Different Contributions of Cytochrome P450 2C19 and 3A4 in the Oxidation of Omeprazole by Human Liver Microsomes: Effects of Contents of These Two Forms in Individual Human Samples

	Abstract	Full	Pdf
Jan 1999	0	3	4
Feb 1999	2	6	6
Mar 1999	1	8	5
Apr 1999	1	6	5
May 1999	0	3	4
Jun 1999	1	2	0
Jul 1999	0	1	3
Aug 1999	0	12	3
Sep 1999	2	3	6
Oct 1999	0	8	7
Nov 1999	6	10	14
Dec 1999	2	6	4
Jan 2000	0	5	4
Feb 2000	1	10	12
Mar 2000	7	15	15
Apr 2000	2	11	2
May 2000	1	13	13
Jun 2000	1	6	12
Jul 2000	1	8	13
Aug 2000	6	11	12
Sep 2000	0	7	6
Oct 2000	1	15	8
Nov 2000	5	6	8
Dec 2000	1	2	5
Jan 2001	4	8	13
Feb 2001	5	19	15
Mar 2001	1	5	13
Apr 2001	2	4	8
May 2001	4	11	14
Jun 2001	1	3	11
Jul 2001	2	12	12
Aug 2001	1	4	7
Sep 2001	4	5	11
Oct 2001	1	6	9
Nov 2001	2	12	18
Dec 2001	1	9	15
Jan 2002	1	27	18
Feb 2002	0	8	15
Mar 2002	2	11	9
Apr 2002	2	7	8
May 2002	1	7	6
Jun 2002	0	5	13
Jul 2002	2	16	22
Aug 2002	0	12	18
Sep 2002	1	14	9
Oct 2002	3	9	4
Nov 2002	2	12	9
Dec 2002	0	9	13
Jan 2003	2	9	10
Feb 2003	1	14	19
Mar 2003	1	10	16
Apr 2003	5	16	24
May 2003	0	12	11
Jun 2003	3	7	13
Jul 2003	14	16	14
Aug 2003	18	26	12
Sep 2003	13	30	25
Oct 2003	22	48	31
Nov 2003	19	31	7
Dec 2003	20	29	24
Jan 2004	14	38	14
Feb 2004	11	26	22
Mar 2004	13	30	15
Apr 2004	15	26	13
May 2004	20	31	11
Jun 2004	28	47	17
Jul 2004	23	47	19
Aug 2004	20	33	36
Sep 2004	12	25	16
Oct 2004	18	25	5
Nov 2004	17	18	11
Dec 2004	8	24	21
Jan 2005	15	14	19
Feb 2005	13	27	15
Mar 2005	16	28	19
Apr 2005	9	31	14
May 2005	7	31	16
Jun 2005	8	32	15
Jul 2005	5	20	18
Aug 2005	6	19	32
Sep 2005	6	15	10
Oct 2005	7	23	18
Nov 2005	3	16	16
Dec 2005	5	8	2
Jan 2006	4	21	7
Feb 2006	5	23	8
Mar 2006	1	19	8
Apr 2006	4	15	17
May 2006	4	20	12
Jun 2006	10	15	14
Jul 2006	4	12	6
Aug 2006	4	19	11
Sep 2006	11	20	13
Oct 2006	8	30	20
Nov 2006	5	20	9
Dec 2006	9	20	10
Jan 2007	12	29	23
Feb 2007	12	19	13
Mar 2007	10	21	20
Apr 2007	13	25	13
May 2007	11	28	21
Jun 2007	7	12	12
Jul 2007	4	10	8
Aug 2007	3	18	16
Sep 2007	4	17	15
Oct 2007	10	21	13
Nov 2007	5	23	21
Dec 2007	9	13	11
Jan 2008	3	9	3
Feb 2008	10	12	12
Mar 2008	19	19	17
Apr 2008	6	18	18
May 2008	6	10	11
Jun 2008	10	16	21
Jul 2008	13	18	17
Aug 2008	3	6	9
Sep 2008	13	11	11
Oct 2008	16	16	16
Nov 2008	14	6	11
Dec 2008	8	11	7
Jan 2009	8	11	14
Feb 2009	13	9	7
Mar 2009	12	17	16
Apr 2009	3	11	9
May 2009	7	9	11
Jun 2009	3	9	8
Jul 2009	5	14	7
Aug 2009	4	13	11
Sep 2009	13	16	6
Oct 2009	12	12	9
Nov 2009	12	10	5
Dec 2009	12	5	5
Jan 2010	7	12	12
Feb 2010	11	10	12
Mar 2010	12	8	6
Apr 2010	10	8	5
May 2010	17	21	13
Jun 2010	2	12	7
Jul 2010	12	5	7
Aug 2010	6	14	8
Sep 2010	5	21	8
Oct 2010	7	12	14
