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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

December 01, 1997; Volume 283,Issue 3

ANALGESIA AND DRUGS OF ABUSE

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    Blood-Brain Disposition and Antinociceptive Effects of [d-Penicillamine2,5]enkephalin in the Mouse
    Cuiping Chen and Gary M. Pollack
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1151-1159;
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    Modulation of Nociception by Microinjection ofDelta-1 and Delta-2 Opioid Receptor Ligands in the Ventromedial Medulla of the Rat
    Sanjay N. Thorat and Donna L. Hammond
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1185-1192;
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    The Competitive α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionate Receptor Antagonist LY293558 Attenuates and Reverses Analgesic Tolerance to Morphine But Not to Delta or Kappa Opioids
    Benjamin Kest, Gabrielle McLemore, Bernard Kao and Charles E. Inturrisi
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1249-1255;
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    Delta Opioid Modulation of the Binding of Guanosine-5′-O-(3-[35S]thio)triphosphate to NG108–15 Cell Membranes: Characterization of Agonist and Inverse Agonist Effects
    Philip G. Szekeres and John R. Traynor
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1276-1284;
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    GR89,696 Is a Kappa-2 Opioid Receptor Agonist and a Kappa-1 Opioid Receptor Antagonist in the Guinea Pig Hippocampus
    Robert M. Caudle, Andrew J. Mannes and Michael J. Iadarola
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1342-1349;
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    Novel Qualitative Structure-Activity Relationships for the Antinociceptive Actions of H2 Antagonists, H3Antagonists and Derivatives
    L. B. Hough, J. W. Nalwalk, B. Y. Li, R. Leurs, W.M.P.B. Menge, H. Timmerman, M. E. Carlile, C. Cioffi and M. Wentland
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1534-1543;

BEHAVIORAL PHARMACOLOGY

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    Nifedipine, an L-type Calcium Channel Blocker, Restores the Hypnotic Response in Rats Made Tolerant to the Alpha-2 Adrenergic Agonist Dexmedetomidine
    Kristina Reid, Tian-Zhi Guo, M. Frances Davies and Mervyn Maze
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 993-999;
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    Discriminative Stimulus Effects of the Mixed-Opioid Agonist/Antagonist Dezocine: Cross-Substitution by Muand Delta Opioid Agonists
    Mitchell J. Picker
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1009-1017;
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    Pharmacokinetic-Pharmacodynamic Modeling of Stimulatory and Sedative Effects of Alprazolam: Timing Performance Deficits
    Chyan E. Lau and Anne C. Heatherington
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1119-1129;
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    The Effect of the Enzyme Inhibitor Phenylmethylsulfonyl Fluoride on the Pharmacological Effect of Anandamide in the Mouse Model of Cannabimimetic Activity
    David R. Compton and Billy R. Martin
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1138-1143;
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    Synergistic Effects of Cocaine with Lateral Hypothalamic Brain Stimulation Reward: Lack of Tolerance or Sensitization
    Pat Bauco and Roy A. Wise
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1160-1167;
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    L-745,870, a Subtype Selective Dopamine D4 Receptor Antagonist, Does Not Exhibit a Neuroleptic-Like Profile in Rodent Behavioral Tests
    Linda J. Bristow, Neil Collinson, Gina P. Cook, Neil Curtis, Stephen B. Freedman, Janusz J. Kulagowski, Paul D. Leeson, Smita Patel, C. Ian Ragan, Mark Ridgill, Kay L. Saywell and Mark D. Tricklebank
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1256-1263;
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    The Selective ς2-Ligand Lu 28-179 Has Potent Anxiolytic-Like Effects in Rodents
    C. Sánchez, J. Arnt, B. Costall, M.E. Kelly, E. Meier, R.J. Naylor and J. Perregaard
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1323-1332;
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    Neonatal Administration of the Selective Serotonin Reuptake Inhibitor Lu 10–134-C Increases Forced Swimming-Induced Immobility in Adult Rats: A Putative Animal Model of Depression?
    H. H. Hansen, C. Sánchez and E. Meier
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1333-1341;
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    In Vivo Effects of Remoxipride and Aromatic Ring Metabolites in the Rat
    Sven Ahlenius, Evalena Ericson, Viveka Hillegaart, Lars B. Nilsson, Peter Salmi and Agneta Wijkström
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1356-1366;

