglas W. Morgan, Craig D. Wegner, Michael L. Curtin, George S. Sheppard, Lianhong Xu, Steven K. Davidsen, James B. Summers and George W. Carter
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 83-88;
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    ONO-4007, an Antitumor Lipid A Analog, Induces Tumor Necrosis Factor-α Production by Human Monocytes Only under Primed State: Different Effects of ONO-4007 and Lipopolysaccharide on Cytokine Production
    Norihito Matsumoto, Yoshiya Aze, Akira Akimoto and Tsuneo Fujita
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 189-195;
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    Detection of Kappa Opioid Receptors on Mouse Thymocyte Phenotypic Subpopulations as Assessed by Flow Cytometry
    Tracey A. Ignatowski and Jean M. Bidlack
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 298-306;
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    SB 207499 (Ariflo), a Potent and Selective Second-Generation Phosphodiesterase 4 Inhibitor: In VitroAnti-inflammatory Actions
    Mary S. Barnette, Siegfried B. Christensen, David M. Essayan, Marilyn Grous, Uma Prabhakar, Julia A. Rush, Anne Kagey-Sobotka and Theodore J. Torphy
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 420-426;

NEUROPHARMACOLOGY

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    Selective Actions of a Detergent on Ligand-Gated Ion Channels Expressed in Xenopus Oocytes
    Tina K. Machu, S. John Mihic and J. E. Dildy-Mayfield
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 32-36;
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    Corticotropin-Releasing Factor Increases Dihydropyridine- and Neurotoxin-Resistant Calcium Currents in Neurons of the Central Amygdala
    Baojian Yu and Patricia Shinnick-Gallagher
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 170-179;
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    Adaptation of γ-Aminobutyric Acid Type A Receptors to Alcohol Exposure: Studies with Stably Transfected Cells
    R. Adron Harris, C. Fernando Valenzuela, Susan Brozowski, Luminita Chuang, Karen Hadingham and Paul J. Whiting
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 180-188;
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    Synthetic Combined Superoxide Dismutase/Catalase Mimetics Are Protective as a Delayed Treatment in a Rat Stroke Model: A Key Role for Reactive Oxygen Species in Ischemic Brain Injury
    Keith Baker, Catherine Bucay Marcus, Karl Huffman, Henry Kruk, Bernard Malfroy and Susan R. Doctrow
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 215-221;
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    Reduction of Cortical Pyramidal Neuron Excitability by the Action of Phenytoin on Persistent Na+ Current
    Ilan Lampl, Peter Schwindt and Wayne Crill
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 228-237;
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    Prenatal Ethanol Exposure Alters the Modulation of the γ-Aminobutyric AcidA Receptor-Gated Chloride Ion Channel in Adult Rat Offspring
    Andrea M. Allan, Hua Wu, Linda L. Paxton and Daniel D. Savage
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 250-257;
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    Trihexyphenidyl Interactions with the Dopamine D1-Selective Receptor Agonist SKF-82958 and the D2-Selective Receptor Agonist N-0923 in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Hemiparkinsonian Monkeys
    Edward F. Domino and Lisong Ni
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 307-311;
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    Metabotropic Glutamate Receptors in the Rat Nucleus Accumbens Contribute to Amphetamine-Induced Locomotion
    Jeong-Hoon Kim and Paul Vezina
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 317-322;

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

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    Cytochromes P450 with Bisallylic Hydroxylation Activity on Arachidonic and Linoleic Acids Studied with Human Recombinant Enzymes and with Human and Rat Liver Microsomes
    Johan Bylund, Tina Kunz, Karin Valmsen and Ernst H. Oliw
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 51-60;
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    Lisofylline Causes Rapid and Prolonged Suppression of Serum Levels of Free Fatty Acids
    Stuart L. Bursten, David Federighi, Jeffrey Wald, Brent Meengs, William Spickler and Edward Nudelman
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 337-345;

PULMONARY PHARMACOLOGY

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    Differential Susceptibility of Tracheal Contraction to Nonadrenergic Noncholinergic Relaxation
    David C. Thompson and Ralph J. Altiere
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 19-24;
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    Novel Phosphodiesterase 4 Inhibitor T-440 Reverses and Prevents Human Bronchial Contraction Induced by Allergen
    Kazuhiko Fujii, Hirotsugu Kohrogi, Hajime Iwagoe, Junji Hamamoto, Naomi Hirata, Eisuke Goto, Osamu Kawano, Kazuteru Wada, Shinsuke Yamagata and Masayuki Ando
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 162-169;
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    Fluticasone Propionate and Pentamidine Isethionate Reduce Airway Hyperreactivity, Pulmonary Eosinophilia and Pulmonary Dendritic Cell Response in a Guinea Pig Model of Asthma
    Tracey E. Lawrence, Lyndell L. Millecchia and Jeffrey S. Fedan
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 222-227;
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    Pharmacological Analysis of the Tachykinin Receptors that Mediate Activation of Nonadrenergic, Noncholinergic Relaxant Nerves that Innervate Guinea Pig Trachealis
    Brendan J. Canning, Axel Fischer and Bradley J. Undem
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 370-377;

RENAL PHARMACOLOGY

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    Probenecid Alters Topotecan Systemic and Renal Disposition by Inhibiting Renal Tubular Secretion
    William C. Zamboni, Peter J. Houghton, Randall K. Johnson, Jeff L. Hulstein, William R. Crom, Pam J. Cheshire, Suzan K. Hanna, Lois B. Richmond, Xiaolong Luo and Clinton F. Stewart
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 89-94;
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    Role of Protein Thiols in Inhibition of Sodium-Coupled Glucose Uptake by Cisplatin in Renal Brush-Border Membrane Vesicles
    Sophie Potdevin, Françoise Courjault-Gautier, Bertrand Monegier Du Sorbier, Pierre Ripoche and Hervé J. Toutain
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 142-150;

TOXICOLOGY

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    The 21-Aminosteroid 16-Desmethyl Tirilazad Mesylate Prevents Necroinflammatory Changes in Experimental Alcoholic Liver Disease
    S. M. Hossein Sadrzadeh and Amin A. Nanji
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 406-412;
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    Liver Toxicity from Norcocaine Nitroxide, an N-Oxidative Metabolite of Cocaine
    Florence M. Ndikum-Moffor, Trenton R. Schoeb and Stephen M. Roberts
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 413-419;

Erratum

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    Correction for vol. 282, p. 1064
    Journal of Pharmacology and Experimental Therapeutics January 1998, 284 (1) 435;
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Journal of Pharmacology and Experimental Therapeutics
Vol. 284, Issue 1
1 Jan 1998
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  • ANALGESIA AND DRUGS OF ABUSE
  • AUTONOMIC PHARMACOLOGY
  • BEHAVIORAL PHARMACOLOGY
  • CARDIOVASCULAR PHARMACOLOGY
  • CELLULAR AND MOLECULAR PHARMACOLOGY
  • DEVELOPMENTAL PHARMACOLOGY
  • DRUG METABOLISM AND DISPOSITION
  • ENDOCRINE PHARMACOLOGY
  • GASTROINTESTINAL PHARMACOLOGY
  • IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS
  • PULMONARY PHARMACOLOGY
  • RENAL PHARMACOLOGY
  • TOXICOLOGY
  • Erratum
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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