Nov 2010	5	16	7
Dec 2010	5	9	5
Jan 2011	4	12	9
Feb 2011	7	20	8
Mar 2011	9	18	12
Apr 2011	10	8	10
May 2011	6	18	17
Jun 2011	4	12	11
Jul 2011	22	12	23
Aug 2011	12	10	12
Sep 2011	10	16	14
Oct 2011	12	11	11
Nov 2011	12	12	11
Dec 2011	10	12	9
Jan 2012	19	8	12
Feb 2012	18	11	4
Mar 2012	15	8	12
Apr 2012	12	13	23
May 2012	19	12	26
Jun 2012	13	25	24
Jul 2012	11	5	10
Aug 2012	13	7	11
Sep 2012	16	11	13
Oct 2012	10	11	17
Nov 2012	14	3	5
Dec 2012	14	6	19
Jan 2013	20	4	14
Feb 2013	16	9	10
Mar 2013	8	9	5
Apr 2013	17	7	14
May 2013	11	16	21
Jun 2013	9	3	7
Jul 2013	15	10	12
Aug 2013	19	8	12
Sep 2013	28	9	12
Oct 2013	9	7	10
Nov 2013	8	10	12
Dec 2013	8	17	12
Jan 2014	10	5	7
Feb 2014	14	11	14
Mar 2014	7	5	4
Apr 2014	19	11	11
May 2014	3	8	6
Jun 2014	6	4	17
Jul 2014	7	9	6
Aug 2014	8	5	8
Sep 2014	8	14	16
Oct 2014	3	9	7
Nov 2014	109	479	11
Dec 2014	30	22	15
Jan 2015	16	14	4
Feb 2015	10	10	10
Mar 2015	10	11	15
Apr 2015	3	8	13
May 2015	2	8	9
Jun 2015	19	7	9
Jul 2015	4	11	8
Aug 2015	14	6	1553
Sep 2015	69	5	18
Oct 2015	5	5	4
Nov 2015	4	18	7
Dec 2015	4	26	5
Jan 2016	12	7	9
Feb 2016	4	7	8
Mar 2016	8	10	13
Apr 2016	9	4	9
May 2016	2	11	6
Jun 2016	5	11	13
Jul 2016	4	5	22
Aug 2016	3	4	11
Sep 2016	4	4	4
Oct 2016	4	9	13
Nov 2016	2	8	12
Dec 2016	0	5	4
Jan 2017	3	5	3
Feb 2017	1	13	15
Mar 2017	2	3	3
Apr 2017	2	5	1
May 2017	3	10	5
Jun 2017	2	12	5
Jul 2017	4	23	5
Aug 2017	4	26	9
Sep 2017	2	20	9
Oct 2017	1	16	7
Nov 2017	0	35	15
Dec 2017	4	15	2
Jan 2018	1	9	6
Feb 2018	2	17	6
Mar 2018	5	21	12
Apr 2018	5	25	23
May 2018	3	19	10
Jun 2018	2	10	11
Jul 2018	3	12	2
Aug 2018	1	7	5
Sep 2018	1	7	4
Oct 2018	0	9	10
Nov 2018	4	11	7
Dec 2018	43	6	4
Jan 2019	13	4	1
Feb 2019	6	3	1
Mar 2019	9	3	2
Apr 2019	4	4	4
May 2019	4	3	3
Jun 2019	8	1	5
Jul 2019	10	1	2
Aug 2019	20	9	4
Sep 2019	12	4	2
Oct 2019	15	1	2
Nov 2019	27	3	1
Dec 2019	8	10	2
Jan 2020	6	2	0
Feb 2020	9	2	1
Mar 2020	8	4	3
Apr 2020	9	2	2
May 2020	8	4	7
Jun 2020	6	1	0
Jul 2020	9	4	4
Aug 2020	21	0	3
Sep 2020	17	4	0
Oct 2020	31	4	2
Nov 2020	12	0	1
Dec 2020	35	9	1
Jan 2021	8	29	5
Feb 2021	7	27	2
Mar 2021	13	4	2
Apr 2021	15	6	4
May 2021	23	6	0
Jun 2021	3	20	5
Jul 2021	11	7	2
Aug 2021	23	13	1
Sep 2021	9	9	1
Oct 2021	21	9	4
Nov 2021	20	2	2
Dec 2021	25	6	4
Jan 2022	16	6	2
Feb 2022	23	2	1
Mar 2022	11	4	3
Apr 2022	19	12	3
May 2022	14	2	1
Jun 2022	7	2	0
Jul 2022	19	2	2
Aug 2022	19	7	5
Sep 2022	10	11	1
Oct 2022	25	15	1
Nov 2022	10	1	1
Dec 2022	14	2	0
Jan 2023	8	6	1
Feb 2023	11	7	1
Mar 2023	23	5	4
Apr 2023	19	8	5
May 2023	16	9	4
Jun 2023	8	4	2
Jul 2023	15	11	0
Aug 2023	10	17	1
Sep 2023	15	4	1
Oct 2023	23	4	2
Nov 2023	14	8	1
Dec 2023	6	12	0