CARDIOVASCULAR PHARMACOLOGY

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    Heparinase III Exerts Endothelial and Cardioprotective Effects in Feline Myocardial Ischemia-Reperfusion Injury
    Reid Hayward, Tareck O. Nossuli and Allan M. Lefer
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1032-1038;
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    Pharmacokinetic-Pharmacodynamic Characterization of the Cardiovascular, Hypnotic, EEG and Ventilatory Responses to Dexmedetomidine in the Rat
    Cornelis J.J.G. Bol, Meindert Danhof, Donald R. Stanski and Jaap W. Mandema
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1051-1058;
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    Angiotensin-Converting Enzyme Inhibition and Angiotensin II Subtype-1 Receptor Blockade during the Progression of Left Ventricular Dysfunction: Differential Effects on Myocyte Contractile Processes
    Francis G. Spinale, Henry H. Holzgrefe, Rupak Mukherjee, Maria L. Webb, R. Barry Hird, Martyn J. Cavallo, James R. Powell and William H. Koster
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1082-1094;
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    Ro 61–1790, a New Hydrosoluble Endothelin Antagonist: General Pharmacology and Effects on Experimental Cerebral Vasospasm
    Sébastien Roux, Volker Breu, Thomas Giller, Werner Neidhart, Henri Ramuz, Philippe Coassolo, Jean Paul Clozel and Martine Clozel
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1110-1118;
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    Pharmacological Characterization of Novel Cyanoguanidines as Vascular KATP Channel Blockers
    Sajida A. Khan, Nicole R. Higdon, Jackson B. Hester and Kaushik D. Meisheri
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1207-1213;
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    Abnormality in Plasma Catecholamines and Myocardial Adrenoceptors in Cardiomyopathic BIO 53.58 Syrian Hamsters and Improvement by Metoprolol Treatment
    Shizuo Yamada, Takashi Ohkura, Tooru Yamadera, Osamu Ito, Ryohei Kimura, Yoshihisa Nozawa, Shuji Hayashi and Hidekazu Miyake
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1389-1395;
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    Influence of Streptozotocin Diabetes on theAlpha-1 Adrenoceptor and Associated G Proteins in Rat Arteries
    Lynn P. Weber and Kathleen M. Macleod
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1469-1478;

CELLULAR AND MOLECULAR PHARMACOLOGY

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    Anabaseine Is a Potent Agonist on Muscle and NeuronalAlpha-Bungarotoxin-Sensitive Nicotinic Receptors
    William R. Kem, Vladimir M. Mahnir, Roger L. Papke and Christopher J. Lingle
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 979-992;
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    SB 202026: A Novel Muscarinic Partial Agonist with Functional Selectivity for M1 Receptors
    J. M. Loudon, S. M. Bromidge, F. Brown, M. S. G. Clark, J. P. Hatcher, J. Hawkins, G. J. Riley, G. Noy and B. S. Orlek
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1059-1068;
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    Inhibition of Guinea Pig Detrusor Contraction by NS-1619 Is Associated with Activation of BKCa and Inhibition of Calcium Currents
    Jeffrey H. Sheldon, N. Wesley Norton and Thomas M. Argentieri
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1193-1200;
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    Regulation of Adenosine Concentration and Cytoprotective Effects of Novel Reversible Adenosine Deaminase Inhibitors
    Jerzy Barankiewicz, Anne M. Danks, Elie Abushanab, Lewis Makings, Torsten Wiemann, Roi Ann Wallis, Palle V. P. Pragnacharyulu, Anthony Fox and Paul J. Marangos
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1230-1238;
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    Ro 25–6981, a Highly Potent and Selective Blocker of N-Methyl-d-aspartate Receptors Containing the NR2B Subunit. Characterization in Vitro
    G. Fischer, V. Mutel, G. Trube, P. Malherbe, J. N. C. Kew, E. Mohacsi, M. P. Heitz and J. A. Kemp
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1285-1292;
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    Neuronal Nicotinic Acetylcholine Receptor Activation Modulates γ-Aminobutyric Acid Release from CA1 Neurons of Rat Hippocampal Slices
    Manickavasagom Alkondon, Edna F. R. Pereira, Catão T. F. Barbosa and Edson X. Albuquerque
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1396-1411;
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    In Vitro Pharmacological Characterization of PD 166285, a New Nanomolar Potent and Broadly Active Protein Tyrosine Kinase Inhibitor
    Robert L. Panek, Gina H. Lu, Sylvester R. Klutchko, Brian L. Batley, Tawny K. Dahring, James M. Hamby, Hussein Hallak, Annette M. Doherty and Joan A. Keiser
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1433-1444;

