Journal of Pharmacology and Experimental Therapeutics: 282 (3)

September 01, 1997; Volume 282,Issue 3

ANALGESIA AND DRUGS OF ABUSE

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Antinociceptive Properties of Propofol: Involvement of Spinal Cord γ-Aminobutyric Acid_A Receptors
R. Nadeson and C. S. Goodchild

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1181-1186;
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Evaluation of Gabapentin and S-(+)-3-Isobutylgaba in a Rat Model of Postoperative Pain
Mark J. Field, Elizabeth F. Holloman, Scott McCleary, John Hughes and Lakhbir Singh

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1242-1246;
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Butorphanol-Mediated Antinociception in Mice: Partial Agonist Effects and Mu Receptor Involvement ^,
H. R. Garner, Timothy F. Burke, C. David Lawhorn, Joanne M. Stoner and William D. Wessinger

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1253-1261;
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Chronic Exposure to Morphine Increases Corticosteroid-Binding Globulin
Bruce Nock, Michele Wich and Theodore J. Cicero

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1262-1268;
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Manipulations of Zinc in the Spinal Cord, by Intrathecal Injection of Zinc Chloride, Disodium-Calcium-EDTA, or Dipicolinic Acid, Alter Nociceptive Activity in Mice
Alice A. Larson and Kelley F. Kitto

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1319-1325;
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Mutual Antagonism Between Nerve Growth Factor and Substance P N-terminal Activity on Nociceptive Activity in Mice
Alice A. Larson and Kelley F. Kitto

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1345-1350;
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Prevention of Tolerance to the Antinociceptive Effects of Systemic Morphine by a Selective Cholecystokinin-B Receptor Antagonist in a Rat Model of Peripheral Neuropathy
Juhana J. Idänpään-Heikkilä, Gisèle Guilbaud and Valérie Kayser

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1366-1372;
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Antisense Mapping of the MOR-1 Opioid Receptor Clone: Modulation of Hyperphagia Induced by DAMGO
Liza Leventhal, Lesley B. Stevens, Grace C. Rossi, Gavril W. Pasternak and Richard J. Bodnar

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1402-1407;
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Acute Tolerance To Spinally Administered Morphine Compares Mechanistically with Chronically Induced Morphine Tolerance
Carolyn A. Fairbanks and George L. Wilcox

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1408-1417;

AUTONOMIC PHARMACOLOGY

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Mechanism of Down-regulation of Alpha-2 Adrenergic Receptor Subtypes
Donald A. Heck and David B. Bylund

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1219-1227;
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α-Adrenoceptor-Mediated Prejunctional Effects of Chloroethylclonidine in the Canine Saphenous Vein
Serafim Guimarães, Maria Q. Paiva and Oduvaldo Pereira

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1326-1330;
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Differentiation of Muscarinic Receptors Mediating Negative Chronotropic and Vasoconstrictor Responses to Acetylcholine in Isolated Rat Hearts
Donald B. Hoover and David A. Neely

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1337-1344;
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Biphasic Alterations in Cardiac Beta-Adrenoceptor Signal Transduction Mechanism Due to Oxyradicals
Sujata Persad, Vijayan Elimban, Jasvinder Kaila and Naranjan S. Dhalla

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1623-1631;
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Phosphodiesterase Inhibition Improves Agonist-Induced Relaxation of Hypertensive Pulmonary Arteries
R. S. Wagner, C. J. Smith, A. M. Taylor and R. A. Rhoades

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1650-1657;

BEHAVIORAL PHARMACOLOGY

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Comparing the Subjective, Psychomotor and Physiological Effects of Intravenous Buprenorphine and Morphine in Healthy Volunteers
James P. Zacny, Kim Conley and Jeff Galinkin

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1187-1197;
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Pharmacological Investigation of (+)- and (−)-cis-2,3,3a,4,5,9b-Hexahydro-1-methyl-1H-pyrrolo[3,2-h]isoquinoline, a Bridged-Nicotine Analog
M. I. Damaj, W. Glassco, M. J. Marks, B. Slobe, J. R. James, E. L. May, J. A. Rosecrans, A. C. Collins and B. R. Martin

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1425-1434;
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Selectivity in the Generalization Profile in Baboons Trained to Discriminate Lorazepam: Benzodiazepines, Barbiturates and Other Sedative/Anxiolytics
Nancy A. Ator and Roland R. Griffiths

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1442-1457;
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SR141716A Antagonizes the Disruptive Effects of Cannabinoid Ligands on Learning in Rats
Jesse Brodkin and Joseph M. Moerschbaecher

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1526-1532;

