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Journal of Pharmacology and Experimental Therapeutics

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Table of Contents

October 01, 1997; Volume 283,Issue 1

BEHAVIORAL PHARMACOLOGY

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    Characterization of Unconditioned Behavioral Effects of Dopamine D3/D2 Receptor Agonists
    Beth Geter-Douglass, Jonathan L. Katz, Ken Alling, Jane B. Acri and Jeffrey M. Witkin
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 7-15;
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    The Relationship between Reinforcing Effects and in Vitro Effects of D1 Agonists in Monkeys
    Michael R. Weed, Ian A. Paul, Linda P. Dwoskin, Susan E. Moore and William L. Woolverton
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 29-38;
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    Cocaine and Alcohol Interactions in Humans: Neuroendocrine Effects and Cocaethylene Metabolism
    Magí Farré, Rafael De La Torre, María L. González, María T. Terán, Pere N. Roset, Esther Menoyo and Jordi Camí
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 164-176;
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    Dose-Dependent Effects of the Dopamine D1 Receptor Agonists A77636 or SKF81297 On Spatial Working Memory in Aged Monkeys
    J. X. Cai and A. F. T. Arnsten
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 183-189;
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    Effects of Chronic Caffeine Administration on Respiration and Schedule-Controlled Behavior in Rhesus Monkeys
    Leonard L. Howell and Alyson M. Landrum
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 190-199;
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    Discriminative Stimulus Effects of Magnesium Chloride: Substitution Studies with Monoamine Uptake Inhibitors and N-Methyl-d-Aspartate Antagonists
    Kathleen M. Kantak, Melissa A. Edwards, Kristin M. Wilcox and Erica Kitchel
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 200-206;
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    Inhibition of Prostaglandin Synthesis and Effects of Ethanol and Pentobarbital in Humans
    Wallace B. Pickworth, Reginald V. Fant and Jack E. Henningfield
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 274-280;
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    Chlorpyrifos Produces Selective Learning Deficits in Rats Working Under a Schedule of Repeated Acquisition and Performance
    Jeffrey Cohn and Robert C. Macphail
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 312-320;

CARDIOVASCULAR PHARMACOLOGY

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    Comparative Effects of Two Direct and Indirect Factor Xa Inhibitors on Free and Clot-Bound Prothrombinase
    J. P. Hérault, A. Bernat, A. M. Pflieger, J. C. Lormeau and J. M. Herbert
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 16-22;
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    Antithrombotic Efficacy of a Recombinant Nematode Anticoagulant Peptide (rNAP5) in Canine Models of Thrombosis after Single Subcutaneous Administration
    Sam S. Rebello, Howard S. Blank, William E. Rote, George P. Vlasuk and Benedict R. Lucchesi
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 91-99;
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    Use of a Nitronyl Nitroxide to Discriminate the Contribution of Nitric Oxide Radical in Endothelium-Dependent Relaxation of Control and Diabetic Blood Vessels
    Galen M. Pieper and Wolfgang Siebeneich
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 138-147;
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    Block of IKs by the Diuretic Agent Indapamide Modulates Cardiac Electrophysiological Effects of the Class III Antiarrhythmic Drug dl-Sotalol
    Céline Fiset, Benoit Drolet, Bettina A. Hamelin and Jacques Turgeon
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 148-156;
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    In Vivo Metabolism-Based Discovery of a Potent Cholesterol Absorption Inhibitor, SCH58235, in the Rat and Rhesus Monkey through the Identification of the Active Metabolites of SCH48461
    Margaret Van Heek, Constance F. France, Douglas S. Compton, Robbie L. Mcleod, Nathan P. Yumibe, Kevin B. Alton, Edmund J. Sybertz and Harry R. Davis
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 157-163;
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    Effect of Cyclopiazonic Acid on the Force-Frequency Relationship in Human Nonfailing  Myocardium
    Robert H. G. Schwinger, Klara Brixius, Udo Bavendiek, Susanne Hoischen, Jochen Müller-Ehmsen, Birgit Bölck and Erland Erdmann
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 286-292;
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    Relationship between Phospholipase D Activation and Endothelial Vasomotor Dysfunction in Rabbit Aorta
    David A. Cox and Marlene L. Cohen
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 305-311;
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    Inhibition of Cell Growth: Effects of the Tyrosine Kinase Inhibitor CGP 53716
    Terry C. Major and Joan A. Keiser
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 402-410;