CHEMOTHERAPY/GENE THERAPY

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    Cell Cycle-Dependent Chronotoxicity of Irinotecan Hydrochloride in Mice
    Shigehiro Ohdo, Tomoko Makinosumi, Takashi Ishizaki, Eiji Yukawa, Shun Higuchi, Shigeyuki Nakano and Nobuya Ogawa
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1383-1388;
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    The Protective Effect of Metallothionein Against Lipid Peroxidation Caused by Retinoic Acid in Human Breast Cancer Cells
    Darin Hurnanen, Hing Man Chan and Stan Kubow
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1520-1528;

DEVELOPMENTAL PHARMACOLOGY

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    Alcohol Dehydrogenase-2*3 Allele Protects Against Alcohol-Related Birth Defects Among African Americans
    D. G. McCarver, H. R. Thomasson, S. S. Martier, R. J. Sokol and T.-K. Li
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1095-1101;

DRUG METABOLISM AND DISPOSITION

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    Selective Brain to Blood Efflux Transport ofpara-Aminohippuric Acid across the Blood-Brain Barrier:In Vivo Evidence by Use of the Brain Efflux Index Method
    Atsuyuki Kakee, Tetsuya Terasaki and Yuichi Sugiyama
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1018-1025;
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    The In Vitro Hepatic Metabolism of Quinine in Mice, Rats and Dogs: Comparison with Human Liver Microsomes
    Xue-Jun Zhao and Takashi Ishizaki
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1168-1176;
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    Isolation, Heterologous Expression and Functional Characterization of a Novel Cytochrome P450 3A Enzyme from a Canine Liver cDNA Library
    David J. Fraser, René Feyereisen, Greg R. Harlow and James R. Halpert
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1425-1432;
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    Irreversible Inhibition of Cytochrome P450 by Nitric Oxide
    Yukiko Minamiyama, Shigekazu Takemura, Susumu Imaoka, Yoshihiko Funae, Yuko Tanimoto and Masayasu Inoue
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1479-1485;
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    Hormonal Regulation of Microsomal Cytochrome P450 2C11 in Rat Liver and Kidney
    Gen-Fu Chen, Martin J. J. Ronis, Paul E. Thomas, David J. Flint and Thomas M. Badger
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1486-1494;
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    Characterization of Interintestinal and Intraintestinal Variations in Human CYP3A-Dependent Metabolism
    Mary F. Paine, Mehraneh Khalighi, Jeannine M. Fisher, Danny D. Shen, Kent L. Kunze, Christopher L. Marsh, James D. Perkins and Kenneth E. Thummel
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1552-1562;

GASTROINTESTINAL PHARMACOLOGY

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    Comparison of Effect of Mosapride Citrate and Existing 5-HT4 Receptor Agonists on Gastrointestinal MotilityIn Vivo and In Vitro
    Yukiko Mine, Takashi Yoshikawa, Seiko Oku, Ryuji Nagai, Naoyuki Yoshida and Kanoo Hosoki
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1000-1008;
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    Positive Modulation of Pepsinogen Secretion by Gastric Acidity After Vagal Cholinergic Stimulation
    Corrado Blandizzi, Rocchina Colucci, Diego Carignani, Gloria Lazzeri and Mario Del Tacca
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1043-1050;
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    Acute Experimental Esophagitis Activates a Second Signal Transduction Pathway in Cat Smooth Muscle from the Lower Esophageal Sphincter
    U. D. Sohn, K. M. Harnett, W. Cao, H. Rich, N. Kim, J. Behar and P. Biancani
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1293-1304;
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    Involvement of Alpha-2 Adrenoceptors in the Effects of Moxonidine on Intestinal Motility and Fluid Transport
    Lu Liu and Ian M. Coupar
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1367-1374;
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    Possible Involvement of 5-HT2 Receptor Activation in Aggravation of Diet-Induced Acute Pancreatitis in Mice
    Takako Yoshino and Isamu Yamaguchi
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1495-1502;

