The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data

	Abstract	Full	Pdf
Jan 1999	4	21	6
Feb 1999	4	13	9
Mar 1999	1	11	4
Apr 1999	3	23	12
May 1999	3	18	20
Jun 1999	1	14	11
Jul 1999	1	45	18
Aug 1999	9	33	25
Sep 1999	2	22	20
Oct 1999	0	17	7
Nov 1999	14	41	31
Dec 1999	4	17	13
Jan 2000	2	31	27
Feb 2000	4	58	45
Mar 2000	5	38	37
Apr 2000	2	20	39
May 2000	3	26	28
Jun 2000	6	17	48
Jul 2000	2	8	29
Aug 2000	4	10	34
Sep 2000	1	37	79
Oct 2000	5	20	70
Nov 2000	3	15	33
Dec 2000	0	26	39
Jan 2001	7	25	68
Feb 2001	7	29	72
Mar 2001	7	26	46
Apr 2001	0	34	104
May 2001	6	21	58
Jun 2001	9	22	70
Jul 2001	12	37	78
Aug 2001	4	17	32
Sep 2001	8	24	47
Oct 2001	5	18	49
Nov 2001	11	42	69
Dec 2001	2	23	48
Jan 2002	11	36	66
Feb 2002	6	51	100
Mar 2002	4	42	65
Apr 2002	5	37	69
May 2002	11	56	90
Jun 2002	5	37	81
Jul 2002	7	34	75
Aug 2002	0	32	73
Sep 2002	7	27	66
Oct 2002	8	27	63
Nov 2002	2	27	68
Dec 2002	1	38	67
Jan 2003	7	41	68
Feb 2003	9	43	84
Mar 2003	9	43	106
Apr 2003	4	40	83
May 2003	6	27	64
Jun 2003	5	39	68
Jul 2003	15	55	87
Aug 2003	14	52	254
Sep 2003	27	85	132
Oct 2003	30	98	142
Nov 2003	31	77	130
Dec 2003	25	80	94
Jan 2004	51	102	128
Feb 2004	28	102	132
Mar 2004	44	117	150
Apr 2004	33	85	73
May 2004	22	102	121
Jun 2004	34	97	120
Jul 2004	33	101	166
Aug 2004	34	112	98
Sep 2004	40	124	115
Oct 2004	35	208	146
Nov 2004	31	143	133
Dec 2004	26	140	116
Jan 2005	19	105	89
Feb 2005	45	162	111
Mar 2005	37	116	131
Apr 2005	23	104	129
May 2005	23	74	101
Jun 2005	27	110	130
Jul 2005	20	85	90
Aug 2005	29	97	152
Sep 2005	29	87	105
Oct 2005	17	121	129
Nov 2005	30	73	87
Dec 2005	17	80	92
Jan 2006	27	114	111
Feb 2006	12	100	98
Mar 2006	27	139	109
Apr 2006	23	114	86
May 2006	48	112	107
Jun 2006	83	77	71
Jul 2006	49	94	107
Aug 2006	46	71	81
Sep 2006	49	68	101
Oct 2006	48	84	134
Nov 2006	58	296	284
Dec 2006	29	58	90
Jan 2007	53	76	116
Feb 2007	72	68	108
Mar 2007	76	99	133
Apr 2007	57	65	119
May 2007	59	90	110
Jun 2007	39	65	102
Jul 2007	46	51	96
Aug 2007	30	39	72
Sep 2007	28	45	78
Oct 2007	49	65	93
Nov 2007	46	51	66
Dec 2007	39	83	97
Jan 2008	44	94	107
Feb 2008	38	52	77
Mar 2008	38	68	77
Apr 2008	46	81	113
May 2008	29	70	99
Jun 2008	23	83	88
Jul 2008	40	77	72
Aug 2008	50	67	81
Sep 2008	49	53	64
Oct 2008	62	62	90
Nov 2008	60	56	67
Dec 2008	43	53	72
Jan 2009	75	64	108
Feb 2009	48	54	99
Mar 2009	60	65	91
Apr 2009	47	78	96
May 2009	44	75	93
Jun 2009	59	52	82
Jul 2009	52	40	67
Aug 2009	76	44	65
Sep 2009	60	52	79
Oct 2009	58	51	68
Nov 2009	59	61	70
Dec 2009	54	31	54
Jan 2010	157	87	122
Feb 2010	145	52	93
Mar 2010	146	51	85
Apr 2010	110	62	96
May 2010	117	51	79
Jun 2010	88	58	71
Jul 2010	55	80	83
Aug 2010	53	90	66
Sep 2010	85	113	98