CELLULAR AND MOLECULAR PHARMACOLOGY

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    Inactivation of Nitric Oxide Synthase by Substituted Aminoguanidines and Aminoisothioureas
    Donald J. Wolff, Douglas S. Gauld, Matthew J. Neulander and Garry Southan
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 265-273;
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    The Novel Calcium Sensitizer Levosimendan Activates the ATP-Sensitive K+ Channel in Rat Ventricular Cells
    Hisashi Yokoshiki, Yasuhiro Katsube, Masanori Sunagawa and Nicholas Sperelakis
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 375-383;

CHEMOTHERAPY/GENE THERAPY

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    Chronopharmacological Study of Interferon-α in Mice
    Satoru Koyanagi, Shigehiro Ohdo, Eiji Yukawa and Shun Higuchi
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 259-264;

DRUG METABOLISM AND DISPOSITION

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    The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
    R. Scott Obach, James G. Baxter, Theodore E. Liston, B. Michael Silber, Barry C. Jones, Fiona Macintyre, David J. Rance and Philip Wastall
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 46-58;
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    Kinetic Analysis of the Disposition of MRK16, an Anti-P-glycoprotein Monoclonal Antibody, in Tumors: Comparison Between in Vitro and in Vivo Disposition
    Yuji Mano, Hiroshi Suzuki, Tetsuya Terasaki, Toshiro Iwahashi, Ken-Ichi Ono, Mikihiko Naito, Takashi Tsuruo and Yuichi Sugiyama
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 391-401;

ENDOCRINE PHARMACOLOGY

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    Estrogen and Selective Estrogen Receptor Modulator LY117018 Enhance Release of Nitric Oxide in Rat Aorta
    Roshanak Rahimian, Ismail Laher, Gregory Dube and Cornelis van Breemen
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 116-122;
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    Insulin-Like Growth Factor (IGF) Gene Expression Is Reduced in Neural Tissues and Liver from Rats with Non-Insulin-Dependent Diabetes Mellitus, and IGF Treatment Ameliorates Diabetic Neuropathy
    Hui-Xin Zhuang, Laura Wuarin, Zhi-Jian Fei and Douglas N. Ishii
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 366-374;

GASTROINTESTINAL PHARMACOLOGY

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    Motor Responses in Rat Ileum Evoked by Nitric Oxide Donorsvs. Field Stimulation: Modulation by Pituitary Adenylate Cyclase-Activating Peptide, Forskolin and Guanylate Cyclase Inhibitors
    E. Ekblad and F. Sundler
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 23-28;
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    Nonlinear Intestinal Absorption of 5-Hydroxytryptamine Receptor Antagonist Caused by Absorptive and Secretory Transporters
    Ikumi Tamai, Ayaka Saheki, Ryoichi Saitoh, Yoshimichi Sai, Ichimaro Yamada and Akira Tsuji
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 108-115;

IMMUNOPHARMACOLOGY

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    Molecular Determinants of Monosodium Urate Crystal-Induced Murine Peritonitis: A Role for Endogenous Mast Cells and a Distinct Requirement for Endothelial-Derived Selectins
    Stephen J. Getting, Roderick J. Flower, Luca Parente, Rinaldo de Médicis, André Lussier, Barry A. Woliztky, Marco A. Martins and Mauro Perretti
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 123-130;
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    FK-506 and Cyclosporin A Potentiate the IgE Antibody Production by Contact Sensitization with Hapten in Mice
    Hiroichi Nagai, Hidetaka Hiyama, Akihiko Matsuo, Yoshifumi Ueda, Naoki Inagaki and Kenji Kawada
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 321-327;
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    Two Differential Effects of Cyclic Adenosine 3′,5′-Monophosphate on IL-5 Production by Antigen-Specific Human T Cell Line
    Osamu Kaminuma, Akio Mori, Koji Ogawa, Kazuteru Wada, Hideo Kikkawa, Kazauaki Naito, Matsunobu Suko and Hirokazu Okudaira
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 345-349;
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    An Anti-Inflammatory Benzamide Derivative Inhibits the Protein Kinase C (PKC)-Dependent Pathway of ERK2 Phosphorylation in Murine Macrophages
    Laurent Vernhet, Jean-Yves Petit and François Lang
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 358-365;
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    Characterization of Functional Chemokine Receptors (CCR1 and CCR2) on EoL-3 Cells: A Model System to Examine the Role of Chemokines in Cell Function
    Henry M. Sarau, Julia A. Rush, James J. Foley, Mary E. Brawner, Dulcie B. Schmidt, John R. White and Mary S. Barnette
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 411-418;