IMMUNOPHARMACOLOGY

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    Active Immunization Alters the Plasma Nicotine Concentration in Rats
    Yoko Hieda, Dan E. Keyler, John T. Vandevoort, Justin K. Kane, Cathy A. Ross, Donna E. Raphael, R. Sam Niedbalas and Paul R. Pentel
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1076-1081;
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    Discovery of Less Nephrotoxic FK506 Analogs and Determining Immunophilin Dependence of Immunosuppressant Nephrotoxicity with a Novel Single-Dose Rat Cisplatin Potentiation Assay
    Karl W. Mollison, Thomas A. Fey, Ruth A. Krause, Janet M. Andrews, Pat T. Bretheim, Julie A. Brandt, Megumi Kawai, Rolf Wagner, Gin C. Hsieh and Jay R. Luly
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1509-1519;

NEUROPHARMACOLOGY

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    Elevated Environmental Temperatures Can Induce Hyperthermia During d-Fenfluramine Exposure and Enhance 5-Hydroxytryptamine (5-HT) Depletion in the Brain
    Christopher W. Stewart, John F. Bowyer and William Slikker
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1144-1150;
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    Chronic Ethanol Exposure Leads to a Selective Enhancement of N-Methyl-d-aspartate Receptor Function in Cultured Hippocampal Neurons
    C. Thetford Smothers, James J. Mrotek and David M. Lovinger
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1214-1222;
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    Effectiveness of Vigabatrin against Focally Evoked Pilocarpine-Induced Seizures and Concomitant Changes in Extracellular Hippocampal and Cerebellar Glutamate, γ-Aminobutyric Acid and Dopamine Levels, a Microdialysis-Electrocorticography Study in Freely Moving Rats
    Ilse Smolders, Ghous M. Khan, Hilde Lindekens, Steven Prikken, Craig A. Marvin, Jacqueline Manil, Guy Ebinger and Yvette Michotte
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1239-1248;
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    Novel Systemically Active Antagonists of the Glycine Site of the N-Methyl-d-aspartate Receptor: Electrophysiological, Biochemical and Behavioral Characterization
    Chris G. Parsons, Wojciech Danysz, Günter Quack, Sabine Hartmann, Bianke Lorenz, Christine Wollenburg, Leokadia Baran, Edmund Przegalinski, Wojciech Kostowski, Pawel Krzascik, Boris Chizh and P. Max. Headley
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1264-1275;
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    Neurotransmitter Receptor and Transporter Binding Profile of Antidepressants and Their Metabolites
    Michael J. Owens, W. Neal Morgan, Susan J. Plott and Charles B. Nemeroff
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1305-1322;
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    Role of Endogenous Dopamine in the Neurochemical Deficits Induced by Methcathinone
    Melanie P. Gygi, Annette E. Fleckenstein, James W. Gibb and Glen R. Hanson
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1350-1355;
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    [(S)-Alpha-Phenyl-2-Pyridine-Ethanamine Dihydrochloride], A Low Affinity Uncompetitive N-Methyl-d-Aspartic Acid Antagonist, Is Effective in Rodent Models of Global and Focal Ischemia
    Edward F. Cregan, James Peeling, Dale Corbett, Alastair M. Buchan, John Saunders, Roland N. Auer, M. Gao, Dennis J. Mccarthy, Mark S. Eisman, T. Mark Campbell, Robert J. Murray, Mary L. Stagnitto and Gene C. Palmer
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1412-1424;
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    Enhanced Dopamine Release and Phosphorylation of Synapsin I and Neuromodulin in Striatal Synaptosomes after Repeated Amphetamine
    Shin-Ichi Iwata, G. H. Keikilani Hewlett, Sandra T. Ferrell, Lana Kantor and Margaret E. Gnegy
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1445-1452;
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    Chronic Administration of a Glycine Partial Agonist Alters the Expression of N-Methyl-d-aspartate Receptor Subunit mRNAs
    S. Bovetto, P.-A. Boyer, P. Skolnick and L. H. Fossom
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1503-1508;

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

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    Inhibition of Cyclooxygenase-2 Rapidly Reverses Inflammatory Hyperalgesia and Prostaglandin E2 Production
    Yan Zhang, Alex Shaffer, Joseph Portanova, Karen Seibert and Peter C. Isakson
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1069-1075;

