Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
OtherGASTROINTESTINAL PHARMACOLOGY

Tachykinergic Neurotransmission Is Enhanced in Small Intestinal Circular Muscle in a Rabbit Model of Inflammation

Jon M. Goldhill, Terez Shea-Donohue, Nasima Ali and Victor M. Piñeiro-Carrero
Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1373-1378;
Jon M. Goldhill
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Terez Shea-Donohue
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nasima Ali
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Victor M. Piñeiro-Carrero
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

Previous electrophysiological studies have shown that tachykinin-mediated excitatory junction potentials are enhanced in a ricin model of inflammatory bowel disease. The present study extends these findings by investigating the contractile response to stimulation of noncholinergic nerves and tachykinin agonists. According to rank order potencies, the rabbit ileal circular muscle was neurokinin (NK)1 preferring, and the response to these agonists was down-regulated by acetylcholine and up-regulated by nitric oxide. In ricin-treated tissue, cholinergic and nitridergic modulation was lost; in the presence of atropine and N-nitro-l-arginine methyl ester, or tetrodotoxin, the response to NK1 and NK2 agonists was enhanced. The noncholinergic response to nerve stimulation was predominantly mediated by NK1receptors, and the enhanced response of ricin-treated tissue to NK1 agonists probably contributes to the increased response to electrical field stimulation observed under these conditions. Increased tachykinin response and loss of control of this response by acetylcholine and nitric oxide are likely to have profound effects on intestinal motility and could contribute to some of the symptomology of inflammatory bowel disease.

Footnotes

  • Send reprint requests to: Dr. Jon M. Goldhill, Synthelabo Recherche, 10 Rue des Carrieres, 92505 Rueil-Malmaison, France.

  • ↵1 This work was funded by grants to T. Shea Donohue (G183EP).

  • Abbreviations:
    CL
    confidence interval
    NK
    neurokinin
    L-NAME
    N-nitro-l-arginine methyl ester
    IBD
    inflammatory bowel disease
    SP
    substance P
    EFS
    electric field stimulation
    EJP
    excitatory junction potential
    KBS
    Krebs-bicarbonate-saline
    PPT
    preprotachykinin
    [SAR]SP
    [Sar9,Met11(O2)]substance P
    β-Ala[NKA]
    [β-Ala8]neurokinin A
    L-NAME
    N-nitro-l-arginine methyl ester
    • Received September 6, 1996.
    • Accepted May 14, 1997.
  • The American Society for Pharmacology and Experimental Therapeutics
View Full Text

JPET articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics
Vol. 282, Issue 3
1 Sep 1997
  • Table of Contents
  • Index by author
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Tachykinergic Neurotransmission Is Enhanced in Small Intestinal Circular Muscle in a Rabbit Model of Inflammation
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
OtherGASTROINTESTINAL PHARMACOLOGY

Tachykinergic Neurotransmission Is Enhanced in Small Intestinal Circular Muscle in a Rabbit Model of Inflammation

Jon M. Goldhill, Terez Shea-Donohue, Nasima Ali and Victor M. Piñeiro-Carrero
Journal of Pharmacology and Experimental Therapeutics September 1, 1997, 282 (3) 1373-1378;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
OtherGASTROINTESTINAL PHARMACOLOGY

Tachykinergic Neurotransmission Is Enhanced in Small Intestinal Circular Muscle in a Rabbit Model of Inflammation

Jon M. Goldhill, Terez Shea-Donohue, Nasima Ali and Victor M. Piñeiro-Carrero
Journal of Pharmacology and Experimental Therapeutics September 1, 1997, 282 (3) 1373-1378;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Inhibitory Effect of Zinc Protoporphyrin IX on Lower Esophageal Sphincter Smooth Muscle Relaxation by Vasoactive Intestinal Polypeptide and Other Receptor Agonists
  • Characterization of the Histamine H2 Receptor Structural Components Involved in Dual Signaling
  • Stabilization of Vasoactive Intestinal Peptide by Lipids
Show more GASTROINTESTINAL PHARMACOLOGY

Similar Articles

  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2021 by the American Society for Pharmacology and Experimental Therapeutics