NEUROPHARMACOLOGY

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    The “Kynurenate Test,” a Biochemical Assay for Putative Cognition Enhancers
    Anna Pittaluga, Daniella Vaccari and Maurizio Raiteri
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 82-90;
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    Effects of Noradrenergic Lesions on MPTP/MPP+Kinetics and MPTP-Induced Nigrostriatal Dopamine Depletions
    Francesco Fornai, Maria Grazia Alessandrì, Maria Tilde Torracca, Lucia Bassi and Giovanni Umberto Corsini
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 100-107;
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    The Pharmacological Characterization of a Novel Selective 5-Hydroxytryptamine1A Receptor Antagonist, NAD-299
    Lars Johansson, Daniel Sohn, Seth-Olof Thorberg, David M. Jackson, Diana Kelder, Lars-Gunnar Larsson, Lucy Rényi, Svante B. Ross, Carin Wallsten, Håkan Eriksson, Ping-Sheng Hu, Eva Jerning, Nina Mohell and Anita Westlind-Danielsson
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 216-225;
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    Clozapine and Haloperidol Modulate N-Methyl-d-aspartate- and Non-N-Methyl-d-aspartate Receptor-Mediated Neurotransmission in Rat Prefrontal Cortical Neurons In Vitro
    V. L. Arvanov, X. Liang, J. Schwartz, S. Grossman and R. Y. Wang
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 226-234;
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    ABT-089 [2-Methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A Potent and Selective Cholinergic Channel Modulator with Neuroprotective Properties
    James P. Sullivan, Diana Donnelly-Roberts, Clark A. Briggs, David J. Anderson, Murali Gopalakrishnan, Iris C. Xue, Marietta Piattoni-Kaplan, Eduardo Molinari, Jeffrey E. Campbell, David G. Mckenna, David E. Gunn, Nan-Horng Lin, Keith B. Ryther, Yun He, Mark W. Holladay, Susan Wonnacott, Michael Williams and Stephen P. Arneric
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 235-246;
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    ABT-089 [2-Methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A Novel Cholinergic Channel Modulator with Effects on Cognitive Performance in Rats and Monkeys
    Michael W. Decker, Anthony W. Bannon, Peter Curzon, Karen L. Gunther, Jorge D. Brioni, Mark W. Holladay, Nan-Horng Lin, Yihong Li, Jerome F. Daanen, Jerry J. Buccafusco, Mark A. Prendergast, William J. Jackson and Stephen P. Arneric
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 247-258;
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    Interaction Between Hyperthermia and Oxygen Radical Formation in the 5-Hydroxytryptaminergic Response to a Single Methamphetamine Administration
    Annette E. Fleckenstein, Diana G. Wilkins, James W. Gibb and Glen R. Hanson
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 281-285;
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    Prevention of Amyloid-Like Deposition by a Selective Prolyl Endopeptidase Inhibitor, Y-29794, in Senescence-Accelerated Mouse
    Akira Kato, Atsushi Fukunari, Yoko Sakai and Tohru Nakajima
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 328-335;
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    Pentobarbital Decreases the γ-Aminobutyric AcidAReceptor Subunit gamma-2 Long/Short mRNA Ratio by a Mechanism Distinct from Receptor Occupation
    R. F. Tyndale, S. V. Bhave, E. Hoffmann, P. L. Hoffman, B. Tabakoff, A. J. Tobin and R. W. Olsen
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 350-357;
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    Sequestration of γ-Aminobutyric AcidA Receptors on Clathrin-Coated Vesicles During Chronic Benzodiazepine Administration In Vivo
    Mohammad H. Jalilian Tehrani and Eugene M. Barnes
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 384-390;