PULMONARY PHARMACOLOGY

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    Effects of Tachykinins on Rapidly Adapting Pulmonary Stretch Receptors and Total Lung Resistance in Anesthetized, Artificially Ventilated Rabbits
    Shigeji Matsumoto, Mamoru Takeda, Chikako Saiki, Toshiaki Takahashi and Kohei Ojima
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1026-1031;
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    Absence of Tachykinin Involvement in Leukotriene D4and Antigen-Induced Contraction of Guinea Pig Isolated Bronchus
    Susan M. Cibulsky and David C. Thompson
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1102-1109;
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    Nonpeptide Endothelin Receptor Antagonists. X. Inhibition of Endothelin-1- and Hypoxia-Induced Pulmonary Pressor Responses in the Guinea Pig by the Endothelin Receptor Antagonist, SB 217242
    David C. Underwood, Steve Bochnowicz, Ruth R. Osborn, Mark A. Luttmann and Douglas W. P. Hay
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1130-1137;
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    Inhibition of Neutrophil Elastase in CF Sputum by L-658,758
    Dianne D. Rees, Joseph D. Brain, Mary Ellen Wohl, John L. Humes and Richard A. Mumford
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1201-1206;
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    Attenuation by Phosphodiesterase Inhibitors of Lipopolysaccharide-Induced Thromboxane Release and Bronchoconstriction in Rat Lungs
    Stefan Uhlig, Roland Lewis Featherstone, Heinz-Dieter Held, Rolf Nüsing, Christian Schudt and Albrecht Wendel
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1453-1459;

RENAL PHARMACOLOGY

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    Interactions of Nonsteroidal Anti-inflammatory Drugs with Rat Renal Organic Anion Transporter, OAT-K1
    Satohiro Masuda, Hideyuki Saito and Ken-Ichi Inui
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1039-1042;
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    Interaction of Alkyl/Arylphosphonates, Phosphonocarboxylates and Diphosphonates with Different Anion Transport Systems in the Proximal Renal Tubule
    K. J. Ullrich, G. Rumrich, T. R. Burke, S. P. Shirazi-Beechey and H.-J. Lang
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1223-1229;
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    Ochratoxin A-Induced Stimulation of Extracellular Signal-Regulated Kinases 1/2 is Associated with Madin-Darby Canine Kidney-C7 Cell Dedifferentiation
    Herbert Schramek, Doris Wilflingseder, Verena Pollack, Ruth Freudinger, Sigrid Mildenberger and Michael Gekle
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1460-1468;
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    Enhanced Renal Toxicity by Inorganic Mercury in Metallothionein-Null Mice
    Masahiko Satoh, Noriko Nishimura, Yoshitaka Kanayama, Akira Naganuma, Tsuguyoshi Suzuki and Chiharu Tohyama
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1529-1533;

TOXICOLOGY

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    Calpains Mediate Calcium and Chloride Influx During the Late Phase of Cell Injury
    Shayla L. Waters, Satinder S. Sarang, Kevin K. W. Wang and Rick G. Schnellmann
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1177-1184;
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    Neutrophil Cytotoxicity of the Chemically Reactive Metabolite(s) of Clozapine: Possible Role in Agranulocytosis
    Dominic P. Williams, Munir Pirmohamed, Dean J. Naisbitt, James L. Maggs and B. Kevin Park
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1375-1382;
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    Nephrotoxicity of the Glutathione and CysteineS-Conjugates of the Sevoflurane Degradation Product 2-(Fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (Compound A) in Male Fischer 344 Rats
    Ramaswamy A. Iyer, Raymond B. Baggs and M. W. Anders
    Journal of Pharmacology and Experimental Therapeutics December 1997, 283 (3) 1544-1551;
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Journal of Pharmacology and Experimental Therapeutics
Vol. 283, Issue 3
1 Dec 1997
  • Table of Contents
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  • ANALGESIA AND DRUGS OF ABUSE
  • BEHAVIORAL PHARMACOLOGY
  • CARDIOVASCULAR PHARMACOLOGY
  • CELLULAR AND MOLECULAR PHARMACOLOGY
  • CHEMOTHERAPY/GENE THERAPY
  • DEVELOPMENTAL PHARMACOLOGY
  • DRUG METABOLISM AND DISPOSITION
  • GASTROINTESTINAL PHARMACOLOGY
  • IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS
  • PULMONARY PHARMACOLOGY
  • RENAL PHARMACOLOGY
  • TOXICOLOGY
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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