Oct 2010	65	75	75
Nov 2010	37	80	73
Dec 2010	25	67	55
Jan 2011	47	85	66
Feb 2011	83	87	82
Mar 2011	61	92	95
Apr 2011	79	50	105
May 2011	74	53	80
Jun 2011	77	56	114
Jul 2011	76	49	88
Aug 2011	87	63	95
Sep 2011	74	50	85
Oct 2011	81	77	101
Nov 2011	64	62	103
Dec 2011	108	64	113
Jan 2012	88	58	86
Feb 2012	75	63	96
Mar 2012	98	68	95
Apr 2012	108	71	86
May 2012	83	57	103
Jun 2012	81	60	85
Jul 2012	76	66	82
Aug 2012	88	56	79
Sep 2012	93	52	66
Oct 2012	119	63	95
Nov 2012	85	77	114
Dec 2012	79	82	88
Jan 2013	82	99	118
Feb 2013	142	108	121
Mar 2013	128	87	113
Apr 2013	139	103	88
May 2013	102	94	145
Jun 2013	140	73	111
Jul 2013	113	73	114
Aug 2013	95	56	77
Sep 2013	78	83	74
Oct 2013	119	56	81
Nov 2013	94	60	60
Dec 2013	118	72	101
Jan 2014	98	65	68
Feb 2014	97	76	85
Mar 2014	103	79	95
Apr 2014	107	81	110
May 2014	180	75	111
Jun 2014	64	52	89
Jul 2014	46	123	119
Aug 2014	91	88	91
Sep 2014	36	100	91
Oct 2014	48	104	52
Nov 2014	38	133	63
Dec 2014	57	113	70
Jan 2015	55	68	74
Feb 2015	13	133	62
Mar 2015	29	168	82
Apr 2015	38	131	75
May 2015	41	136	107
Jun 2015	51	115	153
Jul 2015	43	116	102
Aug 2015	66	94	100
Sep 2015	48	108	97
Oct 2015	93	86	82
Nov 2015	27	95	58
Dec 2015	102	86	52
Jan 2016	30	89	76
Feb 2016	25	101	73
Mar 2016	67	130	114
Apr 2016	37	153	97
May 2016	37	172	108
Jun 2016	27	102	75
Jul 2016	38	99	95
Aug 2016	41	100	90
Sep 2016	25	103	68
Oct 2016	27	80	79
Nov 2016	5	84	62
Dec 2016	0	62	47
Jan 2017	22	78	70
Feb 2017	41	77	71
Mar 2017	44	85	91
Apr 2017	36	55	49
May 2017	47	65	97
Jun 2017	42	70	71
Jul 2017	38	69	98
Aug 2017	26	94	102
Sep 2017	31	125	101
Oct 2017	41	133	105
Nov 2017	31	133	73
Dec 2017	27	54	48
Jan 2018	33	96	74
Feb 2018	3	106	64
Mar 2018	0	94	52
Apr 2018	0	278	62
May 2018	0	201	57
Jun 2018	1	145	68
Jul 2018	22	126	76
Aug 2018	19	89	73
Sep 2018	21	62	57
Oct 2018	27	107	67
Nov 2018	28	119	90
Dec 2018	157	55	35
Jan 2019	126	38	31
Feb 2019	137	18	22
Mar 2019	102	34	29
Apr 2019	107	33	22
May 2019	106	33	22
Jun 2019	87	21	25
Jul 2019	73	34	23
Aug 2019	111	26	20
Sep 2019	108	35	17
Oct 2019	110	43	30
Nov 2019	111	31	25
Dec 2019	102	43	20
Jan 2020	156	40	27
Feb 2020	132	24	17
Mar 2020	264	37	24
Apr 2020	161	36	23
May 2020	191	45	40
Jun 2020	160	23	22
Jul 2020	155	39	25
Aug 2020	95	27	17
Sep 2020	134	44	27
Oct 2020	158	29	25
Nov 2020	115	22	19
Dec 2020	124	39	14
Jan 2021	168	126	11
Feb 2021	119	126	17
Mar 2021	231	57	34
Apr 2021	234	30	26
May 2021	236	73	26
Jun 2021	117	91	13
Jul 2021	142	39	15
Aug 2021	180	116	19
Sep 2021	203	64	9
Oct 2021	271	31	15
Nov 2021	130	28	19
Dec 2021	210	44	22
Jan 2022	173	44	19
Feb 2022	133	24	19
Mar 2022	204	38	31
Apr 2022	177	42	27
May 2022	99	8	6