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

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    Ropivacaine Inhibits Leukocyte Rolling, Adhesion and CD11b/CD18 Expression
    Titti Martinsson, Takaharu Oda, Eva Fernvik, Karin Roempke, Carl-Johan Dalsgaard and Erik Svensjö
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 59-65;
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    Contribution of Constrictor Prostanoids to the Calcium-Dependent Basal Tone in the Aorta from Rats with Aortic Coarctation-Induced Hypertension: Relationship to Nitric Oxide
    Annmarie Dellipizzi, Michael L. Pucci, Aimi Y. Mosny, Katie Deseyn and Alberto Nasjletti
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 75-81;
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    The C-Terminus of the Thromboxane Receptor Contributes to Coupling and Desensitization in a Mouse Mesangial Cell Line
    Robert F. Spurney and Thomas M. Coffman
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 207-215;

PULMONARY PHARMACOLOGY

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    Effects of Tyrosine Kinase Inhibitors on Antigen Challenge of Guinea Pig Lung In Vitro
    W. S. Fred Wong, Diana S. K. Koh, Alan H. M. Koh, W. L. Ting and Peter T. H. Wong
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 131-137;

RENAL PHARMACOLOGY

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    The Digoxin-Propafenone Interaction: Characterization of a Mechanism Using Renal Tubular Cell Monolayers
    Cindy Woodland, Zul Verjee, Esther Giesbrecht, Gideon Koren and Shinya Ito
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 39-45;
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    Metabolism of cAMP to Adenosine in the Renal Vasculature
    Edwin K. Jackson, Zaichuan Mi, Delbert G. Gillespie and Raghvendra K. Dubey
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 177-182;
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    Effects of the Novel Multiple-Action Agent Carvedilol on Severe Nephrosclerosis in Renal Ablated Rats
    Jose C. Rodriguez-Perez, Antonio Losada, Aranzazu Anabitarte, Juan Cabrera, Javier Llobet, Leocadia Palop and Celia Plaza
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 336-344;

TOXICOLOGY

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    Treatment of Cirrhotic Rats withl-Ornithine-l-Aspartate Enhances Urea Synthesis and Lowers Serum Ammonia Levels
    Rolf Gebhardt, Gerhard Beckers, Frank Gaunitz, Wolfram Haupt, Dirk Jonitza, Sabine Klein and Ludger Scheja
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 1-6;
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    Calcium-Dependent Mitochondrial Formation of Species Mediating DNA Single Strand Breakage in U937 Cells Exposed to Sublethal Concentrations of Tert-Butylhydroperoxide
    Andrea Guidarelli, Emilio Clementi, Clara Sciorati, Flaminio Cattabeni and Orazio Cantoni
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 66-74;
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    Kinetic Evidence for Active Efflux Transport across the Blood-Brain Barrier of Quinolone Antibiotics
    Tsuyoshi Ooie, Tetsuya Terasaki, Hiroshi Suzuki and Yuichi Sugiyama
    Journal of Pharmacology and Experimental Therapeutics October 1997, 283 (1) 293-304;
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Journal of Pharmacology and Experimental Therapeutics
Vol. 283, Issue 1
1 Oct 1997
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  • BEHAVIORAL PHARMACOLOGY
  • CARDIOVASCULAR PHARMACOLOGY
  • CELLULAR AND MOLECULAR PHARMACOLOGY
  • CHEMOTHERAPY/GENE THERAPY
  • DRUG METABOLISM AND DISPOSITION
  • ENDOCRINE PHARMACOLOGY
  • GASTROINTESTINAL PHARMACOLOGY
  • IMMUNOPHARMACOLOGY
  • NEUROPHARMACOLOGY
  • PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS
  • PULMONARY PHARMACOLOGY
  • RENAL PHARMACOLOGY
  • TOXICOLOGY
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  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
  • Functional Selectivity and Classical Concepts of Quantitative Pharmacology
  • Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
  • The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
  • A METHOD FOR DETERMINING LOSS OF PAIN SENSATION
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