CARDIOVASCULAR PHARMACOLOGY

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The Orally Active ET_A Receptor Antagonist (+)-(S)-2-(4,6-dimethoxy-pyrimidin-2-yloxy)-3-methoxy-3,3-diphenyl-propionic acid (LU 135252) Prevents the Development of Pulmonary Hypertension and Endothelial Metabolic Dysfunction in Monocrotaline-Treated Rats
Stéphane Prié, Tack Ki Leung, Peter Cernacek, James W. Ryan and Jocelyn Dupuis

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1312-1318;
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Role of Nitric Oxide and Ca⁺⁺-Dependent K⁺ Channels in Mediating Heterogeneous Microvascular Responses to Acetylcholine in Different Vascular Beds
Shawn G. Clark and Leslie C. Fuchs

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1473-1479;
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A Comparison Between Chronotropic Effects of Neostigmine and Edrophonium in Isolated Guinea Pig Right Atrium
Masayuki Endou, Yasuto Tanito and Fukuichiro Okumura

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1480-1486;
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Effects of the Glucocorticoid II Receptor Antagonist Mifepristone on Hypertension in the Obese Zucker Rat
John C. Clapham and Nicholas C. Turner

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1503-1508;
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Superoxide Anions Contribute to Impaired Regulation of Blood Pressure by Nitric Oxide During the Development of Cardiomyopathy
Jose A. Gutierrez, Shawn G. Clark, Ararat D. Giulumian and Leslie C. Fuchs

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1643-1649;

CELLULAR AND MOLECULAR PHARMACOLOGY

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Proliferation of Adult Rat Hepatocytes by Hepatocyte Growth Factor Is Potentiated by Both Phenylephrine and Metaproterenol
Mitsutoshi Kimura and Masahiko Ogihara

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1146-1154;
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Effects of the Neuroprotective Agent Riluzole on the High Voltage-Activated Calcium Channels of Rat Dorsal Root Ganglion Neurons
Chao-Sheng Huang, Jin-Ho Song, Keiichi Nagata, Jay Z Yeh and Toshio Narahashi

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1280-1290;
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Changes in Ryanodine-Induced Contractures by Stimulus Frequency in Malignant Hyperthermia Susceptible and Malignant Hyperthermia Nonsusceptible Dog Skeletal Muscle
Roberto T. Sudo and Thomas E. Nelson

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1331-1336;
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Lead Inhibition of N-Methyl-d-aspartate Receptors Containing NR2A, NR2C and NR2D Subunits
Irina A. Omelchenko, Cole S. Nelson and Charles N. Allen

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1458-1464;
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Protein Kinase A Regulates Inhibition of N- and P/Q-type Calcium Channels by Ethanol in PC12 Cells
Michele Solem, Thomas McMahon and Robert O. Messing

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1487-1495;
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The Interactions of Hexachlorocyclohexane Isomers with Human γ-Aminobutyric Acid_A Receptors Expressed inXenopus Oocytes
L. S. Aspinwall, I. Bermudez, L. A. King and K. A. Wafford

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1557-1564;

CHEMOTHERAPY/GENE THERAPY

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Folate Depletion Induced by Methotrexate Affects Methionine Synthase Activity and Its Susceptibility to Inactivation by Nitrous Oxide
Torunn Fiskerstrand, Per Magne Uel and and Helga Refsum

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1305-1311;
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Interactions with Human Blood in Vitro and Pharmacokinetic Properties in Mice of Liposomal N⁴-Octadecyl-1-β-d-arabinofuranosylcytosine, A New Anticancer Drug
Sibylle K. M. Koller-Lucae, Herbert Schott and Reto A. Schwendener

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1572-1580;

DRUG METABOLISM AND DISPOSITION

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Tissue and Perfusate Pharmacokinetics of Melphalan in Isolated Perfused Rat Hindlimb
Zhen-Yu Wu, B. Mark Smithers and Michael S. Roberts

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1131-1138;
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Phase I Safety and Pharmacokinetic Profile of an Intercellular Adhesion Molecule-1 Antisense Oligodeoxynucleotide (ISIS 2302)
Josephine M. Glover, Janet M. Leeds, Timothy G. K. Mant, Dipti Amin, Daniel L. Kisner, Joan E. Zuckerman, Richard S. Geary, Arthur A. Levin and William R. Shanahan

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1173-1180;
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N-Oxygenation of Phenethylamine to the trans-Oxime by Adult Human Liver Flavin-Containing Monooxygenase and Retroreduction of Phenethylamine Hydroxylamine by Human Liver Microsomes
Jing Lin and John R. Cashman

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1269-1279;
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Human Liver CYP2B6-Catalyzed Hydroxylation of RP 73401
Jeffrey C. Stevens, Rebecca B. White, Shih Hsein Hsu and Michel Martinet

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1389-1395;
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Metabolite Involvement in Bromocriptine-Induced Prolactin Inhibition in Rats
Delphine Valente, Marcel Delaforge, Saik Urien, Dominique Guivarc’H, Raymond Vienet, Jean-Marc Grognet and Eric Ezan

