Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
OtherBEHAVIORAL PHARMACOLOGY

Activation of Metabotropic Glutamate Receptors in the Rat Nucleus Accumbens Increases Locomotor Activity in a Dopamine-Dependent Manner

Jeong-Hoon Kim and Paul Vezina
Journal of Pharmacology and Experimental Therapeutics November 1997, 283 (2) 962-968;
Jeong-Hoon Kim
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paul Vezina
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

The effect on locomotor activity of in vivo activation of metabotropic glutamate receptors (mGluRs) in the nucleus accumbens (NAcc) was investigated in rats. Bilateral intracranial microinjections into the NAcc of the selective mGluR agonist, 1-aminocyclopentane-trans-1,3-dicarboxylic acid [(1S,3R)-ACPD], were made in the freely moving rat and locomotor activity was subsequently measured for 2 hr. Different groups of rats injected with one of four doses of (1S,3R)-ACPD (0.005, 0.05, 0.5, or 2.5 nmol/0.5 μl/side) showed significant dose-dependent increases in both horizontal and vertical locomotor activity relative to control rats that received injections of the saline vehicle. Time-course analyses revealed that these effects, in a manner similar to the locomotor hyperactivity produced by the injection of amphetamine into the NAcc, were most pronounced in the initial 30 min after injection and no longer present after 1 hr of testing. These locomotor-activating effects of (1S,3R)-ACPD were blocked by the co-injection of the mGluR antagonist, (RS)-α-methyl-4-carboxyphenylglycine (2.5 nmol/side), as well as of the dopamine receptor antagonist, fluphenazine (2.0 or 9.8 nmol/side), which suggests that they depend on dopamine neurotransmission. These findings indicate that mGluRs play an important role in the production of locomotor behaviors involving DA-excitatory amino acid interactions in the NAcc.

Footnotes

  • Send reprint requests to: Paul Vezina, Department of Psychiatry, The University of Chicago, 5841 South Maryland Avenue, MC 3077, Chicago, IL 60637.

  • ↵1 Supported by grants to P.V. from The Brain Research Foundation, the Department of Psychiatry and the Division of Biological Sciences of The University of Chicago.

  • Abbreviations:
    mGluRs
    metabotropic glutamate receptors
    NAcc
    nucleus accumbens
    (1S
    3R)-ACPD, 1-aminocyclopentane-trans-1,3-dicarboxylic acid
    (RS)-MCPG
    (RS)-α-methyl-4-carboxyphenylglycine
    DA
    dopamine
    AMPA
    α-amino-3-hydroxy-5-methyl isoxazole-4-propionic acid
    NMDA
    N-methyl-d-aspartate
    iGluRs
    ionotropic glutamate receptors
    ANOVA
    analyses of variance
    AMPH
    amphetamine
    • Received May 9, 1997.
    • Accepted July 15, 1997.
  • The American Society for Pharmacology and Experimental Therapeutics
View Full Text

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 283, Issue 2
1 Nov 1997
  • Table of Contents
  • Index by author
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Activation of Metabotropic Glutamate Receptors in the Rat Nucleus Accumbens Increases Locomotor Activity in a Dopamine-Dependent Manner
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
OtherBEHAVIORAL PHARMACOLOGY

Activation of Metabotropic Glutamate Receptors in the Rat Nucleus Accumbens Increases Locomotor Activity in a Dopamine-Dependent Manner

Jeong-Hoon Kim and Paul Vezina
Journal of Pharmacology and Experimental Therapeutics November 1, 1997, 283 (2) 962-968;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
OtherBEHAVIORAL PHARMACOLOGY

Activation of Metabotropic Glutamate Receptors in the Rat Nucleus Accumbens Increases Locomotor Activity in a Dopamine-Dependent Manner

Jeong-Hoon Kim and Paul Vezina
Journal of Pharmacology and Experimental Therapeutics November 1, 1997, 283 (2) 962-968;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Materials and Methods
    • Results
    • Discussion
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Varenicline and epibatidine as opioid adjuvants
  • MCAM reverses and prevents fentanyl ventilatory depression
  • Kv7 opener SCR2682 alleviates pain
Show more Behavioral Pharmacology

Similar Articles

  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2021 by the American Society for Pharmacology and Experimental Therapeutics