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1418-1424;
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Selective Deficiency of Debrisoquine 4-Hydroxylase Activity in Mouse Liver Microsomes
Yasuhiro Masubuchi, Takashi Iwasa, Shin Hosokawa, Tokuji Suzuki, Toshiharu Horie, Susumu Imaoka, Yoshihiko Funae and Shizuo Narimatsu

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1435-1441;
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Involvement of Human CYP1A Isoenzymes in the Metabolism and Drug Interactions of Riluzole In Vitro
Ger-Jan Sanderink, Bruno Bournique, Jeffrey Stevens, Martine Petry and Michel Martinet

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1465-1472;
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Distributed Model Analysis of 3′-Azido-3′-Deoxythymidine and 2′,3′-Dideoxyinosine Distribution in Brain Tissue and Cerebrospinal Fluid
Katsuko Takasawa, Tetsuya Terasaki, Hiroshi Suzuki, Tsuyoshi Ooie and Yuichi Sugiyama

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1509-1517;
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Receptor Mediated Delivery of Daunomycin Using Immunoliposomes: Pharmacokinetics and Tissue Distribution in the Rat
Jörg Huwyler, Jing Yang and William M. Pardridge

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1541-1546;
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A Major Role for CYP2A6 in Nicotine C-Oxidation by Human Liver Microsomes
E. S. Messina, R. F. Tyndale and E. M. Sellers

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1608-1614;

ENDOCRINE PHARMACOLOGY

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Mechanisms of Bradykinin-Induced Insulin Secretion in Clonalbeta Cell Line RINm5F
Chi Yang, Bumsup Lee, Ter-Hsin Chen and Walter H. Hsu

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1247-1252;
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Unique Preclinical Characteristics of GG745, A Potent Dual Inhibitor of 5AR
H. Neal Bramson, David Hermann, Kenneth W. Batchelor, Frank W. Lee, Michael K. James and Stephen V. Frye

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1496-1502;

GASTROINTESTINAL PHARMACOLOGY

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Intestinal Effects of Isoprostanes: Evidence for the Involvement of Prostanoid EP and TP Receptors
J. L. Elmhurst, P.-A. Betti and P. K. Rangachari

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1198-1205;
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Differences in Partial Agonist Action at Cholecystokinin Receptors of Mouse and Rat Are Dependent on Parameters Extrinsic to Receptor Structure: Molecular Cloning, Expression and Functional Characterization of the Mouse Type A Cholecystokinin Receptor
D. Ghanekar, E. M. Hadac, E. L. Holicky and L. J. Miller

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1206-1212;
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Gastric Hyperemic Response During Vagally Mediated Acid Secretion by TRH Analog in Rats
Shinichi Kato, Takuya Hirata, Motohiro Kitamura and Koji Takeuchi

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1351-1357;
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Tachykinergic Neurotransmission Is Enhanced in Small Intestinal Circular Muscle in a Rabbit Model of Inflammation
Jon M. Goldhill, Terez Shea-Donohue, Nasima Ali and Victor M. Piñeiro-Carrero

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1373-1378;
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The Putative Phospholipase C Inhibitor U73122 and Its Negative Control, U73343, Elicit Unexpected Effects on the Rabbit Parietal Cell
Yuko Muto, Taku Nagao and Tetsuro Urushidani

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1379-1388;
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Proteasome Inhibition Attenuates Nitric Oxide Synthase Expression, VCAM-1 Transcription and the Development of Chronic Colitis
Elaine M. Conner, Stephen Brand, Jonathan M. Davis, F. Stephen Laroux, Vito J. Palombella, John W. Fuseler, David Y. Kang, Robert E. Wolf and Matthew B. Grisham

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1615-1622;

IMMUNOPHARMACOLOGY

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BMS-190394, a Selectin Inhibitor, Prevents Rat Cutaneous Inflammatory Reactions
Gordon Todderud, Xina Nair, Debbie Lee, Julie Alford, Lynda Davern, Paul Stanley, Carol Bachand, Philippe Lapointe, Anne Marinier, Alain Martel, Marcel Menard, John J. Wright, Jurgen Bajorath, Diane Hollenbaugh, Alejandro Aruffo and Kenneth M. Tramposch

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1298-1304;

NEUROPHARMACOLOGY

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Acetylcholine Release and Choline Availability in Rat Hippocampus: Effects of Exogenous Choline and Nicotinamide
Andrea Köppen, Jochen Klein, Christina Erb and Konrad Löffelholz

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1139-1145;
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Time Course of α-Fluorinated Valproic Acid in Mouse Brain and Serum and its Effect on Synaptosomal γ-Aminobutyric Acid Levels in Comparison to Valproic Acid
Wei Tang, Jan Palaty and Frank S. Abbott

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1163-1172;
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Allopregnanolone Affects Sleep in a Benzodiazepine-Like Fashion
Marike Lancel, Johannes Faulhaber, Thomas Schiffelholz, Elena Romeo, Flavia Di Michele, Florian Holsboer and Rainer Rupprecht

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1213-1218;
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In Vitro Characterization of Cocaine Binding Sites in Human Hair
Robert E. Joseph, Wei-Jen Tsai, Li-I Tsao, Tsung-Ping Su and Edward J. Cone

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1228-1241;
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³H-Morphine-6β-Glucuronide Binding in Brain Membranes and an MOR-1-Transfected Cell Line
George P. Brown, Ke Yang, Ouathek Ouerfelli, Kelly M. Standifer, David Byrd and Gavril W. Pasternak

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1291-1297;
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Activation of Protein Kinase C Inhibits Uptake, Currents and Binding Associated with the Human Dopamine Transporter Expressed inXenopus Oocytes
Si-Jia Zhu, Michael P. Kavanaugh, Mark S. Sonders, Susan G. Amara and Nancy R. Zahniser

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1358-1365;
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Dose Response to Intraventricular Glial Cell Line-Derived Neurotrophic Factor Administration in Parkinsonian Monkeys
Zhiming Zhang, Yasuyuki Miyoshi, Paul A. Lapchak, Frank Collins, Dana Hilt, Carl Lebel, Richard Kryscio and Don M. Gash

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1396-1401;
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Substance P Receptors in Brain Stem Respiratory Centers of the Rat: Regulation of NK1 Receptors by Hypoxia
Stuart B. Mazzone, Colin F. Hinrichsen and Dominic P. Geraghty

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1547-1556;
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A Desensitization of Hypothalamic 5-HT_1A Receptors by Repeated Injections of Paroxetine: Reduction in the Levels of G_i and G_o Proteins and Neuroendocrine Responses, but Not in the Density of 5-HT_1AReceptors
Q. Li, N. A. Muma, G. Battaglia and L. D. Van De Kar

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1581-1590;
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Nitric Oxide- and Superoxide-Mediated Toxicity in Cerebral Endothelial Cells
Glenn T. Gobbel, Thelma Y.-Y. Chan and Pak H. Chan

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1600-1607;
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Regional Differences in Cannabinoid Receptor/G-protein Coupling in Rat Brain
Christopher S. Breivogel, Laura J. Sim and Steven R. Childers

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1632-1642;

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

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Generation of the Isoprostane 8-Epi-prostaglandin F_2α In Vitro and In Vivo via the Cyclooxygenases
Thomas Klein, Felix Reutter, Horst Schweer, Hannsjörg W. Seyberth and Rolf M. Nüsing

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1658-1665;

PULMONARY PHARMACOLOGY

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The Effect of Rolipram, a Type IV Phosphodiesterase Inhibitor, onPseudomonas aeruginosa Infection of Respiratory Mucosa
R. B. Dowling, M. Johnson, P. J. Cole and R. Wilson

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1565-1571;

RENAL PHARMACOLOGY

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Influence of Renal Nerves and Sodium Balance on the Acute Antidiuretic Effect of Bendroflumethiazide in Rats with Diabetes Insipidus
Jesper Spannow, Klaus Thomsen, Jørgen Søberg Petersen, Ketil Haugan and Sten Christensen

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1155-1162;
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Disposition of Morphine in the Rat Isolated Perfused Kidney: Concentration Ranging Studies
Kathryn M. Shanahan, Allan M. Evans and Roger L. Nation

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1518-1525;

TOXICOLOGY

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Differential Heat Shock Protein Induction by Acetaminophen and a Nonhepatotoxic Regioisomer, 3′-Hydroxyacetanilide, in Mouse Liver
William F. Salminen, Richard Voellmy and Stephen M. Roberts

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1533-1540;
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Development and Characterization of a New Model of Tacrine-Induced Hepatotoxicity: Role of the Sympathetic Nervous System and Hypoxia-Reoxygenation
Robert F. Stachlewitz, Gavin E. Arteel, James A. Raleigh, Henry D. Connor, Ronald P. Mason and Ronald G. Thurman

Journal of Pharmacology and Experimental Therapeutics September 1997, 282 (3) 1591-1599;

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Table of Contents

ANALGESIA AND DRUGS OF ABUSE

AUTONOMIC PHARMACOLOGY

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR PHARMACOLOGY

CELLULAR AND MOLECULAR PHARMACOLOGY

CHEMOTHERAPY/GENE THERAPY

DRUG METABOLISM AND DISPOSITION

ENDOCRINE PHARMACOLOGY

GASTROINTESTINAL PHARMACOLOGY

IMMUNOPHARMACOLOGY

NEUROPHARMACOLOGY

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

PULMONARY PHARMACOLOGY

RENAL PHARMACOLOGY

TOXICOLOGY

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